IMGT Repertoire (IG and TR)

Locus description: Dog (Canis lupus familiaris) TRB

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DNA

Dog (Canis lupus familiaris) TRB locus on chromosome 16

• The dog (Canis lupus familiaris) TRB locus on chromosome 16 spans 271 kilobases (kb). The orientation of the locus is reverse (REV).
• The dog (Canis lupus familiaris) TRB locus consists of 36 TRBV genes belonging to 25 TRBV subgroups, 2 TRBD genes belonging to 2 TRBD set, 12 TRBJ genes belonging to 2 TRBJ set, and 2 TRBC genes [1-2-3].
• The TRBV genes span 243 kilobases (kb), the TRBD genes span 9926 bases (b), the TRBJ genes span 6728 bases (b) and the TRBC genes span 11609 bases (b).

Clusters

• The TRBV genes are localized in 2 V-CLUSTER:
  • the 5' V-CLUSTER, classically in 5' of the TRBD, TRBJ and TRBC, includes 35 TRBV genes belonging to 24 subgroups (21 genes are functional, 1 gene is ORF and 13 genes are pseudogenes).
  • the 3' V-CLUSTER, downstream of the TRBC in inverted orientation, includes 1 TRBV gene (functional).
• The TRBD, TRBJ and TRBC genes are localized in two D-J-C-CLUSTER between the 5' V-CLUSTER and the 3' V-CLUSTER:
  • the first D-J-C-CLUSTER, in 3' of the 5' V-CLUSTER, includes 1 TRBD gene (functional), 6 TRBJ genes (4 genes are functional, 1 gene is ORF and 1 gene is pseudogene) and 1 TRBC gene (functional). The most C-proximal TRBJ gene, TRBJ1-6, being localized at 2.420 kilobases in 5' of TRBC1.
  • the second D-J-C-CLUSTER, in 5' of the 3' V-CLUSTER, includes 1 TRBD gene (functional), 6 TRBJ genes (5 genes are functional and 1 gene is ORF) and 1 TRBC gene (functional). The most C-proximal TRBJ gene, TRBJ2-6, being localized at 3.118 kilobases in 5' of TRBC2.

Nomenclature

TRBV gene nomenclature

• Dog (Canis lupus familiaris) TRBV genes are designated by a number for the subgroup followed, whenever there are several genes belonging to the same subgroup, by an hyphen and a number for their relative localization in the locus.

TRBJ gene nomenclature

• Dog (Canis lupus familiaris) TRBJ genes are designated by a number for the cluster followed by an hyphen and a number for the localization from 5' to 3' in each cluster.

Created:

21/12/2017

Last updated:

06/02/2018

Author:

Perrine Pégorier

Editors:

Chantal Ginestoux

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