References:

Lefranc M.-P. et al., Eur. J. Immunol., 19, 989-994 (1989), PMID:2526744

Zhang X.M. et al. Eur.J.Immunol., 24, 571-578 (1994), PMID:8125127

• 12-15 TRGV genes belonging to 6 subgroups, on 120 kilobases:
  • 4-6 FUNCTIONAL
  • 3 ORF (Open Reading Frame)
  • 5 PSEUDOGENE

• Potential repertoire: 4-6 FUNCTIONAL TRGV genes belonging to 2 subgroups

TRGV Subgroup	TRGV gene name	Functional	ORF	Pseudogene	Total
1	TRGV1	-	1	-	1
	TRGV2	1	-	-	1
	TRGV3	1	-	-	1
	TRGV3P				0-1**
	TRGV4	0-1**	-	-	0-1**
	TRGV5	0-1**	-	-	0-1**
	TRGV5P	-	-	1	1
	TRGV6	-	-	1	1
	TRGV7	-	-	1	1
	TRGV8	1	-	-	1
2	TRGV9	1	-	-	1
3	TRGV10	-	1	-	1
4	TRGV11	-	1	-	1
A	TRGVA	-	-	1	1
B	TRGVB	-	-	1	1
Total		4-6	3	5	12-15

** Allelic polymorphism by insertion/deletion. The TRGV3P gene, a polymorphic gene by insertion, has been identified by Southern hybridization in a rare haplotype but has not been sequenced (Ghanem N. et al., Hum. Genet., 86, 450-456 (1991), PMID:1673112).
The most frequent haplotype comprises 14 TRGV genes (6 FUNCTIONAL + 3 ORF + 5 PSEUDOGENE) with V4 and V5 present, and V3P absent.

Alignment of the human TRGV1 subgroup genes

Created: 09/04/1997
Last updated: 30/05/2018
Authors: Marie-Paule Lefranc, Géraldine Folch

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