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Different levels of structural organization of an immunoglobulin or of a T cell receptor

The three dimensional (3D) structure of an immunoglobulin (made of two identical heavy chains and two identical light chains) or that of a T cell receptor (heterodimer) is determined as for any other protein, by the amino acid sequences of the polypetides chains and can be described in terms of different levels of folding, each of which is constructed from the preceding one in hierarchical fashion.

See also:
IMGT Index:

  • Colliers de Perles
  • Domain
  • Structure (2D, 3D)

  • IMGT Repertoire:
  • Collier de Perles: Mouse (Mus musculus) IGH V-D-J REGION from 231 (PDB: 1igt_D)

  • IMGT Education:
  • Molecular genetics of immunoglobulins (Figure 1)
  • 3D structure of an IgG immunoglobulin and its organization in domains (8 figures)
  • Strand representation of V-DOMAIN and C-DOMAIN (6 figures)
  • 3D backbone representation of V-DOMAIN and C-DOMAIN (figures and Colliers de Perles)

  • Created: 26/06/2002
    Last updated: Thursday, 26-May-2016 21:00:58 CEST
    Author: Marie-Paule Lefranc Marie-Paule.Lefranc@igh.cnrs.fr
    Editors: Amina Mrani and Chantal Ginestoux

    Software material and data coming from IMGT server may be used for academic research only, provided that it is referred to IMGT®, and cited as "IMGT®, the international ImMunoGeneTics information system® http://www.imgt.org (founder and director: Marie-Paule Lefranc, Montpellier, France)." References to cite: Lefranc, M.-P. et al., Nucleic Acids Res., 27:209-212 (1999); doi: 10.1093/nar/27.1.209 Full text Cover; Ruiz, M. et al., Nucleic Acids Res., 28:219-221 (2000); doi: 10.1093/nar/28.1.219 Full text; Lefranc, M.-P., Nucleic Acids Res., 29:207-209 (2001); doi: 10.1093/nar/29.1.207 Full text; Lefranc, M.-P., Nucleic Acids Res., 31:307-310 (2003); doi: 10.1093/nar/gkg085 Full text; Lefranc, M.-P. et al., In Silico Biol., 5, 0006 (2004) [Epub], 5:45-60 (2005); Lefranc, M.-P. et al., Nucleic Acids Res., 33:D593-597 (2005); doi: 10.1093/nar/gki065 Full text; Lefranc, M.-P. et al., Nucleic Acids Res., 37:D1006-1012 (2009); doi: 10.1093/nar/gkn838 Full text; Lefranc, M.-P. et al., Nucleic Acids Res., 43:D413-422 (2015); doi: 10.1093/nar/gku1056 Full text.
    For any other use please contact Marie-Paule Lefranc Marie-Paule.Lefranc@igh.cnrs.fr.

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