Proteins with known 3D structures
Protein Display: Human Immunoglobulin V-DOMAINs
Overview table Identification of the genes and alleles involved in the rearrangements and expressed in the variable regions Protein display of the Ig V-D-J and V-J REGIONs

Click here to see: Part 2 - Human IGK V-DOMAINs (V-J-REGIONs)
Click here to see: Part 3 - Human IGL V-DOMAINs (V-J-REGIONs)

Part 1 - Human IGH V-DOMAINs (V-D-J-REGIONs)
Reference of this table: Ruiz, M. and Lefranc, M.-P., Immunogenetics, 53, 857-883 (2002) PMID:11862387, LIGM:259

Updates from 09/05/2001 are available in IMGT/3Dstructure-DB. IMGT/3Dstructure-DB entries (cards) are identified by the PDB code.
Click on a PDB code to get the corresponding IMGT/3Dstructure-DB card.
Click on an asterisk (*) to see the Protein Display of the partner light chain.

These sequences were automatically extracted from the the PDB file ATOM records, and correspond to the atomic coordinates present in the PDB file. It is important to note that there may be conflicts between sequence data from the ATOM records and those from the SEQRES records.
Numbering is according to the IMGT unique numbering for V-DOMAIN and V-LIKE-DOMAIN.
_____________________

Protein
 name	   
_____________________
	
	
________

PDB code
	
________  
	  
  ______________________________________________________________________________________________________________________________________________

           FR1-IMGT           CDR1-IMGT       FR2-IMGT      CDR2-IMGT               FR3-IMGT                        CDR3-IMGT          FR4-IMGT
            (1-26)             (27-38)         (39-55)       (56-65)                (66-104)
  __________________________ ____________ _________________ __________ _______________________________________ _____________________ ___________
  1       10        20         30         40        50         60         70       80         90       100        110                120
  .........|.........|...... ...|........ .|.........|..... ....|..... ....|.........|.........|.........|.... .....|.12344321...... ..|........


17B 


17B 

3D6 


9E 

B7-15A2 

Fab-12 


HULYS11 




Hil 


Iga1 



IgmRf2A2 



Kau Cold Agglutinin 


Kol 


M3C65 

Mak33 

Mcg 

Mez 

Newm 

Pot 

Rf-An 

Undefined 
1G9M_H * 
1G9N_H

1GC1_H * 

1DFB_H * 
1OBE_H

1DX3_H * 

1AQK_H * 

1CZ8_H * 
1CZ8_Y

1BVK_B * 
1BVK_E
1BVL_A
1BVL_C

8FAB_B * 
8FAB_D

1IGA_A * 
1IGA_B
1VGE_H

1DEE_B * 
1DEE_D
1DEE_F

1QLR_B * 
1QLR_D

2FB4_H * 
2IG2_H

1DL7_H * 

1FH5_H * 

1MCO_H * 

1DQL_H * 

7FAB_H * 

1IGM_H * 

1ADQ_H * 

1HOU_H * 
  QVQLLESGA-EVKKPGSSVKVSCKAS GDTFIRYS---- FTWVRQAPGQGLEWMGR IITILDVA-- HYAPHLQ-GRVTITADKSTSTVYLELRNLRSDDTAVYFC AGVYEGEADEGEYRNNGFLKH WGQGTLVTVTS


  QVQLLESGA-EVKKPGSSVKVSCKAS GDTFIRYS---- FTWVRQAPGQGLEWMGR IITILDVA-- HYAPHLQ-GRVTITADKSTSTVYLELRNLRSDDTAVYFC AGVYEGEADEGEYDNNGFLKH WGQGTLVTVTS

  EVQLVESGG-GLVQPGRSLRLSCAAS GFTFNDYA---- MHWVRQAPGKGLEWVSG ISWDSSSI-- GYADSVK-GRFTISRDNAKNSLYLQMNSLRAEDMALYYC VKGRDYYDSG..GYFTVAFDI WGQGTMVTVSS


  EVQLVQSGA-EVKKPGASVKVSCKAS GYTFTTYG---- INWVRQAPGQGLEWMGW INTYTGNP-- TYGQGFT-GRLVFSLDTSVSTAYLQINSLEAADTAVYFC ARFAI............KGDY WGQGTLVTVS

  -VQLVESGG-GVVQPGRSLRLSCAAS GFTFNNYA---- IHWVRQAPGKGLEWVAF ISYDGSKN-- YYADSVK-GRFTISRDNSKNTLFLQMNSLRPEDTAIYYC ARVLFQQL.....VLYAPFDI WGQGTMVTVSS

  EVQLVESGG-GLVQPGGSLRLSCAAS GYDFTHYG---- MNWVRQAPGKGLEWVGW INTYTGEP-- TYAADFK-RRFTFSLDTSKSTAYLQMNSLRAEDTAVYYC AKYPYYYG.....TSHWYFDV WGQGTLVTVSS


  QVQLQESGP-GLVRPSQTLSLTCTVS GFSLTGYG---- VNWVRQPPGRGLEWIGM IWGDGNT--- DYNSALK-SRVTMLKDTSKNQFSLRLSSVTAADTAVYYC ARERD...........YRLDY WGQGSLVTVSS




  AVKLVQAGG-GVVQPGRSLRLSCIAS GFTFSNYG---- MHWVRQAPGKGLEWVAV IWYNGSRT-- YYGDSVK-GRFTISRDNSKRTLYMQMNSLRTEDTAVYYC ARDPDIL.......TAFSFDY WGQGVLVTVSS


 QVKLLEQSGA-EVKKPGASVKVSCKAS GYSFTSYG---- LHWVRQAPGQRLEWMGW ISAGTGNT-- KYSQKFR-GRVTFTRDTSATTAYMGLSSLRPEDTAVYYC ARDPYGG.......GKSEFDY WGQGTLVTVSS



  QVQLVESGG-GVVQPGKSLRLSCAAS GFTFSGYG---- MHWVRQAPGKGLEWVAL ISYDESNK-- YYADSVK-GRFTISRDNSKNTLYLQMNSLRAEDTAVYYC AKVKFYD.......PTAPNDY WGQGTLVTVSS



  EVQLQQWGA-GLLKPSETLSLTCAVY GGSFSDYY---- WSWIRQPPGKGLEWIGE INHSGST--- NYNPSLK-SRVTISVDTSKNQFSLKLSSVTAADTAVYYC ARPPHDT.......SGHYWNY WGQGTLVTVSS


  EVQLVQSGG-GVVQPGRSLRLSCSSS GFIFSSYA---- MYWVRQAPGKGLEWVAI IWDDGSDQ-- HYADSVK-GRFTISRNDSKNTLFLQMDSLRPEDTGVYFC ARDGGHGFCS..SASCFGPDY WGQGTPVTVSS


  QVQLKESGP-GLVAPSQSLSITCTVS GFSLTGYG---- VNWVRQPPGKGLEWLGM IWGDGST--- DYNSALK-SRLNISKDKSKSQVFLRMYSLQTDDTARYYC ARDY..............GPY WGQGTLVTVS

  ------SGG-GLVKPAGSLKLSCAAS GFTFSSYY---- MYWVRQTPDKRLEWVAT ISDGGSYT-- YYPDSVK-GRFTISRDNAKNNLYLQMSSLKSEDTAMYYC ARDA..............MDY WGQGTLVTVSA

  PLVLQESGP-GLVKPSEALSLTCTVS GDSINTILYY-- WSWIRQPPGKGLEWIGY IYYSGST--- YGNPSLK-SRVTISVNTSKNQFYSKLSSVTAADTAVYYC ARVPL............VVNP WGQGTLVTVSS

  -VQLVESGG-GLVQPGGSLRLSCAAS GFTFSSYA---- MHWVRQAPGKGLEWVAV ISSDGGNK-- YYTDSVK-GRFTISRNDSKNTLYLQMNSLRTEDTAVFYC ARGNPPYS.....SGWGGGDY WGQGTMVTVSS

  AVQLEQSGP-GLVRPSQTLSLTCTVS GTSFDDYY---- WTWVRQPPGRGLEWIGY VFYTGTT--- LLDPSLR-GRVTMLVNTSKNQFSLRLSSVTAADTAVYYC ARNLIA..........GGIDV WGQGSLVTVSS

  EVHLLESGG-NLVQPGGSLRLSCAAS GFTFNIFV---- MSWVRQAPGKGLEWVSG VFGSGGNT-- DYADAVK-GRFTITRDNSKNTLYLQMNSLRAEDTAIYYC AKHRVSY.......VLTGFDS WGQGTLVTVSS

  EVQLVESGG-GLVQPGRSLRLSCVTS GFTFDDYA---- MHWVRQSPGKGLEWVSG ISWNTGTI-- IYADSVK-GRFIISRDNAKNSLYLQMNSLRVEDTALYYC AKTRSYVV.....AAEYYFHY WGQGILVTVSS

  EVQLLESGG-GLVQPGGSLRLSCAAS GFTFSSYA---- MSWVRQAPGKGLEWVSA ISGSGGST-- YYADSVK-GRFTISRDNSKNTLYLQMNSLRAEDTAVYYC AKGY.............GMDV WGQGTTVTVSS


CDR-IMGT regions are colored as follows:
IGH V-D-J REGION: CDR1-IMGT (red), CDR2-IMGT (orange), CDR3-IMGT (purple)


Created: 11/06/2001
Last updated: Wednesday, 29-Jun-2011 17:05:50 CEST
Author: Manuel Ruiz

Software material and data coming from IMGT server may be used for academic research only, provided that it is referred to IMGT®, and cited as "IMGT®, the international ImMunoGeneTics information system® http://www.imgt.org (founder and director: Marie-Paule Lefranc, Montpellier, France)." References to cite: Lefranc, M.-P. et al., Nucleic Acids Res., 27:209-212 (1999); doi: 10.1093/nar/27.1.209 Full text Cover; Ruiz, M. et al., Nucleic Acids Res., 28:219-221 (2000); doi: 10.1093/nar/28.1.219 Full text; Lefranc, M.-P., Nucleic Acids Res., 29:207-209 (2001); doi: 10.1093/nar/29.1.207 Full text; Lefranc, M.-P., Nucleic Acids Res., 31:307-310 (2003); doi: 10.1093/nar/gkg085 Full text; Lefranc, M.-P. et al., In Silico Biol., 5, 0006 (2004) [Epub], 5:45-60 (2005); Lefranc, M.-P. et al., Nucleic Acids Res., 33:D593-597 (2005); doi: 10.1093/nar/gki065 Full text; Lefranc, M.-P. et al., Nucleic Acids Res., 37:D1006-1012 (2009); doi: 10.1093/nar/gkn838 Full text; Lefranc, M.-P. et al., Nucleic Acids Res., 43:D413-422 (2015); doi: 10.1093/nar/gku1056 Full text.
For any other use please contact Marie-Paule Lefranc Marie-Paule.Lefranc@igh.cnrs.fr.

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