Reviews on immunoglobulin FactsBook
E-STREAMS Vol. 5, No. 8 - August 2002
Immunoglobulin FactsBook, by Marie-Paule Lefranc, Gérard Lefranc
San Diego, CA , Academic Press, 2001
The Immunoglobulin FactsBook is part of the very well respected FactsBook series published by Academic Press. The FactsBook series focuses on protein groups, in this case functional and ORF (Open Reading Frame) immunoglobulin or antibody genes.
The authors, Marie-Paul Lefranc and Gérard Lefranc, are from the IMGT, the international ImMunoGeneTics database, Laboratoire d'ImmunoGénétique Moléculaire, Université Montpellier II, Institut de Génétique Humaine CNRS, Montpellier, France, and both have extensive publication records in the field, as well as being involved in the production of the database.
The book starts with four chapters outlining the organization of the entries and explaining the terms used. The types of immunoglobulins are explained, depending on heavy or light chain, whether they are membrane or secreted, biological function, etc. The review of the synthesis of immunoglobulins includes many useful figures. "Chapter 4 represents a major IMGT contribution by providing, in a unique document, the first complete description of the immunoglobulin germline repertoire in humans." The introduction also covers the standardized numbers the IMGT uses.
After the four introductory chapters, section two is the listing of 203 genes and 459 alleles, for a total of 837 sequences displayed. The entries cover nomenclature, definition and functionality, gene location, gene structure (when known), nucleotide and amino acid sequences, framework (FR) and complementarity determining regions (CDR) for the V-GENE entries, Collier de Perles (two-dimensional graphical representations of the immunoglobulin variable regions) and accession numbers from various databases. References are given after the entries for the different groups covered. Updates and new genes, as well as other databases and software for comparisons and other genome work can be found at the web site for IMGT, the international ImMunoGeneTics database, http://www.imgt.org (an extremely useful site for anyone in the field).
Like the rest of the FactsBook series, this volume was published to help high level researchers-graduate students and above. Recommended for medical school libraries and university science libraries supporting advanced molecular biology programs. Many laboratories will want to purchase this volume for easy reference as well.
Source: E-STREAMS (Electronic Reviews of Science & Technology References, August 2002)
E-Streams (http://www.e-streams.com) is a review web site for librarians.