Dog (Canis lupus familiaris) TRB locus on chromosome 16
- The dog (Canis lupus familiaris) TRB locus on
chromosome 16 spans 271 kilobases
(kb). The orientation of the locus is reverse (REV).
- The dog (Canis lupus familiaris) TRB locus consists
of 36 TRBV genes belonging to 25 TRBV subgroups, 2 TRBD genes
belonging to 2 TRBD set, 12 TRBJ genes belonging to 2 TRBJ set, and
2 TRBC genes [1-2-3].
- The TRBV genes span 243
kilobases (kb), the TRBD genes span 9926 bases
(b), the TRBJ genes span 6728 bases (b) and
the TRBC genes span 11609 bases (b).
Clusters
- The TRBV genes are localized in 2 V-CLUSTER:
- the 5' V-CLUSTER, classically in 5' of the TRBD, TRBJ and
TRBC, includes 35 TRBV genes belonging to 24 subgroups (21 genes
are functional, 1 gene is ORF and 13 genes are pseudogenes).
- the 3' V-CLUSTER, downstream of the TRBC in inverted
orientation, includes 1 TRBV gene (functional).
- The TRBD, TRBJ and TRBC genes are localized in two
D-J-C-CLUSTER between the 5' V-CLUSTER and the 3' V-CLUSTER:
- the first D-J-C-CLUSTER, in 3' of the 5' V-CLUSTER,
includes 1 TRBD gene (functional), 6 TRBJ genes (4 genes are
functional, 1 gene is ORF and 1 gene is pseudogene) and 1 TRBC
gene (functional). The most C-proximal TRBJ gene, TRBJ1-6,
being localized at 2.420 kilobases in 5' of TRBC1.
- the second D-J-C-CLUSTER, in 5' of the 3' V-CLUSTER,
includes 1 TRBD gene (functional), 6 TRBJ genes (5 genes are
functional and 1 gene is ORF) and 1 TRBC gene (functional).
The most C-proximal TRBJ gene, TRBJ2-6, being localized at 3.118
kilobases in 5' of TRBC2.
- Created:
- 21/12/2017
- Last updated:
-
26/10/2018
- Author:
- Perrine Pégorier
- Editors:
- Chantal Ginestoux