Alignment of alleles: Human IGKC

When several alleles are shown, the nucleotide mutations and amino acid changes for a given codon are indicated in red letters.
Dashes indicate identical nucleotides. Dots indicate gaps by comparison to the longest sequence. Blanks indicate partial sequences (blanks at the 5' and/or 3' end).

The nucleotide between parentheses at the beginning of exons comes from a DONOR-SPLICE (n from ngt). The first nucleotide from an INT-DONOR-SPLICE is underlined (n from ngt).

Cysteine involved in the disulfide bridge are shown in purple.
STOP-CODON is indicated by an asterisk.

                                                                                                               
                                                    1.4 1.3 1.2 1.1   1   2   3   4   5   6   7   8   9  10  11
                                                    (R)  T   V   A   A   P   S   V   F   I   F   P   P   S   D 
  J00241  ,IGKC*01                                (C)GA ACT GTG GCT GCA CCA TCT GTC TTC ATC TTC CCG CCA TCT GAT
                                                                                                               
  X67858  ,IGKC*01                                (-)-- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
  
  U72063  ,IGKC*01                                (-)-- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
  
  X96754  ,IGKC*01                                (-)-- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
  
  M11736  ,IGKC*02                                (-)-- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                               
  M11737  ,IGKC*03                                (-)-- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                               
  AF017732,IGKC*04                                (-)-- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                           
  AF113887,IGKC*05 (cDNA)                         (-)-- --- --- --- --- --- --- --- --- --- --- --- --- --- ---

                                                ___AB_______                                            ________
                                               15.1    15.3                                                    
                                 12  13  14  15    15.2      16  17  18  19  20  21  22  23  24  25  26  27  28
                                 E   Q   L   K               S   G   T   A   S   V   V   C   L   L   N   N   F 
  J00241  ,IGKC*01              GAG CAG TTG AAA ... ... ... TCT GGA ACT GCC TCT GTT GTG TGC CTG CTG AAT AAC TTC

  X67858  ,IGKC*01              --- --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- ---
  
  U72063  ,IGKC*01              --- --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- ---
  
  X96754  ,IGKC*01              --- --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                               
  M11736  ,IGKC*02              --- --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                               
  M11737  ,IGKC*03              --- --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                               
  AF017732,IGKC*04              --- --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                               
  AF113887,IGKC*05 (cDNA)       --- --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- ---

                                _________BC_____________________                            ___________CD_______
                                                                                           45.1    45.3    45.5
                                 29  30  31  32  33  34  35  36  39  40  41  42  43  44  45    45.2    45.4    
                                 Y   P           R   E   A   K   V   Q   W   K   V   D   N   A   L   Q   S   G 
  J00241  ,IGKC*01              TAT CCC ... ... AGA GAG GCC AAA GTA CAG TGG AAG GTG GAT AAC GCC CTC CAA TCG GGT

  X67858  ,IGKC*01              --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
  
  U72063  ,IGKC*01               --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
  
  X96754  ,IGKC*01              --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                               
  M11736  ,IGKC*02              --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                         R                                     
  M11737  ,IGKC*03              --- --- ... ... --- --- --- --- --- --- C-- --- --- --- --- --- --- --- --- ---
                                                                                                               
  AF017732,IGKC*04              --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                               
  AF113887,IGKC*05 (cDNA)       --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---

                                ________                                _________________________DE_____________
                                   45.7                                84.1    84.3    84.5    84.7    85.6    
                               45.6      77  78  79  80  81  82  83  84    84.2    84.4    84.6    85.7    85.5
                                         N   S   Q   E   S   V   T   E   Q   D   S   K   D                     
  J00241  ,IGKC*01 (CH1)        ... ... AAC TCC CAG GAG AGT GTC ACA GAG CAG GAC AGC AAG GAC ... ... ... ... ...

  X67858  ,IGKC*01              ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ...
  
  U72063  ,IGKC*01              ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ...
  
  X96754  ,IGKC*01              ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ...
                                                                             E                                 
  M11736  ,IGKC*02              ... ... --- --- --- --- --- --- --- --- --- --G --- --- --- ... ... ... ... ...
                                                                             E                                 
  M11737  ,IGKC*03              ... ... --- --- --- --- --- --- --- --- --- --G --- --- --- ... ... ... ... ...
                                                                                                               
  AF017732,IGKC*04              ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ...
                                                                                                               
  AF113887,IGKC*05 (cDNA)       ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ...

                                ________________                                                _EF_____        
                               85.4    85.2                                                    96.1            
                                   85.3    85.1  85  86  87  88  89  90  91  92  93  94  95  96    96.2  97  98
                                 S   T   Y   S   L   S   S   T   L   T   L   S   K   A   D   Y           E   K 
  J00241  ,IGKC*01              AGC ACC TAC AGC CTC AGC AGC ACC CTG ACG CTG AGC AAA GCA GAC TAC ... ... GAG AAA

  X67858  ,IGKC*01              --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- ---
  
  U72063  ,IGKC*01              --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- ---
  
  X96754  ,IGKC*01              --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- ---
                                                                                                               
  M11736  ,IGKC*02              --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- ---
                                                                                                               
  M11737  ,IGKC*03              --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- ---
                                                                                                               
  AF017732,IGKC*04              --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- ---
                                                         N                                                     
  AF113887,IGKC*05 (cDNA)       --- --- --- --- --- --- -A- --- --- --- --- --- --- --- --- --- ... ... --- ---

                                                        _______________________FG___________________________    
                                                                                                               
                                 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118
                                 H   K   V   Y   A   C   E   V   T   H   Q   G           L   S   S   P   V   T 
  J00241  ,IGKC*01              CAC AAA GTC TAC GCC TGC GAA GTC ACC CAT CAG GGC ... ... CTG AGC TCG CCC GTC ACA

  X67858  ,IGKC*01              --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- ---
  
  U72063  ,IGKC*01              --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- ---
  
  X96754  ,IGKC*01              --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- ---
                                                     G                                                         
  M11736  ,IGKC*02              --- --- --- --- --- G-- --- --- --- --- --- --- ... ... --- --- --- --- --- ---
                                                                                                               
  M11737  ,IGKC*03              --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- ---
                                         L                                                                     
  AF017732,IGKC*04              --- --- C-- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- ---
                                                                                                               
  AF113887,IGKC*05 (cDNA)       --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- ---

                                                               
                                119 120 121 122 123 124 125 126
                                 K   S   F   N   R   G   E   C   *
  J00241  ,IGKC*01              AAG AGC TTC AAC AGG GGA GAG TGT 

  X67858  ,IGKC*01              --- --- --- --- --- --- --- ---
  
  U72063  ,IGKC*01              --- --- --- --- --- --- --- ---
  
  X96754  ,IGKC*01              --- --- --- --- --- --- --- ---
                                                                
  M11736  ,IGKC*02              --- --- --- --- --- --- --- --- 
                                                                
  M11737  ,IGKC*03              --- --- --- --- --- --- --- --- 
                                                                
  AF017732,IGKC*04              --- --- --- --- --- --- --- --- 
                                                                
  AF113887,IGKC*05 (cDNA)       --- --- --- --- --- --- --- --C

IMGT notes:
IGKC*06 (not sequenced at the nucleotide level and therefore not reported here) corresponds to Km1 allele and has amino changes A45.1>V and V101>L. The expected codons are gtc (V45.1) and ctc (L101), respectively (G.Lefranc and M.-P.Lefranc,13/05/2003).


Created: 18/04/2001
Last updated: Tuesday, 03-Apr-2012 08:20:22 CEST
Author: Delphine Guiraudou

Software material and data coming from IMGT server may be used for academic research only, provided that it is referred to IMGT®, and cited as "IMGT®, the international ImMunoGeneTics information system® http://www.imgt.org (founder and director: Marie-Paule Lefranc, Montpellier, France)." References to cite: Lefranc, M.-P. et al., Nucleic Acids Res., 27:209-212 (1999); doi: 10.1093/nar/27.1.209 Full text Cover; Ruiz, M. et al., Nucleic Acids Res., 28:219-221 (2000); doi: 10.1093/nar/28.1.219 Full text; Lefranc, M.-P., Nucleic Acids Res., 29:207-209 (2001); doi: 10.1093/nar/29.1.207 Full text; Lefranc, M.-P., Nucleic Acids Res., 31:307-310 (2003); doi: 10.1093/nar/gkg085 Full text; Lefranc, M.-P. et al., In Silico Biol., 5, 0006 (2004) [Epub], 5:45-60 (2005); Lefranc, M.-P. et al., Nucleic Acids Res., 33:D593-597 (2005); doi: 10.1093/nar/gki065 Full text; Lefranc, M.-P. et al., Nucleic Acids Res., 37:D1006-1012 (2009); doi: 10.1093/nar/gkn838 Full text; Lefranc, M.-P. et al., Nucleic Acids Res., 43:D413-422 (2015); doi: 10.1093/nar/gku1056 Full text.
For any other use please contact Marie-Paule Lefranc Marie-Paule.Lefranc@igh.cnrs.fr.

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