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Announcement: December 2001

A new freely available tool - IMGT/JunctionAnalysis

The IMGT/JunctionAnalysis tool, freely available at IMGT, allows for the identification and analysis of the P, N, and D regions of the junctions of the rearranged immunoglobulin and T cell receptor genes in human and mouse.
The analysis provides, in addition to the P, N, et D regions, the number of somatic mutations for immunoglobulin V, D and J at the junction, the GC nucleotide content of the N regions, and the translation of the junction with the IMGT numbering of the CDR3 amino acids.
This programm can analyze many sequences at a time (several hundreds). Each entry in FASTA format must include:

The IMGT nomenclature for human immunoglobulin and T cell receptor genes [1,2] has been approved by HUGO in 1999 and links have been made to GDB (Toronto) and Entrez Gene (NCBI).

References
[1] The Immunoglobulins FactsBook, M.-P. Lefranc and G. Lefranc, 458 pages, ISBN:012441351X, Academic Press, Hartcourt, 2001
[2] The T cell Receptor FactsBook, M.-P. Lefranc and G. Lefranc, 398 pages, ISBN:0124413528, Academic Press, Hartcourt, 2001

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Marie-Paule.Lefranc@igh.cnrs.fr


Created: 07/05/2002
Last updated: Thursday, 26-May-2016 21:01:06 CEST
Contact: Marie-Paule Lefranc Marie-Paule.Lefranc@igh.cnrs.fr
Editor: Chantal Ginestoux

Software material and data coming from IMGT server may be used for academic research only, provided that it is referred to IMGT®, and cited as "IMGT®, the international ImMunoGeneTics information system® http://www.imgt.org (founder and director: Marie-Paule Lefranc, Montpellier, France)." References to cite: Lefranc, M.-P. et al., Nucleic Acids Res., 27:209-212 (1999); doi: 10.1093/nar/27.1.209 Full text Cover; Ruiz, M. et al., Nucleic Acids Res., 28:219-221 (2000); doi: 10.1093/nar/28.1.219 Full text; Lefranc, M.-P., Nucleic Acids Res., 29:207-209 (2001); doi: 10.1093/nar/29.1.207 Full text; Lefranc, M.-P., Nucleic Acids Res., 31:307-310 (2003); doi: 10.1093/nar/gkg085 Full text; Lefranc, M.-P. et al., In Silico Biol., 5, 0006 (2004) [Epub], 5:45-60 (2005); Lefranc, M.-P. et al., Nucleic Acids Res., 33:D593-597 (2005); doi: 10.1093/nar/gki065 Full text; Lefranc, M.-P. et al., Nucleic Acids Res., 37:D1006-1012 (2009); doi: 10.1093/nar/gkn838 Full text; Lefranc, M.-P. et al., Nucleic Acids Res., 43:D413-422 (2015); doi: 10.1093/nar/gku1056 Full text.
For any other use please contact Marie-Paule Lefranc Marie-Paule.Lefranc@igh.cnrs.fr.

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