Examples of C-DOMAINs: Protein displays of TR C-DOMAINs: Human and mouse TRA, TRB, TRG and TRD C-DOMAINs

The protein display numbering is according to the IMGT unique numbering for C-DOMAIN and C-LIKE-DOMAIN.

Only the C-DOMAIN of the *01 allele of each functional or ORF C-REGION is shown.

Letters in red correspond to amino acids which are polymorphic in the other alleles.
For C-REGIONs, letters in bold correspond to additional positions in the IMGT unique numbering.
For C-REGIONs, letters between parentheses correspond to amino acids resulting from the splicing.

N (Asn, asparagine) of potential N-glycosylation sites (NXS/T, where X is different from P), (N-linked glycosylation) is shown is green (site is underlined in CHS and in pages edited before 14/10/2009).

Protein displays of the complete C-REGIONs is available in IMGT Repertoire.

_____________________________________________________________________________________________________________________________________________________________________________________________

      TR-C
      genes
_____________________________________________________________________________________________________________________________________________________________________________________________
                                               A        AB     B          BC         C      CD     D          DE           E      EF   F            FG          G             CHS
                                        -------------->   ---------->             ------>       ------->              ----------->  ------->               ---------->
                                        1       10   15  16  20 23      30    36 39 41 45      77     84             85  89     96 97    104    110      118  121    130       140       150
                                 7654321|........|....|123|...|...... ...|.....|  |.....|1234567|......|12345677654321|..........|12|....... .....|....... ..|.........|.........|.........|
   EX1
  Homsap  X02883  ,TRAC  (1)       (N)IQNPDPAVYQLRDSK......SSDKSVCLFT DFDS...QTN  VSQSKDS.......DVYITDKTVLDMRSM.DFKSNSAVAWSNKS..........DFAC ANAFNN..............SIIPE DTFFPSP
  Musmus  M64239  ,TRAC            (D)IQNPEPAVYQLKDPR......SQDSTLCLFT DFDS...QIN  VPKTMES.......GTFITDKTVLDMKAM.DSKSNGAIAWSNQT..........SFTC QDIFKE.............TNATYP SSGFEWCPR
  Homsap  M12887  ,TRBC1       (E)DLNKVFPPEVAVFEPSEAEISH..TQKATLVCLAT GFFP..DHVE  LSWWVNGKEVHS..GVSTDPQPLKEQPAL.NDSRYCLSSRLRVSATFWQ.NPRNHFRC QVQFYGLSENDEWTQDRAKPVTQIV SAEAWGRA
  Homsap  M12888  ,TRBC2       (E)DLKNVFPPEVAVFEPSEAEISH..TQKATLVCLAT GFYP..DHVE  LSWWVNGKEVHS..GVSTDPQPLKEQPAL.NDSRYCLSSRLRVSATFWQ.NPRNHFRC QVQFYGLSENDEWTQDRAKPVTQIV SAEAWGRA
  Musmus  X02384  ,TRBC1       (E)DLRNVTPPKVSLFEPSKAEIAN..KQKATLVCLAR GFFP..DHVE  LSWWVNGKEVHS..GVSTDPQAYKESN.....YSYCLSSRLRVSATFWH.NPRNHFRC QVQFHGLSEEDKWPEGSPKPVTQNI SAEAWGRA
  Musmus  M26057  ,TRBC2       (E)DLRNVTPPKVSLFEPSKAEIAN..KQKATLVCLAR GFFP..DHVE  LSWWVNGKEVHS..GVSTDPQAYKESN.....YSYCLSSRLRVSATFWH.NPRNHFRC QVQFHGLSEEDKWPEGSPKPVTQNI SAEAWGRA
  Homsap  M22148  ,TRDC             (R)SQPHTKPSVFVMKNG.......TNVACLVK EFYP..KDIR  INLVSSKKITEF..DPAIVISPSG..........KYNAVKLGKYED......SNSVTC SVQHDN.............KTVHST DFEVKTDST
  Musmus  M23381  ,TRDC             (E)SQPPAKPSVFIMKNG.......TNVACLVK DFYP..KEVT  ISLRSSKKIVEF..DPAIVISPSG..........KYSAVKLGQYGD......SNSVTC SVQHNSE.............TVHST DFEPYANSF
  Homsap  M14996  ,TRGC1      (D)KQLDADVSPKPTIFLPSIAETKL..QKAGTYLCLLE KFFP..DVIK  IHWQEKKSNTIL..GSQEGNTMKTND.......TYMKFSWLTVPEK....SLDKEHRC IVRHENN............KNGVDQ EIIFPPIKT
  Homsap  M15002  ,TRGC2(2x)  (D)KQLDADVSPKPTIFLPSIAETKL..QKAGTYLCLLE KFFP..DIIK  IHWQEKKSNTIL..GSQEGNTMKTND.......TYMKFSWLTVPEE....SLDKEHRC IVRHENN............KNGIDQ EIIFPPIKT
c Homsap  M17323  ,TRGC2(3x)  (D)KQLDADVSPKPTIFLPSIAETKL..QKAGTYLCLLE KFFP..DIIK  IHWQEKKSNTIL..GSQEGNTMKTND.......TYMKFSWLTVPEE....SLDKEHRC IVRHENN............KNGIDQ EIIFPPIKT
  Musmus  M13340  ,TRGC1      (A)KRLDADISPKPTIFLPSVAETNL..HKTGTYLCLLE KFFP..DVIR  VYWKEKDGNTIL..DSQEGDTLKTND.......TYMKFSWLTVPER....AMGKEHRC IVKHENN............KGGADQ EIFFPSIKK
  Musmus  M12834  ,TRGC2      (D)KRLDADISPKPTIFLPSVAETNL..HKTGTYLCLLE KFFP..DVIR  VYWKEKNGNTIL..DSQEGDTLKTKG.......TYMKFSWLTVPER....AMGKEHSC IVKHENN............KGGADQ EIFFPSIKK
  Musmus  M12837  ,TRGC3      (D)KKLDADISPKPTIFLPSVAETNL..HKTGTYLCVLE KFFP..DVIR  VYWKEKKGNTIL..DSQEGDMLKTND.......TYMKFSWLTVPER....SMGKEHRC IVKHENN............KGGADQ EIFFPTIKK
  Musmus  AF021335,TRGC4      (D)KRTDSDFSPKPTIFLPSAAETNL..HKAGTYLCLLE KFFP..EVIR  VYWKEKDGEKIL..ESQEGNTIKTND.......RYMKFSWLTVTED....SMAKEHSC IVKHENN............KRGVDQ EILFPPIGK

c: cDNA sequence

IMGT note:
(1) The first amino acid of the TRA C-REGION which results from the splicing with the J-REGION is N (codon aat), D (codon gat), Y (codon tat) or H (codon cat) for 35, 12, 7 and 4 TRAJ, respectively. See Alignment of alleles: Human TRAJ (overview) for the sequences of the 58 FUNCTIONAL and ORF TRA J-REGION.

Homsap: Homo sapiens (Human)
Musmus: Mus musculus (House mouse)


Created: 02/05/2003
Author: Delphine Guiraudou

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