Proteins with known 3D structures
Protein Display: Human Immunoglobulin V-DOMAINs
Overview table Identification of the genes and alleles involved in the rearrangements and expressed in the variable regions Protein display of the Ig V-D-J and V-J REGIONs

Click here to see: Part 1 - Human IGH V-DOMAINs (V-D-J-REGIONs)
Click here to see: Part 3 - Human IGL V-DOMAINs (V-J-REGIONs)

Part 2 - Human IGK V-DOMAINs (V-J-REGIONs)
Reference of this table: Ruiz, M. and Lefranc, M.-P., Immunogenetics, 53, 857-883 (2002) PMID:11862387, LIGM:259

Updates from 09/05/2001 are available in IMGT/3Dstructure-DB. IMGT/3Dstructure-DB entries (cards) are identified by the PDB code.
Click on a PDB code to get the corresponding IMGT/3Dstructure-DB card.

Click on an asterisk (*) to see the Protein Display of the partner heavy chain.

These sequences were automatically extracted from the the PDB file ATOM records, and correspond to the atomic coordinates present in the PDB file. It is important to note that there may be conflicts between sequence data from the ATOM records and those from the SEQRES records.
Numbering is according to the IMGT unique numbering for V-DOMAIN and V-LIKE-DOMAIN.
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Protein
 name	   
___________________________________
	
	
________

PDB code
	
________  
	  
  ______________________________________________________________________________________________________________________________________

           FR1-IMGT           CDR1-IMGT       FR2-IMGT      CDR2-IMGT               FR3-IMGT                    CDR3-IMGT     FR4-IMGT
            (1-26)             (27-38)         (39-55)       (56-65)                (66-104)
  __________________________ ____________ _________________ __________ _______________________________________ _____________ __________
  1       10        20         30         40        50         60         70        80        90       100        110        120
  .........|.........|...... ...|........ .|.........|..... ....|..... ....|.........|.........|.........|.... .....|....... ..|.......


17B 



3D6 


9E 

Bre 












Fab-12 


HULYS11 




Iga1 



IgmRf2A2 



Kau Cold Agglutinin 


Len 


Len 

Len (mutant) 

Len (mutant) 


M4L/Y(27D)D/Q89D/T94H Mutant Of Len 

M4L/Y(27D)D/Q89D/T94H Mutant Of Len 

M4L/Y(27D)D/T94H Mutant Of Len 


Mak33 

Mez 

Pot 

Q38D Mutant Of Len 

Rec 


Rei 

Rei 


Reiv-T39K 


Undefined 

Undefined 


Wat 

1G9M_L * 
1G9N_L
1GC1_L

1DFB_L * 
1OBE_L

1DX3_L * 

1B0W_A 
1B0W_B
1B0W_C
1BRE_A
1BRE_B
1BRE_C
1BRE_D
1BRE_E
1BRE_F
1QP1_A
1QP1_B
1QP1_C

1CZ8_L * 
1CZ8_X

1BVK_A * 
1BVK_D
1BVL_B
1BVL_D

1IGA_C * 
1IGA_D
1VGE_L

1DEE_A * 
1DEE_C
1DEE_E

1QLR_A * 
1QLR_C

1LVE_ 
2LVE_ 

5LVE_A 

3LVE_ 

4LVE_A 
4LVE_B

1EEU_A 

1EEU_B 

1EEQ_A 
1EEQ_B

1FH5_L * 

1DQL_L * 

1IGM_L * 

1EFQ_A 

1EK3_A 
1EK3_B

1AR2_ 

1REI_A 
1REI_B

1BWW_A 
1BWW_B

1HOU_L * 

1QAC_A 
1QAC_B

1WTL_A 
1WTL_B
  ELELTQSPATLSVSPGERATLSCRAS ESVSSD------ LAWYQQKPGQAPRLLIY GAS------- TRATGVP-ARFSGSG--SGAEFTLTISSLQSEDFAVYYC QQYNNW..PPRYT FGQGTRLEIK



  DIQMTQSPSTLSASVGDRVTITCRAS QSISRW------ LAWYQQKPGKVPKLLIY KAS------- SLESGVP-SRFSGSG--SGTEFTLTISSLQPDDFATYYC QQYN......SYS FGPGTKVDIK


  EIVMTQSPASLSLSPGERATLSCRAS QSVSNY------ LAWYQQKPGQAPRLLIH DAS------- GRATGIP-DRFSGSG--SGTDFTLTISRLEPEDFAVYYC QQRAN...WGTWT FGQGTKVEIK

  DIQMTQSPSSLSASVGDRVTITCQAS QDISDY------ LIWYQQKLGKAPNLLIY DAS------- TLETGVP-SRFSGSG--SGTEYTFTISSLQPEDIATYYC QQYDD....LPYT FGQGTKVEIK












  DIQLTQSPSSLSASVGDRVTITCSAS QDISNY------ LNWYQQKPGKAPKVLIY FTS------- SLHSGVP-SRFSGSG--SGTDFTLTISSLQPEDFATYYC QQYST....VPWT FGQGTKVEIK


  DIQMTQSPSSLSASVGDRVTITCRAS GNIHNY------ LAWYQQKPGKAPKLLIY YTT------- TLADGVP-SRFSGSG--SGTDYTFTISSLQPEDIATYYC QHFWS....TPRT FGQGTKVEIK




  ELVMTQSPSSLSASVGDRVNIACRAS QGISSA------ LAWYQQKPGKAPRLLIY DAS------- NLESGVP-SRFSGSG--SGTDFTLTISSLQPEDFAIYYC QQFNS....YPLT FGGGTKVEIK



  DIQMTQSPSSLSASVGDRVTITCRTS QSISSY------ LNWYQQKPGKAPKLLIY AAS------- SLQSGVP-SRFSGSG--SGTDFTLTISSLQPEDFATYYC QQSYS....APRT FGQGTKVEIK



  EIVLTQSPATLSLSPGERATLSCGAS QSVSSNY----- LAWYQQKPGQAPRLLIY DAS------- SRATGIP-DRFSGSG--SGTDFTLTISRLEPEDFAVYYC QQYGS....SPLT FGGGTKVEIK


  DIVMTQSPDSLAVSLGERATINCKSS QSVLYSSNSKNY LAWYQQKPGQPPKLLIY WAS------- TRESGVP-DRFSGSG--SGTDFTLTISSLQAEDVAVYYC QQYYS....TPYS FGQGTKLEIK


  DIVMTQSPDSLAVSLGERATINCKSS QSVLYSSNSKNY LAWYQQKPGQPPKLLIY WAS------- TRESGVP-DRFSGSG--SGTDFTLTISSLQAEDVAVYYC AQYYS....TPYS FGQGTKLEIK

  DIVMTQSPDSLAVSLGERATINCKSS QSVLYSSNSKNY LAWYQEKPGQPPKLLIY WAS------- TRESGVP-DRFSGSG--SGTDFTLTISSLQAEDVAVYYC QQYYS....TPYS FGQGTKLEIK

  DIVMTQSPDSLAVSLGERATINCKSS QSVLYSSNSTNY LAWYQQKPGQPPKLLIY WAS------- TRESGVP-DRFSGSG--SGTDFTLTISSLQAEDVAVYYC QQYYS....TPYS FGQGTKLEIK


  DIVLTQSPDSLAVSLGERATINCKSS QSVLDSSNSKNY LAWYQQKPGQPPKLLIY WAS------- TRESGVP-DRFSGSG--SGTDFTLTISSLQAEDVAVYYC DQYYS....HPYS FGQGTKLEI

  DIVLTQSPDSLAVSLGERATINCKSS QSVLDSSNSKNY LAWYQQKPGQPPKLLIY WAS------- TRESGVP-DRFSGSG--SGTDFTLTISSLQAEDVAVYYC DQYYS....HPYS FGQGTKLEIK

  DIVLTQSPDSLAVSLGERATINCKSS QSVLDSSNSKNY LAWYQQKPGQPPKLLIY WAS------- TRESGVP-DRFSGSG--SGTDFTLTISSLQAEDVAVYYC QQYYS....HPYS FGQGTKLEIK


  DIVLTQSPATLSVTPGESVSLSCRAS QSISNN------ LHWYQQKSHESPRLLIK YAS------- QSISGIP-SRFSGSG--SGTDFTLSINSVETEDFGMYYC QQSNS....WPLT FGAGTKLELK

  DIQMTQSPSSLSASVGDRVTITCRAS QDIRND------ LGWYQQKPGKAPKKLIY AAS------- SLQSGVP-SRFSGSG--SGTDFTLTISSLQPEDFATYYC LQQN.....SNWT FGQGTKVDIK

  DIQMTQSPSSLSASVGDRVTITCQAS QDISNY------ LAWYQQKPGKAPELRIY DAS------- NLETGVP-SRFSGSG--SGTDFTFTISSLQPEDIATYYC QQYQN....LPLT FGPGTKVDIK

  DIVMTQSPDSLAVSLGERATINCKSS QSVLYSSNSKNY LAWYQDKPGQPPKLLIY WAS------- TRESGVP-DRFSGSG--SGTDFTLTISSLQAEDVAVYYC QQYYS....TPYS FGQGTKLEIK

  DIVMTQSPDSLAVSPGERATINCKSS QNLLDSSFDTNT LAWYQQKPGQPPKLLIY WAS------- SRESGVP-DRFSGSG--SGTDFTLTISSLQAEDVAVYYC QQYYS....TPPT FGGGTKVEIK


TPDIQMTQSPSSLSASVGDRVTITVQAS QDIIKH------ LNWYQQTPGKAPKLLIY EAS------- NLQAGVP-SRFSGSG--SGTDYTFTISSLQPEDIATYYC QQYQS....LPYT FGQGTKLQI

  DIQMTQSPSSLSASVGDRVTITCQAS QDIIKY------ LNWYQQTPGKAPKLLIY EAS------- NLQAGVP-SRFSGSG--SGTDYTFTISSLQPEDIATYYC QQYQS....LPYT FGQGTKLQI


TPDIQMTQSPSSLSASVGDRVTITCQAS QDIIKY------ LNWYQQKPGKAPKLLIY EAS------- NLQAGVP-SRFSGSG--SGTDYTFTISSLQPEDIATYYC QQYQS....LPYT FGQGTKLQI


  DIVMTQTPLSLSVTPGQPASISCKSS QSLLHSDGKTY- LYWYLQKPGQPPQLLIY EVS------- NRFSGVP-DRFSGSG--SGTDFTLKISRVEAEDVGVYYC MQSIQ...LPRWT FGQGTKVEI

  DIVMTQSPDSLAVSLGERATINCKSS QSVLYSSNSKNY LAWYQQKPGQPPKLLIY WAS------- TRESGVP-DRFSGSG--SGTDFTLTISSLQAEDVAVYYC LQYYS....TPYS FGQGTKLEIK


  DIQMTQSPSSLSASVGDRVTITCRAS QDITNY------ VNWFQQRPGQAPKVLIY GAS------- ILETGVP-SRFSGSG--SGTDFTFTISSLQPEDIATYYC QQYDT....LPLT FGGGTKVDIK


CDR-IMGT regions are colored as follows:
IGK V-J REGION: CDR1-IMGT (blue), CDR2-IMGT (green), CDR3-IMGT (greenblue)


Created: 11/06/2001
Last updated: Wednesday, 29-Jun-2011 17:05:50 CEST
Author: Manuel Ruiz

Software material and data coming from IMGT server may be used for academic research only, provided that it is referred to IMGT®, and cited as "IMGT®, the international ImMunoGeneTics information system® http://www.imgt.org (founder and director: Marie-Paule Lefranc, Montpellier, France)." References to cite: Lefranc, M.-P. et al., Nucleic Acids Res., 27:209-212 (1999); doi: 10.1093/nar/27.1.209 Full text Cover; Ruiz, M. et al., Nucleic Acids Res., 28:219-221 (2000); doi: 10.1093/nar/28.1.219 Full text; Lefranc, M.-P., Nucleic Acids Res., 29:207-209 (2001); doi: 10.1093/nar/29.1.207 Full text; Lefranc, M.-P., Nucleic Acids Res., 31:307-310 (2003); doi: 10.1093/nar/gkg085 Full text; Lefranc, M.-P. et al., In Silico Biol., 5, 0006 (2004) [Epub], 5:45-60 (2005); Lefranc, M.-P. et al., Nucleic Acids Res., 33:D593-597 (2005); doi: 10.1093/nar/gki065 Full text; Lefranc, M.-P. et al., Nucleic Acids Res., 37:D1006-1012 (2009); doi: 10.1093/nar/gkn838 Full text; Lefranc, M.-P. et al., Nucleic Acids Res., 43:D413-422 (2015); doi: 10.1093/nar/gku1056 Full text.
For any other use please contact Marie-Paule Lefranc Marie-Paule.Lefranc@igh.cnrs.fr.

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