Translocations and inversions: Human IGL

Translocations involving the IGL locus

Locus Chromosomal localization Translocation Other involved genes (1) Clinical entities (2)
IGL 22q11.2 t(1;22)(q21;q11) BCL9 follicular lymphoma
t(3;22)(q27;q11) BCL6 non-Hodgkin lymphoma (NHL)
diffuse large cell lymphoma (DLCL) (mainly)
t(8;22)(q24;q11) MYC B cell acute lymphoblastic leukemia (B-ALL)
non-Hodgkin lymphoma (NHL), especially in the Burkitt lymphoma
t(18;22)(q21;q11) BCL2 B cell chronic lymphocytic leukemia (B-CLL)

IMGT notes:
(1) For the list of genes (other than IG or TR) involved in the translocations, click here.
(2) Information on clinical entities are from the literature and from the Atlas of Genetics and Cytogenetics in Oncology and Haematology. For a list of the clinical entities quoted in the translocation tables, click here.


Created: 29/03/2001
Last updated: Monday, 11-Jul-2011 12:57:02 CEST
Author: Marie-Paule Lefranc
Editors: Sandrine Béranger and Céline Protat

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