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IMGT Nomenclature Committee (IMGT-NC)

Chairperson

Marie-Paule Lefranc (Marie-Paule.Lefranc@igh.cnrs.fr)
Senior Member of the Institut Universitaire de France;
Professor Emeritus University of Montpellier
IMGT® Founder and Director Emeritus
Head Emeritus of the Laboratoire d'ImmunoGénétique Moléculaire, LIGM
IMGT, LIGM IGH, UMR 9002 CNRS-UM, Montpellier, France

Objectives

The IMGT Nomenclature Committee (IMGT-NC) created in 1989 by Marie-Paule Lefranc at the Tenth International Human Gene Mapping (HGM10) Workshop (June 10-17, 1989, New Haven, Connecticut, USA) is the IMGT Standing Committee in charge of the standardized classification and nomenclature of the immunoglobulins (IG), T cell receptors (TR) and of the Major Histocompatibility (MH) of human and other vertebrate species.[1]

In 1992, the IMGT Nomenclature Committee (IMGT-NC) became the first IUIS Nomenclature Sub-Committee for the antigen receptors of the adaptive immune responses, immunoglobulins (IG) or antibodies and T cell receptors (TR), chaired by Marie-Paule Lefranc. In its interface with the other IUIS Nomenclature Sub-Committees, the IMGT Nomenclature Standing Committee is designated as 'IUIS Immunoglobulins (IG), T cell Receptors (TR) and Major Histocompatibility (MH) Nomenclature Sub-Committee (IMGT-NC)'.

Rules for the nomenclature are described in the IMGT Scientific chart and are based on the concept of CLASSIFICATION of IMGT-ONTOLOGY [2,6-10]. WHO-IUIS Nomenclature Subcommittee for immunoglobulins and T cell receptors report - Aug. 2007 [6,7] pdf

IMGT gene name nomenclature for IG and TR of human and other vertebrates (IMGT Scientific chart)

IMGT allele nomenclature for sequence polymorphisms (IMGT Scientific chart)

Immunoglobulin (IG) and T cell receptor genes (TR): IMGT® and the birth and rise of immunoinformatics [10]

The IMGT Nomenclature Committee (IMGT-NC) is responsible of the coherence of the IG, TR and MH gene and allele nomenclature, as well as that of the related proteins, with the concepts of IDENTIFICATION, DESCRIPTION and NUMEROTATION of IMGT-ONTOLOGY in IMGT®, the international ImMunoGeneTics information system® www.imgt.org [1].

IMGT-NC works in close collaboration with :

Submission of new V alleles to IMGT-NC

The submission of new alleles of V genes requires:

Sequences from NGS are accepted only for known alleles if they complete the germline genomic sequence in 5' or in 3' (a few alleles may have incomplete sequences in 5' or 3' if they were retrieved from the literature before IMGT/GENE-DB was established).

Although new potential V alleles may be identified from NGS from blood sample DNA amplification, they are not considered by the IMGT nomenclature committee (IMGT-NC) because the sequences are not mapped. If a new V allele is suspected by NGS, its sequence needs to be confirmed from a direct Sanger sequencing from the germline gDNA from the individual, or identified in an existing mapped BAC, cosmid or phage of the alternative genomes on the genome browsers, for submission to IMGT-NC.

IMGT-NC reports

IMGT-NC_Report_2017_1_1226_Homsap_IGHV pdf
IMGT-NC_Report_2018_1_0724_Homsap_IGHV pdf
IMGT-NC_Report_2018_2_0824_Homsap_IGHG3 pdf
IMGT-NC_Report_2018-3-0912_Musputfur_TRB pdf

References:
[1] Lefranc, M.-P., Nucleic Acids Res., 31, 307-310 (2003) Full text
[2] Giudicelli, V. and Lefranc, M.-P., Bioinformatics, 15, 1047-1054 (1999) PMID:10745995, LIGM:221 pdf
[3] Wain, H.M. et al., Genomics, 79, 464-470 (2002) PMID: 11944974
[4] Lefranc, M.-P. and Lefranc, G., The Immunoglobulin FactsBook, Academic Press, 458 pages (2001) ISBN: 012441351X
[5] Lefranc, M.-P. and Lefranc, G., The T cell receptor FactsBook, Academic Press, 398 pages (2001) ISBN: 0124413528
[6] WHO-IUIS Nomenclature Subcommittee for immunoglobulins and T cell receptors report - Aug. 2007, Dev. Comp. Immunol., 2007 Nov 6 (2007) PMID: 18036660
[7] WHO-IUIS Nomenclature Subcommittee for immunoglobulins and T cell receptors report - Nov. 2007, Immunogenetics, 59, 899-902 (2007) PMID: 18046549
[8] Giudicelli, V. and Lefranc, M.-P. Ontology for Immunogenetics: IMGT-ONTOLOGY. Bioinformatics, 15, 1047-1054 (1999) PMID: 10745995, LIGM:221 pdf
[9] Giudicelli, V. and Lefranc, M.-P., IMGT-ONTOLOGY 2012. Online access Front Genet. 3:79. doi: 10.3389/fgene.2012.00079. Epub 2012 May 23 (2012) PMID:22654892
[10] Lefranc M-P. Immunoglobulin (IG) and T cell receptor genes (TR): IMGT® and the birth and rise of immunoinformatics. Front Immunol. 2014 Feb 05;5:22. doi: 10.3389/fimmu.2014.00022. Open access. PMID: 24600447

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