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ROG is a member of the POZ family. A majority of the POZ members contain a BTB (broad complex, tramtrack, and bric-à-brac) domain in the N-terminus, and a zinc finger domain in the C-terminus. The BTB domain is a protein-protein interaction domain.

The expression of ROG is induced rapidly in T cells by stimulation via the TcR.

Repressor of the GATA-3

ROG represses the function of GATA-3 in part by preventing the binding of GATA-3 to its DNA target sequence.