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IMGT Nomenclature Committee (IMGT-NC)


Contact us

Chairperson

Sofia Kossida (sofia.kossida@igh.cnrs.fr)
IMGT® Director
Professor University of Montpellier (UM)
IMGT, IGH UMR 9002 CNRS-UM, Montpellier, France

Marie-Paule Lefranc (Marie-Paule Lefranc Curriculum Vitae)
IMGT® Founder
Senior Member of the Institut Universitaire de France;
Chair IUIS NOM 'IG, TR and MH' Nomenclature Sub-Committee (IMGT-NC)
IMGT, IGH UMR 9002 CNRS-UM, Montpellier, France

Assessors

IMGT® Biocuration managers, Géraldine Folch and Joumana Jabado-Michaloud
External IMGT® experts
IMGT® Bioinformatics manager, Véronique Giudicelli
IMGT® Informatics manager, Patrice Duroux

Objectives

The IMGT Nomenclature Committee (IMGT-NC) created in 1989 by Marie-Paule Lefranc at the Tenth International Human Gene Mapping (HGM10) Workshop (June 10-17, 1989, New Haven, Connecticut, USA) is the IMGT Standing Committee in charge of the standardized classification and nomenclature of the immunoglobulins (IG), T cell receptors (TR) and of the Major Histocompatibility (MH) of human and other vertebrate species.[1]

In 1992, the IMGT Nomenclature Committee (IMGT-NC) became the first IUIS Nomenclature Sub-Committee for the antigen receptors of the adaptive immune responses, immunoglobulins (IG) or antibodies and T cell receptors (TR), chaired by Marie-Paule Lefranc. In its interface with the other IUIS Nomenclature Sub-Committees, the IMGT Nomenclature Standing Committee is designated as 'IUIS Immunoglobulins (IG), T cell Receptors (TR) and Major Histocompatibility (MH) Nomenclature Sub-Committee (IMGT-NC)'.

Rules for the nomenclature are described in the IMGT Scientific chart and are based on the concept of CLASSIFICATION of IMGT-ONTOLOGY [2,6-10]. WHO-IUIS Nomenclature Subcommittee for immunoglobulins and T cell receptors report - Aug. 2007 [6,7] pdf

IMGT gene name nomenclature for IG and TR of human and other vertebrates (IMGT Scientific chart)

IMGT allele nomenclature for sequence polymorphisms (IMGT Scientific chart)

Immunoglobulin (IG) and T cell receptor genes (TR): IMGT® and the birth and rise of immunoinformatics [10]

The IMGT Nomenclature Committee (IMGT-NC) is responsible of the coherence of the IG, TR and MH gene and allele nomenclature, as well as that of the related proteins, with the concepts of IDENTIFICATION, DESCRIPTION and NUMEROTATION of IMGT-ONTOLOGY in IMGT®, the international ImMunoGeneTics information system® www.imgt.org [1].

IMGT-NC works in close collaboration with :

Submission of new V genes and alleles to IMGT-NC

The submission of new V genes and alleles requires:

Sequences from NGS are accepted only for known alleles if they complete the germline genomic sequence in 5' or in 3' (a few alleles may have incomplete sequences in 5' or 3' if they were retrieved from the literature before IMGT/GENE-DB was established).

Although new potential V alleles may be identified from NGS from blood sample DNA amplification, they are not considered by the IMGT nomenclature committee (IMGT-NC) because the sequences are not mapped. If a new V allele is suspected by NGS, its sequence needs to be confirmed from a direct Sanger sequencing from the germline gDNA from the individual, or identified in an existing mapped BAC, cosmid or phage of the alternative genomes on the genome browsers, for direct submission to IMGT-NC. Alternatively, if a new V allele is suspected by NGS, its sequence can be submitted to IMGT-NC via the working group (WG) inferred allele review committee (IARC), within the adaptive immune receptor repertoire (AIRR) community. The WG analyses if the criteria for defining inferred alleles from NGS are fulfilled. The WG also insures that IMGT data quality requirements are met, so inferred alleles can be submitted to IMGT-NC. The procedure includes a submission of inferred alleles validated by the WG to a generalist database, before submission to IMGT-NC.

Submission of new D genes and alleles to IMGT-NC

The submission of new D genes and alleles requires:

Submission of new J genes and alleles to IMGT-NC

The submission of new J genes and alleles requires:

Submission of new C genes and alleles to IMGT-NC

The submission of new C genes and alleles requires:

IMGT-NC reports

IMGT-NC reports are IMGT gene and allele approval reports for individual external submissions to IMGT-NC

Gene positions in IMGT-NC reports are those provided at the time of submission. Updated positions are available, after IMGT biocuration and annotation, in IMGT/LIGM-DB Locus reference accession number and in IMGT/GENE-DB Localization in Genome assemblies (http://www.imgt.org/genedb/).

New IMGT-NC reports are announced in IMGT Latest news RSS

IMGT-NC report table

  IMGT-NC_Report_YYYY_n_mmdd      Submitters IMGT® Biocuration Experts SpeciesLocus or GroupNb of genesNb of new alleles ('NEW')Nb of known alleles ('Lit')
 1 IMGT-NC_Report_2017_1_1226_Homsap_IGHV pdfCathrine Scheepers Géraldine Folch Homo sapiens IGHV 11 8 17
 2 IMGT-NC_Report_2018_1_0724_Homsap_IGHV pdfCorey Watson, Steve Kleinstein, Kevin  O'Connors Géraldine Folch Homo sapiens IGHV 4 3 1
 3 IMGT-NC_Report_2018_2_0824_Homsap_IGHG3 pdfDanillo Augusto, Verónica Calonga Solís Géraldine Folch Homo sapiens IGHC 1 1 
 4 IMGT-NC_Report_2018-3-0912_Musputfur_TRB pdfBram Gerritsen, Prof. Dr. Rob J. de Boer Perrine Pégorier Mustela putorius furo TRB 43 43 
 5 IMGT-NC_Report_2018-4-1027_Orycun_TRA_TRD pdfStanislas Mondot, Olivier Lantz, Pierre Boudinot Perrine Pégorier Oryctolagus cuniculus TRA, TRD 108 108 
 6 IMGT-NC_Report_2018-5-1113_Homsap_IGHC pdfDanillo Augusto, Verónica Calonga Solís Géraldine Folch Homo sapiens IGHC 3 27 
 7 IMGT-NC_Report_2019-1-0111_Felcat_IGL pdfRobert Burnett, Anne Avery, Emily Rout Perrine Pégorier Felis catus IGL 97 97 
 8 IMGT-NC_Report_2019-2-0111_Felcat_TRG pdfAraya Radtanakatikanon, Dr. Stefan Keller Géraldine Folch Felis catus TRG 25 25 
 9 IMGT-NC_Report_2019-3-0111_Felcat_TRG pdfBurnett Robert, Avery Anne, Rout Emily Géraldine Folch Felis catus TRG 26 26 
 10 IMGT-NC_Report_2019-4-0116_Felcat_TRB pdfAraya Radtanakatikanon, Dr. Stefan Keller Viviane Nguefack Ngoune Felis catus TRB 46 46 
 11 IMGT-NC_Report_2019-5-0131_Salsal_IGHV pdfAleksei Krasnov, Pierre Boudinot Saida Hadi-Saljoqi Salmo salar IGHV 64 64 
 12 IMGT-NC_Report_2019-6-0218_Felcat_TRA_TRD pdfAraya Radtanakatikanon, Dr. Stefan Keller Morgane Bertignac Felis catus TRA, TRD 142 142 
 13 IMGT-NC_Report_2019-7-0220_Salsal_IGHV pdfAleksei Krasnov, Pierre Boudinot Saida Hadi-Saljoqi Salmo salar IGHV 11 11 
 14 IMGT-NC_Report_2019-8-0314_Homsap_IGHV pdfOscar Rodriguez, William Sinclair Gibson,  Catherine Allison Silver, Melissa Smith, Justin  Thomas Kos, Corey Watson Géraldine Folch Homo sapiens IGHV 7 8 1
 15 IMGT-NC_Report_2019-9-0320_Homsap_IGHG pdfMagalie Dambrun, Célia Dechavanne, Florence  Migot-Nabias Joumana Jabado-Michaloud Homo sapiens IGHC 2 6 4
 16 IMGT-NC_Report_2019-10-0408_Oncmyk_IGH pdfSusana Magadan, Pierre Boudinot Saida Hadi-Saljoqi Oncorhynchus mykiss IGH 181 181 
 17 IMGT-NC_Report_2019-11-0418_Homsap_IGHV pdfAIRR Community inferred allele review  committee (IARC) Géraldine Folch Homo sapiens IGHV 9 6 3
 18 IMGT-NC_Report_2019-12-0924_Homsap_IGHV pdfOscar Rodriguez, William Sinclair Gibson, Catherine Allison Silver, Kaitlyn Marie Shields, Melissa Smith and Corey Watson Géraldine Folch Homo sapiens IGHV 5 4 1
 19 IMGT-NC_Report_2019-16-1031_Homsap_IGLV pdfOscar Rodriguez, David A. Tieri, Sydney E. Smith, William Sinclair Gibson, Catherine Allison Silver, Kaitlyn Marie Shields, Melissa Smith and Corey Watson Géraldine Folch Homo sapiens IGLV 7 7 4
 20 IMGT-NC_Report_2019-17-1118_Homsap_IGHV pdfAIRR Community inferred allele review  committee (IARC) Géraldine Folch Homo sapiens IGHV 3 3 1
 21 IMGT-NC_Report_2019-18-1218_Homsap_IGHV pdfAIRR Community inferred allele review  committee (IARC) Géraldine Folch Homo sapiens IGHV 4 3 1
 22 IMGT-NC_Report_2020-1-0917_Homsap_IGLV pdfAbdullah Gamal Dorgham, William Gibson Sinclair, Oscar Rodriguez, Kaitlyn Marie Shields, Catherine Allison Silver, Melissa Laird, Andrew Collins, Mats Ohlin, William Lees, Martin Corcoran, Cathrine Scheepers and Corey Watson Géraldine Folch Homo sapiens IGLV 3 0 3
 23 IMGT-NC_Report_2020-2-1008_Homsap_IGHV pdfAbdullah Gamal Dorgham, William Sinclair Gibson, Oscar Rodriguez and Corey Watson Géraldine Folch Homo sapiens IGHV 5 4 1
 24 IMGT-NC_Report_2020-3-1120_Homsap_IGKV_IGLV pdfAIRR Community inferred allele review committee (IARC) Géraldine Folch Homo sapiens IGKV, IGLV 6 3 3

References

[1] Lefranc, M.-P., Nucleic Acids Res., 31, 307-310 (2003) Full text
[2] Giudicelli, V. and Lefranc, M.-P., Bioinformatics, 15, 1047-1054 (1999) PMID:10745995, LIGM:221 pdf
[3] Wain, H.M. et al., Genomics, 79, 464-470 (2002) PMID: 11944974
[4] Lefranc, M.-P. and Lefranc, G., The Immunoglobulin FactsBook, Academic Press, 458 pages (2001) ISBN: 012441351X
[5] Lefranc, M.-P. and Lefranc, G., The T cell receptor FactsBook, Academic Press, 398 pages (2001) ISBN: 0124413528
[6] WHO-IUIS Nomenclature Subcommittee for immunoglobulins and T cell receptors report - Aug. 2007, Dev. Comp. Immunol., 2007 Nov 6 (2007) PMID: 18036660
[7] WHO-IUIS Nomenclature Subcommittee for immunoglobulins and T cell receptors report - Nov. 2007, Immunogenetics, 59, 899-902 (2007) PMID: 18046549
[8] Giudicelli, V. and Lefranc, M.-P. Ontology for Immunogenetics: IMGT-ONTOLOGY. Bioinformatics, 15, 1047-1054 (1999) PMID: 10745995, LIGM:221 pdf
[9] Giudicelli, V. and Lefranc, M.-P., IMGT-ONTOLOGY 2012. Online access Front Genet. 3:79. doi: 10.3389/fgene.2012.00079. Epub 2012 May 23 (2012) PMID:22654892
[10] Lefranc M-P. Immunoglobulin (IG) and T cell receptor genes (TR): IMGT® and the birth and rise of immunoinformatics. Front Immunol. 2014 Feb 05;5:22. doi: 10.3389/fimmu.2014.00022. Open access. PMID: 24600447
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