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Correspondence between chain types and C genes : IG and TR (all vertebrate species)

Definitions

IG chain Definition
IG-Heavy-Nu refers to Immunoglobulin Heavy Nu constant gene or chain, previously designated as NAR or IgNAR, and described in the nurse shark (Ginglymostoma cirratum) and the spotted wobbegong shark (Orectolobus maculatus).
IG-Heavy-Rho refers to Immunoglobulin Heavy Rho constant gene or chain, previously designated as "Xi", and described in the clearnose skate (Raja eglanteria) and the little skate (Leucoraja erinacea).
IG-Heavy-Upsilon refers to Immunoglobulin Heavy Upsilon gene or chain (axolotl, frog, chicken, duck).
IG-Heavy-Omega refers to Immunoglobulin Heavy Omega constant gene or chain, in Chondrichthyes [previously designated as NARC, and described in the sandbar shark (Carcharhinus plumbeus) and the nurse shark (Ginglymostoma cirratum)], and in lungfish [previously designated as IgW-Like, and described in the African lungfish (Protopterus aethiopicus)].
IG-Heavy-Omicron refers to Immunoglobulin Heavy Omicron constant gene or chain, in Platypus (Ornithorhynchus anatinus) [3]
IG-Heavy-Xi refers to Immunoglobulin Heavy Xi constant gene or chain (frog).
IG-Heavy-Tau refers to Immunoglobulin Heavy Tau constant gene or chain (some teleostei).
IG-Heavy-Zeta refers to Immunoglobulin Heavy Zeta constant gene or chain (some teleostei).
IG-Heavy-Phi refers to Immunoglobulin Heavy Phi constant gene or chain (anura amphibian). [1]
IG-Heavy-Pi refers to Immunoglobulin Heavy Pi constant gene or chain (caudata or urodela amphibian). [2]
IG-Light-Iota refers to Immunoglobulin Light Iota constant gene or chain (in Chondrichthyes and Actinopterygii -which include the Teleostei-).
IG-Light-Rho refers to Immunoglobulin Light Rho constant gene or chain (frog).
IG-Light-Sigma refers to Immunoglobulin Light Sigma constant gene or chain (in Chondrichthyes and frog).

IG heavy chains

IG heavy chain type IG C-GENE group IG C-GENE subgroup IG receptor class
IG-Heavy-Alpha IGHC IGHA IgA
IG-Heavy-Delta IGHC IGHD IgD
IG-Heavy-Epsilon IGHC IGHE IgE
IG-Heavy-Gamma IGHC IGHG IgG
IG-Heavy-Xi IGHC IGHX IgX
IG-Heavy-Mu IGHC IGHM IgM
IG-Heavy-Nu IGHC IGHN IgN (IgNAR) (1)
IG-Heavy-Omega IGHC IGHW IgW
IG-Heavy-Omicron IGHC IGHO IgO
IG-Heavy-Phi IGHC IGHF IgF
IG-Heavy-Pi IGHC IGHP IgP
IG-Heavy-Rho IGHC IGHR IgR
IG-Heavy-Tau IGHC IGHT IgT
IG-Heavy-Upsilon IGHC IGHY IgY
IG-Heavy-Zeta IGHC IGHZ IgZ

IG light chains

IG light chain type IG C-GENE group IG V-GENE group
IG-Light-Iota IGIC IGIV
IG-Light-Kappa IGKC IGKV
IG-Light-Lambda IGLC IGLV
IG-Light-Rho IGRC IGRV
IG-Light-Sigma IGSC IGSV

TR chains

TR chain type TR C-GENE group TR receptor type
TR-Alpha TRAC TR-Alpha_Beta
TR-Beta TRBC TR-Alpha_Beta
TR-Delta TRDC TR-Gamma_Delta
TR-Gamma TRGC TR-Gamma_Delta
IMGT Note:
  1. (1) Due to the absence of the CH1 domain, the IG-Heavy-Nu chain cannot associate with a light chain and the IGN receptor only comprises two heavy chains.
IMGT references:
  1. [1] Zhao, Y. et al., PNAS, 103, 12087-12092 (2006). PMCID: PMC1567701
  2. [2] Schaerlinger, B. and Frippiat, J.P., Dev. Comp. Immunol., 32, 908-915 (2008). PMID: 18280565
  3. [3] Zhao, . et al., J. Immunol., 183, 3285-3293 (2009). PMID: 19675164
See also (IMGT index):
More information:
Created:
28/01/2002
Last updated:
Friday, 27-May-2016 21:01:42 CEST
Authors:
Dominique Scaviner and Marie-Paule Lefranc
Editors:
Elodie Foulquier, Céline Protat, Chantal Ginestoux