Number of germline genes and potential repertoire: Mouse (Mus musculus) IGHV

The mouse (Mus musculus) IGHV genes mentioned in table on the left, as those of the IMGT Gene tables, are not yet mapped and refer to several strains. Sequences, in some cases, may therefore represent alleles of a same gene rather than genes different, and therefore this table does not take into account data from the Mouse Genome Sequencing and is provisional. Recent data from the C57BL/6 genome sequencing [1] are shown in the table on the right.

Subgroup Functional ORF Pseudogene Total
IGHV1 110 1 25 136
IGHV2 5 - - 5
IGHV3 7 - - 7
IGHV4 2 - - 2
IGHV5 25 - 1 26
IGHV6 4 - - 4
IGHV7 3(+1)* - (1)* 4
IGHV8 5 - 4 9
IGHV9 8 - - 8
IGHV10 4 - 1 5
IGHV11 1 - - 1
IGHV12 1 - 1 2
IGHV13 1 - - 1
IGHV14 4 - - 4
IGHV15 1 - - 1
Total 181(+2)* 1 32(+2)* 216
Subgroup Intact genes Pseudogenes Total
IGHV1 43 31 74 (1)
IGHV2 8 3 11
IGHV3 6 2 8
IGHV4 1 1 2
IGHV5 10 16 26
IGHV6 5 1 6
IGHV7 3 2 5
IGHV8 8 4 12 (1)
IGHV9 4 0 4
IGHV10 2 4 6
IGHV11 2 1 3
IGHV12 1 2 3
IGHV13 3 1 4
IGHV14 4 0 4
IGHV15 1 1 2
Total 101 69 170

* PSEUDOGENE or FUNCTIONAL (IGHV1S30, IGHV7S2)

Click here for: Correspondence between mouse (Mus musculus) IGHV nomenclatures

IMGT note:
(1) An additional 10 to 20 IGHV1 and IGHV8 subgroup genes remains to be sequenced in 200-300 kb at the 5' end of the locus [1].

IMGT reference:
[1] Riblet, R. In: Molecular Biology of B cells. Honjo, T., Alt, F.W. and Neuberger, M. eds, Elsevier Academic Press, London, pp 19-26 (2004).


Created: 26/07/2002
Last updated: Friday, 29-Jul-2011 22:30:31 CEST
Author: Géraldine Folch

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