Marie-Paule Lefranc (Marie-Paule.Lefranc@igh.cnrs.fr)
Senior Member of the Institut Universitaire de France;
Professor Emeritus University of Montpellier
IMGT® Founder and Director Emeritus
Head Emeritus of the Laboratoire d'ImmunoGénétique Moléculaire, LIGM IMGT, LIGM IGH, UMR 9002 CNRS-UM, Montpellier, France
The IMGT Nomenclature Committee (IMGT-NC) created in 1989 by Marie-Paule Lefranc at the Tenth International Human
Gene Mapping (HGM10) Workshop (June 10-17, 1989, New Haven, Connecticut, USA) is the IMGT Standing Committee in
charge of the standardized classification and nomenclature of the immunoglobulins (IG),
T cell receptors (TR) and of the Major Histocompatibility (MH) of human and other vertebrate species.
The IMGT Nomenclature Committee (IMGT-NC) is responsible of the coherence of the
IG, TR and MH gene and allele nomenclature, as well as that of the related proteins,
with the concepts of IDENTIFICATION, DESCRIPTION and NUMEROTATION of IMGT-ONTOLOGY
in IMGT®, the international ImMunoGeneTics information system® www.imgt.org.
The submission of new alleles of V genes requires:
a genomic germline sequence (germline gDNA)
a complete sequence from the atg (INIT-CODON)of L-PART1 to the V-RS included
a mapped sequence (cloned from BAC, cosmid, phage).
Sequences from NGS are accepted only for known alleles if they complete the germline genomic sequence in 5' or in 3' (a few alleles
may have incomplete sequences in 5' or 3' if they were retrieved from the literature before IMGT/GENE-DB was established).
Although new potential V alleles may be identified from NGS from blood sample DNA amplification, they are not considered by
the IMGT nomenclature committee (IMGT-NC) because the sequences are not mapped. If a new V allele is suspected by NGS, its
sequence needs to be confirmed from a direct
Sanger sequencing from the germline gDNA from the individual, or identified in an existing mapped BAC, cosmid or phage of
the alternative genomes on the genome browsers, for submission to IMGT-NC.
 Lefranc, M.-P., Nucleic Acids Res., 31,
307-310 (2003)Full text
 Giudicelli, V. and Lefranc, M.-P., Bioinformatics, 15, 1047-1054 (1999)
 Wain, H.M. et al., Genomics, 79, 464-470 (2002)
 Lefranc, M.-P. and Lefranc, G., The Immunoglobulin FactsBook, Academic Press, 458 pages (2001)
 Lefranc, M.-P. and Lefranc, G., The T cell receptor FactsBook, Academic Press, 398 pages (2001)
 WHO-IUIS Nomenclature Subcommittee for immunoglobulins and T cell receptors report - Aug. 2007,
Dev. Comp. Immunol., 2007 Nov 6 (2007)
 WHO-IUIS Nomenclature Subcommittee for immunoglobulins and T cell receptors report - Nov. 2007,
Immunogenetics, 59, 899-902 (2007)
 Giudicelli, V. and Lefranc, M.-P. Ontology for Immunogenetics: IMGT-ONTOLOGY. Bioinformatics,
15, 1047-1054 (1999) PMID: 10745995, LIGM:221
 Giudicelli, V. and Lefranc, M.-P., IMGT-ONTOLOGY 2012. Online access Front Genet. 3:79.
doi: 10.3389/fgene.2012.00079. Epub 2012 May 23 (2012) PMID:22654892
 Lefranc M-P. Immunoglobulin (IG) and T cell receptor genes (TR): IMGT® and the birth and rise of immunoinformatics. Front Immunol. 2014 Feb 05;5:22. doi: 10.3389/fimmu.2014.00022.
Open access. PMID: 24600447