Translocations and inversions: Human IGH

Click here to see Part 2 - Inversions involving the human IGH locus

Part 1 - Translocations involving the human IGH locus

Locus Chromosomal localization Translocation Other involved genes (1) Clinical entities (2)

IGH

14q32.33

t(1;14)(p22;q32) BCL10 B cell lymphoma [Mucosa-Associated Lymphoid Tissue (MALT)]
B cell lymphoma marginal zone
t(1;14)(q21;q32) MUC1 B cell peripheral neoplasm, NOS
t(2;14)(p13;q32) BCL11A B cell chronic lymphocytic leukemia (B-CLL)
t(3;14)(q27;q32) BCL6 non-Hodgkin lymphoma (NHL)
diffuse large cell lymphoma (DLCL) (mainly)
agressive lymphoma
t(4;14)(p16;q32) FGFR3 plasma cell leukemia (PCL)
multiple myeloma (MM)
t(5;14)(q31;q32) IL3 B cell acute lymphoblastic leukemia (B-ALL) with hypereosinophilia
t(6;14)(p21;q32) CCND3 B-cell lymphoma splenic marginal zone
t(8;14)(q11;q32) unknown (8q11) B cell acute lymphoblastic leukemia (B-ALL) (mainly)
chronic myelogenous leukemia (CML)
B cell lymphoma (histiocyte-rich)
t(8;14)(q24;q32) MYC B cell acute lymphoblastic leukemia (B-ALL)
non-Hodgkin lymphomas (NHL), especially in Burkitt lymphoma
t(9;14)(p13;q32) PAX5 lymphoplasmatic lymphoma
t(10;14)(q24;q32) NFKB2 B cell lymphoma
B cell acute lymphoblastic leukemia (B-ALL)
non-Hodgkin lymphoma (NHL)
t(11;14)(q13;q32) CCND1 mantle cell lymphoma
B cell prolymphocytic leukemia (B-PLL)
plasma cell leukemia (PCL)
splenic lymphoma with villous lymphocytes
B cell chronic lymphocytic leukemia (B-CLL)
multiple myeloma (MM)
other B cell lymphoproliferations
t(14;18)(q32;q21) BCL2 follicular lymphoma (mainly)
diffuse large cell lymphoma (DLCL)
chronic lymphoproliferative disease (rarely) (CLD)
t(14;19)(q32;q13.1) BCL3 B cell chronic lymphocytic leukemia (B-CLL)
non-Hodgkin lymphoma (NHL), especially in Burkitt lymphoma

IMGT notes:
(1) For the list of genes (other than IG or TR) involved in the translocations, click here.
(2) Information on clinical entities are from the literature and from the Atlas of Genetics and Cytogenetics in Oncology and Haematology. For a list of the clinical entities quoted in the translocation tables, click here.

Part 2 - Inversion involving the human IGH locus

Locus Chromosomal localization Inversion Other involved genes Clinical entities
IGH 14q32.33 inv(14)(q11;q32) TRA T cell lymphoma


Created: 29/03/2001
Last updated: Wednesday, 29-Jun-2011 17:06:03 CEST
Author: Marie-Paule Lefranc
Editors: Sandrine Béranger and Céline Protat

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