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How to make 108 different T cell receptor beta chains?

ANSWER to question 4:

From the TRB genes to the T cell receptor beta chains?

The TRB V-D-J rearrangements (D-J then V to D-J rearrangements) in the T cells create a combinatorial diversity of 960-1248 recombinations. One important additional mechanism contributes to the T cell receptor beta diversity: the N diversity (N, for nucleotides) which results from deletion and/or addition of nucleotides at random by the terminal deoxynucleotidyltransferase and creates, at the V-D-J JUNCTION, two regions not encoded in the germline DNA. In contrast to the immunoglobulin loci, there is no mechanism of somatic mutations in the T cell receptor loci.

Created: 11/06/2001
Last updated: Wednesday, 29-Jun-2011 17:01:45 CEST
Author: Marie-Paule Lefranc
Editor: Elodie Foulquier