Number of germline genes and potential repertoire: Human TRGV at 7p14

References:
Lefranc M.-P. et al., Eur. J. Immunol., 19, 989-994 (1989), PMID:2526744
Zhang X.M. et al. Eur.J.Immunol., 24, 571-578 (1994), PMID:8125127

TRGV
Subgroup
TRGV
gene name
Functional ORF Pseudogene Total
1 TRGV1 - 1 - 1
TRGV2 1 - - 1
TRGV3 1 - - 1
TRGV3P       0-1**
TRGV4 0-1** - - 0-1**
TRGV5 0-1** - - 0-1**
TRGV5P - - 1 1
TRGV6 - - 1 1
TRGV7 - - 1 1
TRGV8 1 - - 1
2 TRGV9 1 - - 1
3 TRGV10 - 1 - 1
4 TRGV11 - 1 - 1
A TRGVA - - 1 1
B TRGVB - - 1 1
Total 4-6 3 5 12-15

** Allelic polymorphism by insertion/deletion. The TRGV3P gene, a polymorphic gene by insertion, has been identified by Southern hybridization in a rare haplotype but has not been sequenced (Ghanem N. et al., Hum. Genet., 86, 450-456 (1991), PMID:1673112).
The most frequent haplotype comprises 14 TRGV genes (6 FUNCTIONAL + 3 ORF + 5 PSEUDOGENE) with V4 and V5 present, and V3P absent.


Created: 09/04/1997
Last updated: Wednesday, 29-Jun-2011 17:06:09 CEST
Authors: Marie-Paule Lefranc, Géraldine Folch

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