IMGT engineered variant nomenclature: IGHG variants

Amino acid positions involved in ADCC, CDC, half life and half-IG exchange

Species IMGT gene name IMGT engineered variant nomenclature IGHG gene variant description Property modifications
IMGT IGHG gene variant number hinge (h) or CH2 AA and IMGT position in h or CH2 of IGHG gene variant CH3 AA and IMGT position in CH3 of IGHG gene variant ADCC enhancement or reduction, ADCP enhancement, B cell inhibition CDC enhancement or reduction Half-IG exchange reduction, Half-life increase, Knobs-into-holes
Homo sapiens IGHG1 Homsap IGHG1v1 CH2 P1.4 v1 CH2 P1.4 ADCC reduction
Homsap IGHG1v2 CH2 V1.3 v2 CH2 V1.3 ADCC reduction
Homsap IGHG1v3 CH2 A1.2 v3 CH2 A1.2 ADCC reduction
Homsap IGHG1v4 CH2 A114 v4 CH2 A114 ADCC reduction CDC reduction
Homsap IGHG1v5 CH2 W109 v5 CH2 W109 ADCC reduction CDC enhancement
Homsap IGHG1v6 CH2 A85.4, A118, A119 v6 CH2 A85.4, A118, A119 ADCC enhancement
Homsap IGHG1v7 CH2 D3, E117 v7 CH2 D3, E117 ADCC enhancement
Homsap IGHG1v8 CH2 D3, L115, E117 v8 CH2 D3, L115, E117 ADCC enhancement CDC reduction
Homsap IGHG1v9 CH2 L7, P83, L85.2, I88; CH3 L83 v9 CH2 L7, P83, L85.2, I88 CH3 L83 ADCC enhancement
Homsap IGHG1v10 CH2 Y1.3, Q1.2, W1.1, M3, D30, E34, A85.4 v10 CH2 Y1.3, Q1.2, W1.1, M3, D30, E34, A85.4 ADCC enhancement
Homsap IGHG1v11 CH2 E34, D109, M115, E119 v11 CH2 E34, D109, M115, E119 ADCC enhancement
Homsap IGHG1v12 CH2 A1.1, D3, L115, E117 v12 CH2 A1.1, D3, L115, E117 ADCC enhancement
Homsap IGHG1v13 CH2 A1.1, D3, E117 v13 CH2 A1.1, D3, E117 ADCP enhancement
Homsap IGHG1v14 CH2 A1.3, A1.2 v14 CH2 A1.3, A1.2 ADCC reduction CDC reduction
Homsap IGHG1v15 CH2 S118 v15 CH2 S118 CDC enhancement
Homsap IGHG1v16 CH2 W109, S118 v16 CH2 W109, S118 CDC enhancement
Homsap IGHG1v17 CH2 E29, F30, T107 v17 CH2 E29, F30, T107 CDC enhancement
Homsap IGHG1v18 CH3 R1, G109, Y120 v18 CH3 R1, G109, Y120 CDC enhancement
Homsap IGHG1v19 CH2 A34 v19 CH2 A34 CDC reduction
Homsap IGHG1v20 CH2 A105 v20 CH2 A105 CDC reduction
Homsap IGHG1v21 CH2 Y15.1, E18 v21 CH2 Y15.1, E18 Half-life increase
Homsap IGHG1v22 CH2 Y15.1, T16, E18; CH3 K113, F114 v22 CH2 Y15.1, T16, E18 CH3 K113, F114 Half-life increase
Homsap IGHG1v23 CH2 E1.2 v23 CH2 E1.2 ADCC reduction CDC reduction
Homsap IGHG1v24 CH3 L107, S114 v24 CH3 L107, S114 Half-life increase
Homsap IGHG1v25 CH2 E29, F113 v25 CH2 E29, F113 B cell inhibition
Homsap IGHG1v26 CH3 Y22, T86 v26 CH3 Y22, T86 Knobs-into-holes
IGHG2
Homsap IGHG2v1 CH2 L1.3, L1.2, G1.1, G1 v1 CH2 L1.3, L1.2, G1.1, G1 ADCC enhancement
Homsap IGHG2v2 CH2 Q30, L92, S115, S116 v2 CH2 Q30, L92, S115, S116 ADCC reduction CDC reduction
Homsap IGHG2v3 CH2 A1.3, A1, S2, A30, L92, S115, S116 v3 CH2 A1.3, A1, S2, A30, L92, S115, S116 ADCC reduction CDC reduction
Homsap IGHG2v4 CH2 Q14 v4 CH2 Q14 Half-life increase
Homsap IGHG2v5 CH3 L107 v5 CH3 L107 Half-life increase
IGHG3 Homsap IGHG3v1 CH3 H115 v1 CH3 H115 Half-life increase
IGHG4
Homsap IGHG4v1 CH2 L1.3 v1 CH2 L1.3 ADCC enhancement
Homsap IGHG4v2 CH2 P116 v2 CH2 P116 CDC enhancement
Homsap IGHG4v3 CH2 E1.2 v3 CH2 E1.2 ADCC reduction CDC reduction
Homsap IGHG4v4 CH2 A1.3, A1.2 v4 CH2 A1.3, A1.2 ADCC reduction CDC reduction
Homsap IGHG4v5 h P10 v5 h P10 Half-IG exchange reduction
Homsap IGHG4v6 CH3 K88 v6 CH3 K88 Half-IG exchange reduction
Homsap IGHG4v21 CH2 Y15.1, E18 v21 CH2 Y15.1, E18 Half-life increase
Mus musculus IGHG2B
Musmus IGHG2Bv1 CH2 L1.2 v1 CH2 L1.2 ADCC enhancement
Musmus IGHG2Bv2 CH2 A101 v2 CH2 A101 CDC reduction
Musmus IGHG2Bv3 CH2 A103 v3 CH2 A103 CDC reduction
Musmus IGHG2Bv4 CH2 A105 v4 CH2 A105 CDC reduction

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