Proteins with known 3D structures
Overview: Human Immunoglobulins
Overview table  Identification of the genes and alleles involved in the rearrangements and expressed in the variable regions Protein display of the Ig V-D-J and V-J REGIONs

"OVERVIEW" gives information on proteins whose three-dimensional structure has been determined.
"IDENTIFICATION AND COLLIERS DE PERLES" provides
  • the identification of the genes and alleles expressed in the IGH V-DOMAINs (V-D-J-REGIONs) and in the IGK and IGL V-DOMAINs (V-J-REGIONs)
  • the Colliers de Perles of the IGH, IGK and IGL V-DOMAINs.
    "PROTEIN DISPLAY" provides the Protein displays of the IGH, IGK and IGL V-DOMAINs.

    Click here to see: Part 2 - Human immunoglobulin proteins (in the PDB code order)

    Part 1 - Human immunoglobulin proteins (in alphabetic order)
    Reference of this table: Ruiz, M. and Lefranc, M.-P., Immunogenetics, 53, 857-883 (2002) PMID:11862387, LIGM:259

    Updates from 09/05/2001 are available in IMGT/3Dstructure-DB. IMGT/3Dstructure-DB entries (cards) are identified by the PDB code.
    Click on a PDB code to get the corresponding IMGT/3Dstructure-DB card.

    Protein Name
    PDB Code
    Fragment (1) Ligands Experimental Technique Resolution PDB Release Date References
    17B
    1g9m
    Fab
    HIV-1 gp120 (envelope protein)/CD4
    X-ray diffraction
    2.20
    27-dec-00
    28
    17B
    1g9n
    Fab
    HIV-1 gp120 (envelope protein)/CD4
    X-ray diffraction
    2.90
    27-dec-00
    42
    17B
    1gc1
    Fab
    HIV-1 gp120 (envelope protein)/CD4
    X-ray diffraction
    2.50
    19-aug-98
    28
    3D6
    1dfb
    Fab
     
    X-ray diffraction
    2.70
    31-oct-93
    10
    3D6
    1obe
    Fab
    HIV-1 gp41 synthetic peptide
    theoretical model
     
    15-may-97
    17
    9E
    1dx3
    Fv
     
    theoretical model
     
    15-dec-00
    38
    B7-15A2
    1aqk
    Fab
     
    X-ray diffraction
    1.84
    04-feb-98
    26
    Bre
    1b0w
    VL
     
    X-ray diffraction
    1.80
    22-dec-99
    31
    Bre
    1bre
    VL
     
    X-ray diffraction
    2.00
    15-oct-95
    16
    Bre
    1qp1
    (VL)3
     
    X-ray diffraction
    2.06
    28-jun-99
    37
    Cle
    1lil
    L2
     
    X-ray diffraction
    2.65
    15-may-97
    20
    Fab-12
    1cz8
    Fab
    Vascular endothelial growth factor
    X-ray diffraction
    2.40
    20-mar-00
    33
    HULYS11
    1bvk
    Fv
    Lysozyme [hen egg white]
    X-ray diffraction
    2.70
    16-feb-99
    27
    HULYS11
    1bvl
    Fv
     
    X-ray diffraction
    2.87
    16-feb-99
    22
    Hil
    8fab
    Fab
     
    X-ray diffraction
    1.80
    31-oct-93
    8
    IgE Cepsilon2
    1g84
    CH2
     
    NMR, 15 structures
     
    16-may-01
    48
    IgG1
    1fc1
    Fc
     
    X-ray diffraction
    2.90
    15-jul-92
    3
    IgG1
    1fc2
    Fc
    Fragment B of protein A [Staphylococcus aureus]
    X-ray diffraction
    2.80
    15-jul-92
    3
    IgG1
    1iis
    Fc
    Fc gamma III low affinity receptor
    X-ray diffraction
    3.00
    09-may-01
    49
    IgG1
    1iix
    Fc
    Fc gamma III low affinity receptor
    X-ray diffraction
    3.50
    09-may-01
    49
    Iga1
    1iga
    IgA
     
    theoretical model; scattering fitting
     
    15-jun-99
    32
    Ige Epsilon-1
    1fp5
    Fc
     
    X-ray diffraction
    2.30
    27-sep-00
    46
    IgmRf2A2
    1dee
    Fab
     
    X-ray diffraction
    2.70
    14-jun-00
    41
    Jto
    1cd0
    (VL)2
     
    X-ray diffraction
    1.90
    06-mar-00
    36
    Kau Cold Agglutinin
    1qlr
    Fab
     
    X-ray diffraction
    2.83
    14-sep-00
    50
    Kol
    2fb4
    Fab
     
    X-ray diffraction
    1.90
    12-jul-89
    6
    Kol
    2ig2
    Fab
     
    X-ray diffraction
    3.00
    12-jul-89
    6
    Len (mutant)
    3lve
    VL
     
    X-ray diffraction
    2.00
    18-may-99
    30
    Len (mutant)
    4lve
    (VL)2
     
    X-ray diffraction
    2.30
    18-may-99
    29
    Len
    1lve
    VL
     
    X-ray diffraction
    1.95
    21-jan-98
    23
    Len
    2lve
    VL
     
    X-ray diffraction
    2.70
    18-may-99
    29
    Len
    5lve
    VL
     
    X-ray diffraction
    2.00
    18-feb-00
    30
    Loc
    1bjm
    L2
     
    X-ray diffraction
    2.20
    07-dec-95
    19
    Loc
    3bjl
    L2
     
    X-ray diffraction
    2.30
    07-dec-95
    19
    Loc
    4bjl
    L2
     
    X-ray diffraction
    2.40
    07-dec-95
    19
    Loi
    2loi
    (VL)2
     
    theoretical model
     
    29-dec-99
    35
    M3C65
    1dl7
    Fv
     
    X-ray diffraction
    2.35
    13-dec-00
    39
    M4L/Y(27D)D/Q89D/T94H Mutant Of Len
    1eeu
    (VL)2
     
    X-ray diffraction
    1.60
    03-feb-01
    51
    M4L/Y(27D)D/T94H Mutant Of Len
    1eeq
    (VL)2
     
    X-ray diffraction
    1.50
    01-feb-01
    51
    Mak33
    1fh5
    Fab
     
    X-ray diffraction
    2.90
    13-sep-00
    47
    Mcg-Weir Hybrid
    1mcw
    L2
     
    X-ray diffraction
    3.50
    15-oct-90
    7
    Mcg
    1a8j
    L2
    Aspartame
    X-ray diffraction
    2.70
    17-jun-98
    25
    Mcg
    1dcl
    L2
     
    X-ray diffraction
    2.30
    15-may-97
    5
    Mcg
    1mcb
    L2
    N-Acetyl-L-Gln-D-Phe-L-His-D-Pro-OH
    X-ray diffraction
    2.70
    31-jan-94
    13
    Mcg
    1mcc
    L2
    N-Acetyl-L-Gln-D-Phe-L-His-D-Pro-NH2
    X-ray diffraction
    2.70
    31-jan-94
    13
    Mcg
    1mcd
    L2
    N-Acetyl-D-Phe-B-Ala-L-His-D-Pro-NH2
    X-ray diffraction
    2.70
    31-jan-94
    12
    Mcg
    1mce
    L2
    N-Acetyl-L-Gln-D-Phe-L-His-D-Pro-B-Ala-OH
    X-ray diffraction
    2.70
    31-jan-94
    13
    Mcg
    1mcf
    L2
    N-Acetyl-L-Gln-D-Phe-L-His-D-Pro-B-Ala-B-Ala-OH
    X-ray diffraction
    2.70
    31-jan-94
    12
    Mcg
    1mch
    L2
    N-Acetyl-L-Gln-D-Phe-L-His-D-Pro-B-Ala-B-Ala-OH
    X-ray diffraction
    2.70
    31-jan-94
    13
    Mcg
    1mci
    L2
    N-Acetyl-D-Phe-L-His-D-Pro-OH
    X-ray diffraction
    2.70
    31-jan-94
    13
    Mcg
    1mcj
    L2
    N-Acetyl-D-Phe-L-His-D-Pro-NH2
    X-ray diffraction
    2.70
    31-jan-94
    13
    Mcg
    1mck
    L2
    N-Acetyl-D-Glu-L-His-D-Pro-NH2
    X-ray diffraction
    2.70
    31-jan-94
    13
    Mcg
    1mcl
    L2
    N-Acetyl-D-His-L-Pro-OH
    X-ray diffraction
    2.70
    31-jan-94
    13
    Mcg
    1mcn
    L2
    N-Acetyl-D-His-L-Pro-NH2
    X-ray diffraction
    2.70
    31-jan-94
    13
    Mcg
    1mco
    Ig with a hinge deletion
     
    X-ray diffraction
    3.20
    31-jan-94
    14
    Mcg
    1mcq
    L2
    N-Acetyl-L-His-D-Pro-NH2
    X-ray diffraction
    2.70
    31-jan-94
    13
    Mcg
    1mcr
    L2
    N-Acetyl-L-His-D-Pro-OH
    X-ray diffraction
    2.70
    31-jan-94
    13
    Mcg
    1mcs
    L2
    N-Acetyl-L-Gln-D-Phe-L-His-D-Pro-OH
    X-ray diffraction
    2.70
    31-jan-94
    13
    Mcg
    2mcg
    L2
     
    X-ray diffraction
    2.00
    15-jul-92
    2
    Mcg
    3mcg
    L2
     
    X-ray diffraction
    2.00
    15-oct-90
    5
    Mez
    1dql
    Fv
     
    X-ray diffraction
    2.60
    04-oct-00
    44
    Newm (2)
    7fab
    Fab
     
    X-ray diffraction
    2.00
    31-jan-94
    11
    Pot
    1igm
    Fv
     
    X-ray diffraction
    2.30
    31-oct-93
    9
    Q38D Mutant Of Len
    1efq
    VL
     
    X-ray diffraction
    1.60
    09-feb-01
    51
    Rec
    1ek3
    (VL)2
     
    X-ray diffraction
    1.90
    06-mar-01
    51
    Rei
    1ar2
    VL
     
    X-ray diffraction
    2.80
    12-nov-97
    24
    Rei
    1rei
    (VL)2
     
    X-ray diffraction
    2.00
    17-feb-84
    1
    Reiv-T39K
    1bww
    VL
     
    X-ray diffraction
    1.70
    29-dec-99
    24
    Rf-An
    1adq
    Fab
    Autoantigen IgG Fc
    X-ray diffraction
    3.15
    16-sep-98
    21
    Rhe
    2rhe
    VL
     
    X-ray diffraction
    1.60
    09-oct-88
    4
    Tr1.9
    1vge
    Fab
     
    X-ray diffraction, single crystal
    2.00
    10-jun-96
    18
    Undefined
    1e4k
    Fc
    Fc gamma III low affinity receptor (CD16)
    X-ray diffraction
    3.20
    06-aug-00
    45
    Undefined
    1f6a
    Fc
    Fc epsilon RI alpha (high-affinity receptor)
    X-ray diffraction
    3.50
    20-jul-00
    40
    Undefined
    1hou
    Fv
     
    theoretical model
     
    23-dec-99
    34
    Undefined
    1qac
    (VL)2
     
    X-ray diffraction
    1.80
    23-feb-00
    43
    Wat
    1wtl
    (VL)2
     
    X-ray diffraction
    1.90
    01-nov-94
    15
    Wil
    2cd0
    (VL)2
     
    X-ray diffraction
    1.80
    08-mar-00
    36


    IMGT notes:

    (1) Fragment legend :
    VHIg heavy V-DOMAIN.
    VLIg light V-DOMAIN.
    FabFragment antigen-binding. Complete light chain (Ig light V-DOMAIN and C-DOMAIN) disulfide-linked with an Ig heavy V-DOMAIN and CH1 C-DOMAIN.
    FvIg heavy V-DOMAIN (VH) non covalently linked with an Ig light V-DOMAIN (VL).
    FcFragment crystallizable. Two identical disulfide-linked Ig heavy CH2 and CH3 C-DOMAINs.
    (VL)nn Ig light V-DOMAINs non covalently linked.
    L2Dimer of two non covalently linked complete light chains.
    IgAComplete Immunoglobulin A.
    scFvTwo Ig (or by extension T cell receptor) V-DOMAINs covalently linked.
    CH2Ig heavy CH2 C-DOMAIN.

    (2) Click here for "Particularities in protein designations: Human immunoglobulins: New and Newm "


    Created: 26/06/2001
    Last updated: Wednesday, 29-Jun-2011 17:05:50 CEST
    Author: Manuel Ruiz

    Software material and data coming from IMGT server may be used for academic research only, provided that it is referred to IMGT®, and cited as "IMGT®, the international ImMunoGeneTics information system® http://www.imgt.org (founder and director: Marie-Paule Lefranc, Montpellier, France)." References to cite: Lefranc, M.-P. et al., Nucleic Acids Res., 27:209-212 (1999); doi: 10.1093/nar/27.1.209 Full text Cover; Ruiz, M. et al., Nucleic Acids Res., 28:219-221 (2000); doi: 10.1093/nar/28.1.219 Full text; Lefranc, M.-P., Nucleic Acids Res., 29:207-209 (2001); doi: 10.1093/nar/29.1.207 Full text; Lefranc, M.-P., Nucleic Acids Res., 31:307-310 (2003); doi: 10.1093/nar/gkg085 Full text; Lefranc, M.-P. et al., In Silico Biol., 5, 0006 (2004) [Epub], 5:45-60 (2005); Lefranc, M.-P. et al., Nucleic Acids Res., 33:D593-597 (2005); doi: 10.1093/nar/gki065 Full text; Lefranc, M.-P. et al., Nucleic Acids Res., 37:D1006-1012 (2009); doi: 10.1093/nar/gkn838 Full text; Lefranc, M.-P. et al., Nucleic Acids Res., 43:D413-422 (2015); doi: 10.1093/nar/gku1056 Full text.
    For any other use please contact Marie-Paule Lefranc Marie-Paule.Lefranc@igh.cnrs.fr.

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