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QUESTION 5:

What is the structure of an alpha-beta T cell receptor?


ANSWER to question 5:

There are two types of T cell receptors: the alpha-beta T cell receptors, and the gamma-delta T cell receptors which are expressed at the surface of different T cells.
An alpha-beta T cell receptor is made of two glycosylated transmembrane chains, the alpha chain (43-49 kDa) and the beta chain (38-44 kDa).
The variable domain (V-D-J-REGION) of the T cell receptor beta chain is encoded by the rearrangement of 3 genes: 1 TRBV, 1TRBD and 1 TRBJ. The constant domain (C-REGION) is encoded by one of the two TRBC genes.


Created: 11/06/2001
Last updated: Wednesday, 29-Jun-2011 17:01:45 CEST
Author: Marie-Paule Lefranc Marie-Paule.Lefranc@igh.cnrs.fr
Editor: Elodie Foulquier