DAP10 (also called KAP10) is transmembrane adapter protein. Like CD3z, the Fc common γ-chain (FcRγ) and DAP12, DAP10 associates with membrane receptors and provides activating signals to the interior of the cell.
DAP10 is very closely linked to DAP12 and in inverted orientations on human chromosome 19q13.1 and on mouse chr 7.
Unlike CD3ζ, FcRγ and DAP12, which utilize classical ITAMs to transmit signals to the cell, DAP10 possesses a YINM motif in the cytoplasmic region. Following phosphorylation of the tyrosine residue of this motif, DAP10 can associate with PI-3 kinase (PI-3K) and Grb-2. It is also a potential binding site for the adapter molecule Shc.
In both humans and mice, DAP10 associates with NKG2D. The NKG2D/DAP10 complex is a potent activator of both NK cells and T cells.