IMGT®, the international ImMunoGeneTics information system®

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IMGT® Founder and Executive Director Emeritus

Professor Emeritus Marie-Paule Lefranc

Marie-Paule Lefranc IMGT®, the international ImMunoGeneTics information system®, Senior member of the Institut Universitaire de France
Chair of Immunogenetics and Immunoinformatics
Professor Emeritus Université de Montpellier
Head Emeritus of the Laboratoire d'ImmunoGénétique Moléculaire, LIGM
Département d'Enseignement Biologie-Mécanismes du Vivant (Bio-MV)
Institut de Génétique Humaine, IGH, UMR9002 CNRS-UM, (DR13)

Mail address:
IMGT®, the international ImMunoGeneTics information system®
Laboratoire d'ImmunoGénétique Moléculaire
Institut de Génétique Humaine, IGH, UMR9002 CNRS-UM
141 rue de la Cardonille
34396 Montpellier Cedex 5, France

+33 (0)4 34 35 99 65
+33 (0)4 34 35 99 01
Marie-Paule.Lefranc@igh.cnrs.fr

Marie-Paule Lefranc Curriculum Vitae (Summary)

Marie-Paule Lefranc, née Brasselet, was born in 1943, Oignies, France. Married since 1968 to Gérard Lefranc, they have five children, Anne-Christelle, Eric, Bénédicte, Isabelle and Anne-Cécile.

Marie-Paule Lefranc is presently Senior member of the Institut Universitaire de France, Chair of Immunogenetics and Immunoinformatics, since 2002. She is also Professor of Immunogenetics and Immunology, at the Université Montpellier 2, Montpellier, France, since 1985, Director with Gérard Lefranc of the Laboratoire d'ImmunoGénétique Moléculaire, LIGM at the UPR CNRS 1142, Institut de Génétique Humaine, IGH, Montpellier, France, and founder and director of IMGT®, the international ImMunoGeneTics information system®, she created in 1989 at Montpellier, France.

Prof. M.-P. Lefranc received:

  • Licence d'Enseignement in Natural Sciences, University of Lille, 1963
  • Diplôme d'Etudes Supérieures in Natural Sciences, Lille, 1965
  • Agrégation in Natural Sciences (prepared at the Ecole Normale Supérieure, rue d'Ulm, Paris), Paris, 1966
  • Pharmacien d'Etat, Lille, 1977
  • Doctorate of Pharmacy, Paris, 1980
  • PhD thesis in Molecular Immunogenetics, Montpellier, 1984.

Prof. M.-P. Lefranc held the following positions:

  • 1963-1964
    Research Assistant, at the Centre Technique Forestier Tropical at Cotonou, Benin
  • 1964-1965
    Lecturer, at the Catholic University of Lille
  • 1965-1966
    Fellow, at the Ecole Normale Supérieure, Paris
  • 1966-1967
    Graduate Student and Fulbright Fellow, at the University of California, Berkeley, USA
  • 1967-1968
    Professeur Agrégé de Sciences Naturelles, Strasbourg
  • 1968-1975
    Professeur Agrégé de Sciences Naturelles, Beirut, Lebanon, where she trained students for the competitive entrance examination for the "Ecoles Nationales Supérieures d'Agronomie Françaises"
  • 1976-1981
    Lecturer in Biochemistry, at the Faculty of Pharmacy, Monastir, Tunisia, where she contributed to the creation of the Biochemistry Department
  • 1981-1984
    Senior Lecturer in Biochemical and Molecular Genetics and Immunology, at the Université Montpellier 2
  • 1984-1985
    EMBO Fellow, at the Medical Research Council, Cambridge, UK
  • Since 1985
    Professor of Biochemical and Molecular Genetics and Immunology at the Université Montpellier 2
    Director with Prof. Gérard Lefranc of the Laboratoire d'ImmunoGénétique Moléculaire, LIGM (CNRS and Université Montpellier 2)
  • 1993
    Professor exceptional class PRCE1, Université Montpellier 2
  • 1997
    Professor exceptional class PRCE2, Université Montpellier 2
  • since 2002
    Senior member of the Institut Universitaire de France, Chair of Immunogenetics and Immunoinformatics

Prof. M.-P. Lefranc has authored more than 300 publications in international journals. She received the Rosen Prize of Cancerology in 1988. She married Gérard Lefranc, currently Professor of Immunogenetics at the Montpellier 2 University, in 1968 and they have five children. Dr. Lefranc is a member of several international societies. She serves on the Editorial Board of Developmental and Comparative Immunology, Experimental and Clinical Immunogenetics, Immunogenetics, Molecular Immunology, Research in Immunology, on the review panel of more than 30 journals, and on the grant review committees of the National Science Foundation (NSF), Washington, USA (1994); International Human Frontier Science Program Organization (HFSPO), Strasbourg, France (1994); BIOMED2 programme of the European Community, Brussels (1995); Medical Research Council (MRC), Canada (1996); The Welcome Trust, London, UK (1996,1998); United States-Israël Binational Science Foundation (BSF), Israël (1997); Fonds National Suisse de la Recherche Scientifique, Suisse (1997); Biotechnology and Biological Sciences Research Council (BBSRC), Swindon, UK (1998); 5e PCRDT programme of the European Community, Brussels (2001).

Her major research areas are on the human immunoglobulin and T cell receptor genes (chromosomes 2, 7, 14 and 22), clinical applications and therapeutical approaches (antibody engineering). Contribution in genome research includes molecular genetics of the IGH locus, complete characterization of the human T cell receptor gamma TRG locus, cloning of the human CTLA-4 gene, complete mapping of the human lambda IGL locus (1995). More than 40 genomic probes are released by HGRC, UK, JCRB, Japan and ATCC, USA.

Marie-Paule Lefranc is founder and director of the International ImMunoGeneTics information system®, IMGT®, she created in 1989 and on the Web since July 1995.

CV Marie-Paule Lefranc

Date of birth: 6 March 1943
Married, 5 children
Nationality: French

University diplomas
  • 1963 Licence d'Enseignement in Natural Sciences, Biological Sciences, 1st class honours, University of LILLE, France
  • 1965 Diplôme d'Etudes Supérieures in Natural Sciences, 1st class honours with distinction, University of LILLE, France
  • 1966 CAPES of Natural Sciences theoretical, PARIS (1st in France)
  • 1966 AGREGATION of Natural Sciences prepared at the Ecole Normale Supérieure, rue d'Ulm, PARIS
  • 1977 PHARMACIEN d'ETAT (major in Biology), University of LILLE, France
  • 1980 DOCTORAT of 3rd CYCLE in the pharmaceutical disciplines, 1st class honours with distinction and Congratulations of the Jury, Faculty of Pharmacy Université PARIS-SUD
  • 1984 DOCTORAT d'ETAT ès-SCIENCES, 1st class honours with distinction and Congratulations of the Jury, Université Montpellier 2, France
Professional experience

1963-1968

  • 1963-1964 Researcher at the Centre Technique Forestier Tropical (CTFT) at COTONOU (DAHOMEY, now BENIN)
  • 1964-1965 Lecturer at the Faculty of Pharmacy, Catholic University of LILLE, France, Academy of LILLE
  • 1965-1966 Fellow at the Ecole Normale Supérieure, rue d'Ulm, PARIS, France
  • 1966-1967 Graduate student and Fulbright fellow at the University of California, BERKELEY, US
  • 1967-1968 Professor Agrégé in Natural Sciences, appointed with tenure to the Lycée d'Etat Fustel de Coulanges, STRASBOURG, France

1968-1975 at BEIRUT (Lebanon)

Professor Agrégé in Natural Sciences in the "Classes Préparatoires (SUP'C et SPE'C) à l'Institut National Agronomique de PARIS et aux Ecoles Nationales Supérieures Agronomiques (ENSA) Françaises", BEIRUT Centre, depending from the French Embassy.

1976-1981 at MONASTIR (Tunisia)

Lecturer in Biochemistry at the Faculty of Pharmacy, MONASTIR, founded in november 1975. Responsible for the creation of the Biochemistry Department and the Laboratory of Immunogenetics and Biochemistry.

1981 to date at MONTPELLIER (France)

  • 1981-1984, Senior Lecturer 1st class in Biochemistry at the Université Montpellier 2
  • 1984-1985, EMBO fellow and secondment to the Medical Research Council at CAMBRIDGE (UK)
  • 1985, Professor with tenure at the Université Monpellier II
  • Head of the Laboratoire d'ImmunoGénétique Moléculaire (CNRS, Université Montpellier 2), since its creation in 1983
  • Professor exceptional class, PRCE, Université Montpellier 2, since 1993 (PRCE1 1993, PRCE2 1997)
  • Coordinator of IMGT®, the international ImMunoGeneTics information system®, http://www.imgt.org, she created in 1989, the global reference in immunogenetics and immunoinformatics
  • Senior Member of the Institut Universitaire de France, Chair of Immunogenetics and Immunoinformatics, since 2002
Prizes and awards
  • 1988 ROSEN prize of Cancerology, by the Foundation for Medical Research
  • 1988 Silver Medal of Paris
  • 1994 Life Sciences Prize for "Innovation-Research-Enterprise" by the Association for Education and Research Development (ADER) 1994 for the K20 antibody humanization and expression in insect cell
  • 1998 Knight in the order of the Academic Palms
  • 2002 Senior Member of the Institut Universitaire de France
  • 2003 Life Sciences Prize for "Innovation-Research-Enterprise" by the Association for Education and Research Development (ADER) for the implementation of IMGT/PRIMER-DB
Publications - Books - Communications - DEA - Theses- Patents
  • More than 300 international publications (206 publications on MEDLINE) of which 3 Nature, 2 Cell, 3 EMBO J., 2 PNAS, 13 Eur. J. Immunol., 19 Hum. Genet., 30 Exp. Clin. Immunogen., 19 Nucl. Acids Res. (+ 17 reports RFLP et STS), Genomics, J. Exp. Med., International Immunology, Mol. Immunol., Am. J. Hum. Genet., J. Immunol., J. Immunogenet., Immunogenetics, FEBS Letters, Leukemia, Blood, Gene, Cytogenet. Cell Genet., Mol. Biol. Med., Hum. Molec. Genet.
  • 25 chapters of books of which the chapters "T cell receptors" in Encyclopedia of Molecular Biology (1994), "Consanguinity" in Encyclopedia of Genetics (Eds S. Brenner and J H. Miller, Academic Press, 2001).
  • 1 Book as Editor: Ingénierie des anticorps. Banques combinatoires, Editions INSERM/SFI, 1997
  • 2 Books as Co-author: The Immunoglobulin FactsBook, Academic Press, 2001, The T cell Receptor FactsBook, Academic Press, 2001.
  • more thant 400 communications
  • more than 200 invited conferences (Europe, USA, Canada, China, Japan, Singapore)
  • 18 DEA (since 1983)
  • 19 PhD theses (since 1983) of which 9 in bioinformatics
  • 2 patents
Editorial Boards
  • Associate editor-Editorial Board of "Exp. Clin. Immunogenet.", Karger (1990 - 2001)
  • Advisory editor of "Molecular Immunology", Pergamon Press (since 1991)
  • Associate editor-Editorial Board of "Research in Immunology", Elsevier (1992 - 1996)
  • Associate editor-Editorial Board of "Immunogenetics", Springer (since 1997)
  • Associate editor-Editorial Board of "Immunome Research", BioMed Central (since 2005)
  • IMGT Locus in Focus Section Editor of "Dev. Comp. Immunol.", Pergamon Elsevier (since 2003)
  • Specialist advisor to Genome Database (GDB), Swiss-Prot, Entrez Gene (NCBI, USA), Human Genome Organization (HUGO) Nomenclature committee (HGNC) (since 1996)
Evaluation committees
  • International Science Foundation (ISF), Washington, USA (1994)
  • National Science Foundation (NSF), Washington, USA (1994)
  • International Human Frontier Science Program Organization (HPSPO), Strasbourg, France (1994)
  • BIOTECHNOLOGY Programme of the European Community (EC), Brussels, Belgium
  • Evaluation Committee - Orientation of the Scientific Co-operation with Chile, Mexico and Uruguay (ECOS), Paris, France
  • Programme BIOMED 2 of the European Community (EC), Brussels, Belgium (1995)
  • Medical Research Council (MRC), Canada (1996), UK (2004)
  • The Wellcome Trust, London, UK (1996,1998, 2005)
  • United States - Israel Binational Science Foundation (BSF), Israel (1997)
  • Swiss National Funds of the Scientific Research, Switzerland (1997)
  • Biotechnology and Biological Sciences Research Council (BBSRC), Swindon, UK (1998)
  • 5th PCRDT Programme of the European Community (EC), Brussels, Belgium (2001)
Reading panels - Scientific societies
  • Member of more than thirty review committees for international journals (Am. J. Hum. Genet., Applied Bioinformatics, Bioinformatics, Blood, EMBO J., Genomics, Hum. Genet., Immunogenetics, J. Immunol., PNAS, and many others...)
  • Member of National Scientific Societies (ASSIM, SFG, SFI, SFH, SFBBM) and International Scientific Societies (AAAS, ASHG, ESHG, HUGO).