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Strand representation of two associated V-DOMAINs
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3D representation: Mouse (Mus musculus) two associated V-DOMAINs from D1.3Fv
VH, V-BETA or V-DELTA
IGH, TRB or TRD
the 2 V-DOMAINs
V-KAPPA, V-LAMBDA, V-ALPHA, or V-GAMMA
IGK, IGL, TRA or TRG
- Arrows indicate the direction of the beta strands of the FR-IMGT.
A to G refer to the strand designation in 3D structures.
||Length in amino acids
|FR1-IMGT||1 to 26 (with 1st-CYS 23)
||strand A (15)and strand B (11)|
|FR2-IMGT||39 to 55 (with CONSERVED-TRP 41)
||strand C (8) and strand C'(9)|
|FR3-IMGT||66 to 104 (with 2nd-CYS 104)
||strand C'' (9) and strand D (10)||strand E (12) and strand F (8)
|FR4-IMGT||from 118 (J-TRP or J-PHE 118) to|
the terminal end of J-REGION
(1) Between parentheses the number of amino acids per strand. Amino acids of the AB and CC' beta turns
and those of the DE and EF loops are included in the adjacent strands. See Alignments of alleles
of the J-REGIONs for the length of strand G.
The maximum length of the CDR1-IMGT (BC loop) is 12 amino acids (positions 27 to 38).
The maximum length of the CDR2-IMGT (C'C'' loop) is 10 amino acids (positions 56 to 65).
The V-DOMAIN CDR3-IMGT (FG loop) length may vary from 2 to 30 or more. However,
80% of the IMGT/LIGM-DB immunoglobulin and T cell receptor rearranged sequences have a CDR3-IMGT less than or equal to 13 amino acids.
(Manuel Ruiz and Marie-Paule Lefranc, April 2001)
- Strands facing the inside of the V-DOMAINs are shown in hatching.
- Positions of the 1st-CYS (C23), 2nd-CYS (C104), CONSERVED-TRP (W41), J-TRP or J-PHE (118) are indicated.
Definition of the FR-IMGT and CDR-IMGT regions in IMGT Scientific Chart.
Last updated: Monday, 20-Jan-2020 21:00:14 CET
Author: Marie-Paule Lefranc Marie-Paule.Lefranc@igh.cnrs.fr
Editor: Elodie Foulquier