IMGT®, the international ImMunoGeneTics information system®

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Publications

2017

458) Marillet S, Lefranc M-P, Boudinot P, Cazals F.
Novel structural parameters of Ig-Ag complexes yield a quantitative description of interaction specificity and binding affinity
Front. Immunol. 2017, 8:34. doi: 10.3389/fimmu.2017.00034 Free PMC Article.

2016

457) Aouinti S, Giudicelli V, Duroux P, Malouche D, Kossida S, Lefranc M-P.
IMGT/StatClonotype for Pairwise Evaluation and Visualization of NGS IG and TR IMGT Clonotype (AA) Diversity or Expression from IMGT/HighV-QUEST.
Front Immunol. 2016 Sep 9;7:339. doi: 10.3389/fimmu.2016.00339. eCollection 2016. Free PMC Article. PMID: 27667992

456) Besbes S, Hamadou WS, Boulland ML, Lefranc M-P, Ben Youssef Y, Achour B, Khelif A, Fest T, Soua Z.
Combined IKZF1 and IG markers as new tools for diagnosis and minimal residual disease assessment in Tunisian B-ALL.
Bull Cancer. 2016 Sep 7. pii: S0007-4551(16)30188-6. doi:10.1016/j.bulcan.2016.07.008. [Epub ahead of print].. PMID: 27614734

455) Tahiat A, Badran YR, Chou J, Cangemi B, Lefranc G, Labgaa ZM, Oussalam S, Kaddouri-Slimani A, Belarbi A, Bendissari-Bouzid K, Gharnaout M, Geha RS, Djidjik R, Massaad MJ.
Epidermodysplasia verruciformis as a manifestation of ARTEMIS deficiency in a young adult.
J Allergy Clin Immunol. 2016 Aug 24. pii: S0091-6749(16)30854-5. doi: 10.1016/j.jaci.2016.07.024. [Epub ahead of print]. PMID: 27568080

454) Linguiti G, Antonacci R, Tasco G, Grande F, Casadio R, Massari S, Castelli V, Consiglio A, Lefranc M-P, Ciccarese S.
Genomic and expression analyses of Tursiops truncatus T cell receptor gamma (TRG) and alpha/delta (TRA/TRD) loci reveal a similar basic public γδ repertoire in dolphin and human.
BMC Genomics. 2016 Aug 15;17(1):634. doi: 10.1186/s12864-016-2841-9. Open access. PMID: 27528257

453) Yu GY, Mate S, Garcia K, Ward MD, Brueggemann E, Hall M, Kenny T, Sanchez-Lockhart M, Lefranc M-P, Palacios G.
Cynomolgus macaque (Macaca fascicularis) immunoglobulin heavy chain locus description.
Immunogenetics. 2016 Jul;68(6-7):417-28. doi: 10.1007/s00251-016-0921-2. Epub 2016 May 27. PMID: 27233955

452) Boudinot P, Mondot S, Jouneau L, Teyton L, Lefranc M-P, Lantz O.
Restricting nonclassical MHC genes coevolve with TRAV genes used by innate-like T cells in mammals.
Proc Natl Acad Sci U S A. 2016 May 24;113(21):E2983-92. doi: 10.1073/pnas.1600674113. Epub 2016 May 11. PMID: 27170188

2015

451) Busby GB, Hellenthal G, Montinaro F, Tofanelli S, Bulayeva K, Rudan I, Zemunik T, Hayward C, Toncheva D, Karachanak-Yankova S, Nesheva D, Anagnostou P, Cali F, Brisighelli F, Romano V, Lefranc G, Buresi C, Ben Chibani J, Haj-Khelil A, Denden S, Ploski R, Krajewski P, Hervig T, Moen T, Herrera RJ, Wilson JF, Myers S, Capelli C.
The Role of Recent Admixture in Forming the Contemporary West Eurasian Genomic Landscape.
Curr Biol. 2015 Oct 5;25(19):2518-26. doi: 10.1016/j.cub.2015.08.007. Epub 2015 Sep 17. Free PMC Article . PMID: 26387712

450) Aouinti S, Malouche D, Giudicelli V, Kossida S, Lefranc M-P
IMGT/HighV-QUEST statistical significance of IMGT clonotype (AA) diversity per gene for standardized comparisons of next generation sequencing immunoprofiles of immunoglobulins and T cell receptors.
PLoS ONE. 2015 Nov 5;10(11):e0142353. doi: 10.1371/journal.pone.0142353. eCollection 2015. Free Article PMID: PMID: 26540440 Correction: PLoS ONE 2016 Jan 5;11(1): e0146702. doi: 10.1371/journal.pone.0146702 View correction. PMID: 26731095.

449) Piccinni B, Massari S, Caputi Jambrenghi A, Giannico F, Lefranc M-P, Ciccarese S, Antonacci R
Sheep (Ovis aries) T cell receptor alpha (TRA) and delta (TRD) genes and genomic organization of the TRA/TRD locus.
BMC Genomics. 2015 Sep 18;16(1):709. doi: 10.1186/s12864-015-1790-z. Open access. PMID: 26383271

448) Giudicelli V, Duroux P, Lavoie A, Aouinti S, Lefranc M-P, Kossida S
From IMGT-ONTOLOGY to IMGT/HighV-QUEST for NGS immunoglobulin (IG) and T cell receptor (TR) repertoires in autoimmune and infectious diseases
Autoimmun Infec Dis. 2015 Aug 10. 1(1): doi: 10.16966/aidoa.103. Free Article.

447) Lefranc M-P.
Antibody Informatics: IMGT, the International ImMunoGeneTics Information System, In: Crowe J, Boraschi D, Rappuoli R (Eds)
Antibodies for Infectious Diseases. ASM Press, Washington, DC. doi: 10.1128/microbiolspec. AID-0001-2012, 2015, pp. 363-379..

446) Denden S, Bouden B, Boudawara Keskes N, Knani J, Hassine M, Lefranc G, Ben Chibani J, Haj Khelil A
COPD characteristics in subjects carrying the rare alpha-1 antitrypsin variant PIMMmalton.
Rev Mal Respir. 2015 Jun 9. pii: S0761-8425(15)00218-1. doi: 10.1016/j.rmr.2015.05.002. [Epub ahead of print] French. PMID: 26071129

445) Li L, Wang XH, Williams C, Volsky B, Steczko O, Seaman MS, Luthra K, Nyambi P, Nadas A, Giudicelli V, Lefranc M-P, Zolla-Pazner S, Gorny MK
A broad range of mutations in HIV-1 neutralizing human monoclonal antibodies specific for V2, V3, and the CD4 binding site.
Mol Immunol. 2015 May 18;66(2):364-374. doi: 10.1016/j.molimm.2015.04.011. Epub 2015 May 18. PMID: 25965315

444) Engelhardt KR, Gertz ME, Keles S, Schäffer AA, Sigmund EC, Glocker C, Saghafi S, Pourpak Z, Ceja R, Sassi A, Graham LE, Massaad MJ, Mellouli F, Ben-Mustapha I, Khemiri M, Kilic SS, Etzioni A, Freeman AF, Thiel J, Schulze I, Al-Herz W, Metin A, Sanal Ö, Tezcan I, Yeganeh M, Niehues T, Dueckers G, Weinspach S, Patiroglu T, Unal E, Dasouki M, Yilmaz M, Genel F, Aytekin C, Kutukculer N, Somer A, Kilic M, Reisli I, Camcioglu Y, Gennery AR, Cant AJ, Jones A, Gaspar BH, Arkwright PD, Pietrogrande MC, Baz Z, Al-Tamemi S, Lougaris V, Lefranc G, Megarbane A, Boutros J, Galal N, Bejaoui M, Barbouche MR, Geha RS, Chatila TA, Grimbacher B.
The extended clinical phenotype of 64 patients with dedicator of cytokinesis 8 deficiency.
J Allergy Clin Immunol. 2015 Feb 25. pii: S0091-6749(15)00071-8. doi: 10.1016/j.jaci.2014.12.1945. [Epub ahead of print]. PMID: 25724123

443) Baliakas P, Agathangelidis A, Hadzidimitriou A, Sutton LA, Minga E, Tsanousa A, Scarfò L, Davis Z, Yan XJ, Shanafelt T, Plevova K, Sandberg Y, Vojdeman FJ, Boudjogra M, Tzenou T, Chatzouli M, Chu CC, Veronese S, Gardiner A, Mansouri L, Smedby KE, Pedersen LB, Moreno D, Van Lom K, Giudicelli V, Francova HS, Nguyen-Khac F, Panagiotidis P, Juliusson G, Angelis L, Anagnostopoulos A, Lefranc M-P, Facco M, Trentin L, Catherwood M, Montillo M, Geisler CH, Langerak AW, Pospisilova S, Chiorazzi N, Oscier D, Jelinek DF, Darzentas N, Belessi C, Davi F, Ghia P, Rosenquist R, Stamatopoulos K.
Not all IGHV3-21 chronic lymphocytic leukemias are equal: prognostic considerations.
Blood. 2015 Jan 29;125(5):856-9. doi: 10.1182/blood-2014-09-600874. Epub 2014 Dec 17. PMID: 25634617

442) Xochelli A, Agathangelidis A, Kavakiotis I, Minga E, Sutton LA, Baliakas P, Chouvarda I, Giudicelli V, Vlahavas I, Maglaveras N, Bonello L, Trentin L, Tedeschi A, Panagiotidis P, Geisler C, Langerak AW, Pospisilova S, Jelinek DF, Oscier D, Chiorazzi N, Darzentas N, Davi F, Ghia P, Rosenquist R, Hadzidimitriou A, Belessi C, Lefranc M-P, Stamatopoulos K.
Immunoglobulin heavy variable (IGHV) genes and alleles: new entities, new names and implications for research and prognostication in chronic lymphocytic leukemia.
Immunogenetics. 2015 67(1):61-6.doi: 10.1007/s00251-014-0812-3. Epub 2014 Nov 12. PMID: 25388851

441) Lefranc M-P, Giudicelli V, Duroux P, Jabado-Michaloud J, Folch G, Aouinti S, Carillon E, Duvergey H, Houles A, Paysan-Lafosse T, Hadi-Saljoqi S, Sasorith S, Lefranc G, Kossida S.
IMGT®, the international ImMunoGeneTics information system® 25 years on.
Nucleic Acids Res. 2015 Jan;43(Database issue):D413-22. doi: 10.1093/nar/gku1056. Epub 2014 Nov 5 Free Article. PMID: 25378316

2014

440) Lefranc M-P
Immunoglobulins: 25 years of Immunoinformatics and IMGT-ONTOLOGY.
Biomolecules. 2014, 4(4), 1102-1139; doi:10.3390/biom4041102 Open access. PMID: 25521638

439) Janssen E, Morbach H, Ullas S, Bannock JM, Massad C, Menard L, Barlan I, Lefranc G, Su H, Dasouki M, Al-Herz W, Keles S, Chatila T, Geha RS, Meffre E.
Dedicator of cytokinesis 8-deficient patients have a breakdown in peripheral B-cell tolerance and defective regulatory T cells.
J Allergy Clin Immunol. 2014; 134(6):1365-1374. pii: S0091-6749(14)01046-X. doi: 10.1016/j.jaci.2014.07.042. Epub 2014 Sep 11.

438) Lefranc M-P
IMGT® immunoglobulin repertoire analysis and antibody humanization.
In: Alt, F.W, Honjo, T, Radbruch A. and Reth, M. (Eds.), Molecular Biology of B cells, Second edition, Academic Press, Elsevier Ltd, London, UK, Chapter 26, 2014, pp. 481-514. dx.doi.org, ISBN : 978-0-12-397933-9.

437) Lefranc M-P
How to use IMGT® for therapeutic antibody engineering
In: Dübel S. and Reichert J. (Eds), Handbook of Therapeutic Antibodies (4 vol.), Second edition, Wiley, Volume 1: Defining the right antibody composition, Chapter 10, 2014, pp. 229-264.

436) Shirai H, Prades C, Vita R, Marcatili P, Popovic B, Xu J, Overington JP, Hirayama K, Soga S, Tsunoyama K, Clark D, Lefranc M-P, Ikeda K.
Antibody informatics for drug discovery.
Biochim Biophys Acta. 2014 Nov;1844(11):2002-2015. pii: S1570-9639(14)00174-5. doi: 10.1016/j.bbapap.2014.07.006. Epub 2014 Aug 8. PMID: 25110827

435) Lefranc M-P.
Immunoinformatics of the V, C, and G Domains: IMGT® Definitive System for IG, TR and IgSF, MH, and MhSF
Methods Mol Biol. 2014;1184:59-107. doi: 10.1007/978-1-4939-1115-8_4. PMID: 25048119

434) Keles S, Jabara HH, Reisli I, McDonald DR, Barlan I, Hanna-Wakim R, Dbaibo G, Lefranc G, Al-Herz W, Geha RS, Chatila TA
Plasmacytoid dendritic cell depletion in DOCK8 deficiency: rescue of severe herpetic infections with IFN-α 2b therapy.
J Allergy Clin Immunol. 2014 Jun;133(6):1753-1755.e3. doi: 10.1016/j.jaci.2014.03.032. Epub 2014 Apr 24. PMID: 24767873

433) Gogoladze, G, Grigolava, M, Vishnepolsky, B, Chubinidze, M, Duroux, P, Lefranc, M.-P, Pirtskhalava, M.
DBAASP: Database of Antimicrobial Activity and Structure of Peptides
FEMS Microbiol Lett. 2014 Aug; 357(1):63-68. doi: 10.1111/1574-6968.12489. Epub 2014 Jul 10. PMID: 24888447

432) Ciccarese S, Vaccarelli G, Lefranc M-P, Tasco G, Consiglio A, Casadio R, Linguiti G, Antonacci R.
Characteristics of the somatic hypermutation in the Camelus dromedarius T cell receptor gamma (TRG) and delta (TRD) variable domains.
Dev Comp Immunol. 2014 May Oct;46(2):300-313. doi: 10.1016/j.dci.2014.05.001. Epub 2014 May 13. PMID: 24836674

431) Alamyar A, Giudicelli V, Duroux P and Lefranc M-P.
Antibody V and C domain sequence, structure and interaction analysis with special reference to IMGT®
In: Ossipow V and Fischer N. (Eds.), Monoclonal antibodies: Methods and Protocols, Second edition. Humana Press, Springer Science+Business Media, LLC, New York, USA. Methods Mol Biol. 2014.1131:337-81. doi: 10.1007/978-1-62703-992-5_21. PMID: 24515476

430) Lefranc M-P.
Antibody informatics: IMGT®, the international ImMunoGeneTics information system®, the international ImMunoGeneTics information system®
Microbiol Spectrum 2014, 2(2):AID-0001-2012. doi:10.1128/microbiolspec.AID-0001-2012.

429) Lefranc M-P.
Immunoglobulin (IG) and T cell receptor genes (TR): IMGT® and the birth and rise of immunoinformatics.
Front Immunol. 2014 Feb 05;5:22. doi: 10.3389/fimmu.2014.00022. Open access. PMID: 24600447

428) Janssen E, Tsitsikov E, Al-Herz W, Lefranc G, Megarbane A, Dasouki M, Bonilla FA, Chatila T, Schneider L, Geha RS.
Flow cytometry biomarkers distinguish DOCK8 deficiency from severe atopic dermatitis.
Clin Immunol. 2014 Feb;150(2):220-4. doi: 10.1016/j.clim.2013.12.006. Epub 2013 Dec 31. PMID: 24440647

427) Ouled-Haddou, H, Ghamlouch, H, Regnier, A, Trudel, S, Herent, D, Lefranc, M.-P, Marolleau, J, and Gubler, B.
Characterization of a new V gene replacement in the absence of activation-induced cytidine deaminase and its contribution to human BcR diversity.
Immunology. 2014 Feb;141(2):268-75. doi: 10.1111/imm.12192. PMID: 24134819

2013

426) Khaib Dit Naib O, Aribi M, Idder A, Chiali A, Sairi H, Touitou I, Lefranc G, Barat-Houari M.
Association Analysis of IL10, TNF-α, and IL23R-IL12RB2 SNPs with Behçet's Disease Risk in Western Algeria.
Front Immunol. 2013 Oct 21;4:342. doi: 10.3389/fimmu.2013.00342. eCollection 2013. Open access. PMID: 24151497

425) Brahami N, Aribi M, Sari BE, Khau Van Kien P, Touitou I, Lefranc G, Barat-Houari M.
Lack of TEK Gene Mutation in Patients with Cutaneomucosal Venous Malformations from the North-Western Region of Algeria.
Genet Res Int. 2013;2013:784789. doi: 10.1155/2013/784789. Epub 2013 Dec 9. Open access. PMID: 24386570

424) Six, A., Mariotti-Ferrandiz, M.E., Chaara, W., Magadan, S., Pham, H.-P., Lefranc, M.-P., Mora, T., Thomas-Vaslin, V., Walczak, A.M., and Boudinot P.
The past, present and future of immune repertoire biology - the rise of next-generation repertoire analysis.
Front Immunol. 2013 Nov 27;4:413. doi: 10.3389/fimmu.2013.00413 Open access. PMID: 24348479

423) Lefranc M.-P.
IMGT Collier de Perles
In: W. Dubitzky, O.Wolkenhauer, K.-H. Cho, and H. Yokota (Eds.), Encyclopedia of Systems Biology, New York: Springer Science+Business Media, LLC, 2013, p. 944-952.

422) Lefranc M.-P.
IMGT unique numbering
In: W. Dubitzky, O.Wolkenhauer, K.-H. Cho, and H. Yokota (Eds.), Encyclopedia of Systems Biology, New York: Springer Science+Business Media, LLC, 2013, p. 952-959.

421) Giudicelli V. and Lefranc M.-P.
IMGT-ONTOLOGY
In: W. Dubitzky, O.Wolkenhauer, K.-H. Cho, and H. Yokota (Eds.), Encyclopedia of Systems Biology, New York: Springer Science+Business Media, LLC, 2013, p. 964-972.

420) Lefranc M.-P.
IMGT® information system
In: W. Dubitzky, O.Wolkenhauer, K.-H. Cho, and H. Yokota (Eds.), Encyclopedia of Systems Biology, Springer Science+Business Media, LLC, New York, 2013, p. 959-964.

419) Li, S., Lefranc, M.-P., Miles, J.J., Alamyar, E., Giudicelli, V., Duroux, P., Freeman, J.D., Corbin, V.D.A., Scheerlinck, J.-P., Frohman M.A., Cameron P.U., Plebanski, M., Loveland, B., Burrows, S.R., Papenfuss, A.T., and Gowans, E.J.
IMGT/HighV-QUEST paradigm for T cell receptor IMGT clonotype diversity and next generation repertoire immunoprofiling
Nat. Commun. 4:2333 doi: 10.1038/ncomms3333 (2013) Open access. PMID: 23995877

418) Lefranc M.-P. and Lefranc G.
Consanguinity
In: Stanley Maloy and Kelly Hughes, editors. Brenner's Encyclopedia of Genetics 2nd edition, Vol 2. San Diego: Academic Press; 2013. p. 158-162.

417) Lanternier F., Pathan S., Vincent Q.B., Liu L., Cypowyj S., Prando C., Migaud M., Taibi L., Ammar-Khodja A., Stambouli O.B., Guellil B., Jacobs F., Goffard J.C., Schepers K., del Marmol V., Boussofara L., Denguezli M., Larif M., Bachelez H., Michel L., Lefranc G., Hay R., Jouvion G., Chretien F., Fraitag S., Bougnoux M.E., Boudia M., Abel L., Lortholary O., Casanova J.L., Picard C., Grimbacher B., Puel A.
Deep dermatophytosis and inherited CARD9 deficiency
N Engl J Med 2013 Oct 31; 369(18):1704-1714. doi: 10.1056/NEJMoa1208487. Epub 2013 Oct 16. PMID: 24131138

416) Jabara H.H., Ohsumi T., Chou J., Massaad M.J., Benson H., Megarbane A., Chouery E., Mikhael R., Gorka O., Gewies A., Portales P., Nakayama T., Hosokawa H., Revy P., Herrod H., Le Deist F., Lefranc G., Ruland J., Geha R.S.
A homozygous mucosa-associated lymphoid tissue 1 (MALT1) mutation in a family with combined immunodeficiency
J Allergy Clin Immunol. 2013 Jul; 132(1):151-158. doi: 10.1016/j.jaci.2013.04.047. PMID: 23727036

415) Mégarbané A., Noguier F., Stora S., Manchon L., Mircher C., Bruno R., Dorison N., Pierrat F., Rethoré M.O., Trentin B., Ravel A., Morent M., Lefranc G., Piquemal D.
The intellectual disability of trisomy 21: differences in gene expression in a case series of patients with lower and higher IQ
Eur J Hum Genet. 2013 Nov; 21(11):1253-1259. doi: 10.1038/ejhg.2013.24. Epub 2013 Feb 20. PMID: 23422941

414) Castro R., Jouneau L., Pham H.P., Bouchez O., Giudicelli V., Lefranc M-P., Quillet E., Benmansour A., Cazals F., Six A., Fillatreau S., Sunyer O., Boudinot P.
Teleost fish mount complex clonal IgM and IgT responses in spleen upon systemic viral infection
PLoS Pathog. 2013 Jan;9(1):e1003098. doi: 10.1371/journal.ppat.1003098. Epub 2013 Jan 10. PMID: 23326228

413) Mégarbané A., Pangrazio A., Villa A., Chouery E., Maarawi J., Sabbagh S., Lefranc G., Sobacchi C.
Homozygous stop mutation in the SNX10 gene in a consanguineous Iraqi boy with osteopetrosis and corpus callosum hypoplasia
Eur J Med Genet. 2013 Jan;56(1):32-5. doi: 10.1016/j.ejmg.2012.10.010. Epub 2012 Oct 31. PMID: 23123320

2012

412) Buonocore F., Castro R., Randelli E., Lefranc M.-P., Six A., Kuhl H., Reinhardt R., Facchiano A., Boudinot P., Scapigliati G.
Diversity, molecular characterization and expression of T cell receptor gamma in a teleost fish, the sea bass (Dicentrarchus labrax, L)
PLoS One. 2012;7(10)e47957. PMID: 23133531

411) Dechavanne C., Guillonneau F., Chiappetta G., Sago L., Lévy P., Salnot V., Guitard E., Ehrenmann F., Broussard C., Chafey P., Le Port A., Vinh J., Mayeux P., Dugoujon J.-M., Lefranc M.-P., Migot-Nabias F.
UMass spectrometry detection of G3m and IGHG3 alleles and follow-up of differential mother and neonate IgG3
PLoS One. 2012;7(9):e46097. doi: 10.1371/journal.pone.0046097. Epub 2012 Sep 25. PMID: 23049948

410) Lefranc M.-P., Ehrenmann F., Ginestoux C., Duroux P., Giudicelli V.
Use of IMGT® databases and tools for antibody engineering and humanization
In: P. Chames (Ed.), Antibody engineering, chap 1, Humana Press, Springer, New York, USA. Methods Mol Biol. 2012; 907:3-37. PMID: 22907343

409) Chou J., Hanna-Wakim R., Tirosh I., Kane J., Fraulino D., Lee Y.N., Ghanem S., Mahfouz I., Mégarbané A., Lefranc G., Inati A., Dbaibo G., Giliani S., Notarangelo L.D., Geha R.S., Massaad M.J.
A novel homozygous mutation in recombination activating gene 2 in 2 relatives with different clinical phenotypes: Omenn syndrome and hyper-IgM syndrome
J. Allergy Clin. Immunol. 2012 Dec; 130(6):1414-1416.doi: 10.1016/j.jaci.2012.06.012. Epub 2012 Jul 25 . PMID: 22841008

408) Jabara, H.H., McDonald, D.R., Janssen, E., Massaad, M.J., Ramesh, N., Borzutzky, A., Rauter, I., Benson, H., Schneider, L., Baxi, S., Recher, M., Notarangelo, L.D., Wakim, R., Dbaibo, G., Dasouki, M., Al-Herz, W., Barlan, I., Baris, S., Kutukculer, N., Ochs, H.D., Plebani, A., Kanariou, M., Lefranc, G., Reisli, I., Fitzgerald, K.A., Golenbock, D., Manis, J., Keles, S., Ceja, R., Chatila, T.A., Geha, R.S.
DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation
Nat Immunol. 2012 May 13;13(6):612-20. doi: 10.1038/ni.2305. PMID: 22581261

407) Cliffe, S.T., Bloch, D.B., Suryani, S., Kamsteeg, E.J., Avery, D.T., Palendira, U., Church, J.A., Wainstein, B.K., Trizzino, A., Lefranc, G., Akatcherian, C., Mégarbané, A., Gilissen, C., Moshous, D., Reichenbach, J., Misbah, S., Salzer, U., Abinun, M., Ong, P.Y., Stepensky, P., Ruga, E., Ziegler, J.B., Wong, M., Tangye, S.G., Lindeman, R., Buckley, M.F., Roscioli, T.
Clinical, molecular, and cellular immunologic findings in patients with SP110-associated veno-occlusive disease with immunodeficiency syndrome
J. Allergy Clin. Immunol. 130(3) 735-742.e6. Epub 2012 May 21 . PMID: 22621957

406) Lefranc, M.-P. and Lefranc, G.
Human Gm, Km and Am allotypes and their molecular characterization: a remarkable demonstration of polymorphism
In: B. Tait, F. Christiansen (Eds.), Immunogenetics, chap. 34, Humana Press, Springer, New York, USA. Methods Mol. Biol. 2012; 882, 635-680. PMID: 22665258

405) Ehrenmann, F. and Lefranc, M.-P.
IMGT/DomainGapAlign: the IMGT® tool for the analysis of IG, TR, MHC, IgSF and MhcSF domain amino acid polymorphism
In: B. Tait and F. Christiansen (Eds.), Immunogenetics, chap. 33, Humana Press, Springer, New York, USA. Methods Mol. Biol. 2012; 882:605-633. PMID: 22665257

404) Alamyar, E., Duroux, P., Lefranc, M.-P. and Giudicelli, V.
IMGT tools for the nucleotide analysis of immunoglobulin (IG) and T cell receptor (TR) V-(D)-J repertoires, polymorphisms, and IG mutations: IMGT/V-QUEST and IMGT HighV-QUEST for NGS
In: B. Tait and F. Christiansen (Eds.), Immunogenetics, chap 32, Humana Press, Springer, New York, USA. Methods Mol. Biol. 2012; 882:569-604. PMID: 22665256

403) Lana, E., Mégarbané, A., Tourrière, H., Sarda, P., Lefranc, G., Claustres, M., De Sario, A.
DNA replication is altered in Immunodeficiency Centromeric instability Facial anomalies (ICF) cells carrying DNMT3B mutations
Eur J Hum Genet. 2012 Feb 29. doi:10.1038/ejhg.2012.41. 20(10), 1044-1050. Epub 2012. Fev 29. PMID: 22378288

402) Agathangelidis, A., Darzentas, N., Hadzidimitriou, A., Brochet, X., Murray, F., Yan, X.J., Davis, Z., van Gastel-Mol E.J., Tresoldi, C., Chu, C.C., Cahill, N., Giudicelli, V., Tichy, B., Pedersen, L.B., Foroni, L., Bonello, L., Janus, A., Smedby, K., Anagnostopoulos, A., Merle-Beral, H., Laoutaris, N., Juliusson, G., di Celle, P.F., Pospisilova, S., Jurlander, J., Geisler, C., Tsaftaris, A., Lefranc, M.-P., Langerak, A.W., Oscier, D.G., Chiorazzi, N., Belessi, C., Davi, F., Rosenquist, R., Ghia, P., Stamatopoulos, K.
Stereotyped B-cell receptors in one third of chronic lymphocytic leukemia: towards a molecular classification with implications for targeted therapeutic interventions
Blood. 2012 May 10; 119(19):4467-4475. Epub 2012 Mar 13. PMID: 22415752

401) Giudicelli, V. and Lefranc, M.-P.
IMGT-ONTOLOGY 2012
Frontiers in Bioinformatics and Computational Biology Online access. Front. Genet. 2012; 3:79. Epub 2012 May 23. PMID: 22654892

400) Alamyar, E., Giudicelli, V., Shuo, L., Duroux, P. and Lefranc, M.-P.
IMGT/HighV-QUEST: the IMGT® web portal for immunoglobulin (IG) or antibody and T cell receptor (TR) analysis from NGS high throughput and deep sequencing
Immunome Res. 2012, April 20;8:1:2. doi: 10.4172/1745-7580.1000056. PMID: 22647994 pdf

399) Schwartz, J.C., Lefranc, M.-P., Murtaugh, M.P.
Organization, complexity and allelic diversity of the porcine (Sus scrofa domestica) immunoglobulin lambda locus
Immunogenetics. 2012 May;64(5):399-407. Epub 2011 Dec 21. PMID: 22186825

398) Schwartz, J.C., Lefranc, M.-P., Murtaugh, M.P.
Evolution of the porcine (Sus scrofa domestica) immunoglobulin kappa locus through germline gene conversion
Immunogenetics. 2012 Apr;64(4):303-311. Epub 2011 Nov 23. PMID: 22109540

397) Kostareli, E., Gounari, M., Janus, A., Murray, F., Brochet, X., Giudicelli, V., Pospisilova, S., Oscier, D., Foroni, L., di Celle, P. F., Tichy, B., Pedersen, L.B., Jurlander, J., Ponzoni, M., Kouvatsi, A., Anagnostopoulos, A., Thompson, K., Darzentas, N., Lefranc, M.-P., Belessi, C., Rosenquist, R., Davi, F., Ghia, P., Stamatopoulos, K.
Antigen receptor stereotypy across B-cell lymphoproliferations: the case of IGHV4-59/IGKV3-20 receptors with rheumatoid factor activity
Leukemia. 2012 May;26(5):1127-1131. doi: 10.1038/leu.2011.311. Epub 2011 Nov 4. PMID: 22051533

396) Giest, S., McWinnie, A., Lefranc, M.-P., Little, A.M., Grace, S., Mackinnon, S., Madrigal, J.A. and Travers, P.J.
CMV specific CD8+ T cells targeting different peptide / HLA combinations demonstrate varying T cell receptor diversity
Immunology 2012 Jan;135(1):27-39. doi: 10.1111/j.1365-2567.2011.03508.x. PMID: 22044339

395) Chouery, E., Abou-Ghoch, J., Corbani, S., El Ali, N., Korban, R., Salem, N., Castro, C., Klayme, S., Azoury-Abou Rjeily M., Khoury-Matar, R., Debo, G., Germanos-Haddad, M., Delague, V., Lefranc, G., Mégarbané, A.
A novel deletion in ZBTB24 in a Lebanese family with immunodeficiency, centromeric instability, and facial anomalies syndrome type 2
Clin Genet. 2012 Nov;82(5):489-493. doi: 10.1111/j.1399-0004.2011.01783.x. Epub 2011 Oct 5.. PMID: 21906047

2011

394) Lakhdar, R., Denden, S., Knani, J., Leban, N., Daimi, H., Hassine, M., Lefranc, G., Chibani, J.B., Khelil, A.H.
Combined analysis of EPHX1, GSTP1, GSTM1 and GSTT1 gene polymorphisms in relation to chronic obstructive pulmonary disease risk and lung function impairment
Dis Markers. 2011;30(5):253-63. doi: 10.3233/DMA-2011-0782. PMID: 21734345

393) Castro, R., Bernard, D., Lefranc M.-P., Six ,A., Benmansour, A., Boudinot, P.
T cell diversity and TcR repertoires in teleost fish
Fish Shellfish Immunol. 2011 Nov;31(5):644-654. Epub 2010 Sep 6. PMID: 20804845

392) Ehrenmann, F., Lefranc, M.-P.
IMGT/3Dstructure-DB: Querying the IMGT Database for 3D Structures in Immunology and Immunoinformatics (IG or Antibodies, TR, MH, RPI, and FPIA)
Cold Spring Harb Protoc. 2011 Jun 1;2011(6): 750-761. pii: pdb.prot5637. doi: 10.1101/pdb.prot5637. PMID: 21632774
IMGT booklet high resolutionpdficon lower resolutionpdficon 'With generous provision from Cold Spring Harbor (CSH) Protocols'.

391) Ehrenmann, F., Lefranc, M.-P.
IMGT/DomainGapAlign: IMGT Standardized Analysis of Amino Acid Sequences of Variable, Constant, and Groove Domains (IG, TR, MH, IgSF, MhSF)
Cold Spring Harb Protoc. 2011 Jun 1;2011(6): 737-749. pii: pdb.prot5636. doi: 10.1101/pdb.prot5636. PMID: 21632775
IMGT booklet high resolutionpdficon lower resolutionpdficon 'With generous provision from Cold Spring Harbor (CSH) Protocols'.

390) Ehrenmann, F., Giudicelli., V, Duroux, P., Lefranc, M.-P.
IMGT/Collier de Perles: IMGT Standardized Representation of Domains (IG, TR, and IgSF Variable and Constant Domains, MH and MhSF Groove Domains)
Cold Spring Harb Protoc. 2011 Jun 1;2011(6): 726-736. pii: pdb.prot5635. doi: 10.1101/pdb.prot5635. PMID: 21632776
IMGT booklet high resolutionpdficon lower resolutionpdficon 'With generous provision from Cold Spring Harbor (CSH) Protocols'.

389) Giudicelli, V., Lefranc, M.-P.
IMGT/JunctionAnalysis: IMGT Standardized Analysis of the V-J and V-D-J Junctions of the Rearranged Immunoglobulins (IG) and T Cell Receptors (TR)
Cold Spring Harb Protoc. 2011 Jun 1;2011(6): 716-725. pii: pdb.prot5634. doi: 10.1101/pdb.prot5634. PMID: 21632777
IMGT booklet high resolutionpdficon lower resolutionpdficon 'With generous provision from Cold Spring Harbor (CSH) Protocols'.

388) Giudicelli, V., Brochet, X., Lefranc, M.-P.
IMGT/V-QUEST: IMGT Standardized Analysis of the Immunoglobulin (IG) and T Cell Receptor (TR) Nucleotide Sequences
Cold Spring Harb Protoc. 2011 Jun 1;2011(6): 695-715. pii: pdb.prot5633. doi: 10.1101/pdb.prot5633. PMID: 21632778
IMGT booklet high resolutionpdficon lower resolutionpdficon 'With generous provision from Cold Spring Harbor (CSH) Protocols'.

387) Lefranc, M.-P.
IMGT Collier de Perles for the Variable (V), Constant (C), and Groove (G) Domains of IG, TR, MH, IgSF, and MhSF
Cold Spring Harb Protoc. 2011 Jun 1;2011(6): 643-651. pii: pdb.ip86. doi: 10.1101/pdb.ip86. PMID: 21632788
IMGT booklet high resolutionpdficon lower resolutionpdficon 'With generous provision from Cold Spring Harbor (CSH) Protocols'.

386) Lefranc, M.-P.
IMGT Unique Numbering for the Variable (V), Constant (C), and Groove (G) Domains of IG, TR, MH, IgSF, and MhSF
Cold Spring Harb Protoc. 2011 Jun 1;2011(6): 633-642. pii: pdb.ip85. doi: 10.1101/pdb.ip85. PMID: 21632789
IMGT booklet high resolutionpdficon lower resolutionpdficon 'With generous provision from Cold Spring Harbor (CSH) Protocols'.

385) Lefranc, M.-P.
From IMGT-ONTOLOGY CLASSIFICATION Axiom to IMGT Standardized Gene and Allele Nomenclature: For Immunoglobulins (IG) and T Cell Receptors (TR)
Cold Spring Harb Protoc. 2011 Jun 1;2011(6): 627-632. pii: pdb.ip84. doi: 10.1101/pdb.ip84. PMID: 21632790
IMGT booklet high resolutionpdficon lower resolutionpdficon 'With generous provision from Cold Spring Harbor (CSH) Protocols'.

384) Lefranc, M.-P.
From IMGT-ONTOLOGY DESCRIPTION Axiom to IMGT Standardized Labels: For Immunoglobulin (IG) and T Cell Receptor (TR) Sequences and Structures
Cold Spring Harb Protoc. 2011 Jun 1;2011(6): 614-626. pii: pdb.ip83. doi: 10.1101/pdb.ip83. PMID: 21632791
IMGT booklet high resolutionpdficon lower resolutionpdficon 'With generous provision from Cold Spring Harbor (CSH) Protocols'.

383) Lefranc, M.-P.
From IMGT-ONTOLOGY IDENTIFICATION Axiom to IMGT Standardized Keywords: For Immunoglobulins (IG), T Cell Receptors (TR), and Conventional Genes
Cold Spring Harb Protoc. 2011 Jun 1;2011(6): 604-613. pii: pdb.ip82. doi: 10.1101/pdb.ip82. PMID: 21632792
IMGT booklet high resolutionpdficon lower resolutionpdficon 'With generous provision from Cold Spring Harbor (CSH) Protocols'.

382) Lefranc, M.-P.
IMGT, the International ImMunoGeneTics Information System
Cold Spring Harb Protoc. 2011 Jun 1;2011(6): 595-603. pii: pdb.top115. doi: 10.1101/pdb.top115. PMID: 21632786
IMGT booklet high resolutionpdficon lower resolutionpdficon 'With generous provision from Cold Spring Harbor (CSH) Protocols'.

381) Braoudaki, M., Katsibardi, K., Giudicelli, V., Karamolegou, K., Papathanassiou, C., Lefranc, M.-P.
Analysis of somatic hypermutations of immunoglobulin gene rearrangements in childhood acute lymphoblastic leukemia. Cancer Invest
Cancer Invest. 2011 Jun;29(5):360-364. PMID: 21599512

380) Lakhdar, R., Denden, S., Kassab, A., Leban, N., Knani, J., Lefranc, G, Miled, A., Ben Chibani, J.B., Haj-Khelil, A.H.
Update in chronic obstructive pulmonary disease: role of antioxidant and metabolizing gene polymorphisms
Exp Lung Res. 2011 Aug;37(6):364-375. Epub 2011 Jul 1. PMID: 21721950

379) Brun, M.-E., Lana, E., Rivals, I., Lefranc, G., Sarda, P., Claustres, M., Mégarbané, A. and de Sario, A.
Heterochromatic genes undergo epigenetic changes and escape silencing in Immunodeficiency, Centromeric Instability, Facial Anomalies (ICF) Syndrome
PLOS One April 2011, vol.6, issue 4, e19464. PMID: 21559330

378) Antonacci, R., Mineccia, M., Lefranc, M.-P., Ashmaoui, H.M., Lanave, C., Piccinni, B., Pesole, G., Hassanane, M.S., Massari, S., Ciccarese, S.
Expression and genomic analyses of Camelus dromedarius T cell receptor delta (TRD) genes reveal a variable domain repertoire enlargement due to CDR3 diversification and somatic mutation
Mol. Immunol. 2011 Jul;48(12-13):1384-96. Epub 2011 Apr 20. PMID: 21511341

377) Medlej-Hashim, M., Chouery, E., Salem, N., Delague, V., Lefranc, G., Loiselet, J. and Mégarbané, A.
Familial Mediterranean fever in a large Lebanese family: Multiple MEFV mutations and evidence for a Founder effect of the p.[M694I] mutation
Eur. J. Med. Genet. 2011 Jan-Feb;54(1):50-54. Epub 2010 Oct 15. PMID: 20937419

376) Lakhdar, R., Denden, S., Mouhamed, M.H., Chalgoum, A., Leban, N., Knani, J., Lefranc, G., Miled, A., Chibani, J.B. and Khelil, A.H.
Correlation of EPHX1, GSTP1, GSTM1, and GSTT1 genetic polymorphisms with antioxidative stress markers in chronic obstructive pulmonary disease
Exp Lung Res. 2011 May;37(4):195-204. Epub 2011 Feb 11. PMID: 21309732

375) Lefranc, M-P.
Antibody nomenclature: From IMGT-ONTOLOGY to INN definition
MAbs. 2011 3(1):1-2. Epub 2011 Jan 1. PMID: 21099347 pdf

2010

374) Lakhdar, R., Denden, S., Knani, J., Leban, N., Daimi, H., Hassine, M., Lefranc, G., Chibani, J.B. and Khelil, AH.
Microsomal epoxide hydrolase gene polymorphisms and susceptibility to chronic obstructive pulmonary disease in the tunisian population
Genet. Test. Mol. Biomarkers. 2010 Dec;14(6):857-863. Epub 2010 Oct 9. PMID: 20932192

373) Robert, R., Lefranc, M.-P., Ghochikyan, A., Agadjanyan, M.G., Cribbs, D.H., Van Nostrand, W.E., Wark, K.L. and Dolezal, O.
Restricted V gene usage and VH/VL pairing of mouse humoral response against the N-terminal immunodominant epitope of the amyloid β peptide
Mol. Immunol., 48(1-3):59-72 (2010). PMID: 20970857

372) Ehrenmann, F., Duroux, P., Giudicelli, V. and Lefranc, M.-P.
Standardized sequence and structure analysis of antibody using IMGT®
In: Antibody engineering, Vol. 2, Kontermann R. and Dübel S. (eds), Springer-Verlab Berlin Heidelberg, chap. 2, pp. 11-31 (2010). ISBN: 978-3-642-01146-7

371) Leban, N., Aloui, S., Touati, D., Lakhdhar, R., Skhiri, H., Lefranc, G., Achour, A., Elmay, M., Lopez-Trascasa, M., Sanchez-Corral, P., Chibani, J. and Haj Khelil, A.
Atypical hemolytic uremic syndrome in the Tunisian population
Int. Urol. Nephrol. 2011, 43(2):559-564. doi: 10.1007/s11255-010-9754-3. Epub 2010 May 25. PMID: 20499172

370) Lakhdar, R., Denden, S., Knani, J., Leban, N., Daimi, H., Hassine, M., Lefranc, G., Ben Chibani, J., Haj Khelil, A.
Association of GSTM1 and GSTT1 Polymorphisms with Chronic Obstructive Pulmonary Disease in a Tunisian Population
Biochem. Genet., 48, 647-657 (2010). Epub 2010 May 21. PMID: 20495862

369) Lakhdar, R., Denden, S., Knani, J., Leban, N., Daimi, H., Hassine, M., Lefranc, G., Ben Chiban, J., Haj Khelil, A.
Relationship between glutathione S-transferase P1 polymorphisms and chronic obstructive pulmonary disease in a Tunisian population
Genet. Mol. Res. 2010 May 11;9(2):897-907. PMID: 20467983 pdf

368) Denden, S., Lakhdar, R., Leban, N., Daimi, H., El Hayek, D., Knani, J., Perrin, P., Lefranc, G., Ben Chibani, J. and Haj Khelil, A.
Mise au point: déficit en alpha 1 antitrypsine. A review: alpha1 antitrypsin deficiency.
Rev. Med. Genet. Hum., 1, 26-33 (2010).

367) Lane, J., Duroux, P. and Lefranc, M.-P.
From IMGT-ONTOLOGY to IMGT/LIGMotif: the IMGT® standardized approach for immunoglobulin and T cell receptor gene identification and description in large genomic sequences.
BMC Bioinformatics 2010, 11:223; doi:10.1186/1471-2105-11-223. PMID: 20433708

366) Chouery, E., Pangrazio, A., Frattini, A., Villa, A., Van Wesenbeeck, L., Piters, E., Van Hul, W., Coxon, F., Schouten, T., Helfrich, M., Lefranc, G., Mégarbané, A.
A new familial sclerosing bone dysplasia.
J. Bone Miner. Res., 25(3): 676-680 (2010). PMID: 20422625

365) Haj Khelil, A., Denden, S., Leban, N., Daimi, H., Lakhdhar, R., Lefranc, G., Ben Chibani, J. and Perrin, P.
Hemoglobinopathies in North Africa: a review.
Hemoglobin., 34(1):1-23 (2010). PMID: 20113284

364) Halling-Brown, M., Pappalardo, F., Rapin, N., Zhang, P., Alemani, D., Emerson, A., Castiglione, F., Duroux, P., Pennisi, M., Miotto, O., Churchill, D., Rossi, E., Moss, D.S., Sansom, C.E., Bernaschi, M., Lefranc, M.-P., Brunak, S., Lund, O., Motta, S., Lollini, P.-L., Murgo, A., Palladini, A., Basford, K.E., Brusic, V. and Shepherd, A.J.
ImmunoGrid: Towards agent-based simulations of the human immune system at a natural scale.
Philos. Transact. A Math. Phys. Eng. Sci., 368(1920), 2799-2815 (2010). PMID: 20439274 pdf

363) Pappalardo, F., Lefranc, M.-P., Lollini, P.-L. and Motta, S.
A novel paradigm for cell and molecular interaction: from the CMM model to IMGT-ONTOLOGY.
Immunome Res. 6(1) :1-11 (2010); doi:10.1186/1745-7580-6-1. Free PMC Article. PMID: 20167082 pdf

362) Herzig, T.A., Lefranc, M.-P. and Baldwin, C.L.
Annotation and classification of the bovine T cell receptor delta genes.
BMC Genomics, 11:100 (2010); doi:10.1186/1471-2164-11-100. PMID: 20144200

361) Ehrenmann, F., Kaas, Q. and Lefranc, M.-P.
IMGT/3Dstructure-DB and IMGT/DomainGapAlign: a database and a tool for immunoglobulins or antibodies, T cell receptors, MHC, IgSF and MhcSF.
Nucl. Acids Res., 38, D301-307 (2010). Epub 2009 Nov 9; doi:10.1093/nar/gkp946. PMID: 19900967 pdf

2009

360b) Lefranc, M.-P.
Antibody databases and tools: The IMGT® experience
In: Therapeutic monoclonal antibodies: from Bench to Clinic. Zhiqiang An (ed) John Wiley & Sons, Inc. Chap. 4, pp. 91-114 (2009). ISBN: 978-0-470-11791-0

360) Dayanithi, G., Richard, I., Viero, C., Mazuc, E., Mallie, S., Valmier, J., Bourg, N., Herasse, M., Marty, I., Lefranc, G., Mangeat, P. and Baghdiguian, S.
Alteration of sarcoplasmic reticulum ca release in skeletal muscle from calpain 3-deficient mice.
Int J Cell Biol. (2009); 2009:340346. Epub 2010 Mar 14. PMID: 20300593

359) Lefranc, M.-P.
Antibody databases: IMGT®, a French platform of world-wide interest. Bases de données anticorps: IMGT®, une plate-forme française d'intérêt mondial "Anticorps monoclonaux en thérapeutique"
Médecine/Sciences, 25, 1020-1023 (2009). PMID: 20035673

358) Denden, S., Braham, W., Amri, F., Lakhdar, R., Lefranc, G., Knani, J., Ben Chibani, J. and Haj Khelil, A.
Biochemical and molecular diagnosis of alpha 1 antitrypsin deficiency in a Tunisian family
Ann Biol Clin 2009, 67, 441-445. French. PMID: 19654085

357) Giudicelli, V. and Lefranc, M.-P.
IMGT® standardized analysis of immunoglobulin rearranged sequences.
In: Immunoglobulin Gene Analysis in Chronic Lymphocytic Leukemia (Ghia, P., Rosenquist, R. and Davi, F. eds), Wolters Kluwer Health Italy Ltd, Milan, Italy, chap. 2, pp. 33-52. (2009). ISBN: 978-88-7556-377-6

356) Aouacheri, W., Saka S., Djafer, R., Lefranc, G.
Protective effect of diclofenac towards the oxidative stress induced by paracetamol toxicity in rats
Ann Biol Clin (Paris). Nov-Dec;67(6):619-27 (2009). French. PMID: 19939765

355) Pelat, T., Hust, M., Hale, M., Lefranc, M.-P., Dübel, S. and Thullier, P.
Isolation of a human-like antibody fragment (scFv) that neutralizes ricin biological activity
BMC Biotechnology, 9:60. Epub 2009 Jun 30 (2009); doi:10.1186/1472-6750-9-60. PMID: 19563687

354) Jefferis, R and Lefranc, M.-P.
Human immunoglobulin allotypes: Possible implications for immunogenicity
MAbs, 1(4), 332-338 (2009). PMID: 20073133 pdf

353) Massari, S., Bellahcene, F., Vaccarelli, G., Carelli, G., Mineccia, M., Lefranc, M.-P., Antonacci, R. and Ciccarese, S.
The deduced structure of the T cell receptor gamma locus in Canis lupus familiaris
Mol. Immunol., 2009, 46, 2728-2736. Epub 2009 Jun 17. PMID: 19539375 pdf

352) Pappalardo, F., Halling-Brown, M., Rapin, N., Zhang, P., Alemani, D., Emerson, A., Paci, P., Duroux, P., Penissi, M., Palladini, A., Miotto, O., Churchill, D., Rossi, E., Shepherd, A.J., Moss, D.S., Castiglione, F., Bernaschi, M., Lefranc, M-P., Brunak, S., Motta, S., Lollini, P.L., Basford, K.E. and Brusic, V.
ImmunoGrid, an integrative environment for large-scale simulation of the immune system for vaccine discovery, design, and optimization
Briefings in Bioinformatics, 10, 330-340 (2009). PMID: 19383844

351) Magdelaine-Beuzelin, C., Vermeire, S., Goodall, M., Baert, F., Noman, M., Van Assche, G., Ohresser, M., Degenne, D., Dugoujon, J.M., Jefferis, R., Rutgeerts, P., Lefranc, M.-P. and Watier, H.
IgG1 heavy chain-coding gene polymorphism (G1m allotypes) and development of antibodies-to-infliximab
Pharmacogenetics and Genomics, 19, 383-387 (2009). PMID: 19319024 pdf

350) Hansen, J.D., Pasquier, L.D., Lefranc, M.-P., Lopez, V., Benmansour, A. and Boudinot, P.
The B7 family of immunoregulatory receptors: A comparative and evolutionary perspective
Mol. Immunol. 2009, 46, 457-72. Epub 2008 Dec 9. PMID: 19081138

349) Lefranc, M.-P., Giudicelli, V., Ginestoux, C., Jabado-Michaloud, J., Folch, G., Bellahcene, F., Wu, Y., Gemrot, E., Brochet, X., Lane, J., Regnier, L., Ehrenmann, F., Lefranc, G. and Duroux, P.
IMGT®, the international ImMunoGeneTics information system®
Nucl. Acids Res, 37, D1006-D1012 (2009); doi:10.1093/nar/gkn838. PMID: 18978023 pdf

2008

348) Pelat, T., Bedouelle, H., Rees, A.R., Crennell, S.J., Lefranc, M.-P. and Thullier, P.
Germline humanization of a non-human Primate antibody that neutralizes the anthrax toxin, by in vitro and in silico engineering
J. Mol. Biol. 2008, 384, 1400-1407. Epub 2008 Oct 19. PMID: 18976662 pdf

347) Haj-Khelil, A., Denden, S., Hlioui, L., Hattab, N., Daimi, H., Leban, N., Perrin, P., Lefranc, G. and Ben Chibani, J.
Alpha 1 antitrypsin polymorphism associated to asthma and emphysema in a central Tunisian population
Ann. Biol. Clin. (Paris), 66, 379-384 (2008) (French). PMID: 18725338

346) Jiao, H., Tóth, B., Erdõs, M., Fransson, I., Rákóczi, E., Balogh, I., Magyarics, Z., Dérfalvi, B., Csorba, G., Szaflarska, A., Megarbane, A., Akatcherian, C., Dbaibo, G., Rajnavölgyi, E., Hammarström, L., Kere, J., Lefranc, G. and Maródi, L.
Novel and recurrent STAT3 mutations in hyper-IgE syndrome patients from different ethnic groups
Mol. Immunol., 46, 202-206 (2008). PMID: 18706697

345) Bleakley, K., Lefranc, M.-P. and Biau, G.
Recovering probabilities for nucleotide trimming processes for T cell receptor TRA and TRG V-J junctions analyzed with IMGT tools
BMC Bioinformatics, 9, 408 (2008). PMID: 18831754 pdf

344) Brochet, X., Lefranc, M.-P. and Giudicelli, V.
IMGT/V-QUEST: the highly customized and integrated system for IG and TR standardized V-J and V-D-J sequence analysis
Nucl. Acids Res, 36, W503-508 (2008). PMID: 18503082 pdf

343) Lefranc, M.-P., Giudicelli, V., Regnier, L. and Duroux, P.
IMGT®, a system and an ontology that bridge biological and computational spheres in bioinformatics
Briefings in Bioinformatics, 9(4):263-275 (2008) doi:10.1093/bib/bbn014. PMID: 18424816 pdf

342) Lefranc, M.-P.
IMGT®, the international ImMunoGeneTics information system® for immunoinformatics. Methods for querying IMGT® databases, tools and Web resources in the context of immunoinformatics
Mol. Biotechnol., 40, 101-111 (2008). Epub 2008 May 8. PMID: 18463990

341) Berniell-Lee, G., Plaza, S., Bosch, E., Calafell, F., Jourdan, E., Césari, M., Lefranc, G., Comas, D.
Admixture and sexual bias in the population settlement of La Réunion Island (Indian Ocean).
Am J Phys Anthropol. 2008, 136, 100-107. PMID: 18186507 pdf

340) Benayoun, B., Baghdiguian, S., Lajmanovich, A., Bartoli, M., Daniele, N., Gicquel, E., Bourg, N., Raynaud, F., Pasquier, M.-A., Suel, L., Lochmuller, H., Lefranc, G. and Richard, I.
NF-kB dependent expression of the antiapoptotic factor c-FLIP is regulated by calpain 3, the protein involved in limb-girdle muscular dystrophy type 2A
FASEB J. 2008, 22, 1521-1529. Epub 2007 Dec11. PMID: 18073330 pdf

339) Kaas, Q., Duprat, E., Tourneur, G. and Lefranc, M.-P.
IMGT standardization for molecular characterization of the T cell receptor/peptide/MHC complexes
In: Immunoinformatics (Schoenbach C., Ranganathan S. and Brusic V. eds.), Immunomics Reviews, Series of Springer Science and Business Media LLC, Springer, New York, USA chap. 2, pp.19-49 (2008). pdf

338) Lefranc, M.-P.
IMGT-ONTOLOGY, IMGT® databases, tools and Web resources for Immunoinformatics
In: Immunoinformatics (Schoenbach C., Ranganathan S. and Brusic V. eds.), Immunomics Reviews, Series of Springer Science and Business Media LLC, Springer, New York, USA chap. 1, pp.1-18 (2008). pdf

337) Duroux, P., Kaas, Q., Brochet, X., Lane, J., Ginestoux, C., Lefranc, M.-P. and Giudicelli, V
IMGT-Kaleidoscope, the Formal IMGT-ONTOLOGY paradigm
Biochimie, 90, 570-583 (2008). Epub 2007 Sep11. PMID: 17949886 pdf

336) Lefranc, M.-P.
WHO-IUIS Nomenclature Subcommittee for Immunoglobulins and T cell receptors report
Immunoglobulins and T cell receptors report August 2007, 13th International Congress of Immunology, Rio de Janeiro, Brazil.
Dev. Comp. Immunol., 32, 461-463 (2008). Epub 2007 Nov6, doi:10.1016/j.dci.2007.09.008. PMID: 18036660 pdf with permission from Elsevier

335) Denden, S., Haj Khelil, A., Perrin, P., Daimi, H., Leban, N., Ouaja, A., Mahdouani, K., Hlioui, L., Lefranc, G., Ben, Chibani, J.
Alpha 1 antitrypsin polymorphism in the tunisian population with special reference to pulmonary disease
Pathol. Biol. (Paris), 2008, 56, 106-110. Epub 2007 Nov 26. PMID: 18031952

2007

334) Lefranc, M.-P.
WHO-IUIS Nomenclature Subcommittee for Immunoglobulins and T cell receptors report
Immunogenetics, 59, 899-902 (2007), Epub 2007 Nov29. PMID: 18046549

333) Kaas, Q., Ehrenmann, F. and Lefranc, M.-P.
IG, TR, MHC, IgSf and MhcSF: what do we learn from the IMGT Colliers de Perles?
Brief. Funct. Genomic Proteomic, 2007, 6, 253-264. Epub 2008 Jan 21. doi:10.1093/bfgp/elm032. PMID: 18208865 pdf

332) Duroux, P., Giudicelli, V., Kaas, Q., Jabado-Michaloud, J., Folch, G., Ginestoux, C., Brochet, X., Lane, J., Regnier, L., Wu, Y., Garapati, V.P., Bellahcene, F., Servier, E.-J., Ehrenmann, F., Lefranc, G and Lefranc, M.-P.
IMGT®, the international ImMunoGeneTics information system®, the reference in immunogenetics and immunoinformatics
In: Proceedings First International Congress on Macromolecular Biochemistry and Genetics
Gafsa, Tunisia, 12-16 April 2007
A Focus on Biochemistry and Genetics: from concepts to therapeutic advances (Ed. Fattoum A.), pp. 185-198 (2007). pdf

331) Lefranc, G.
Genetic diseases in consanguineous families: Invaluable contribution to the fundamental research
In: Proceedings First International Congress on Macromolecular Biochemistry and Genetics.
Gafsa, Tunisia, 12-16 April 2007.
A Focus on Biochemistry and Genetics: from concepts to therapeutic advances (Ed. Fattoum A.) pp. 33-48 (2007). pdf

330) Lefranc, M.-P.
IMGT®, the international ImMunoGeneTics information system® for immunoinformatics. Methods for querying IMGT® databases, tools and Web resources in the context of immunoinformatics
In: Methods in Molecular Biology. Immunoinformatics: Predicting immunogenicity in silico (Flower D.R. Ed.), Humana Press Inc. Totowa N.J. USA, 409, chap. 2, pp. 19-42 (2007). PMID: 18449990 pdf with permission from Springer

329) Giudicelli, V. and Lefranc, M.-P.
Le paradigme IMGT-ONTOLOGY
In: Biologie Systémique Standards et modèles (Roux M. Ed.), Collection Ecrin, Omniscience, Presses Universitaires de France, Paris, 2007, Chapitre 6, pp143-164. ISBN: 978-2-916097-12-1

328) Alroy, J., Pfannl,, A., Lefranc, G., Frattini, A., Mégarbané, A.
Electron microscopic findings in skin biopsies from patients with infantile osteopetrosis and neuronal storage disease
Ultrastruct Pathol., 31, 333-338 (2007). PMID: 17963182

327) Magdelaine-Beuzelin, C., Kaas, Q., Wehbi, V., Ohresser, M., Jefferis, R., Lefranc, M.-P., Watier, H.
Structure-function relationships of the variable domains of monoclonal antibodies approved for cancer treatment
Critical reviews in Oncology and Hematology, 2007, 64, 210-225. Epub 2007 July 12. PMID: 17624800 pdf

326) Pelat, T., Hust, M., Laffly, E., Condemine, F., Bottex, C., Vidal, D., Lefranc, M.-P., Dubel, S. and Thullier, P.
A high affinity, human-like antibody fragment (scFv) neutralising the lethal factor (LF) of Bacillus anthracis by inhibiting PA-LF complex formation
Antimicrob Agents Chemother., May 21 (2007) [Epub ahead of print], 51, 2758-2764 (2007). PMID: 17517846 pdf

325) Garapati, V.P., Lefranc, M.-P.
IMGT Colliers de Perles and IgSF domain standardization for T cell costimulatory activatory (CD28, ICOS) and inhibitory (CTLA4, PDCD1 and BTLA) receptors
Dev. Comp. Immunol., 31, 1050-1072 (2007). PMID: 17391759 pdf

324) Souraty, N., Noun, P., Djambad-Khayat, C., Chouery, E., Pancrazio, A., Villa, A., Lefranc, G., Frattini, A. and Mégarbané, A.
Molecular study of six families originating from the Middle-East and presenting with autosomal recessive osteopetrosis
Eur. J. Med. Genet., 50, 188-199 (2007). PMID: 17400532

323) Leban, N., Haj Khelil, A., Daimi, H., Denden, S., Slimene, F., Mehdouani, K., Abdennaji Guenounou, B., Lefranc, G., Perrin, P. and Ben Chibani, J.
Polymorphisme du C3 du complément chez des patients atteints de bronchopneumopathie chronique obstructive en Tunisie
Ann. Biol. Clin., 65, 251-256 (2007). PMID: 17502296

322) Kaas, Q. and Lefranc, M.-P.
IMGT Colliers de Perles: standardized sequence-structure representations of the IgSF and MhcSF superfamily domains
Current Bioinformatics, 2, 21-30 (2007). pdf

321) Martinez, O., Gangi, E., Mordi, D., Gupta, S., Dorevitch, S., Lefranc, M.-P. and Prabhakar, B.S.
Diversity in the Complementarity Determining Region 3 (CDR3) of Antibodies from mice with evolving anti-TSHR antibody responses
Endocrinology, Epub 2006 Oct 26; 148, 752-761 (2007). PMID: 17068139

320) Conrad, M.L., Mawer, M.A., Lefranc, M.-P., McKinneli, L., Whitehead, J., Davis, S.K., Pettman, R. and Koop, B.F.
The genomic sequence of the bovine T cell receptor gamma TRG loci and localization of the TRGC5 cassette
Vet. Immunol. Immunopathol., Epub 2006 Dec 1; 115, 346-356 (2007). PMID: 17141331 pdf

319) Bernard, D., Hansen, J.D., du Pasquier, L., Lefranc, M.-P., Benmansour, A. and Boudinot, P.
Costimulatory receptors in jawed vertebrates: conserved CD28, odd CTLA4 and multiple BTLAs
Dev. Comp. Immunol., Epub 2006 Aug 4; 2007, 31, 255-271. PMID: 16928399 pdf

2006

318) Bleakley, K., Giudicelli, V., Wu, Y., Lefranc, M.-P. and Biau, G.
IMGT standardization for statistical analyses of T cell receptor junctions: the TRAV-TRAJ example
In Silico Biol., Epub 2006, 6, 0051, 6, 573-588 (2006). PMID: 17518765 pdf

317) Abed, R.E., Khechine, A.E., Omri, H.E., Youssef, S., Laatiri, A., Lefranc, M.-P., Khelif, A., Soua, Z.
Chemiluminescent detection of clonal immunoglobulin and T cell receptor gene rearrangements in Tunisian lymphoid malignancies, leukemias and lymphomas
Leuk Lymphoma., 47, 1129-1137 (2006). PMID: 16840206

316) Capelli, C., Redhead, N., Romano, V., Cali, F., Lefranc, G., Delague, V., Mégarbané, A., Felice, A.E., Pascali, V.L., Neophytou, P.I., Poulli, Z., Novelleto, A., Malaspina, P., Terrenato, L., Berebbi, A., Fellous, M., Thomas, M.G. and Goldstein, D.B.
Population structure in the Mediterranean basin: a Y chromosome perspective
Annals of Human Genetics, 70, 207-225 (2006). PMID: 16626331

315) Baum, T.P., Hierle, V., Pascal, N., Bellahcene, F., Chaume, D., Lefranc, M.-P., Jouvin-Marche, E., Marche, P.N. and Demongeot, J.
IMGT/GeneInfo: T cell receptor gamma TRG and delta TRD genes in database give access to all TR potential V(D)J recombinations
BMC Bioinformatics, 7, 224 (2006). PMID: 16640788 pdf

314) Buhler, S., Mégarbané, A., Lefranc, G., Tiercy, J.M. and Sanchez-Mazas, A.
HLA-C molecular characterization of a Lebanese population and genetic structure of 39 populations from Europe to India-Pakistan
Tissue Antigens, 68, 44-57 (2006). PMID: 16774539

313) Pangrazio, A., Poliani, P.L., Mégarbané, A., Lefranc, G., Lanino, E., Di Rocco, M., Rucci, F., Lucchini, F., Ravanini, M., Facchetti, F., Abinun, M., Vezzoni, P., Villa, A. and FRATTINI A.
Mutations in OSTM1 (Grey Lethal) define a particular severe form of autosomal recessive osteopetrosis with neural involvement
Journal of Bone and Mineral Research, 21, 1098-1105 (2006). PMID: 16813530

312) Herzig, C., Blumerman, S., Lefranc, M.-P. and Baldwin, C.
Bovine T cell receptor gamma variable and constant genes: combinatorial usage by circulating γδ T cells
Immunogenetics. Epub 2006 Mar 16, 58, 138-151 (2006). PMID: 16541255 pdf

311) Lefranc, M.-P.
Using bioinformatics tools for the sequence analysis of the immunoglobulins and T cell receptors
In: Current Protocols in Immunology (J. E. Coligan, B.E. Bierer, D.E. Margulies, E.M. Shevach and W. Strober, eds.), John Wiley and Sons, Hoboken N.J., pp. A.1W.1-A.1W.15 (2006). PMID: 18432961

310) Lefranc, M.-P.
Web sites of Interest to Immunologists
In: Current Protocols in Immunology (J. E. Coligan, B.E. Bierer, D.E. Margulies, E.M. Shevach and W. Strober, eds.), John Wiley and Sons, Hoboken N.J., pp. A.1J.1-A.1J.74 (2006). PMID: 18432959

309) Duprat, E., Lefranc, M.-P. and Gascuel, O.
A simple method to predict protein binding from aligned sequences - application to MHC superfamily and beta2-microglobulin
Bioinformatics, 22, 453-459 (2006). Epub 2005 Dec 13. PMID: 16352655 pdf

308) Gueguen, Y., Garnier, J., Robert, L., Lefranc, M.-P., Mougenot, I., de Lorgeril, J., Janech, M., Gross, P., Warr, G., Cuthbertson, B., Barracco, M.A., Bulet, P., Aumelas, A., Yang, Y., Bo, D., Xiang, J., Tassanakajon, A., Piquemal, D. and Bachère, E.
PenBase, the shrimp antimicrobial peptide penaeidin database: sequence-based classification and recommended nomenclature
Dev. Comp. Immunol.,15, 30, 283-288 (2006). Epub 2005 June . PMID: 15963564 pdf

307) Giudicelli, V., Duroux, P., Ginestoux, C., Folch, G., Jabado-Michaloud, J., Chaume, D. and Lefranc, M.-P.
IMGT/LIGM-DB, the IMGT® comprehensive database of immunoglobulin and T cell receptor nucleotide sequences
Nucleic Acids Res., 34, D781-D784 (2006). PMID: 16381979 pdf

2005

306) Kaas, Q. and Lefranc, M.-P.
T cell receptor/peptide/MHC molecular characterization and standardized pMHC contact sites in IMGT/3Dstructure-DB
In Silico Biology.Epub 2005, 5, 0046 Oct 20, 5, 505-528 (2005). PMID: 16268793 pdf

305) Medlej-Hashim, M., Serre, J.L., Corbani, S., Saab, O., Jalkh, N., Delague, V., Chouery, E., Salem, N., Loiselet, J., Lefranc, G. and Mégarbané, A.
Familial Mediterranean fever (FMF) in Lebanon and Jordan: a population genetics study and report of three novel mutations
Eur. J. Med. Genet. Epub 2005 Jun 20, 48, 412-20 (2005). PMID: 16378925 pdf

304) Lefranc, M.-P.
IMGT-ONTOLOGY and IMGT databases, tools and Web resources for Immunoinformatics. From the IMGT genomics, genetics and structural approaches to IMGT-Choreography
Interdisciplinary seminar series. Computer Science and IT with/for Biology.
Keet C.M. and Franconi E. (eds), Free University of Bozen-Bolzano, Italy, pp. 26-38 (2005).

303) Lefranc, M.-P.
IMGT, the international ImMunoGeneTics information system®: a standardized approach for immunogenetics and immunoinformatics
Immunome Res., 2005, Sept 20;1(3):1-11, doi:10.1186/1745-7580-1-3 (2005). Free PMC Article. PMID: 16305737 pdf

302) Kaas, Q., Chiche, L. and Lefranc, M.-P.
IMGT unique numbering for standardized contact analysis of immunoglobulin/antigen and T cell receptor/peptide/MHC complexes.
In: BIOINFO2005, Proceedings of the 2005 International Joint Conference of InCoB, AASBi and KSBI, Lee, D., Wong, L., Kim D.-W., Kim, C., Tan T.W. and Lee K.-H. (eds), Kaist Press, Daejeon, Korea, pp. 209-214 (2005). ISBN: 89-89453-12-7 93560

301) Frigoul, A. and Lefranc, M.-P.
MICA: standardized IMGT allele nomenclature, polymorphisms and diseases
In: Recent Research Developments in Human Genetics (Pandalai S.G., ed.), Research Signpost, Trivandrum, Kerala, India, 2005, 3, 95-145. ISBN: 81-7736-244-5 pdf

300) Laffly, E., Danjou, L., Condemine, F., Vidal, D., Drouet, E., Lefranc, M.-P., Bottex, C. and Thullier, P.
Selection of a macaque Fab with human-like framework regions, high affinity, and that neutralizes the protective antigen (PA) of Bacillus anthracis
Antimicrob. Agents Chemother., 49, 3414-3420 (2005). PMID: 16048955

299) Chaume, D., Combres, K., Giudicelli, V. and Lefranc, M.-P.
Retrieving factual data and documents using IMGT-ML in the IMGT information system®
Technologies and technological platforms of interest to the field, with emphasis on: Ontologies, Databases and Applications of Semantics in Bioinformatics.
NETTAB 2005 Workflows management: new abilities for the biological information overflow. Naples, Italy.
NETTAB., 47-51 (2005). pdf

298) Giudicelli, V., Chaume, D., Jabado-Michaloud, J. and Lefranc, M.-P.
Immunogenetics sequence annotation: the strategy of IMGT based on IMGT-ONTOLOGY
The XIXth International Congress of the European Federation for Medical Informatics, Geneva, Switzerland, MIE 2005, Geneva, Switzerland, August 28- September 1, 2005.
In: Connecting Medical Informatics and Bio-informatics. Proceedings of the Medical Informatics Europe MIE 2005 (Engelbrecht R., Geissbuhler A., Lovis C. and Mihalas G. eds.), IOS Press, Technology and Informatics.
Stud. Health Technol. Inform. 2005, 116, 3-8 . PMID: 16160227

297) Giudicelli V. and Lefranc M.-P.
Interactive IMGT on-line tools for the analysis of immunoglobulin and T cell receptor repertoires
In: New Research on Immunology (B.A. Veskler, ed.), Nova Science, pp.77-105 (2005). ISBN: 1-59454-289-9

296) Lefranc, M.-P., Duprat, E., Kaas, Q., Tranne, M., Thiriot, A. and Lefranc, G.
IMGT unique numbering for MHC groove G-DOMAIN and MHC superfamily (MhcSF) G-LIKE-DOMAIN
Dev. Comp. Immunol., 29, 917-938 (2005). PMID: 15936075 pdf with permission from Elsevier

295) Chaume, D., Giudicelli, V., Combres, K., Ginestoux, C. and Lefranc, M.-P.
IMGT-Choreography: processing of complex immunogenetics knowledge
Computational Methods in Systems Biology CMSB 2004, Paris, France, May 26-28, 2004 (Danos V. and Schachter, V., eds)
In: Lecture Notes in Computer Science, Springer-Verlag GmbH Berlin Heidelberg, pp 73-84 (2005). ISBN: 3-540-25375-0

294) Lefranc, M.-P., Clément, O., Kaas, Q., Duprat, E., Chastellan, P., Coelho, I., Combres, K., Ginestoux, C., Giudicelli, V., Chaume, D. and Lefranc, G.
IMGT-Choreography for Immunogenetics and Immunoinformatics
In Silico Biology, 5, 45-60, Epub 2005, 5, 0006, 24 Dec 2004 (2005). PMID: 15972004 pdf

293) Lefranc, M.-P., Pommié, C., Kaas, Q., Duprat, E., Bosc, N., Guiraudou, D., Jean, C., Ruiz, M., Da Piedade, I., Rouard, M., Foulquier, E., Thouvenin, V. and Lefranc, G.
IMGT unique numbering for immunoglobulin and T cell receptor constant domains and Ig superfamily C-like domains
Dev. Comp. Immunol., 29, 185-203 (2005). PMID: 15572068 pdf with permission from Elsevier

292) Giudicelli, V., Chaume, D. and Lefranc, M.-P.
IMGT/GENE-DB: a comprehensive database for human and mouse immunoglobulin and T cell receptor genes
Nucl. Acids Res., 33, D256-D261 (2005). PMID: 15608191 pdf

291) Lefranc, M.-P., Giudicelli, V., Kaas, Q., Duprat, E., Jabado-Michaloud, J., Scaviner, D., Ginestoux, C., Clément, O., Chaume, D., Lefranc, G.
IMGT, the international ImMunoGeneTics information system®
Nucl. Acids Res., 33, D593-D597 (2005). PMID: 15608269 pdf

2004

290b) Medlej-Hashim, M., Loiselet, J., Lefranc, G. and Mégarbané, A.
Familial Mediterranean Fever (FMF): from diagnosis to treatment
Sante. Review. French, 14, 261-266 (2004). PMID: 15745878 pdf

290) Duprat, E., Kaas, Q., Garelle, V., Lefranc, G. and Lefranc, M.-P.
IMGT standardization for alleles and mutations of the V-LIKE-DOMAINs and C-LIKE-DOMAINs of the immunoglobulin superfamily
Recent Research Developments in Human Genetics, 2, 111-136 (2004). pdf

289) Yousfi Monod, M., Giudicelli, V., Chaume, D. and Lefranc, M.-P.
IMGT/JunctionAnalysis: the first tool for the analysis of the immunoglobulin and T cell receptor complex V-J and V-D-J JUNCTIONs
Bioinformatics, 20 Supplement 1, I379-I385 (2004). PMID: 15262823 pdf

288) Bertrand, G., Duprat, E., Lefranc, M.-P., Marti, J. and Coste, J.
Characterization of human FCGR3B*02 (HNA-1b, NA2) cDNAs and IMGT standardized description of FCGR3B alleles
Tissue Antigens Cover, 64, 119-131 (2004). PMID: 15245367

287) Giudicelli, V., Chaume, D., and Lefranc, M.-P.
IMGT/V-QUEST, an integrated software for immunoglobulin and T cell receptor V-J and V-D-J rearrangement analysis
Nucl. Acids Res., 32, W435-440 (2004). PMID: 15215425 pdf

286) Chassagne, S., Laffly, E., Drouet, E., Herodin, F., Lefranc, M.-P. and Thullier, P.
A high affinity macaque antibody Fab with human-like framework regions obtained from a small phage display immune library.
Mol. Immunol., 41, 539-546 (2004). PMID: 15183932

285) Medlej-Hashim, M., Delague, V., Chouery, E., Salem, N., Rawashdeh, M., Lefranc, G., Loiselet, J., and Mégarbané, A.
Amyloidosis in familial Mediterranean fever patients: correlation with MEFV genotype and SAA1 and MICA polymorphisms effects
Biomed Central BMC Medical Genetics, 5, 4 (2004).

284) Pommié, C., Levadoux, S., Sabatier, R., Lefranc, G. and Lefranc, M.-P.
IMGT standardized criteria for statistical analysis of immunoglobulin V-REGION amino acid properties
J. Mol. Recognit., 17, 17-32 (2004). PMID: 14872534 pdf

283) Megarbane, H., Zablit, C., Waked, N., Lefranc, G., Tomb, R. and Mégarbané, A.
Ichthyosis Follicularis, Alopecia, and Photophobia (IFAP) Syndrome: Report of a New Family With Additional Features and Review
American Journal of Medical Genetics., 124A, 323-327 (2004). PMID: 14708109 pdf

282b) Happle R. Invited comment.
What is IFAP Syndrome?
American Journal of Medical Genetics, 124A, 328 (2004) (2004). PMID: 14708110 pdf

282) Baum, P., Pasqual, N., Thuderoz, F., Hierle, V., Chaume, D., Lefranc, M.-P., Jouvin-Marche, E., Marche, N. and Demongeot, J.
IMGT/GeneInfo: enhancing V(D)J recombination database accessibility
Nucl. Acids. Res., 32, D51-D54 (2004). PMID: 14681357 pdf

281) Kaas, Q., Ruiz, M. and Lefranc, M.-P.
IMGT/3Dstructure-DB and IMGT/StructuralQuery, a database and a tool for immunoglobulin, T cell receptor and MHC structural data
Nucl. Acids. Res., 32, D208-D210 (2004). PMID: 14681396 pdf

280) Lefranc, M.-P.
IMGT-ONTOLOGY and IMGT databases, tools and web resources for immunogenetics and immunoinformatics
Mol. Immunol., 40, 647-660 (2004). PMID: 14644091 pdf

279) Lefranc, M.-P. and Lefranc, G.
Immunoglobulin lambda (IGL) genes of human and mouse
In: Molecular Biology of B cells
(Honjo, T., Alt, F. W. and Neuberger, M. S. eds), Academic Press, Elsevier Science, pp. 37-59 (2004). ISBN: 120536412

278) Lefranc, M.-P., Giudicelli, V., Ginestoux, C., Bosc, N., Folch, G., Guiraudou, D., Jabado-Michaloud, J., Magris, S., Scaviner, D., Thouvenin, V., Combres, K., Girod, D., Jeanjean, S., Protat, C., Yousfi Monod, M., Duprat, E., Kaas, Q., Pommié, C., Chaume, D. and Lefranc, G.
IMGT-ONTOLOGY for Immunogenetics and Immunoinformatics, http://www.imgt.org
In Silico Biol. Epub 2003, 0004, 22 Nov 2003, 4, 17-29 (2004). PMID: 15089751 pdf

277) Lefranc, M.-P.
IMGT, the international ImMunoGenetics information system®, http://www.imgt.org
In: Antibody engineering methods and protocols, 2nd edition (Lo B.K.C., ed).
Methods in Molecular Biology, Humana Press, Totowa, NJ, USA, 2004. Vol. 248, chap. 3, pp. 27-49.
Hardcover 1-58829-092-1 eBook 1-59259-666-5
Methods Mol. Biol., 248, 27-49 (2004). PMID: 14970490

2003

276) Lefranc, M.-P.
IMGT, the international ImMunoGeneTics information system®, http://www.imgt.org
In: Immunoinformatics: Bioinformatic strategies for better understanding of immune function (Bock, G and Goode, J. ed), Novartis Foundation Symposium 254, John Wiley and sons
Chichester, UK, pp. 126-126, discussion 136-142, 216-222, 250-252 (2003). PMID: 14712935

275) Lefranc, M.-P., Giudicelli, V., Ginestoux, C. and Chaume, D.
IMGT, the international ImMunoGenetics information system®, http://www.imgt.org: the reference in immunoinformatics
Stud. Health Technol. Inform, 95, 74-79 (2003). PMID: 14663966

274) Plaza, S., Calafell, F., Helal, A., Bouzerna, N., Lefranc, G., Bertranpetit, J. and Comas, D.
Joining the pillars of Hercules: mtDNA sequences show multidirectional gene flow in the Western Mediterranean
Annals of Human Genetics, 67, 312-328 (2003). PMID: 12914566

273) Elemento, O. and Lefranc, M.-P.
IMGT/PhyloGene: an online software package for phylogenetic analysis of immunoglobulin and T cell receptor genes
Dev. Comp. Immunol., 27, 763-779 (2003). PMID: 12818634 pdf

272) Giudicelli, V. and Lefranc, M.-P.
IMGT-ONTOLOGY: gestion et découverte de connaissances au sein d'IMGT
In: Extraction et gestion des connaissances EGC 2003, Extraction des connaissances et apprentissage
Revue des Sciences et Technologies de l'Information RSTI, Ed. Lavoisier, Series RIA-ECA, 17, 13-23 (2003).

271) Bosc, N. and Lefranc, M.-P.
IMGT Locus in Focus: The mouse (Mus musculus) T cell receptor alpha (TRA) and delta (TRD) variable genes
DOI 10.1016/S0145-305X (03)00027-2 (on-line 20/02/2002)
Dev. Comp. Immunol., 27, 465-497 (2003). PMID: 12697305 pdf

270b) Warr, G.W., Clem, L.W. and Söderhall, K.
Editorial - The International ImMunoGeneTics database IMGT
DOI 10.1016/S0145-305X (02)00094-0
Dev. Comp. Immunol., 27, 1-2 (2003). PMID: 12477495

270) Lefranc, M.-P.
IMGT® databases, web resources and tools for immunoglobulin and T cell receptor sequence analysis, http://www.imgt.org
Leukemia, 17, 260-266 (2003). PMID: 12529691

269) Haddad, M., Lefranc, G. and Aftimos, G.
Local application of IGF1 on dental pulp mechanically exposed; in vivo study on rabbit
Bull. Group. Int. Rech. Sci. Stomatol. Odontol, 45, 12-17 (2003). PMID: 14535054

268) Lefranc, M.-P., Pommié, C., Ruiz, M., Giudicelli, V., Foulquier, E., Truong, L., Thouvenin-Contet, V. and Lefranc, G.
IMGT unique numbering for immunoglobulin and T cell receptor variable domains and Ig superfamily V-like domains
Dev. Comp. Immunol., 27, 55-77 (2003). PMID: 12477501 pdf with permission from Elsevier

267) Lefranc, M.-P.
IMGT, the international ImMunoGeneTics database®
Nucl. Acids Res., 31, 307-310 (2003). PMID: 12520009 pdf

2002

266) Verrelli, B.C., McDonald, J.H., Argyropoulos, G., Destro-Bisol, G., Froment, A., Drousiotou, A., Lefranc, G., Helal, A.N., Loiselet, J. and Tishkoff, S.A.
Evidence for Balancing Selection from Nucleotide Sequence Analyses of Human G6PD
Am. J. Hum. Genet., 71, 1112-1128 (2002). PMID: 12378426

265) Elemento, O. and Gascuel, O.
An efficient and accurate distance based algorithm to reconstruct tandem duplication trees
ECCB 2002, Bioinformatics, 18 Suppl. 2, pp. S92-S99 (2002). PMID: 12385990

264) De la Salle, H., Saulquin, X., Mansour, I., Klaymé, S., Fricker, D., Zimmer, J., Cazenave, J.-P., Hanau, D., Bonneville, M., Houssaint, E., Lefranc, G., Naman, R.
Asymptomatic deficiency in the peptide transporter associated to antigen processing (TAP)
Clinical and Experimental Immunology, 128, 525-531 (2002). PMID: 12067308

263) Lefranc, M.-P.
IMGT, the international ImMunoGeneTics database: a high-quality information system for comparative immunogenetics and immunology, http://www.imgt.org
Dev. Comp. Immunol., 26, 697-705 (2002). PMID: 12206833 pdf

262) Chardes, T., Chapal, N., Bresson, D., Bes, C., Giudicelli, V., Lefranc, M.-P. and Peraldi-Roux, S.
The human anti-thyroid peroxidase autoantibody repertoire in Graves' and Hashimoto's autoimmune thyroid diseases
Immunogenetics, 54, 141-157 (2002). PMID: 12073143 pdf

261) Lefranc, M.-P. and Lefranc, G.
Consanguinity
In: Encyclopedia of Genetics
Brenner, S. and Miller, J.H. eds, Academic Press, London, UK, Vol. 1, pp. 456-457 (2002). ISBN: 122270319 (set 3 Vol. ISBN:0122270300)

260) Elemento, O., Gascuel, O. and Lefranc, M.-P.
Reconstructing the duplication history of tandemly repeated genes
Mol. Biol. Evol., 19, 278-288 (2002). PMID: 11861887

259) Ruiz, M. and Lefranc, M.-P.
IMGT gene identification and Colliers de Perles of human immunoglobulin with known 3D structures
Immunogenetics, 53, 857-883 (2002). PMID: 11862387 pdf

258) Medlej-Hashim, M., Salem, N., Chouery, E., Rawashdeh, M., Delague, V., Haffar, M., Mansour, I., Naman, R., Lefranc, G., Loiselet, J. and Mégarbané, A.
Familial mediterranean fever: the potential for misdiagnosis of E148V using the E148Q usual RFLP detection method
Clinical Genetics, 61, 71-73 (2002). PMID: 11903360

2001

257) Medlej-Hashim, M., Petit, I., Adib, S., Chouery, E., Salem, N., Delague, V., Rawashdeh, M., Mansour, I., Lefranc, G., Naman, R., Loiselet, J., Lecron, J.-C., Serre, J.-L. and Mégarbané, A.
Familial mediterranean fever: association of elevated IgD plasma levels with specific MEFV mutations
European Journal of Human Genetics, 9, 849-854 (2001). PMID: 11781702

256) Martinez-Jean, C., Folch, G. and Lefranc, M.-P.
Nomenclature and overview of the Mouse (Mus musculus and Mus sp.) Immunoglobulin Kappa (IGK) Genes
Exp. Clin. Immunogenet., 18, 255-279 (2001). PMID: 11872956 pdf

255) Yacoubi Loveslati, B., Sanchez-Mazas, A., Ennafaa, H., Marrakchi, R., Dugoujon, J.-M., Lefranc, M.-P. and Ben Ammar Elgaaied, A.
A study of GM allotypes and gamma immunoglobulins heavy chain genes in Berbers, Arabs and sub-Saharan Africans from the Jerba Island (Tunisia)
European Journal of Immunogenetics, 28, 531-538 (2001). PMID: 11881820

254) Lefranc, M.-P.
Nomenclature of the human immunoglobulin lambda (IGL) genes
Exp. Clin. Immunogenet., 18, 242-254 (2001). PMID: 11872955 pdf

253) Dard, P., Lefranc, M.-P., Osipova, L. and Sanchez-Mazas, A.
DNA sequence variability of IGHG3 genes associated to the main G3m haplotypes in human populations
European Journal of Human Genetics, 9, 765-772 (2001). PMID: 11781688 pdf

252) Sanchez-Mazas, A., Butler-Brunner, E., Butler, R., Calderon, R., Chaventre, A., Dugoujon, J.-M., Hammond, M., Lefranc, G., Matsumoto, H., Osipova, L., Politis, C., Pullman, R. and Langaney, A.
A wordwide analysis of AG molecular diversity inferred from serology
Human Biology, 73, 637-659 (2001). PMID: 11758687

251) Lefranc, M.-P.
Nomenclature of the human immunoglobulin kappa (IGK) genes
Exp. Clin. Immunogenet., 18, 161-174 (2001). PMID: 11549845 pdf

250) Tishkoff, S.A., Varkonyi, R., Cahinhinan, N., Abbes, S., Argyropoulos, G., Destro-Bisol, G., Drousiotou, A., Dangerfield, B., Lefranc, G., Loiselet, J., Piro, A., Stoneking, M., Tagarelli, A., Tagarelli, G., Touma, E.H., Williams, S.M. and Clark, A.G.
Haplotype diversity and linkage disequilibrium at human G6PD: Recent origin of alleles that confer malarial resistance
Science, 293, 455-462 (2001). PMID: 11423617 pdf

249) Baghdiguian, S., Richard, I., Martin, M., Coopman, P., Beckmann, J.S., Mangeat, P. and Lefranc, G.
Pathophysiology of limb girdle muscular dystrophy type 2A: hypothesis and new insights in the IκBα/NF-κB survival pathway
Journal of Molecular Medicine, 79, 254-261 (2001). PMID: 11485017

248) Chaume, D., Giudicelli, V. and Lefranc, M.-P.
IMGT-ML a XML language for IMGT-ONTOLOGY and IMGT/LIGM-DB data
In: CORBA and XML: Towards a Bioinformatics Integrated Network Environment, Proceedings of NETTAB 2001, Network Tools and Applications in Biology, pp 71-75 (2001).

247) Raux, G., Gilbert, D., Joly, P., Martel, P., Roujeau, J.-C., Prost, C., Lefranc, M.-P. and Tron, F.
IGHV3 associated restriction fragment length polymorphisms confer susceptibility to bullous pemphigoid
Exp. Clin. Immunogenet., 18, 59-66 (2001). PMID: 11340293

246) Lefranc, M.-P.
Nomenclature of the human immunoglobulin heavy (IGH) genes
Exp. Clin. Immunogenet., 18, 100-116 (2001). PMID: 11340299 pdf

245) Bosc, N., Contet, V. and Lefranc, M.-P.
The Mouse (Mus musculus) T cell Receptor Delta Variable (TRDV), Diversity (TRDD), and Joining (TRDJ) Genes
Exp. Clin. Immunogenet., 18, 51-58 (2001). PMID: 11150853 pdf

244) Mansour, I., Delague, V., Cazeneuve, C., Dode, C., Chouery, E., Pecheux, C., Medlej-Hachim, M., Salem, N., Al Zein, L., Levan-Petit, I., Lefranc, G., Goossens, M., Delpech, M., Amselem, S., Mégarbané, A., Grateau, G., Loiselet, J. and Naman, R.
Familial mediterranean fever in Lebanon: mutation spectrum, evidence for cases in Maronites, Greek orthodoxes, Greek catholics, Syriacs and Chiites and for an association between amyloidosis and M694V and M694I mutations
European Journal of Human Genetics, 9, 51-55 (2001). PMID: 11175300

243) Lefranc, M.-P.
IMGT, the international ImMunoGeneTics database
Nucleic Acids Research, 29, 207-209 (2001). PMID: 11125093 pdf

2000

242) Ruiz, M. and Lefranc, M.-P.
IMGT sequence profile: a standardized visualization for the immunoglobulin and T cell receptor V-REGIONs applicable to other protein alignments
Currents in Computational Molecular Biology, Frontiers Science Series n°30, Universal Academy Press, Tokyo, 64,pp 126-127 (2000). pdf

241) Richard, I., Roudaut, C., Marchand, S., Baghdiguian, S., Herasse, M., Stockholm, D., Ono, Y., Suel, L., Bourg, N., Sorimachi, H., Lefranc, G., Fardeau, M., Sebille, A., and Beckmann, J.S.
Loss of calpain 3 proteolytic activity leads to muscular dystrophy and to apoptosis-associated IκBα/NF-κB pathway perturbation in mice
The Journal of Cell Biology, 151, 1583-1590 (2000). PMID: 11134085

240) Bosc, N. and Lefranc, M.-P.
The Mouse (Mus musculus) T cell Receptor Beta Variable (TRBV), Diversity (TRBD), and Joining (TRBJ) Genes
Exp. Clin. Immunogenet., 17, 216-228 (2000). PMID: 11096260 pdf

239) Comas, D., Calafell, F., Benchemsi, N., Helal, A., Lefranc, G., Stoneking, M., Batzer, M.A., Bertranpetit, J., and Sajantila, A.
Alu insertion polymorphisms in Northwest Africa and the Iberian Peninsula: evidence for a strong genetic boundary through the Gilbraltar Straits
Human Genetics DOI 10.1007/s00439 0000 370 (on line 15/09/2000)
Human Genetics, 107, 312-319 (2000). PMID: 11129330

238) Lefranc, M.-P.
IMGT ImMunoGeneTics Database
International BIOforum, 4, 98-100 (2000).

237) Medlej-Hashim, M., Rawashdeh, M., Chouery, E., Mansour, I., Delague, V., Lefranc, G., Naman, R., Loiselet, J. and Mégarbané, A.
Genetic screening of fourteen mutations in Jordanian Familial Mediterranean Fever patients
Human Mutation, Mutations in Brief#310, 2000, HUMU Online, Human Mutation, 15, 384 (2000). PMID: 10737992

236) Folch, G., Scaviner, D., Contet, V. and Lefranc, M.-P.
Protein displays of the human T cell Receptor Alpha, Beta, Gamma and Delta Variable and Joining regions
Exp. Clin. Immunogenet., 17, 205-215 (2000). PMID: 11096259 pdf

235) Artero, S. and Lefranc, M.-P.
The Teleostei Immunoglobulin Light IGL1 and IGL2 V, J and C genes
Exp. Clin. Immunogenet., 17, 162-172 (2000). PMID: 10899741 pdf

234) Artero, S. and Lefranc, M.-P.
The Teleostei Immunoglobulin Heavy IGH genes
Exp. Clin. Immunogenet., 17, 148-161 (2000). PMID: 10899740 pdf

233) Folch, G. and Lefranc, M.-P.
The human T cell Receptor Beta Diversity (TRBD) and Beta Joining (TRBJ) genes
Exp. Clin. Immunogenet., 17, 107-114 (2000). PMID: 10810227 pdf

232) Scaviner, D. and Lefranc, M.-P.
The human T cell Receptor Alpha Joining (TRAJ) genes
Exp. Clin. Immunogenet., 17, 97-106 (2000). PMID: 10810226 pdf

231) Lefranc, M.-P.
Nomenclature of the human T cell receptor genes
In: Current Protocols in Immunology (J. E. Coligan, B.E. Bierer, D.E. Margulies, E.M. Shevach and W. Strober, eds.), John Wiley and Sons, Hoboken N.J., pp. A.1O.1-A.1O.23 (2000). PMID: 18432649

230) Lefranc, M.-P.
Nomenclature of the human immunoglobulin genes
In: Current Protocols in Immunology (J. E. Coligan, B.E. Bierer, D.E. Margulies, E.M. Shevach and W. Strober, eds.), John Wiley and Sons, Hoboken N.J., pp. A.1P.1-A.1P.37 (2000). PMID: 18432650

229) Lefranc, M.-P.
Web sites of interest to immunologists
In: Current Protocols in Immunology (J. E. Coligan, B.E. Bierer, D.E. Margulies, E.M. Shevach and W. Strober, eds.), John Wiley and Sons, Hoboken N.J., pp. A.1J.1-A.1J.33 (2000).

228) Scaviner, D. and Lefranc, M.-P.
The human T cell Receptor Alpha Variable (TRAV) genes
Exp. Clin. Immunogenet., 17, 83-96 (2000). PMID: 10810225 pdf

227) Folch, G. and Lefranc, m.-P.
The human T cell Receptor Beta Variable (TRBV) genes
Exp. Clin. Immunogenet., 17, 42-54 (2000). PMID: 10686482 pdf

226) Peneff, C., Lefranc, M.-P. and Dariavach, P.
Characterisation and specificity of two single-chain Fv antibodies directed to the protein tyrosine kinase Syk
Journal of Immunological Methods, 236, 105-115 (2000). PMID: 10699584

225) Giudicelli, V., Chaume, D. and Lefranc, M.-P.
IMGT (ImMunoGénéTique), base de données internationale spécialisée et intégrée en immunogenetique
La Gazette du CINES, 2, 5-7 (2000).

224) Ruiz, M., Giudicelli, V., Ginestoux, C., Stoehr, P., Robinson, J., Bodmer, J., Marsh, S., Bontrop, R., Lemaitre, M., Lefranc, G., Chaume, D. and Lefranc, M.-P.
IMGT, the international ImMunoGeneTics database
Nucleic Acid. Res., 28, 219-221 (2000). PMID: 10592230 pdf

223) Lefranc, M.-P.
Locus maps and genomic repertoire of the human T cell receptor genes
The Immunologist, 8/3, 72-79 (2000). pdf

222) Lefranc, M.-P.
Locus maps and genomic repertoire of the human immunoglobulin genes
The Immunologist, 8/3, 80-87 (2000). pdf

1999

221) Giudicelli, V. and Lefranc, M.-P.
Ontology for Immunogenetics: IMGT-ONTOLOGY
Bioinformatics, 15, 1047-1054 (1999). PMID: 10745995 pdf

220) Osipova, L.P., Posukh, O.L., Wiebe, V.P., Miyazaki, T., Matsumoto, H., Lefranc, G. and Lefranc, M.-P.
BamHI-SacI RFLP and Gm analysis of the immunoglobulin IGHG genes in the Northern Selkups (West Siberia): new haplotypes with deletion, duplication and triplication
Published on line 17 November 1999 - DOI10.1007/s004399900187, Human Genetics, 105, 530-541 (1999). PMID: 10647886

219) Hérasse, M., Baghdigiuan, S., Fougerousse, F., Martin, M., Stockholm, D., Beckmann, J.S., Lefranc, G. and Richard I.
Calpaïne 3 et dystrophie musculaire des ceintures de type 2A
Médecine/Sciences, 15, 1428-1434 (1999). pdf with permission from editors

218) Scaviner, D., Barbié, v., Ruiz, M. and LefranC, M.-P.
Protein displays of the human immunoglobulin heavy, kappa and lambda variable and joining regions
Exp. Clin. Immunogenet., 16, 234-240 (1999). PMID: 10575277 pdf

217) Lefranc, M.-P.
The IMGT unique numbering for Immunoglobulins, T cell receptors and Ig-like domains
The Immunologist, 7, 132-136 (1999). pdf

216) Baghdigiuan, S., Martin, M., Richard, I., Pons, F., Astier, C., Bourg, N., Hay, R.T., Chemaly, R., Halaby, G., Loiselet, J., Anderson, L.V.B., Lopez de Munain, A., Fardeau, M., Mangeat, P., Beckmann, J.S. and Lefranc, G.
Calpain 3 deficiency is associated with myonuclear apoptosis and profound perturbation of the IkappaBalpha/NF-kappaB pathway in limb-girdle muscular dystrophy type 2A
Nature Medicine, 5, 503-511 (1999). PMID: 10229226

215) Chaume, D.
Towards database interoperability, ontologies and biological data mining (Invited author)
Immunology News, 6, 135-137 (1999).

214) Lefranc, M.-P.
Trends and challenges of Bioinformatics (Editorial - Guest editor)
Immunology News, 6, 131-132 (1999).

213) Ruiz, M., Giudicelli, V. and Lefranc, M.-P.
IMGT, base de données internationale en ImMunoGénéTique, http://imgt.cnusc.fr:8104
Regard sur la Biochimie, 2, 25-31 (1999).

212) Lefranc, M.-P., Pallarès, N. and Frippiat, J.-P.
Allelic polymorphisms and RFLP in the human immunoglobulin lambda light chain locus
Human Genetics, 104, 361-369 (1999). PMID: 10394926

211) Ruiz, M., Pallarès, N., Contet, V., Barbié, V. and Lefranc M.-P.
The human immunoglobulin heavy diversity (IGHD) and joining (IGHJ) segments
Exp. Clin. Immunogenet., 16, 173-184 (1999). PMID: 10394055 pdf

210) Pallarès, N., Lefebvre, S., Contet, V., Matsuda, F. and Lefranc, M.-P.
The human immunoglobulin heavy variable (IGHV) genes
Exp. Clin. Immunogenet., 16, 36-60 (1999). PMID: 10087405 pdf

209) Lefranc, M.-P., Giudicelli, V., Ginestoux, C., Bodmer, J., Müller, W., Bontrop, R., Lemaitre, M., Malik, A., Barbié, V. and Chaume, D.
IMGT, the international ImMunoGeneTics database
Nucleic Acid. Res., 27, 209-212 (1999). PMID: 9847182 pdf

1998

208d) Lefranc, m.-p.
imgt, the international Immunogenetics database (Talwar g.p, Nath, I., Ganguly, N.K. and Rao, k. V. S., ed)
In: The 10th International Congress of Immunology Proceedings, New Delhi, Monduzzi Editore. International Proceedings, Division, S. p. a., Bologna (Italy), pp. 105-109 (1998).

208c) Lefranc, M.-P.
Quelle génétique demain?
In: Quelle médecine demain?, Editions privat, pp 85-90 (1998). ISBN: 2-7089-0410-8

208b) Barbié, V., Lemaitre, M. and Lefranc, M.-p.
imgt/primer-db - Une base de données pour la construction de banques combinatoires de fragments d'anticorps et de peptides
In: Banques combinatoires de peptides et de fragments d'anticorps à la surface de bactériophages - Peptide and antibody combinatorial phage display, Atelier 102, INSERM Editions, 7 pages (1998).

208) Martinez, C. and Lefranc, M.-P.
The mouse (Mus musculus) immunoglobulin kappa variable (IGKV) genes and joining (IGKJ) segments
Exp. Clin. Immunogenet., 15, 184-193 (1998). PMID: 9813415 pdf

207) Barbié, V. and Lefranc, M.-P.
The human immunoglobulin kappa variable (IGKV) genes and joining (IGKJ) segments
Exp. Clin. Immunogenet., 15, 171-183 (1998). PMID: 9813414 pdf

206) Bell, M.V., Cowper, A.E., Lefranc, M.-P., Bell, J.I. and Screaton, G.R.
Influence of Intron length on Alternative Splicing of CD44
Molecular and Cellular Biology, 18, 5930-5941 (1998). PMID: 9742110

205) Jabara, H.H., Buckley, R.H., Roberts, J.L., Lefranc, G., Loiselet, J., Khalil, G., and Geha, R.S.
Role of JAK3 in CD40-mediated signaling
Blood, 92, 2435-2440 (1998). PMID: 9746783

204) Bozzi, F., Lefranc, G., Villa, A., Badolato, R., Schumacher. R.F., KhaliL, G., Loiselet, J., Bresciani. S., O'Shea. J.J., Vezzoni, P., Notarangelo, L.D., and Candotti, F.
Molecular and biochemical characterization of JAK3 deficiency in a patient with severe combined immunodeficiency over 20 years after bone marrow transplantation : implications for treatment
Brit. J. Haematol., 102, 1363-1366 (1998). PMID: 9753072

203) Giudicelli, V., Chaume, D., Mennessier, G., Althaus, H.-H., Müller, W., Bodmer, J., Malik, A. and Lefranc, M.-P.
IMGT, the international ImMunoGeneTics database : a new design for immunogenetics data access
MEDINFO' 1998 (Cesnik B., Mc Gray A.T. and Scherrer J.R. eds), IOS Press, Amsterdam. Medinfo., 9, 351-355 (1998), Stud Health Technol Inform 1998, 52 Pt 1 :351-355. PMID: 10384476

202) Giudicelli, V., Chaume, D. and Lefranc M.-P.
IMGT/LIGM-DB : A systematized approach for ImMunoGeneTics database coherence and data distribution improvement
Proceedings Sixth International Conference on Intelligent Systems for Molecular Biology ISBM-98. Proc. Int. Conf. Intell. Syst. Mol. Biol., 6, 59-68 (1998). PMID: 9783210

201) Posukh, O.L., Osipova, L.P., Kashinskaya, Yu. O., Ivakin, E.A., Kryukov, Yu.A., Karafet, T.M., Kazakovtseva, M.A., Skobel'tsina, L.M., Crawford, M.G., Lefranc, M.-P. and Lefranc, G.
A genetic study of the south Altaian population of the Mendur-Sokkon village, Altai Republic
Russian Journal of Genetics, 1998, 34, 92-98, Translated from Genetika, 34, 106-113 (1998). PMID: 9532456

200) Pallarès, N., Frippiat, J.-P., Giudicelli, V. and Lefranc, M.-P.
The human immunoglobulin lambda variable (IGLV) genes and joining (IGLJ) segments
Exp. Clin. Immunogenet., 15, 8-18 (1998). PMID: 9619396 pdf

199) Lefranc, M.-P.
IMGT Locus on Focus : a new section of Experimental and Clinical Immunogenetics
Exp. Clin. Immunogenet., 15, 1-7 (1998). PMID: 9619395 pdf

198) Souriau, C., Hua, T.D., Lefranc, M.-P. and Weill, M.
Présentation à la surface du phage filamenteux : les multiples applications du phage display
Médecine/Sciences, 14, 300-309 (1998). pdf with permission from editors

197) Lenormand, B., Béné, M.-C., Lesesve, J.-F., Bastard, C., Tilly, H., Lefranc, M.-P., Faure, G.-C., Garand, R., Falkenrodt, A., Kandel, G., Solary, E., Maynadié, M., Callat, M.-P., thouret, F., Monconduit, M., Vannier, J.-P. and The Groupe d'Étude Immunologique des Leucémies (G.E.I.L.).
PreB1 (CD10-) acute lymphoblastic leukaemia : immunophenotypic and genomic characteristics, clinical features and outcome in 38 adults and 26 children
Leukemia and lymphoma, 28, 329-342 (1998). PMID: 9517504

196) Kerlan-Candon, S., Soua, Z., Lefranc, M.-P., Clot, J. and Eliaou, J.-F.
Detection of antigen receptor gene rearrangements in lymphoproliferative malignancies by fluorescent polymerase chain reaction
Tissue Antigens, 51, 20-29 (1998). PMID: 9459500

195) Lefranc, M.-P., Giudicelli, V., Busin, C., Bodmer, J., Müller, W., Bontrop, R., Lemaitre, M., Malik, A. and Chaume, D.
IMGT, the international ImMunoGeneTics database
Nucleic Acids Research, 26, 297-303 (1998). PMID: 9399859 pdf

1997

194h) Hua, T.D.
Détection de faibles activités catalytiques : perspectives pour la détection directe de l'activité d'anticorps catalytiques (Lefranc M.-P. et Lefranc G., ed.)
In: Ingénierie des anticorps. Banques combinatoires. Techniques en Immunologie, Editions INSERM-SFI,Chapitre 7,pp. 61-66 (1997). ISBN: 2 85598-687-7

194g) Souriau, C., Hua, T.D., Lefranc, M.-P. et Weill, M.
Production et purification de fragments d'anticorps Fab et scFv (Lefranc M.-P. et Lefranc G., ed.)
In: Ingénierie des anticorps. Banques combinatoires. Techniques en Immunologie, Editions INSERM-SFI,Chapitre 6,pp. 55-60 (1997). ISBN: 2 85598-687-7

194f) Hua, T.D., Souriau, C., Marin, M., Lefranc, M.-P. et Weill, M.
Construction d'un répertoire de fragments d'anticorps scFv et son expression à la surface de phages filamenteux (Lefranc M.-P. et Lefranc G., ed.)
In: Ingénierie des anticorps. Banques combinatoires. Techniques en Immunologie, Editions INSERM-SFI,Chapitre 5,pp. 39-54 (1997). ISBN: 2 85598-687-7

194e) Frippiat, J.-P. et Lefranc, M.-P.
Méthode de fragmentation Alu pour l'étude des YAC du locus lambda des immunoglobulines humaines (Lefranc M.-P. et Lefranc G., ed.)
In: Ingénierie des anticorps. Banques combinatoires. Techniques en Immunologie, Editions INSERM-SFI,Chapitre 4,pp. 29-37 (1997). ISBN: 2 85598-687-7

194d) Poul, M.-A., Cerutti, M., Devauchelle, G. et Lefranc, M.-P.
Construction de vecteurs de transfert baculovirus pour l'expression d'anticorps dans les cellules d'insectes (Lefranc M.-P. et Lefranc G., ed.)
In: Ingénierie des anticorps. Banques combinatoires. Techniques en Immunologie, Editions INSERM-SFI,Chapitre 2,pp. 13-18 (1997). ISBN: 2 85598-687-7

194c) Poul, M.-A. et Lefranc M.-P.
Humanisation des anticorps monoclonaux de souris (Lefranc M.-P. et Lefranc G., ed.)
In: Ingénierie des anticorps. Banques combinatoires. Techniques en Immunologie, Editions INSERM-SFI,Chapitre 1,pp. 1-12 (1997). ISBN: 2 85598-687-7

194b) Lefranc, M.-P. and Lefranc G. (Editeurs)
Ingénierie des anticorps. Banques combinatoires.
Techniques en Immunologie, Editions INSERM-SFI, 9 chapitres, 104 pages (1997). ISBN: 2 85598-687-7

194) Lefranc, M.-P.
Unique database numbering system for immunogenetic analysis
Immunology Today, 18, 509 (1997). PMID: 9386342

193) Kim, N., Kage, K., Matsuda, F., Lefranc, M.-P. and Storb, U.
B lymphocytes or Xeroderma Pigmentosum or Cockayne Syndrome patients with inherited defects in nucleotide excision repair are fully capable of somatic hypermutation of immunoglobulin genes
J. Exp. Med., 186, 413-419 (1997). PMID: 9236193

192) Passos, G.A.S. Jr and Lefranc, M.-P.
A 37-kb restriction map of the human immunoglobulin lambda variable locus, VB cluster, harboring four functional genes and two non-coding Vlambda sequences
Brazilian Journal of Genetics, 20, 725-730 (1997).

191) Tilz, G.P., Demel, U., Bischoff, R., Ponstingl, H. and Lefranc, M.-P.
Infektionen und gestörte körpereigene Abwehr - diagnose und therapie
Top medizin, 11, 41-45 (1997).

190) Souriau, C., Fort, P., Roux, P., Hartley, O., Lefranc, M.-P. and Weill, M.
A simple luciferase assay for signal transduction activity detection of epidermal growth factor displayed on phage
Nucleic Acids Research, 25, 1585-1590 (1997). PMID: 9092666 pdf

189) Richard, I., Brenguier, L., Dinçer, P., Roudaut, C., Bady, b., Burgunder, j.-M., Chemaly, R., Garcia, C.A., Halaby, G., Jackson, C.E., Kurnit, D.M., Lefranc, G., Legum, C., Loiselet, J., Merlini, L., Nivelon-Chevallier A., Ollagnon-Roman, E., Restagno, G., Topaloglu, H. and Beckmann, J.S.
Multiple independant molecular etiology for limb-girdle muscular dystrophy type 2A patients from various geographical origins
American Journal of Human Genetics, 60, 1128-1138 (1997). PMID: 9150160

188) Leduc, I., Drouet, M., Bodinier, M.-C., Helal, A. and Cogné, M.
Membrane isoforms of human immunoglobulins of the A1 and A2 isotypes : structural and functional study
Immunology, 90, 330-336 (1997). PMID: 9155637

187) Dard, P., Huck, S., Frippiat, J.-P., Lefranc, G., Langaney, A., Lefranc, M.-P. and Sanchez-Manzas, A.
The IGHG3 gene shows a structural polymorphism characterized by different hinge lengths : sequence of a new 2-exon hinge gene
Human Genetics, 99, 138-141 (1997). PMID: 9003512

186) Giudicelli, V., Chaume, D., Bodmer, J., Müller, W., Busin, C., Marsh, S., Bontrop, R., Lemaitre, M., Malik, A. and Lefranc, M.-P.
IMGT, the international ImMunoGeneTics database
Nucleic Acids Research, 25, 206-211 (1997). PMID: 9016537 pdf

185) Frippiat, J.-P., Dard, P., Marsh, S., Winter, G. and Lefranc, M.-P.
Immunoglobulin lambda light chain orphons on human chromosome 8q11.2
European Journal of Immunology, 27, 1260-1265 (1997). PMID: 9174619

1996

184) Beckmann, J.S., Richard, I., Broux, O., Fougerousse, F., Allamand, V., Chiannilkulchai, N., Lim, L.E., Duclos, F., Bourg, N., Brenguier, L., Pasturaud, P., Quétier, F., Roudaut, C., Sunada, Y., Meyer, J., Dinçer, P., Lefranc, G., Merlini, L., Topaloglu, H., Tomé, F.M.S., Cohen, D., Jackson, C.E., Campbell, K.P. and Fardeau, M.
Identification of muscle-specific calpain and beta-sarcoglycan genes in progressive autosomal recessive muscular dystrophies
Neuromusc. Disord., 6, 455-462 (1996). PMID: 9027855

183) Williams*, S.C., Frippiat*, J.-P., Tomlinson, I.M., Ignatovich, O., Lefranc, M.-P. and Winter, G.
Sequence and evolution of the human germline Vlambda repertoire * égale contribution des deux premiers auteurs
Journal Molecular Biology, 264, 220-232 (1996). PMID: 8951372

182) Engström, P.-E., Norhagen, E.G., Osipova, L., Helal, A., Wiebe, V., Brusco, A., Carbonara, A.O., Lefranc, G. and Lefranc, M.-P.
Salivary IgG subclasses in individuals with and without homozygous IGHG gene deletions
Immunology, 89, 178-182 (1996.) Free PMC Article. PMID: 8943711 pdf

181) Popov, A.V., Bützler, C., Frippiat, J.-P., Lefranc, M.-P., and Brüggemann, M.
Assembly and extension of yeast artificial chromosomes to build up a large locus
Gene, 177, 195-201 (1996). PMID: 8921867

180) Dard, P., Sanchez-Mazas, A., Dugoujon, J.-M., De Lange, G., Langaney, A., Lefranc, M.-P. and Lefranc, G.
DNA analysis of the immunoglobulin IGHG loci in a Mandenka population from eastern Senegal : correlation with Gm haplotypes and hypotheses for the evolution of the Ig CH region
Human Genetics, 98, 36-47 (1996). PMID: 8682504

179) Hua, T.D., Lamaty, F., Souriau, C., Rolland-Fulcrand, V., Lazaro, R., Viallefont, P., Lefranc, M.-P. and Weill, M.
Specific recognition of a tetrahedral phosphonamidate transition state analogue group by a recombinant antibody Fab fragment
Amino Acids, 10, 167-172 (1996).

178) Fest, T., Pron, B., Lefranc, M.-P., Pierre, C., Angonin, R., De Wazières, B., Soua, Z. and Dupond, j.-L.
Detection of a clonal BCL2 gene rearrangement in tissues from a patient with Whipple disease
Annals of Internal Medicine, 124, 738-740 (1996). PMID: 8633834

177) Hua, T.D., Rolland-Fulcrand, V., Lazaro, R., Viallefont, P., Lefranc, M.-P. and Weill, M.
Detection of enzyme activity at trace levels : a new perspective for the direct screening of active catalytic antibodies
Tetrahedron Letters, 37, 175-178 (1996).

176) Zhang, X.-M., Cathala, G., Soua, Z., Lefranc, M.-P. and Huck, S.
The human T-cell receptor gamma variable pseudogene V10 is a distinctive marker of human speciation
Immunogenetics, 43, 196-203 (1996). PMID: 8575818

1995

175) Poul, M.-A., Cerutti, M., Chaahibi, H., Kaczorek, M., Devauchelle, G. and Lefranc, M.-P.
Design of cassette baculovirus vectors for the production of therapeutic antibodies in insect cells
Immunotechnology, 1, 189-196 (1995). PMID: 9373347

174) Zhang, X.-M., Huck, S., Dariavach, P., Spilliaert, R., Arnason, A., Soua, Z., Lefranc, G. and Lefranc, M.-P.
Isolation of Tcell receptor gamma/delta chain constant genes from Minke whale
Experimental and Clinical Immunogenetics, 12, 245-252 (1995). PMID: 8919357

173) Huck, S. and Zouali, M.
Le répertoire B humain: expression normale et pathologique
Médecine/Sciences, 11, 1566-1575 (1995).

172) Poul, M.-A. and Lefranc, M.-P.
Structural correspondences between mouse and human immunoglobulin VH genes : Application to the humanization of mouse monoclonal antibodies
Annals of the New York Academy of Sciences, 764, 359-361 (1995). PMID: 7486546

171) Lefranc, M.-P., Giudicelli, V., Busin, C., Malik, A., Mougenot, I., Déhais, P. and Chaume, D.
LIGM-DB/IMGT : an integrated database of Ig and TcR, part of the Immunogenetics database
Annals of the New York Academy of Sciences, 764, 47-49 (1995). PMID: 7486568

170) Poul, M.-A., Cerutti, M., Chaabihi, H., Ticchioni, M., Deramoudt, F.-X., Bernard, A., Devauchelle, G., Kaczorek, M. and Lefranc, m.-p.
Cassette baculovirus vectors for the production of chimeric, humanized or human antibodies in insect cells
European Journal of Immunology, 25, 2005-2009 (1995). PMID: 7542600

169) Frippiat, J.-P., Williams, S.C., Tomlinson, I.M., Cook, G.P., Cherif, D., Le Paslier, D., Collins, J.E., Dunham, I., Winter, G. and Lefranc, M.-P.
Organization of the human immunoglobulin lambda light-chain locus on chromosome 22q11.2
Human Molecular Genetics, 4, 983-991 (1995). PMID: 7655473

168) Lefranc, M.-P. and Alexandre, D.
Gamma/delta lineage-specific transcription of human T cell receptor gamma genes by a combination of a non-lineage-specific enhancer and silencers
European Journal of Immunology, 25, 617-622 (1995). PMID: 7875223

167) Poul, M.-A., Ticchioni, M., Bernard, A. and Lefranc, M.-P.
Inhibition of T cell activation with a humanized anti-beta1 integrin chain mAb
Molecular Immunology, 32, 101-116 (1995). PMID: 7532786

166) Soua, Z., Khelif, A., Ennabli, S., Jemmali, M., Taib, J., Lefranc, g., and Lefranc, M.-P.
First study of immunoglobulin and T cell receptor gene rearrangements in chronic and acute lymphoblastic leukemias from Tunisia
Experimental and Clinical Immunogenetics, 12, 16-30 (1995). PMID: 7710761

1994

165d) Lefranc, M.-P., Giudicelli, V., Busin, C., Malik, A., Déhais, P. et Chaume, D.
Une base de données intégrée en Immunogénétique, LIGM-DB / IMGT
In: L'Immuno-Intervention. De la biothérapie à la thérapie génique. Chouaib S. and Mencia-Huerta J.M. ed., pp. 25-32 (1994).

165c) Lefranc, M.-P.
The T cell receptors
In: Immunochemistry (Van Oss and Van Regenmortel M.H.V., ed.). Marcel Dekker, inc.,Chapitre 6,pp. 129-157 (1994).

165b) Lefranc, M.-P.
T cell receptor (s)
In: The Encyclopedia of Molecular Biology (Kendrew J., ed.). Blackwell Scientific Publications, Oxford, UK, pp. 1055-1059 (1994).

165) Passos, G.A.S. Jr, Frippiat, J.-P. and Lefranc, M.-P.
Definition of a sequence-tagged site for the human immunoglobulin IGLV9S1 gene located at chromosome 22q11
Experimental and Clinical Immunogenetics, 11, 222-226 (1994). PMID: 7857668

164) Theodorou, I., Raphael, M., Biborgne, C., Fourcade, C., Lahet, C., Cochet, G., Lefranc, M.-P., Gaulard, P. and Farcet, J.-P.
Recombination pattern of the TCRgamma locus in human peripheral T-cell lymphomas
Journal of Pathology, 174, 233-242 (1994). PMID: 7884584

163) Lenormand, B., Bizet, M., Fruchart, C., Tilly, H., Daliphard, S., Thouret, F., Canipel, C., Callat, M.-P., Piguet, H., Lefranc, M.-P. and Monconduit, M.
Residual disease in B-cell chronic lymphocytic leukemia patients and prognostic value
Leukemia, 8, 1019-1026 (1994). PMID: 8207975

162) Hua, T.D., Fulcrand-Rolland, V., Lefranc, M.-P. and Weill, M.
Anticorps catalytiques
Médecine/Sciences, 10, 672-678 (1994).

161) Frippiat, J.-P. and Lefranc, M.-P.
Genomic organisation of 34 kb of the human immunoglobulin lambda locus (IGLV) : restriction map and sequences of new VlambdaIII genes
Molecular Immunology, 31, 657-670 (1994). PMID: 8028600

160) Zhang, X.M., Tonnelle, C., Lefranc, M.-P. and Huck, S.
T cell receptor gamma cDNA in human fetal liver and thymus : Variable regions of gamma chains are restricted to VgammaI or V9, due to the absence of splicing of the V10 and V11 leader intron
European Journal of Immunology, 24, 571-578 (1994). PMID: 8125127

159) Wiebe, V., Helal, A., Lefranc, M.-P. and Lefranc, G.
Molecular analysis of the T17 immunoglobulin CH multigene deletion (del A1-GP-G2-G4-E)
Human Genetics, 93, 520-528 (1994). PMID: 8168828

158) Sanchez-Mazas, A., Bütler-Brunner, E., Excoffier, L., Ghanem, N., Ben Salem, M., Breguet, G., Dard, P., Pellegrini, B., Tikkanen, M.J., Langaney, A., Lefranc, G. and Bütler, r.
New data for AG haplotype frequencies in Caucasoid populations and selective neutrality of the AG polymorphism
Human Biology, 66, 27-48 (1994).

1993

157c) Boëtsch Gilles
Article mentionnant les travaux de LIGM au Maghreb
Les Recherches sur la biologie des populations du Maghreb (1975-1994)
In: Annuaire de l'Afrique du Nord, tome XXXII. CNRS Editions, pp. 325-360 (1993).

157b) Lefranc, M.-P., Hammarström, L., Smith, C.I.E. and Lefranc, G.
Gene deletions in the human immunoglobulin heavy chain constant region locus : molecular and immunological analysis
In: Immunodeficiencies (Rosen F.S. and Seligmann M., ed.). Harwood Academic Publishers,Chapitre 5,pp. 99-109 (1993).

157) Commes, T., Clofent, G., Ghanem, N., Zhang, X.G., Lefranc, M.-P., Bataille, R. and Klein, B.
Analysis of the B-cell compartment in plasma cell leukemia and multiple myeloma : immunoglobulin gene rearrangement of EBV-infected B-cell lines
Leukemia, 7, 609-617 (1993). PMID: 7681918

156) Williams, G.T., Dariavach, P., Venkitaraman, A.R., Gilmore, D.J. and Neuberger, M.S.
Membrane immunoglobulin without sheath or anchor
Molecular Immunology, 30, 1427-1432 (1993). PMID: 8232328

155) Riechmann, L. and Weill, M.
Phage display and selection of a site-directed randomized single-chain antibody Fv fragment for its affinity improvement
Biochemistry, 32, 8848-8855 (1993). PMID: 8364031

154) Neuberger, M.S., Patel, K.J., Dariavach, P. , Nelms, K., Peaker, C.J.G. and Williams, G.T.
The mouse B-cell antigen receptor : Definition and assembly of the core receptor of the five immunoglobulin isotypes
Immunological reviews, 132, 147-161 (1993). PMID: 8349294

153) Zhang, X.M. and Lefranc, M.-P.
PCR-based detection of one BamHI polymorphic site in the human T cell receptor delta gene TCRDV2
Human Genetics, 92, 100 (1993). PMID: 8103500

152) Chuchana, P., Frippiat, J.-P., Blancher, A., Lefranc, G. and Lefranc, M.-P.
Haplotypes of the human immunoglobulin lambda IGLV7SI and IGLVISI genes defined by restriction-site polymorphism and insertion/deletion of a 6-kb DNA fragment
American Journal of Human Genetics, 53, 518-525 (1993). PMID: 8101043

1992

151d) Debre, P., Lefranc, M.-P., Mc Donald, H.R., Milstein, C., Neuberger, M.S. and Zouali, M.
The variable gene repertoire of B and T cells : development in normal and pathological conditions
Le répertoire des gènes variables des lymphocytes B et T
In: Conférences Philippe Laudat 1991. INSERM ed, Paris, pp. 5-59 (1992).

151c) Lefranc, M.-P. et Lefranc, G.
Les Immunoglobulines humaines
In: L'hématologie de Bernard Dreyfus (Breton-Gorius J., Reyes F., Rochant H., Rosa J. and Vernant J.P., ed.). Médecine-Sciences Flammarion,Chapitre 20,pp. 197-254 (1992).

151b) Lefranc, M.-P. and Lefranc, G.
The constant region genes of the immunoglobulin heavy chains
In: Advances in Nephrology (Grünfeld J.P., Bach J.F., Kreis H. and Maxwell M.H., ed.). Mosby-Year Book, Inc Chicago, 21,pp. 3-12 (1992). PMID: 1348900

151) Riechmann, L., Weill, M. and Cavanagh, J.
Improving the antigen affinity of an antibody Fv-fragment by protein design
Journal Molecular Biology, 224, 913-918 (1992). PMID: 1569579

150) Chaouni, I., Lefranc, M.-P., Dupuy D'Angeac, A., Zanin, C., Pellet, F., Clot, J., Combe, B., Sany, J. and Reme, T.
T cell receptor gamma variable gene locus polymorphism in patients with rheumatoid arthritis
Arthritis and Rheumatism, 35, 756-760 (1992). PMID: 1352450

149) Martinetti, M., Cuccia, M., Amoroso, A., Borelli, I., Cappello, N., Daielli, C., D'Alfonso, S., Dondi, E., Ducret, F., Dugoujon, J.M., Hiratska, T., Lefranc, M.-P., Luger, A.M., Mazzola, G., Naito, S., Richiardi, P., Salvaneschi, L., Walker, R.E.W. and Zhang, X.M.
Idiopathic IgA mesangial nephropathy : an immunogenetic study
In: HLA 1991. Proceedings of the Eleventh International histocompatibility workshop and Conference, Tsuji, K., Aizawa, M., and Sasazuki, T., (eds.), Oxford Science Publications, 1, 749-755 (1992).

148) Alexandre, D. and Lefranc, M.-P.
The human gamma/delta+ and alpha/beta+ T cells : a branched pathway of differentiation
Molecular Immunology, 29, 447-451 (1992). PMID: 1533010

147) Weill, M., Zhang, X.M., Bernard, F., Lefranc, G. and Lefranc, M.-P.
A rare genetic variant of the T cell receptor gamma joining segment TRGJI
Human Genetics, 88, 355 (1992). PMID: 1346388

1991

146d) Lefranc, M.-P. et Lefranc, G.
Génétique Moléculaire des Immunoglobulines
In: Actualités Néphrologiques Jean Hamburger, 1991. Médecine-Sciences Flammarion, pp. 7-28 (1991).

146c) Lefranc, M.-P.
Récepteurs spécifiques pour l'antigène
In: Immunologie générale, 2ème édition (ASSIM, ed.). MEDSI/Mc GRAW-HILL,Chapitre 3,pp. 53-60 (1991).

146b) Lefranc, M.-P. and Rabbitts, T.H.
Genetic organization of the human T cell receptor gamma locus
In: Function and specificity of g/d T cells. Current Topics in Microbiology and Immunology (Pfeffer K. et al., ed.). Springer-Verlag, 173,pp. 3-9 (1991). PMID: 1655357

146) Venkitaraman, A.R., Williams, G.T., Dariavach, P. and Neuberger, M.S.
The B-cell antigen receptor of the five immunoglobulin classes
Nature, 352, 777-781 (1991). PMID: 1881434

145) Dariavach, P., Williams, G.T., Campbell, K., Pettersson, S. and Neuberger, M.S.
The mouse IgH 3'-enhancer
European Journal of Immunology, 21, 1499-1504 (1991). PMID: 1904361

144) Kanavaros, P., Farcet, J.P., Gaulard, P., Haioun, C., Divine, M., Le Couedic, J.P., Lefranc, M.-P. and Reyes, F.
Recombinative events of the T-cell antigen receptor delta gene in peripheral T cell lymphomas
Journal Clinical Investigation, 87, 666-672 (1991). PMID: 1991851

143) Lenormand, B., Ghanem, N., Tilly, H., Boussemart, C., Monconduit, M., Piguet, H., Lefranc, G. and Lefranc, M.-P.
Rearrangements of immunoglobulin light and heavy chain genes and correlation with phenotypic markers in B-Cell chronic lymphocytic leukemia
Leukemia, 5, 928-936 (1991). PMID: 1961033

142) Ben Salem, M., Ghanem, N., Kneissi, T., Abbal, M., Dugoujon, J.M., Ben Chibani, J., Ellouze, F. and Lefranc, G.
Marqueurs immuno-génétiques (BF, C2, C4, 21-OH, TNFalpha, TCRbeta, Ig) et diabète insulino-dépendant dans une population tunisienne : études sérologique et moléculaire
Ann. Biol. Clin., 49, 389-396 (1991). PMID: 1684890

141) Poul, M.-A., Zhang, X.M., Ducret, F. and Lefranc, M.-P.
The IGLJ6 joining segment as a STS in the human immunoglobulin lambda light chain constant region gene locus (located at 22q11)
Nucleic Acids Research, 19, 4785 (1991). PMID: 1909788

140) Alexandre, D., Chuchana, P., Roncarolo, M.G., Yssel, H., Spits, H., Lefranc, G. and Lefranc, M.-P.
Reciprocal hybrid joints demonstrate successive V-J rearrangements on the same chromosome in the human TCR gamma locus
International Immunology, 3, 973-982 (1991). PMID: 1836738

139) Bensmana, M., Bernard, F., Zhang, X.M., Chuchana, P., Lefranc, M.-P. and Lefranc, G.
RFLP detected by the transmembrane exon probe of the human immunoglobulin IGHA genes
Nucleic Acids Research, 19, 5098 (1991). PMID: 1681503

138) Chuchana, P., Alexandre, D., Lefranc, G. and Lefranc, M.-P.
The IGLVA gene as a STS in the human immunoglobulin lambda light chain variable gene locus (located at 22q11)
Nucleic Acids Research, 19, 4786 (1991). PMID: 1909789

137) Sawkat-Hassan, M., Abedi-Valugerdi, M., Lefranc, G., Hammarström, L. and Smith, C.I.E.
Biological half-life of normal and truncated human IgG3 in scid mice
European Journal of Immunology, 21, 1319-1322 (1991). PMID: 2037016

136) Bernard, F., Ducret, F., Buresi, C., Lefranc, G. and Lefranc, M.-P.
HindIII/EcoRI RFLP of the human immunoglobulin IGHE gene detected with a Cepsilon probe in the French and Tunisian populations
Human Genetics, 87, 101 (1991). PMID: 1674713

135) Keyeux, G., Nusbaum, P., Alexandre, D., Lesavre, P. and Lefranc, M.-P.
New RFLPs of Immunoglobulin switch alpha region in mesangial IgA glomerulonephritis
Human Genetics, 86, 624 (1991). PMID: 1673962

134) Lefranc, M.-P., Hammarström, L., Smith, C.I.E. and Lefranc, G.
Gene deletions in the human immunoglobulin heavy chain constant region locus : molecular and immunological analysis
Immunodeficiency reviews, 2, 265-281 (1991). PMID: 1905558

133) Bensmana, M., Chuchana, P., Lefranc, G. and Lefranc, M.-P.
Sequence of the CH1 and hinge-CH2 exons of the human immunoglobulin IGHA2 A2m(2) allele : comparison with the nonallelic and allelic IGHA genes
Cytogenetics Cell Genetics, 56, 128 (1991). PMID: 1901541

132) Ghanem, N., Soua, Z., Zhang, X.G., Zijun, M., Zhiwei, Y., Lefranc, G. and Lefranc, M.-P.
Polymorphism of the T-cell receptor gamma variable and constant region genes in a Chinese population
Human Genetics, 86, 450-456 (1991). PMID: 1673112

131) Lefranc, M.-P.
Ingénierie moléculaire des anticorps et perspectives en thérapeutique
Regards sur la Biochimie, 1, 58-66 (1991).

130) Bensmana, M., Mattei, M.G. and Lefranc, M.-P.
Localization of the human T-cell receptor gamma locus (TCRG) to 7p14-p15 by in situ hybridization
Cytogenetics and Cell Genetics, 56, 31-32 (1991). PMID: 1825973

129) Chuchana, P., Bernard, F., Lefranc, G. and Lefranc, M.-P.
An STS in the human T-cell receptor delta locus located at 14q11
Nucleic Acids Research, 19, 410 (1991). PMID: 2014183

1990

128b) Lefranc, M.-P. and Lefranc, G.
Molecular genetics of Immunoglobulin allotype expression
In: The Human IgG subclasses: molecular analysis of structure, function and regulation (Shakib F., ed.). Pergamon Press, pp. 43-78 (1990).

128) Bernard, F., Chuchana, P., Lefranc, G. and Lefranc, M.-P.
An STS in the human T cell receptor gamma locus (located at 7p14-15)
Nucleic Acids Research, 18, 6170 (1990). PMID: 2235525

127) Lefranc, M.-P.
The human T-cell receptor delta genes. The mouse T-cell receptor gamma genes
Research in Immunology, 141, 692-695 (1990).

126) Lefranc, M.-P. and Rabbitts, T.H.
A nomenclature to fit the organization of the human T cell receptor gamma and delta genes
Research in Immunology, 141, 615-618 (1990). PMID: 2151348

125b) Lefranc, M.-P. and Bonneville, M.
Gamma delta T cells
Research in Immunology, 141, 579-581 (1990). PMID: 2095601

125) Lefranc, M.-P. and Rabbitts, T.H.
Genetic organization of the human T-cell receptor gamma and delta loci
Research in Immunology, 141, 565-577 (1990). PMID: 1965674

124) Lefranc, M.-P.
Organization of the human T-cell receptor genes
European Cytokine Network, 1, 121-130 (1990). PMID: 2129796

123) Ghanem, N., Lobaccaro, J.M., Buresi, C., Abbal, M., Halaby, G., Sultan, C. and Lefranc, G.
Defective, deleted or converted CYP21B gene and negative association with a rare restriction fragment length polymorphism allele of the factor B gene in congenital adrenal hyperplasia
Human Genetics, 86, 117-125 (1990). PMID: 1979956

122) Frippiat, J.-P., Chuchana, P., Bernard, F., Buluwela, L., Lefranc, G. and Lefranc, M.-P.
First genomic sequence of a human Ig variable lambda gene belonging to subgroup III
Nucleic Acids Research, 18, 7134 (1990). PMID: 2124677

121) Bensmana, M. and Lefranc, M.-P.
Gene segments encoding membrane domains of the human immunoglobulin gamma 3 and alpha chains
Immunogenetics, 32, 321-330 (1990). PMID: 1979064

120) Engström, P.E., Gunilla Norhagen, E., Bottaro, A., Carbonara, A.O., Lefranc, G., Steinitz, M., Söder, P.O., Smith, C.I.E. and Hammarström, L.
Subclass distribution of antigen-specific IgA antibodies in normal donors and individuals with homozygous Calpha1 or Calpha2 gene deletions
The Journal of Immunology, 145, 109-116 (1990). PMID: 2162886

119) Alexandre, D., Bernard, F., Buresi, C., Lefranc, G. and Lefranc, M.-P.
A SacI RFLP of the human T-cell receptor delta (TCRD) joining segment J2
Nucleic Acids Research, 18, 7195 (1990). PMID: 1979862

118) Lefranc, G. and Lefranc, M.-P.
Régulation de la transcription des gènes des Immunoglobulines
Regard sur la Biochimie, 2, 25-36 (1990).

117) Bernard, F., Chuchana, P., Frippiat, J.-P., Buluwela, L. and Lefranc, M.-P.
Genomic sequence of IGLV1S2, a human immunoglobulin variable lambda gene belonging to subgroup I
Nucleic Acids Research, 18, 7139 (1990). PMID: 2124678

116) Lefranc, G. and Lefranc, M.-P.
Antibody engineering and perspectives in therapy
Biochimie, 72, 639-651 (1990). PMID: 2126204

115) Lobaccaro, J.M., Ghanem, N., lefranc, G. and Sultan, Ch.,
CYP21B gene conversion and complete CYP21A gene deletion in congenital adrenal hyperplasia
Annales de Génétique, 33, 70-75 (1990). PMID: 1978631

114) Lefranc, G. and Lefranc, M.-P.
Regulation of the immunoglobulin gene transcription
Biochimie, 72, 7-17 (1990). PMID: 2111179

113) Chuchana, P., Blancher, A., Brockly, F., Alexandre, D., Lefranc, G. and Lefranc, M.-P.
Definition of the human immunoglobulin variable lambda (IGLV) gene subgroups
European Journal of Immunology, 20, 1317-1325 (1990). PMID: 2114999

112) Chuchana, P., Blancher, A., Lefranc, G. and Lefranc, M.-P.
HindIII RFLP of the human immunoglobulin VlambdaIII subgroup genes
Nucleic Acids Research, 18, 6179 (1990). PMID: 1978298

111) Blancher, A., Chuchana, P., Lefranc, G. and Lefranc, M.-P.
HindIII restriction fragment alleles of the human immunoglobulin VlambdaII subgroup genes
Nucleic Acids Research, 18, 6178 (1990). PMID: 1978296

110) Keyeux, G., Gilgenkrantz, S., Lefranc, G. and Lefranc, M.-P.
Distal trisomy 14q - II. Molecular study of the 14q32 locus in two cases of chromosome 14 rearrangements with partial duplication
Human Genetics, 85, 617-622 (1990). PMID: 1977685

109) Gilgenkrantz, S., Vigneron, J., Peter, M.-O., Dufier, J.L., Teboul, M., Chery, M., Keyeux, G. and Lefranc, M.-P.
Distal Trisomy 14q - I. Clinical and cytogenetical studies
Human Genetics, 85, 612-616 (1990). PMID: 2227953

108) Chevailler, A., Ifrah, N., Monteiro, R.C., Keyeux, G., Renier, G., Lefranc, M.-P., Lesavre, P. and Hurez, D.
Association between acute lymphoblastic leukemia and partial IgA deficiency in a young man- A family study
Nouvelle Revue Française d'Hématologie, 32, 159-164 (1990). PMID: 2377448

107) Schiff, C., Bensmana, M., Guglielmi, P., Milili, M., Lefranc, M.-P. and Fougereau, M.
The immunoglobulin lambda-like gene cluster (14.1, 16.1, and Flambda1) contains gene(s) selectively expressed in pre-B cells and is the human counterpart of the mouse lambda5 gene
International Immunology, 2, 201-207 (1990). PMID: 2128466

106) Keyeux, G., Lefranc, M.-P., Chevailler, A. and Lefranc, G.
Molecular analysis of the IGHA and MHC class III region genes in one family with IgA and C4 deficiencies
Experimental and Clinical Immunogenetics, 7, 170-180 (1990). PMID: 1974449

105) Hammarström, L., Ghanem, N., Smith, C.I.E., Lefranc, G. and Lefranc, M.-P.
RFLP of human immunoglobulin genes
Experimental and Clinical Immunogenetics, 7, 7-19 (1990). PMID: 1971761

104) Lefranc, M.-P. et Lefranc, G.
Special issue : Restriction Fragment Length Polymorphism
Experimental and Clinical Immunogenetics, 7, 5-6 (1990).

1989

103) Lefranc, M.-P.
Organisation des gènes des récepteurs alpha/beta et gamma/delta des lymphocytes T humains
Médecine/Sciences, 5, 754-761 (1989).

102) Clofent, G., Brockly, F., Commes, T., Lefranc, M.-P., Bataille, R. and Klein, B.
No preferential use of the VH(V) family in human multiple myeloma
British Journal of Haematology, 73, 486-490 (1989). PMID: 2611136

101) Ghanem, N., Buresi, C., Moisan, J.-P., Bensmana, M., Chuchana, P., Huck, S., Lefranc, G. and Lefranc, M.-P.
Deletion, insertion, and restriction site polymorphism of the T-cell receptor gamma variable locus in French, Lebanese, Tunisian and Black African populations
Immunogenetics, 30, 350-360 (1989). PMID: 2572547

100) Dariavach, P. and Lefranc, M.-P.
The promoter regions of the T-cell receptor V9 gamma (TRGV9) and V2 delta (TRDV2) genes display short direct repeats but no TATA box
FEBS Letters, 256, 185-191 (1989). PMID: 2806544

99) Dariavach, P. and Lefranc, M.-P.
First genomic sequence of the human T-cell receptor delta2 gene (TRDV2)
Nucleic Acids Research, 17, 4880 (1989). PMID: 2526321

98) Le Cam, G., Lefranc, M.-P. and Brochier, J.
Cell lyophilization for safe conservation and transportation in view of DNA analysis
Nucleic Acids Research, 17, 6423 (1989). PMID: 2771662

97) Huck, S., Lefranc, G. and Lefranc, M.-P.
A human immunoglobulin IGHG3 allele (Gmb0, b1, c3, c5, u) with an IGHG4 converted region and three hinge exons
Immunogenetics, 30, 250-257 (1989). PMID: 2571587

96) Brockly, F., Alexandre, D., Chuchana, P., Huck, S., Lefranc, G. and Lefranc, M.-P.
First nucleotide sequence of a human immunoglobulin variable lambda gene belonging to subgroup II
Nucleic Acids Research, 17, 3976 (1989). PMID: 2499872

95) Alexandre, D., Chuchana, P., Brockly, F., Blancher, A., Lefranc, G. and Lefranc, M.-P.
First genomic sequence of a human Ig variable lambda gene, belonging to subgroup I. Functional genes, pseudogenes and vestigial sequences are interspersed in the IGLV locus
Nucleic Acids Research, 17, 3975 (1989). PMID: 2499871

94) Keyeux, G., Ghanem, N., Lefranc, G. and Lefranc, M.-P.
Identification of the PvuII RFLPs from the switch human immunoglobulin alpha (IGSA) regions
Nucleic Acids Research, 17, 3623 (1989). PMID: 2566980

93) Keyeux, G., Lefranc, G. and Lefranc, M.-P.
A specific switch alpha probe of the human immunoglobulin IGHA locus
Nucleic Acids Research, 17, 3624 (1989). PMID: 2566981

92) Soua, Z., Ghanem, N., Ben Salem, M., Lefranc, G. and Lefranc, M.-P.
Frequencies of the human immunoglobulin IGHA2*M1 and IGHA2*M2 alleles corresponding to the A2m(1) and A2m(2) allotypes in the French, Lebanese, Tunisian and Black African populations
Nucleic Acids Research, 17, 3625 (1989). PMID: 2566982

91) Chuchana, P., Soua, Z., Brockly, F., Zhang, X.G., Ghanem, N., Lefranc, G. and Lefranc, M.-P.
BamHI restriction fragment alleles of the human T-cell receptor delta (TRD) variable region V2
Nucleic Acids Research, 17, 3622 (1989). PMID: 2566979

90) Sturm, E., Braakman, E., Bontrop, R.E., Chuchana, P., Van De Griend, R.J., Koning, F., Lefranc, M.-P. and Bolhuis, R.L.H.
Coordinated Vgamma and Vdelta gene segment rearrangements in human T cell receptor gamma/delta+ lymphocytes
European Journal of Immunology, 19, 1261-1265 (1989). PMID: 2547624

89) Lefranc, M.-P., Chuchana, P., Dariavach, P., Nguyen, C., Huck, S., Brockly, F., Jordan, B. and Lefranc, G.
Molecular mapping of the human T cell receptor gamma (TRG) genes and linkage of the variable and constant regions
European Journal of Immunology, 19, 989-994 (1989). PMID: 2526744

88) Ghanem, N., Bensmana, M., Dugoujon, J.M., Constans, J., Lefranc, M.-P. and Lefranc, G.
BamHI and SacI RFLPs of the human immunoglobulin IGHG genes with reference to the Gm polymorphism in African people : evidence for a major polymorphism
Human Genetics, 83, 37-44 (1989). PMID: 2570016

87) Chuchana, P., Soua, Z., Ghanem, N., Brockly, F., Lefranc, G. and Lefranc, M.-P.
Two KpnI restriction fragment alleles of the human T-cell receptor delta (TRD) joining segment J2
Nucleic Acids Research, 17, 1275 (1989). PMID: 2564184

86) Keyeux, G., Lefranc, G. and Lefranc, M.-P.
A multigene deletion in the human IGH constant region locus involves highly homologous hot spots of recombination
Genomics, 5, 431-441 (1989). PMID: 2613231

85) Keyeux, G., Gilgenkrantz, S., Lefranc, G. and Lefranc, M.-P.
Molecular characterization of a ring chromosome 14 showing that the PI locus is centromeric to the D14S1 and IGH loci
Human Genetics, 82, 219-222 (1989). PMID: 2543620

84) Lefranc, M.P. and Rabbitts, T.H.
The human T-cell receptor gamma (TRG) genes
TIBS, 14, 214-218 (1989). PMID: 2527426

83) Ghanem, N., Dariavach, P., Lefranc, G. and Lefranc, M.-P.
A TaqI RFLP of the human T-cell receptor gamma (TRG) variable gene V11
Nucleic Acids Research, 17, 1270 (1989). PMID: 2564180

82) Ghanem, N., Chuchana, P., Dariavach, P., Brockly, F., Lefranc, G. and Lefranc, M.-P.
SacI polymorphism defined by human T-cell receptor gamma (TRG) variable gene V11
Nucleic Acids Research, 17, 1271 (1989). PMID: 2564181

81) Buresi, C., Ghanem, N., Huck, S., Lefranc, G. and Lefranc, M.-P.
Exon duplication and triplication in the human T-cell receptor gamma constant region genes and RFLP in French, Lebanese, Tunisian, and Black African populations
Immunogenetics, 29, 161-172 (1989). PMID: 2564370

80) Clofent, G., Klein, B., Commes, T., Ghanem, N., Lefranc, M.-P. and Bataille, R.
No detectable malignant B cells in the peripheral blood of patients with multiple myeloma
British Journal Haematology, 71, 357-361 (1989). PMID: 2649139

79) Clofent, G., Klein, B., Commes, T., Vincent, C., Ghanem, N., Lenoir, G., Lefranc, M.-P. and Bataille, R.
Limiting dilution cloning of B cells from patients with multiple myeloma : emergence of non-malignant B-cell lines
Int. J. Cancer, 43, 578-586 (1989). PMID: 2539329

78) Ghanem, N., Buresi, C., Lefranc, G. and Lefranc, M.-P.
A unique RFLP in the human T-cell receptor gamma constant region gene TRGC1
Nucleic Acids Research, 17, 471 (1989). PMID: 2563159

77) Ghanem, N., Dugoujon, J.M., Lefranc, M.-P. and Lefranc, G.
BstEII restriction fragment alleles and haplotypes of the human IGHG genes with reference to the BamHI/SacI RFLPs and to the Gm polymorphism
Experimental and Clinical Immunogenetics, 6, 39-54 (1989). PMID: 2576520

76) Moisan, J.P., Bonneville, M., Bouyge, I., Moreau, J.F., Soulillou, J.P. and Lefranc, M.-P.
Characterization of T-cell receptor gamma (TRG) gene rearrangements in alloreactive T-cell clones
Human Immunology, 24, 95-110 (1989). PMID: 2538410

75) Hammarström, L., Dugoujon, J.M., De Lange, G.G., Ghanem, N., Lefranc, G. and Smith, C.I.E.
No influence of conversions affecting allotype expression on the IgG subclass restriction of specific antibodies
Experimental and Clinical Immunogenetics, 6, 60-67 (1989). PMID: 2629888

1988

74b) Bonneville, M., Moisan, J.P., Moreau, J.F., Bouyge, I., Hallet, M.M., Lefranc, M.-P. and Soulillou, J.P.
TRG alpha, beta, and gamma gene rearrangements in human alloreactive T cell clones extracted from a rejected kidney
Transplant Proc., 20, 196-198 (1988). PMID: 3284039

74) Lobaccaro, J.M., Ghanem, N., Sultan, C. and Lefranc, G.
A new Taq I polymorphism of the complement factor B gene
Nucleic Acids Research, 16, 11851 (1988). PMID: 2905448

73) Dariavach, P., Mattei, M.-G., Golstein, P. and Lefranc M.-P.
Human Ig superfamily CTLA-4 gene : chromosomal localization and identity of protein sequence between murine and human CTLA-4 cytoplasmic domains
European Journal of Immunology, 18, 1901-1905 (1988). PMID: 3220103

72) Lefranc, M.-P., Forster, A. and Rabbitts, T.H.
Genomic organisation of the constant regions of the human T-cell rearranging gene gamma
Lymphocyte Activation and Differentiation (J.C. Mani and J. Dornand ed.), pp. 545-548 (1988).

71) Forster, A., Huck, S., Ghanem, N., Lefranc, M.-P. and Rabbitts, T.H.
New subgroups in the human T-cell rearranging Vgamma gene locus
Lymphocyte Activation and Differentiation (J.C. Mani and J. Dornand ed.), pp. 541-543 (1988).

70) Lefranc, M.-P., Forster, A. and Rabbitts, T.H.
The Human T-cell rearranging gamma genes (TRGgamma)
Lymphocyte Activation and Differentiation (J.C. Mani et J. Dornand ed.), pp. 153-158 (1988).

69) Chen, Z., Font, M.P., Loiseau, P., Bories, J.C., Degos, L., Lefranc, M.-P. and Sigaux, F.
The human T-cell Vgamma gene locus : cloning of new segments and study of Vgamma rearrangements in neoplastic T and B cells
Blood, 72, 776-783 (1988). PMID: 2969758

68) Triebel, F., Lefranc, M.-P. and Hercend, T.
Further evidence for a sequentially ordered activation of T cell Rearranging gamma genes during T lymphocyte differentiation
European Journal of Immunology, 18, 789-798 (1988). PMID: 2967764

67) Ghanem, N., Dugoujon, J.M., Bensmana, M., Huck, S., Lefranc, M.-P. and Lefranc, G.
Restriction fragment haplotypes in the human immunoglobulin IGHG locus and their correlation with the Gm polymorphism
European Journal of Immunology, 18, 1067-1072 (1988). PMID: 2900148

66) Ghanem, N., Lefranc, M.-P. and Lefranc, G.
Definition of the RFLP alleles in the human immunoglobulin IGHG gene locus
European Journal of Immunology, 18, 1059-1065 (1988). PMID: 2900147

65) Bensmana, M., Huck, S., Lefranc, G. and Lefranc, M.-P.
The Human immunoglobulin pseudo-gamma IGHGP gene shows no major structural defect
Nucleic Acids Research, 16, 3108 (1988). PMID: 3130612

64) Ghanem, N., Uring-Lambert, B., Abbal, M., Hauptmann, G., Lefranc, M.-P. and Lefranc, G.
Polymorphism of MHC class III genes : definition of restriction fragment linkage groups and evidence for frequent deletions and duplications
Human Genetics, 79, 209-218 (1988). PMID: 2900212

63) Ghanem, N., Dariavach, P., Bensmana, M., Chibani, J., Lefranc, M.-P. and Lefranc, G.
Polymorphism of immunoglobulin lambda constant region genes in populations from France, Lebanon and Tunisia
Experimental and Clinical Immunogenetics, 5, 186-195 (1988). PMID: 2908491

62) Huck, S., Dariavach, P. and Lefranc, M.-P.
Variable region genes in the human T-cell rearranging gamma (TRG) locus : V-J junction and homology with the mouse genes
The EMBO Journal, 7, 719-726 (1988). PMID: 2969332

61) Helal, A.N., De Lange, G., Van Loghem, E. and Lefranc, G.
Uncommon Gm* haplotypes in the Tunisian population : Further contribution to the genetics of the IgG immunoglobulins
Experimental and Clinical Immunogenetics, 5, 24-38 (1988). PMID: 3272813

60) Persson, M.A.A., Brown, S.E., Steward, M.W., Hammarström, L., Smith, C.I.E., Howard, C.R., Wahl, M., Rynnel-Dagöö, B., Lefranc, G. and Carbonara, A.O.
IgG subclass associated affinity differences of specific antibodies in humans
The Journal of Immunology, 140, 3875-3879 (1988). PMID: 3131419

59) Lefranc, M.-P.
The human T-cell rearranging gamma (TRG) genes and the gamma T-cell receptor
Biochimie, 70, 901-908 (1988). PMID: 3145025

58) Lefranc, M.-P. and Lefranc, G.
The constant region genes of the immunoglobulin heavy chains
Molecular Genetics (Life Sci. Adv.), 7, 39-45 (1988).

57) Triebel, F., Faure, F., Graziani, M., Jitsukawa, S., Lefranc, M.-P. and Hercend, T.
A unique V-J-C rearranged gene encodes a gamma protein expressed on the majority of CD3+ T cell receptor alpha/beta circulating lymphocytes
Journal Experimental Medecine, 167, 694-699 (1988). PMID: 2450164

56) Migone, N., Casorati, G., Francia Di Celle, P., Lusso, P., Foa, R. and Lefranc, M.-P.
Nonrandom TRGgamma variable gene rearrangement in normal human T cells and T cell leukemias
European Journal of Immunology, 18, 173-178 (1988). PMID: 3257920

55) Helal, A.N., Rivat-Peran, L., Van Loghem, E., De Lange, G., Langaney, A. and Lefranc, G.
Further contribution of common Gm*-Am* haplotypes and Km* alleles in the characterization of the Tunisian population
Experimental and Clinical Immunogenetics, 5, 1-14 (1988). PMID: 3155402

54) Lefranc, M.-P., Forster, A. and Rabbitts, T.H.
Organisation of the human T cell rearranging gamma genes (TRGgamma)
In: The T-cell Receptor, Alan Liss Inc., (eds J. Kappler and M. Davis),Vol. 73,pp 25-29 (1988).

1987

53) Hammarström, L., Carbonara, A.O., Demarchi, M., Lefranc, G., Möller, G., Smith, C.I.E. and Zegers, B.J.M.
Subclass restriction pattern of antigen-specific antibodies in donors with defective expression of IgG or IgA subclass heavy chain constant region genes
Clinical Immunology and Immunopathology, 45, 461-470 (1987). PMID: 2445511

52) Ghanem, N., Lefranc, M.-P. and Lefranc, G.
Polymorphism of the complement C3 gene in the Lebanese population
Experimental and Clinical Immunogenetics, 4, 222-226 (1987). PMID: 2908514

51) Huck, S. and Lefranc, M.-P.
Rearrangements to the JP1, JP and JP2 segments in the human T-cell rearranging gamma gene (TRGgamma) locus
FEBS Letters, 224, 291-296 (1987). PMID: 2961609

50) Dariavach, P., Lefranc, G. and Lefranc, M.-P.
Human immunoglobulin Clambda6 gene encodes the Kern+Oz- lambda chain and Clambda4 and Clambda5 are pseudogenes
Proc. Natl. Acad. Sci. USA, 84, 9074-9078 (1987). PMID: 3122211

49) Forster, A., Huck, S., Ghanem, N., Lefranc, M.-P. and Rabbitts, T.H.
New subgroups in the human T cell rearranging Vgamma gene locus
The EMBO Journal, 6, 1945-1950 (1987). PMID: 2820713

48) Foa, R., Casorati, G., Giubellino, M.C., Basso, G., Schiro, R., Pizzolo, G., Lauria, F., Lefranc, M.-P., Rabbitts, T.H. and Migone, N.
Rearrangements of immunoglobulin and T cell Receptor beta and gamma genes are associated with terminal deoxynucleotidyl transferase expression in acute myeloid leukemia
J. Exp. Med., 165, 879-890 (1987). PMID: 3102679

47) Hammarström, L., Carbonara, A.O., De Marchi, M., Lefranc, G., Lefranc, M.-P. and Smith, C.I.E.
Generation of the antibody repertoire in individuals with multiple immunoglobulin heavy chain constant region gene deletions
Scandinavian Journal of Immunology, 25, 189-194 (1987). PMID: 3823791

46) Lefranc, M.-P. and Lefranc, G.
Human immunoglobulin heavy-chain multigene deletions in healthy individuals
FEBS Letters, 213, 231-237 (1987). PMID: 3104087

45) Lefranc, M.-P.
Organisation, réarrangement et diversité des gènes TRG gamma des lymphocytes T humains
Médecine/Sciences, 3, 150-156 (1987).

44) Rabbitts, T.H., Baer, R., Chen, K.C., Forster, A., Lefranc, M.-P., Smith, S. and Stinson, M.A.
Joining of the human T-cell receptor alpha chain gene with an immunoglobulin gene in a chromosome 14 inversion (q11 ; q32) of T-cell leukemia
In New avenues in developmental cancer chemotherapy, vol. 8 (eds K.R. Harrap and T.A. Connors), Academic Press, 8, 485-494 (1987).

1986

43) Rabbitts, T.H., Baer, R., Chen, K.C., Forster, A., Lefranc, M.P. and Stinson, M.A.
Rearrangement of human T cell receptor a chain and involvement in a marker chromosome inversion 14 (q11 ; q32) in T cell lymphoma
In Primary Immunodeficiency Diseases (eds. M.M. Eibl and F.S. Rosen) Elsevier Science Publishers B.V., pp 145-151 (1986).

42) Lefranc, M.-P. and Lefranc, G.
Délétion de gènes de la région constante des chaînes lourdes des immunoglobulines humaines
Médecine/Sciences, 2, 508-513 (1986).

41) Huck, S., Keyeux, G., Ghanem, N., Lefranc, M.-P. and Lefranc, G.
A gamma 3 hinge region probe : first specific human immunoglobulin subclass probe
FEBS Letters, 208, 221-230 (1986). PMID: 2877902

40) Lefranc, M.-P., Forster, A. and Rabbitts, T.H.
Genetic polymorphism and exon changes of the constant regions of the human T-cell rearranging gene gamma
Proc. Natl. Acad. Sci. USA, 83, 9596-9600 (1986). PMID: 2879283

39) Rabbitts, T.H., Baer, R., Chen, K.C., Forster, A., Lefranc, M.-P., Smith, S. and Stinson M.A.
A fusion gene of immunoglobulin and T-cell receptor DNA segments in a chromosome 14 inversion of T-cell leukaemia
Regulation of Immune Gene Expression (eds. M. Feldmann and A. Mc Michael), Humana Press. Inc., Clifton USA, 155-165 (1986).

38) Lefranc, M.-P., Forster, A., Baer, R., Stinson, M.A. and Rabbitts, T.H.
Diversity and rearrangement of the human T cell rearranging gamma genes : Nine germ-line variable genes belonging to two subgroups
Cell, 45, 237-246 (1986). PMID: 2938743 pdf

37) Hammarström, L., Lefranc, G., Lefranc, M.-P., Persson, M.A.A. and Smith, C.I.E.
Aberrant pattern of anti-carbohydrate antibodies in immunoglobulin class or subclass deficient donors
Monographs in Allergy, 20, 50-56 (1986). PMID: 3773912

36) Lefranc, M.-P., Forster, A. and Rabbitts, T.H.
Rearrangement of two distinct T-cell gamma-chain variable-region genes in human DNA
Nature, 319, 420-422 (1986). PMID: 3003579

35) Huck, S., Fort, P., Crawford, D.H., Lefranc, M.-P. and Lefranc, G.
Sequence of a human immunoglobulin gamma 3 heavy chain constant region gene : comparison with the other human Cgamma genes
Nucleic Acids Research, 14, 1779-1789 (1986). PMID: 3081877

34) Lefranc, M.-P., Helal, A.N., De Lange, G., Chaabani, H., Van Loghem, E. and Lefranc, G.
Gene conversion in human immunoglobulin gamma locus shown by unusual location of IgG allotypes
FEBS Letters, 196, 96-102 (1986). PMID: 2417889

33) Baer, R., Lefranc, M.-P., Minowada, J., Forster, A., Stinson, M.A. and Rabbitts, T.H.
Organization of the T-cell receptor alpha-chain gene and rearrangement in human T-cell leukaemias
Molecular Biology and Medicine, 3, 265-277 (1986). PMID: 3016457

1985

32) Lefranc, M.-P. and Rabbitts, T.H.
Two tandemly organized human genes encoding the T-cell gamma constant-region sequences show multiple rearrangement in different T-cell types
Nature, 316, 464-466 (1985). PMID: 2991773

31) Rabbitts, T.H., Lefranc, M.-P., Stinson, M.A., Sims, J.E., Schroder, J., Steinmetz, M., Spurr, N.L., Solomon, E. and Goodfellow, P.N.
The chromosomal location of T-cell receptor genes and a T-cell rearranging gene : possible correlation with specific translocations in human T-cell leukaemia
The EMBO Journal, 4, 1461-1465 (1985). PMID: 3875483

30) Chibani, J., Lefranc, G. and Constans, J.
Serum protein polymorphism among Tunisian Berbers : haptoglobin, transferrin and group-specific component subtypes, C3 and BF types
Annals of Human Biology, 12, 449-462 (1985). PMID: 3851637

1984

29) Lefranc, M.-P. and Rabbitts, T.H.
Human immunoglobulin heavy chain A2 gene allotype determination by restriction fragment length polymorphism
Nucleic Acids Research, 12, 1303-1311 (1984). PMID: 6322103

28) Flanagan, J.G., Lefranc, M.-P. and Rabbitts, T.H.
Mechanisms of divergence and convergence of the human immunoglobulin alpha1 and alpha2 constant region gene sequences
Cell, 36, 681-688 (1984). PMID: 6421489

27) Davrinche, C., Charlionet, R., Rivat, C., Helal, A.N. and Lefranc, G.
Inulin-induced activation of factor B in whole serum : description of structural modifications in the Ba fragment
European Journal of Immunology, 14, 957-961 (1984). PMID: 6567528

26) Chaabani, H., Martin, J.P., Frants, R.R. and Lefranc, G.
Genetic study of Tunisian Berbers : II Alpha1-Antitrypsin (Pi) polymorphism : Report of a new allele (Pi S Berber)
Experimental and Clinical Immunogenetics, 1, 19-24 (1984). PMID: 6400989

25) Chaabani, H., Helal, A.N., Van Loghem, E., Langaney, A., Benammar Elgaaied, A., Rivat-Peran, L. and Lefranc, G.
Genetic study of Tunisian Berbers. I.Gm, Am and Km immunoglobulin allotypes and ABO blood groups
Journal of Immunogenetics, 11, 107-113 (1984). PMID: 6427354

1983

24) Helal, A.N., Lefranc, G., Hauptmann, G., Goetz, J., Tongio, M.M., Davrinche, C., Rivat, C., Cavelier, B., Chibani, J. and Chaabani, H.
HLA A*, B*-BF* and C4 A*, B* allele associations, with special reference to BF*S07, in the Tunisian population
Journal of Immunogenetics, 10, 205-208 (1983). PMID: 6576063

23) Lefranc, M.-P., Lefranc, G., De Lange, G., Out, T.A., Van Den Broek, P.J., Van Nieuwkoop, J., Radl, J., Helal, A.N., Chaabani, H., Van Loghem, E. and Rabbitts, T.H.
Instability of the human immunoglobulin heavy chain constant region locus indicated by different inherited chromosomal deletions
Molecular Biology and Medicine, 1, 207-217 (1983). PMID: 6438434

22) Rabbitts, T.H., Flanagan, J.G. and Lefranc, M.-P.
Flexibility and change within the human immunoglobulin gene locus
Genetic Rearrangement (eds K.F. Chater et al.) Croom Helm, pp. 143-154 (1983).

21) Lefranc, G., Chaabani, H., Van Loghem, E., Lefranc, M.-P., De Lange, G. and Helal, A.N.
Simultaneous absence of the human IgG1, IgG2, IgG4 and IgA1 subclasses : immunological and immunogenetical considerations
European Journal of Immunology, 13, 240-244 (1983). PMID: 6832214

1982

20) Lefranc, M.-P., Lefranc, G. and Rabbitts, T.H.
Inherited deletion of immunoglobulin heavy chain constant region genes in normal human individuals
Nature, 300, 760-762 (1982). PMID: 6817143

19) Van Loghem, E., De Lange, G., Van Leeuwen, A.M., Van Eede, P.H., Nijenhuis, L.E., Lefranc, M.-P. and Lefranc, G.
Human IgG allotypes co-occurring in more than one IgG subclass
Vox Sanguinis, 43, 301-309 (1982). PMID: 7179858

18) Lefranc, G., Lefranc, M.-P., Helal, A.N., Boukef, K., Chaabani, H., Sfar-Gandoura, M. and Van Loghem, E.
Unusual heavy chains of human IgG immunoglobulins : Rearrangements of the CH domain exons
Journal of Immunogenetics, 9, 1-9 (1982). PMID: 6176657

17) Lefranc, G., Lefranc, M.-P., Chaabani, H., Helal, A.N., Ellouze, F., Boukef, K. and Van Loghem, E.
Absence de sous-classes d'immunoglobulines IgG et IgA et grossesses normales
Annales de Biologie Clinique, 40, 53 (1982).

1981

16) Lefranc, M.P., Lefranc, G., Farhat, M., Jmour, R., Boukef, K., Beuzard, Y., Galacteros, F. and Rosa, J.
Frequency of human Agamma75Thr globin chain in a population from Tunisia
Human Genetics, 59, 89-91 (1981). PMID: 10819032

15) Lefranc, M.P., Chibani, J., Helal, A.N., Boukef, K., Seger, J. and lefranc, G.
Human Transferrin (Tf) and Group-Specific Component (Gc) subtypes in Tunisia
Human Genetics, 59, 60-63 (1981). PMID: 10819023

14) Davrinche, C., Rivat, C., Rivat-Peran, L., Helal, A.N., Boukef, K., Lefranc, M.-P. and Lefranc, G.
Genetic variants of human C3 and properdin factor B in a population from Tunisia
Human Heredity, 31, 299-303 (1981). PMID: 6916696

13) Lefranc, G., Lefranc, M.-P., Seger, J., Salier, J.P., Chakhachiro, L. and Loiselet, J.
Sex limited ahaptoglobinaemia
Human Genetics, 58, 294-297 (1981). PMID: 7327550

1980

12) Lefranc, G. and Lefranc, M.-P.
Discontinuous genes and DNA sequence transposition : A model for immunoglobulin chain synthesis
Journal of Immunogenetics, 7, 207-214 (1980). PMID: 7410874

11) Van Loghem, E., Sukernik, R.I., Osipova, L.P., Zegers, B.J.M., Matsumoto, H., De Lange, G. and Lefranc, G.
Gene deletion and gene duplication within the cluster of human heavy chain genes. Selective absence of IgG sub-classes
Journal of Immunogenetics, 7, 285-299 (1980). PMID: 6778930

10) Salier, J.P., Rivat, L., Daveau, M., Lefranc, G., Breton, P., De Menibus, C.H., Henocq, A. and Fudenberg, H.H.
Quantitative studies of Gm allotypes. V. Simultaneous presence of latent Gm allotypes and deficient Gm genes in a family with hypogammaglobulinaemic probands
Journal of Immunogenetics, 7, 123-135 (1980). PMID: 7381229

1979

9) Lefranc, G., De Lange, G., Rivat, L., Langaney, A., Lefranc, M.P., Ellouze, F., Sfar, G., Sfar, M. and Van Loghem, E.
Gm, Am and Km immunoglobulin allotypes of two populations in Tunisia
Human Genetics, 50, 199-211 (1979). PMID: 511135

8) Lefranc, G., Dumitresco, S.M., Salier, J.P., Rivat, L., De Lange, G., Van Loghem, E. and Loiselet, J.
Familial lack of the IgG3 subclass : Gene elimination or turning off expression and neutral evolution in the immune system
Journal of Immunogenetics, 6, 215-221 (1979). PMID: 521664

7) Serre, J.L., Lefranc, G., Loiselet, J. and Jacquard, A.
HLA markers in six Lebanese religious subpopulations
Tissue Antigens, 14, 251-255 (1979). PMID: 93316

1978

6) Lefranc, G., Rivat, L., Serre, J.L., Lalouel, J.M., Pison, G., Loiselet, J., Ropartz, C., De Lange, G. and Van Loghem, E.
Common and uncommon immunoglobulin haplotypes among Lebanese communities
Human Genetics, 41, 197-209 (1978). PMID: 640654

1977

5) Lefranc, G., Rivat, L., Salier, J.P., Van Loghem, E., Aydenian, H., Zalzal, P., Chakhachiro, L., Loiselet, J. and Ropartz, C.
Recombination, mutation or constitutive expression at a Gm locus and familial hypergammaglobulinemia
American Journal of Human Genetics, 29, 523-536 (1977). PMID: 900125

1976

4) Geha, R.S., Malakian, A., Lefranc, G., Chaiban, D. and Serre, J.L.
Immunologic reconstitution in severe combined immunodeficiency following transplantation with parental bone marrow
Pediatrics, 58, 451-455 (1976). PMID: 785357

3) Lefranc, G., Loiselet, J., Rivat, L. and Ropartz, C.
Gm, Km and Isf allotypes in the Lebanese population
Acta Anthropogenetica, 1, 34-45 (1976). pdf

2) Lalouel, J.M., Loiselet, J., Lefranc, G., Chayban, D., Chakhachiro, L., Rivat, L. and Ropartz, C.
Genetic differentiation among Lebanese communities
Acta Anthropogenetica, 1, 15-331 (1976).

1) Lefranc, G., Rivat, L., Rivat, C., Loiselet, J. and Ropartz, C.
Evidence for deleted or silent genes homozygous at the locus coding for the constant region of the gamma 3 chain
American Journal of Human Genetics, 28, 51-61 (1976). PMID: 12470202