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IMGT Locus in Focus

'IMGT Locus in Focus' has been launched in the April 1998 issue of Experimental and Clinical Immunogenetics (Lefranc, 1998) and published from April 1998 to December 2001 in that journal. Since January 2003, 'IMGT Locus in Focus' is a new section of Developmental and Comparative Immunology, edited by Elsevier Science (Editorial by Warr et al., 2003 [20]).

'IMGT Locus in Focus' gives the more updated and extensive overview of the IMGT Repertoire and of the current status of the different IG and TR genes in IMGT, with standardization of gene nomenclature, functionality, and polymorphism, according to the IMGT rules of the IMGT Scientific chart.

The nomenclature of IG and TR genes and alleles has been approved by the WHO-IUIS Nomenclature Subcommittee/IMGT Nomenclature (IMGT-NC) Subcommittee for immunoglobulins and T cell receptors [22].

The tables below indicate the immunoglobulin (IG) and T cell receptor (TR) groups with, between brackets, the 'IMGT Locus in Focus' report number.







Human

Nomenclature

IGH [16] IGK [17] IGL [18]

Immunoglobulin groups
IGHV [4] IGKV [2] IGLV [1] Protein display [6]
IGHD [5] - - -
IGHJ [5] IGKJ [2] IGLJ [1] Protein display [6]
IGHC IGKC IGLC -
T cell Receptor groups
TRAV [8] TRBV [7] TRGV TRDV Protein display [13]
- TRBD [10] - TRDD -
TRAJ [9] TRBJ [10] TRGJ TRDJ Protein display [13]
TRAC TRBC TRGC TRDC -

Mouse (Mus musculus)

Nomenclature

IGK [19]

Immunoglobulin groups
IGHV IGKV [3,19] IGLV
IGHD - -
IGHJ IGKJ [3,19] IGLJ
IGHC IGKC [19] IGLC
T cell Receptor groups
TRAV [21] TRBV [14] TRGV TRDV [15]
- TRBD [14] - TRDD [15]
TRAJ TRBJ [14] TRGJ TRDJ [15]
TRAC TRBC TRGC TRDC

Teleostei



Immunoglobulin groups
IGHV [11] IGL1V [12] IGL2V [12]
IGHD - -
IGHJ [11] IGL1J [12] IGL2J [12]
IGHC [11] IGL1C [12] IGL2C [12]




References:
[0] Lefranc, M.-P., "IMGT Locus in Focus: a new section of Experimental and clinical Immunogenetics", Exp.Clin.Immunogenet., 15, 1-7 (1998). PMID: 9619395 UI:98283154 LIGM:199 pdf
[1] Pallarès, N., Frippiat, J.-P., Giudicelli, V. and Lefranc, M.-P., "The human immunoglobulin lambda variable (IGLV) genes and joining (IGLJ) segments", Exp. Clin. Immunogenet., 15, 8-18 (1998). PMID: 9619396 UI:98283155 LIGM:200 pdf
[2] Barbié, V. and Lefranc, M.-P., "The human immunoglobulin kappa variable (IGKV) genes and joining (IGKJ) segments", Exp. Clin. Immunogenet., 15, 171-183 (1998). PMID: 9813414 UI:99032882 LIGM:207 pdf
[3] Martinez, C. and Lefranc, M.-P., "The mouse (Mus musculus) immunoglobulin kappa variable (IGKV) genes and joining (IGKJ) segments", Exp. Clin. Immunogenet., 15, 184-193 (1998). PMID: 9813415 UI:99032883 LIGM:208 pdf
[4] Pallarès, N., Lefebvre, S., Contet, V., Mastuda, F. and Lefranc, M.-P., "The human immunoglobulin heavy variable (IGHV) genes", Exp. Clin. Immunogenet.,16, 36-60 (1999). PMID: 10087405 UI:99189133 LIGM:210 pdf
[5] Ruiz, M., Pallarès, N., Contet, V., Barbié, V. and Lefranc, M.-P., "The human immunoglobulin heavy diversity (IGHD) and joining (IGHJ) segments", Exp. Clin. Immunogenet., 16, 173-184 (1999). PMID: 10394055 UI:99323824 LIGM:211 pdf
[6] Scaviner, D., Barbié, V., Ruiz, M. and Lefranc, M.-P., "Protein displays of the human immunoglobulin heavy, kappa and lambda variable and joining regions", Exp. Clin. Immunogenet., 16, 234-240 (1999). PMID: 10575277 UI:20044446 LIGM:218 pdf
[7] Folch, G. and Lefranc, M.-P., "The human T cell Receptor Beta Variable (TRBV) genes", Exp. Clin. Immunogenet., 17, 42-54 (2000). PMID: 10686482 UI:20153272 LIGM:227 pdf
[8] Scaviner, D. and Lefranc, M.-P., "The human T cell Receptor Alpha Variable (TRAV) Genes", Exp. Clin. Immunogenet., 17, 83-96 (2000). PMID: 10810225 UI:20271759 LIGM:228 pdf
[9] Scaviner, D. and Lefranc, M.-P., "The human T cell Receptor Alpha joining (TRAJ) Genes", Exp. Clin. Immunogenet., 17, 97-106 (2000). PMID: 10810226 UI:20271760 LIGM:232 pdf
[10] Folch, G. and Lefranc, M.-P., "The human T cell Receptor Beta Diversity (TRBD) and Beta Joining (TRBJ) Genes", Exp. Clin. Immunogenet., 17, 107-114 (2000). PMID: 10810227 UI:20271761 LIGM:233 pdf
[11] Artero, S. and Lefranc, M.-P., "The Teleostei Immunoglobulin Heavy IGH Genes", Exp. Clin. Immunogenet., 17, 148-161 (2000). PMID: 10899740 UI:20359114 LIGM:234 pdf
[12] Artero, S. and Lefranc, M.-P., "The Teleostei Immunoglobulin Light IGL1 and IGL2 V, J and C Genes", Exp. Clin. Immunogenet., 17, 162-172 (2000). PMID: 10899741 UI:20359115 LIGM:235 pdf
[13] Folch, G., Scaviner, D., Contet, V. and Lefranc, M.-P.,"Protein displays of the Human T cell Receptor Alpha, Beta, Gamma and Delta Variable and Joining Regions", Exp. Clin. Immunogenet., 17, 205-215 (2000). PMID: 11096259 LIGM:236 pdf
[14] Bosc, N. and Lefranc, M.-P., "The Mouse (Mus musculus) T-cell receptor beta variable (TRBV), diversity (TRBD) and joining (TRBJ) genes", Exp. Clin. Immunogenet., 17, 216-228 (2000). PMID: 11096260 LIGM:240 pdf
[15] Bosc, N., Contet, V. and Lefranc, M.-P., "The mouse (Mus musculus) T cell receptor delta variable (TRDV), diversity (TRDD) and joining (TRDJ) genes", Exp. Clin. Immunogenet., 18, 51-58 (2001). PMID: 11150853 LIGM:245 pdf
[16] Lefranc, M.-P., "Nomenclature of the human immunoglobulin heavy (IGH) genes", Exp. Clin. Immunogenet., 18, 100-116 (2001). PMID: 11340299 LIGM:246 pdf
[17] Lefranc, M.-P., "Nomenclature of the human immunoglobulin kappa (IGK) genes", Exp. Clin. Immunogenet., 18, 161-174 (2001). PMID: 11549845 LIGM:251 pdf
[18] Lefranc, M.-P., "Nomenclature of the human immunoglobulin lambda (IGL) genes", Exp. Clin. Immunogenet., 18, 242-254 (2001). PMID: 11872955 LIGM:254 pdf
[19] Martinez-Jean, C., Folch, G. and Lefranc, M.-P., "Nomenclature and overview of the mouse (Mus musculus and Mus sp.) immunoglobulin kappa (IGK) genes", Exp. Clin. Immunogenet., 18, 255-279 (2001). PMID: 11872956 LIGM:256 pdf
[20] Warr, G.W., Clem, W. and Söderhäll, K. Editorial, "The International ImMunoGeneTics database IMGT", Dev. Comp. Immunol., 27, 1 (2003). PMID: 12477495 pdf
[21] Bosc, N. and Lefranc, M.-P., "IMGT Locus in Focus: The mouse (Mus musculus) T cell receptor alpha (TRA) and delta (TRD) variable genes", Dev. Comp. Immunol., 27, 465-497 (2003). PMID: 12697305 LIGM:271
[22] WHO-IUIS Nomenclature Subcommittee for immunoglobulins and T cell receptors report - Aug. 2007, Dev. Comp. Immunol., 32, 461-463 (2008). Epub 2007 Nov6, doi:10.1016/j.dci.2007.09.008. PMID: 18036660. LIGM:336 pdf with permission from Elsevier"

Acknowledgments:
We thank S. Karger AG, Medical and Scientific Publishers, for allowing IMGT to make available, on the IMGT site, the PDF files of the IMGT Locus in Focus reports, published in Experimental and Clinical Immunogenetics, from April 1998 to December 2001.