Chemical characteristics classes (IMGT amino acid)
IMGT has defined eleven IMGT amino acid chemical characteristics classes .
IMGT standardized criteria for statistical analysis, based on the definition of eleven IMGT amino acid chemical characteristics classes, have provided IMGT Colliers de Perles statistical profiles for the human expressed IGHV and IGKV repertoires .
Amino acids of a given IMGT Colliers de Perles, assigned to IMGT amino acid chemical classes, can be compared to the FR-IMGT positions which define the human IGHV and IGKV chemical profiles (41 and 59 positions at >80% threshold, respectively, Plate 3 in ). Such a comparison of domain sequences with the IMGT Colliers de Perles statistical profiles may be useful to identify potential immunogenic residues at given positions.
Reference, Citing IMGT amino acid chemical characteristics classes:
 Giudicelli, V. and Lefranc, M.-P., Bioinformatics, 15, 1047-1054 (1999) Pommié, C. et al., J. Mol. Recognit., 17, 17-32 (2004) PMID: 14872534, LIGM:284