Alignment of alleles: Macaques ( Macaca arctoides, Macaca assamensis, Macaca cyclopis, Macaca fascicularis, Macaca nemestrina, Macaca silenus, Macaca thibetana) IGHA

When several alleles are shown, the nucleotide mutations and amino acid changes for a given codon are indicated in red letters.
Dashes indicate identical nucleotides. Dots indicate gaps by comparison to the longest sequence. Blanks indicate partial sequences (blanks at the 5' and/or 3' end).

The nucleotide between parentheses at the beginning of exons comes from a DONOR-SPLICE (n from ngt). The first nucleotide from an INT-DONOR-SPLICE is underlined (n from ngt).

Exon names are shown between parentheses on the first line.
The Cysteines involved in the IG CH1, CH2 and CH3 intrachain disulfide bridge are shown with a larger letter C in purple. The Cysteines involved in the H-L or H-H interchain disulfide bridge are shown with a larger letter C in black.
STOP-CODON is indicated by an asterisk.

N (Asn, asparagine) of potential N-glycosylation sites (NXS/T, where X is different from P), (N-linked glycosylation) is shown is green (site is underlined in CHS and in pages edited before 14/10/2009).

Stump-tailed macaque (Macaca arctoides)

                                  1   2   3   4   5   6   7   8  
                                 V   P   P   P   K   P   C   L    
  AB013754,IGHA*01 (H) (1)    (G)TT CCC CCA CCC AAG CCT TGC TTA
                                                            
  AB013755,IGHA*01            (-)-- --- --- --- --- --- --- ---



                                                                           
                                                            1.2 1.1   1   2
                                                             C   D   K   P  
  AB013754,IGHA*01 (CH2)                                    TGT GAC AAA CCC CG
                                                                            
  AB013755,IGHA*01                                          --- --- --- --- --


Assam macaque (Macaca assamensis)

                                                                                                               
                                119 120 121 122 123
                                     A   V   P   C  
  AB013770,IGHA*01 (CH1)            GCT GTG CCC TGC G



                                  1   2   3   4   5   6   7   8   9  10
                                 V   L   P   P   N   S   C   L  
  AB013770,IGHA*01 (H) (1)       TT CTC CCA CCC AAC TCT TGC TTA ... ... 
                                     S   Q   T   K   P          
  AB013753,IGHA*02               -- TC- -A- A-- --G C-- --- --- ... ...
                                     P       I   T   P   P   C   P   S
  AB013762,IGHA*03               -- -C- --- AT- -CA C-C CCA -GT CCC TCA
                                     P       I   T   P   P   C   P   S
  AB013763,IGHA*03               -- -C- --- AT- -CA C-C CCA -GT CCC TCA



                                                                                                               
                                                            1.2 1.1   1   2   3   4   5   6   7   8   9  10  11
                                                             C   D   E   P   R   L   S   L   R   R   P   A   L 
  AB013770,IGHA*01 (CH2)                                    TGT GAT GAA CCC CGA CTG TCG CTG CGC CGA CCA GCC CTC
                                                                     K      
  AB013753,IGHA*02                                          --- --C A-- --- --
                                                                 C          
  AB013762,IGHA*03                                          --C TGC --G --- --
                                                                 C          
  AB013763,IGHA*03                                          --C TGC --G --- --

                                                ___AB_______                                            ________
                                               15.1    15.3                                                    
                                 12  13  14  15    15.2      16  17  18  19  20  21  22  23  24  25  26  27  28
                                 E   D   L   L   L           G   S   E   A   N   L   T   C   T   L   T   G   L   
  AB013770,IGHA*01 (CH2)        GAG GAC CTG CTC CTA ... ... GGT TCA GAA GCG AAC CTC ACG TGC ACA CTG ACC GGC CTG 

                                _________BC_____________________
                                                   
                                 29  30  31  32  33  34  35  36
                                 R   D   P       S   G   A   T  
  AB013770,IGHA*01 (CH2)        AGA GAT CCC ... TCG GGT GCC ACC 


Taiwan macaque (Macaca cyclopis)

                                                                                                                                                                 
                                119 120 121 122 123
                                     A   V   P   C  
  AB013766,IGHA*01 (CH1)            GCT GTG CCC TGC G



                                  1   2   3   4   5   6   7   8   9  10
                                 V   P   P   I   T   P   P   C   P   S  
  AB013766,IGHA*01 (H) (1)       TT CCC CCA ATC ACA CCC CCA TGT CCC TCA 
                                     S   Q   T   K       C   L  
  AB013756,IGHA*02               -- T-- -A- -C- -AG --T TGC -TA 



                                                                                                               
                                                            1.2 1.1   1   2   3   4   5   6   7   8   9  10  11
                                                             C   C   E   P   R   L   S   L   R   R   P   A   L 
  AB013766,IGHA*01 (CH2)                                    TGC TGC GAG CCC CGA CTG TCG CTG CGC CGG CCG GCC CTC
                                                                 D   K      
  AB013756,IGHA*02                                          --T GA- A-A --- --

                                                ___AB_______                                            ________
                                               15.1    15.3                                                    
                                 12  13  14  15    15.2      16  17  18  19  20  21  22  23  24  25  26  27  28
                                 E   D   L   L   L           G   S   E   A   N   L   T   S   T   L   T   G   L   
  AB013766,IGHA*01 (CH2)        GAG GAC CTG CTC CTA ... ... GGT TCA GAA GCG AAC CTC ACG TCC ACA TTG ACA GGC CTG 

                                _________BC_____________________
                                                   
                                 29  30  31  32  33  34  35  36
                                 K   D   P       S   G   A   T  
  AB013766,IGHA*01 (CH2)        AAA GAT CCC ... TCG GGT GCC ACC 


Crab-eating macaque (Macaca fascicularis)

                                                                                                               
                                                    1.4 1.3 1.2 1.1   1   2   3   4   5   6   7   8   9  10  11
                                                     A   S   P   T   R   P   K   V   F   P   L   S   L   E   G 
  X53705  ,IGHA*01 (CH1)                          (G)CA TCC CCG ACC AGA CCC AAG GTC TTC CCG CTG AGC CTC GAG GGC
                                                                                                               
  X53389  ,IGHA*01                                (-)-- --- --- --- --- --- --- --- --- --- --- --- --- --- ---

                                                ___AB_______                                            ________
                                               15.1    15.3                                                    
                                 12  13  14  15    15.2      16  17  18  19  20  21  22  23  24  25  26  27  28
                                 T   Q                       S   D   N   V   V   V   A   C   L   V   Q   G   F 
  X53705  ,IGHA*01 (CH1)        ACC CAG ... ... ... ... ... TCA GAT AAC GTG GTC GTC GCC TGC CTG GTC CAG GGC TTC
                                                                                                               
  X53389  ,IGHA*01              --- --- ... ... ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- ---

                                _________BC_____________________                            ___________CD_______
                                                                                           45.1    45.3    45.5
                                 29  30  31  32  33  34  35  36  39  40  41  42  43  44  45    45.2    45.4    
                                 F   P   Q       E   P   L   N   V   T   W   S   K   S   G   A   G   V         
  X53705  ,IGHA*01 (CH1)        TTC CCC CAG ... GAG CCA CTC AAC GTG ACC TGG AGC AAA AGC GGA GCG GGC GTG ... ...
                                                                                                               
  X53389  ,IGHA*01              --- --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ...

                                ________                                _________________________DE_____________
                                   45.7                                84.1    84.3    84.5    84.7    85.6    
                               45.6      77  78  79  80  81  82  83  84    84.2    84.4    84.6    85.7    85.5
                                         T   V   I   N   F   P   P   S   Q   D   A   S   G                     
  X53705  ,IGHA*01 (CH1)        ... ... ACC GTC ATA AAC TTC CCG CCC AGC CAG GAC GCC TCC GGG ... ... ... ... ...
                                                                                                               
  X53389  ,IGHA*01              ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ...

                                ________________                                                _EF_____        
                               85.4    85.2                                                    96.1            
                                   85.3    85.1  85  86  87  88  89  90  91  92  93  94  95  96    96.2  97  98
                                 G   L   Y   T   T   S   S   Q   L   T   L   P   A   A   Q   C           P   A 
  X53705  ,IGHA*01 (CH1)        GGC CTG TAC ACC ACG AGC AGC CAG CTG ACC CTG CCG GCC GCA CAG TGC ... ... CCA GCC
                                                                                                               
  X53389  ,IGHA*01              --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- ---

                                                        _______________________FG___________________________    
                                                                                                               
                                 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118
                                 R   E   S   V   T   C   H   V   E   H   Y               T   N   P   S   Q   D 
  X53705  ,IGHA*01 (CH1)        AGG GAG TCC GTG ACA TGC CAC GTG GAG CAC TAC ... ... ... ACG AAT CCC AGC CAG GAT
                                                                                                               
  X53389  ,IGHA*01              --- --- --- --- --- --- --- --- --- --- --- ... ... ... --- --- --- --- --- ---

                                                   
                                119 120 121 122 123
                                 V   A   V   P   C  
  X53705  ,IGHA*01 (CH1)        GTG GCC GTG CCC TGC G
                                                    
  X53389  ,IGHA*01              --- --- --- --- --- -



                                  1   2   3   4   5   6   7   8   9  10
                                 V   S   E   T   K   P   C   L  
  X53705  ,IGHA*01 (H) (1)       TT TCC GAA ACC AAG CCT TGC TTA ... ... 
                                                                
  X53389  ,IGHA*01               -- --- --- --- --- --- --- --- ... ... 
                                     P   P   P   N   S          
  AB013758,IGHA*02               -- C-- CC- C-- --C T-- --- --- ... ... 
                                     P   P   I   T       P   C   P   S
  AB013764,IGHA*03               -- C-- CC- -T- -CA --C CCA -GT CCC TCA



                                                                                                               
                                                            1.2 1.1   1   2   3   4   5   6   7   8   9  10  11
                                                             C   D   K   P   R   L   S   L   R   R   P   A   L 
  X53705  ,IGHA*01 (CH2)                                    TGT GAC AAA CCC CGA CTG TCA CTG CGC CGG CCG GCC CTC
                                                                                                               
  X53389  ,IGHA*01                                          --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                            
  AB013758,IGHA*02                                          --- --- --- --- --
                                                                 C   E      
  AB013764,IGHA*03                                          --C TG- G-G --- --

                                                ___AB_______                                            ________
                                               15.1    15.3                                                    
                                 12  13  14  15    15.2      16  17  18  19  20  21  22  23  24  25  26  27  28
                                 E   D   L   L   L           G   S   E   A   N   L   T   C   T   L   T   G   L 
  X53705  ,IGHA*01 (CH2)        GAG GAC CTG CTC CTA ... ... GGT TCA GAA GCG AAC CTC ACG TGC ACA CTG ACC GGC CTG
                                    
  X53389  ,IGHA*01              --- 

                                _________BC_____________________                            ___________CD_______
                                                                                           45.1    45.3    45.5
                                 29  30  31  32  33  34  35  36  39  40  41  42  43  44  45    45.2    45.4    
                                 R   N   P       S   G   A   T   F   T   W   T   P   S   S   G   K   N         
  X53705  ,IGHA*01 (CH2)        AGA AAT CCC ... TCG GGT GCC ACC TTC ACC TGG ACG CCC TCA AGT GGG AAG AAC ... ...

                                ________                                _________________________DE_____________
                                   45.7                                84.1    84.3    84.5    84.7    85.6    
                               45.6      77  78  79  80  81  82  83  84    84.2    84.4    84.6    85.7    85.5
                                         A   V   Q   Q   S   P   K   R   D   P   C   G                         
  X53705  ,IGHA*01 (CH2)        ... ... GCT GTC CAA CAG TCA CCT AAG CGT GAC CCC TGT GGC ... ... ... ... ... ...

                                ________________                                                _EF_____        
                               85.4    85.2                                                    96.1            
                                   85.3    85.1  85  86  87  88  89  90  91  92  93  94  95  96    96.2  97  98
                                     C   Y   S   V   S   S   V   L   P   G   C   A   E   P   W           N   N 
  X53705  ,IGHA*01 (CH2)        ... TGC TAC AGT GTG TCC AGT GTC CTG CCC GGC TGT GCC GAG CCA TGG ... ... AAC AAT

                                                        _______________________FG___________________________    
                                                                                                               
                                 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118
                                 R   V   T   F   T   C   T   A   E   H   P   E           L   E   T   Q   L   T 
  X53705  ,IGHA*01 (CH2)        AGG GTG ACC TTC ACC TGC ACT GCT GAG CAC CCT GAG ... ... TTG GAG ACC CAA CTA ACT

                                                       
                                119 120 121 122 123 124
                                 A   T   I   S   K   P  
  X53705  ,IGHA*01 (CH2)        GCC ACC ATC TCA AAA CCC G



                                                                                                               
                                                    1.4 1.3 1.2 1.1   1   2   3   4   5   6   7   8   9  10  11
                                                     G   N   T   F   R   P   E   V   H   L   L   P   P   P   S 
  X53705  ,IGHA*01 (CH3)                             GA AAC ACA TTC CGG CCC GAG GTC CAC CTG CTG CCG CCG CCG TCG

                                                ___AB_______                                            ________
                                               15.1    15.3                                                    
                                 12  13  14  15    15.2      16  17  18  19  20  21  22  23  24  25  26  27  28
                                 E   E   L   A   L           N   E   L   V   T   L   T   C   L   A   R   G   F 
  X53705  ,IGHA*01 (CH3)        GAG GAG CTG GCC CTG ... ... AAC GAG CTG GTG ACG CTG ACG TGC CTG GCA CGC GGC TTC

                                _________BC_____________________                            ___________CD_______
                                                                                           45.1    45.3    45.5
                                 29  30  31  32  33  34  35  36  39  40  41  42  43  44  45    45.2    45.4    
                                 S   P           E   D   V   L   V   R   W   L   K   G   T   E   Q   L   P   R 
  X53705  ,IGHA*01 (CH3)        AGC CCC ... ... GAG GAT GTG CTG GTT CGC TGG CTG AAG GGA ACA GAA CAG CTG CCC CGT

                                ________                                _________________________DE_____________
                                   45.7                                84.1    84.3    84.5    84.7    85.6    
                               45.6      77  78  79  80  81  82  83  84    84.2    84.4    84.6    85.7    85.5
                                 D       K   Y   L   T   W   E   S   R   K   E   P   S   Q   G               T 
  X53705  ,IGHA*01 (CH3)        GAC ... AAG TAC CTG ACT TGG GAA TCC CGG AAG GAG CCC AGC CAG GGC ... ... ... ACC

                                ________________                                                _EF_____        
                               85.4    85.2                                                    96.1            
                                   85.3    85.1  85  86  87  88  89  90  91  92  93  94  95  96    96.2  97  98
                                 T   T   F   A   V   T   S   I   L   R   V   A   A   E   D   W           K   K 
  X53705  ,IGHA*01 (CH3)        ACC ACC TTC GCC GTG ACC AGC ATA CTG CGC GTG GCA GCC GAG GAC TGG ... ... AAG AAG

                                                        _______________________FG___________________________    
                                                                                                               
                                 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118
                                 G   D   T   F   S   C   M   V   G   H   E   A       L   P   L   A   F   T   Q 
  X53705  ,IGHA*01 (CH3)        GGG GAC ACC TTC TCC TGC ATG GTG GGC CAC GAG GCC ... CTG CCG CTG GCC TTC ACA CAG

                                                                        ____________________________________CHS
                                                                                                               
                                119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138
                                 K   T   I   D   R   L   A               G   K   P   T   H   V   N   V   S   V 
  X53705  ,IGHA*01 (CH3)        AAG ACC ATC GAC CGC CTG GCG ... ... ... GGT AAA CCC ACC CAC GTC AAT GTG TCT GTG

                                ________________________________________
                                                                       
                                139 140 141 142 143 144 145 146 147 148
                                 V   M   A   E   V   D   G   T   C   Y   *  
  X53705  ,IGHA*01 (CH3)        GTC ATG GCG GAA GTG GAC GGC ACC TGC TAC 


Pig-tailed macaque (Macaca nemestrina)

                                                                                                               
                                119 120 121 122 123
                                     A   V   P   C  
  AB013765,IGHA*01 (CH1)            GCT GTG CCC TGC G
                                                    
  AB013771,IGHA*02                  --C --- --- --- -



                                  1   2   3   4   5   6   7   8   9  10
                                 V   P   P   I   T   P   P   C   P   S  
  AB013765,IGHA*01 (H) (1)       TT CCC CCA ATC ACA CCC CCA TGT CCC TCA 
                                     S   Q   T   K       C   L  
  AB013771,IGHA*02               -- T-- -A- -C- -AG --T TGC -TA 



                                                                                                               
                                                            1.2 1.1   1   2   3   4   5   6   7   8   9  10  11
                                                             C   C   E   P   R   L   S   L   R   R   P   A   L 
  AB013765,IGHA*01 (CH2)                                    TGC TGC GAG CCC CGA CTG TCG CTG CGC CGG CCG GCC CTC
                                                                 D   K                                         
  AB013771,IGHA*02                                          --T GA- A-A --- --- --- --A --- --- --- --- --- ---

                                                ___AB_______                                            ________
                                               15.1    15.3                                                    
                                 12  13  14  15    15.2      16  17  18  19  20  21  22  23  24  25  26  27  28
                                 E   D   L   L   L           G   S   E   A   N   L   T   C   T   L   T   G   L   
  AB013765,IGHA*01 (CH2)        GAG GAC CTG CTC CTA ... ... GGT TCA GAA GCG AAC CTC ACG TGC ACA CTG ACC GGC CTG 

  AB013771,IGHA*02              --- --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- 

                                _________BC_____________________
                                                   
                                 29  30  31  32  33  34  35  36
                                 R   D   P       S   G   A   T  
  AB013765,IGHA*01 (CH2)        AGA GAT CCC ... TCG GGT GCC ACC 
                                     N 
  AB013771,IGHA*02              --- A-- --- ... --- --- --- ---


Liontail macaque (Macaca silenus)

                                                                                                               
                                 119 120 121 122 123
                                     A   V   P   C  
  AB013775,IGHA*01 (CH1)            GCC GTG CCC TGC G



                                  1   2   3   4   5   6   7   8
                                 V   S   Q   T   K   P   C   L  
  AB013775,IGHA*01 (H) (1)       TT TCC CAA ACC AAG CCT TGC TTA 



                                                                                                               
                                                            1.2 1.1   1   2   3   4   5   6   7   8   9  10  11
                                                             C   D   K   P   R   L   S   L   R   R   P   A   L 
  AB013775,IGHA*01 (CH2)                                    TGT GAC AAA CCC CGA CTG TCG CTG CGC CGG CCG GCC CTC

                                                ___AB_______                                            ________
                                               15.1    15.3                                                    
                                 12  13  14  15    15.2      16  17  18  19  20  21  22  23  24  25  26  27  28
                                 E   D   L   L   L           G   S   E   A   N   L   T   C   T   L   T   G   L      
  AB013775,IGHA*01 (CH2)        GAG GAC CTG CTC CTA ... ... GGT TCA GAA GCG AAC CTC ACG TGC ACA TTG ACC GGC CTG

                                _________BC_____________________
                                                       
                                 29  30  31  32  33  34  35  36 
                                 R   N   P       S   G   A   T  
  AB013775,IGHA*01 (CH2)        AGA AAT CCC ... TCG GGT GCC ACC 


Pere David's macaque (Macaca thibetana)

                                  1   2   3   4   5   6   7   8
                                 V   P   P   P   K   P   C   L  
  AB013752,IGHA*01 (H) (1)    (G)TT CCC CCA CCC AAG CCT TGC TTA 



                                                                           
                                                            1.2 1.1   1   2
                                                             C   D   K   P  
  AB013752,IGHA*01 (CH2)                                    TGT GAC AAA CCC CG


IMGT note:

(1) In the IGHA gene, the hinge (H) and the (CH2) are joined in a single exon.


This alignment has been generated with the IMGT/AlleleAlign tool developed by Mehdi Yousfi (31/07/2001)

Created: 04/11/2002
Author: Nathalie Bosc

Software material and data coming from IMGT server may be used for academic research only, provided that it is referred to IMGT®, and cited as "IMGT®, the international ImMunoGeneTics information system® http://www.imgt.org (founder and director: Marie-Paule Lefranc, Montpellier, France)." References to cite: Lefranc, M.-P. et al., Nucleic Acids Res., 27:209-212 (1999); doi: 10.1093/nar/27.1.209 Full text Cover; Ruiz, M. et al., Nucleic Acids Res., 28:219-221 (2000); doi: 10.1093/nar/28.1.219 Full text; Lefranc, M.-P., Nucleic Acids Res., 29:207-209 (2001); doi: 10.1093/nar/29.1.207 Full text; Lefranc, M.-P., Nucleic Acids Res., 31:307-310 (2003); doi: 10.1093/nar/gkg085 Full text; Lefranc, M.-P. et al., In Silico Biol., 5, 0006 (2004) [Epub], 5:45-60 (2005); Lefranc, M.-P. et al., Nucleic Acids Res., 33:D593-597 (2005); doi: 10.1093/nar/gki065 Full text; Lefranc, M.-P. et al., Nucleic Acids Res., 37:D1006-1012 (2009); doi: 10.1093/nar/gkn838 Full text; Lefranc, M.-P. et al., Nucleic Acids Res., 43:D413-422 (2015); doi: 10.1093/nar/gku1056 Full text.
For any other use please contact Marie-Paule Lefranc Marie-Paule.Lefranc@igh.cnrs.fr.

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