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QUESTION 5:

What is the structure of a gamma-delta T cell receptor?


ANSWER to question 5:

There are two types of T cell receptors: the alpha-beta T cell receptors, and the gamma-delta T cell receptors which are expressed at the surface of different T cells.
A gamma-delta T cell receptor is made of two glycosylated transmembrane chains, the gamma chain (40-55 kDa) and the delta chain (40-50 kDa).
The variable domain (V-J-REGION) of the T cell receptor gamma chain is encoded by the rearrangement of 2 genes: 1 TRGV and 1 TRGJ. The constant domain (C-REGION) is encoded by one of the two TRGC genes.
The gamma1 chain is disulphide-linked whereas the gamma2 chain is non dilsulphide-linked.


Created: 11/06/2001
Last updated: Wednesday, 29-Jun-2011 17:01:43 CEST
Author: Marie-Paule Lefranc Marie-Paule.Lefranc@igh.cnrs.fr
Editor: Elodie Foulquier