References:

Lefranc M.-P. et al., Eur. J. Immunol., 19, 989-994 (1989), PMID:2526744

Zhang X.M. et al. Eur.J.Immunol., 24, 571-578 (1994), PMID:8125127

• 12-15 TRGV genes belonging to 6 subgroups, on 120 kilobases:
  • 4-6 FUNCTIONAL
  • 3 ORF (Open Reading Frame)
  • 5 PSEUDOGENE

• Potential repertoire: 4-6 FUNCTIONAL TRGV genes belonging to 2 subgroups

TRGV Subgroup	TRGV gene name	Functional	ORF	Pseudogene	Total
1	TRGV1	-	1	-	1
	TRGV2	1	-	-	1
	TRGV3	1	-	-	1
	TRGV3P				0-1**
	TRGV4	0-1**	-	-	0-1**
	TRGV5	0-1**	-	-	0-1**
	TRGV5P	-	-	1	1
	TRGV6	-	-	1	1
	TRGV7	-	-	1	1
	TRGV8	1	-	-	1
2	TRGV9	1	-	-	1
3	TRGV10	-	1	-	1
4	TRGV11	-	1	-	1
A	TRGVA	-	-	1	1
B	TRGVB	-	-	1	1
Total		4-6	3	5	12-15

** Allelic polymorphism by insertion/deletion. The TRGV3P gene, a polymorphic gene by insertion, has been identified by Southern hybridization in a rare haplotype but has not been sequenced (Ghanem N. et al., Hum. Genet., 86, 450-456 (1991), PMID:1673112).
The most frequent haplotype comprises 14 TRGV genes (6 FUNCTIONAL + 3 ORF + 5 PSEUDOGENE) with V4 and V5 present, and V3P absent.

Created: 09/04/1997
Last updated: 24/01/2019
Authors: Marie-Paule Lefranc, Géraldine Folch

IMGT Home page | IMGT Repertoire (IG and TR) | IMGT Repertoire (MH) | IMGT Repertoire (RPI) | IMGT Index | IMGT Scientific chart | IMGT Education | IMGT Latest news

Software material and data coming from IMGT server may be used for academic research only, provided that it is referred to IMGT®, and cited as "IMGT®, the international ImMunoGeneTics information system® http://www.imgt.org (founder and director: Marie-Paule Lefranc, Montpellier, France)." References to cite: Lefranc, M.-P. et al., Nucleic Acids Res., 27:209-212 (1999); doi: 10.1093/nar/27.1.209 Full text Cover; Ruiz, M. et al., Nucleic Acids Res., 28:219-221 (2000); doi: 10.1093/nar/28.1.219 Full text; Lefranc, M.-P., Nucleic Acids Res., 29:207-209 (2001); doi: 10.1093/nar/29.1.207 Full text; Lefranc, M.-P., Nucleic Acids Res., 31:307-310 (2003); doi: 10.1093/nar/gkg085 Full text; Lefranc, M.-P. et al., In Silico Biol., 5, 0006 (2004) [Epub], 5:45-60 (2005); Lefranc, M.-P. et al., Nucleic Acids Res., 33:D593-597 (2005); doi: 10.1093/nar/gki065 Full text; Lefranc, M.-P. et al., Nucleic Acids Res., 37:D1006-1012 (2009); doi: 10.1093/nar/gkn838 Full text; Lefranc, M.-P. et al., Nucleic Acids Res., 43:D413-422 (2015); doi: 10.1093/nar/gku1056 Full text.
For any other use please contact Marie-Paule Lefranc Marie-Paule.Lefranc@igh.cnrs.fr.

IMGT® Founder and Executive Director Emeritus:

Marie-Paule Lefranc Marie-Paule.Lefranc@igh.cnrs.fr

IMGT® Director:

Sofia Kossida Sofia.Kossida@igh.cnrs.fr

Bioinformatics manager:

Véronique Giudicelli Veronique.Giudicelli@igh.cnrs.fr

Computer manager:

Patrice Duroux Patrice.Duroux@igh.cnrs.fr

Webmaster:

Amélie Houles

Citing IMGT | Warranty disclaimer and copyright notice | Privacy policy and advertisement policy

© Copyright 1995-2019 IMGT®, the international ImMunoGeneTics information system®