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Clan

Citing this page:
Elemento, O. and Lefranc, M.-P. "IMGT/PhyloGene: an online software package for phylogenetic analysis of immunoglobulin and T cell receptor genes", Dev. Comp. Immunol., 27, 763-779 (2003) PMID: 12818634
Lefranc, M.-P. and Lefranc, G. "The Immunoglobulin FactsBook" Academic Press, London, UK (458 pages) (2001) ISBN: 012441351X

Definition

A clan is a set of subgroups, eventually from different species, which appear related on phylogenetic trees (IGHV, IGKV, IGLV clans).
The 'clan' concept is part of the 'CLASSIFICATION' concept of IMGT-ONTOLOGY [10].

IMGT clans correspond to the categorization of variable gene subgroups based on nucleotide sequences similarity of the FR-IMGT [1].

IMGT/PhyloGene allows to perform directly clan analysis for the human and mouse genes [2] or for any variable nucleotide region provided with gaps according to the IMGT unique numbering.

IMGT/PhyloGene analysis does not include pseudogenes for which FR-IMGT and CDR-IMGT delimitations are not defined.

IGHV clans

IGHV clans, first defined for human IGHV genes [3], comprise the following human [1,4,5] and mouse IGHV subgroup genes:

IGKV clans

IGKV clans comprise the following human [1,5,6] and mouse [7] IGKV subgroup genes:

IGLV clans

IGLV clans comprise the following human [1,5,8,9] and mouse [9] subgroup genes:

More information:
IGHV clans for Homo sapiens and Mus musculus
IGKV clans for Homo sapiens and Mus musculus
IGLV clans for Homo sapiens and Mus musculus

References:
[1] Lefranc, M.-P. and Lefranc, G., "
The Immunoglobulin FactsBook", Academic Press, London, UK (458 pages) (2001) ISBN: 012441351X
[2] Elemento, O. and Lefranc, M.-P., Dev. Comp. Immunol., 27, 763-779 (2003) PMID: 12818634 LIGM:273
[3] Kirkham, P.M. et al., EMBO J., 11, 603-609 (1992). PMID: 1537339
[4] Lefranc, M.-P., Exp. Clin. Immunogenet., 18, 100-116 (2001) PMID: 11340299 LIGM:246 pdf
[5] Scaviner, D. et al., Exp. Clin. Immunogenet., 16, 234-240 (1999) PMID: 10575277 LIGM:218 pdf
[6] Lefranc, M.-P., Exp. Clin. Immunogenet., 18, 161-174 (2001) PMID: 11549845 LIGM:251 pdf
[7] Martinez-Jean, C. et al., Exp. Clin. Immunogenet., 18, 255-279 (2001) PMID: 11872956 LIGM:256 pdf
[8] Lefranc, M.-P., Exp. Clin. Immunogenet., 18, 242-254 (2001) PMID: 11872955 LIGM:254 pdf
[9] Lefranc, M.-P. and Lefranc, G., "Immunoglobulin lambda (IGL) genes of human and mouse", In: Molecular Biology of B cells (Honjo T., Alt, F. W. and Neuberger, M. S. eds), Academic Press, Elsevier Science, pp. 37-59 (2004) ISBN: 0120536412
[10] Giudicelli, V. and Lefranc, M.-P., Bioinformatics, 15, 1047-1054 (1999) PMID: 10745995 LIGM:221 pdf