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When several alleles are shown, the nucleotide mutations and amino acid changes for a given codon are indicated in red letters. These polymorphic mutations are reported in Tables of alleles.
Dashes indicate identical nucleotides. Dots indicate gaps according to the IMGT unique numbering. Blanks indicate partial sequences (blanks at the 5' and/or 3' end).

Clicking on the allele name gives access to the IMGT/GENE-DB.
Clicking on the accession number gives access to the IMGT/LIGM-DB.

	
	
	

The alleles IGHG1*05p (G1m17,1,28), IGHG1*06p (G1m17,1,27,28), IGHG1*07p (G1m17,1,2) and IGHG1*08p (G1m3,1), described in Lefranc and Lefranc [1], will be assigned with a definitive allele number (based on a chronological basis, and therefore unrelated to the provisional 'p' number) when a complete genomic sequence will be available.


                                                                                

                                     1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                      A   S   T   K   G   P   S   V   F   P   L   A   P   S   S   K
  J00228   IGHG1*01   F   CH1 gDNA                   gcc tcc acc aag ggc cca tcg gtc ttc ccc ctg gca ccc tcc tcc aag
                                                                                                                   
  Z17370   IGHG1*02   F   CH1 gDNA                   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                   
  Y14737   IGHG1*03  (F)  CH1 cDNA                   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                   
  JN582178 IGHG1*04  (F)  CH1 cDNA                   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                   
  AL122127 IGHG1*05   F   CH1 gDNA                   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                                 _____AB_____                                            ____________
                                                 15.1    15.3
                                      13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                      S   T   S               G   G   T   A   A   L   G   C   L   V   K   D   Y   F
  J00228   IGHG1*01   F   CH1 gDNA   agc acc tct ... ... ... ggg ggc aca gcg gcc ctg ggc tgc ctg gtc aag gac tac ttc
                                                                                                                   
  Z17370   IGHG1*02   F   CH1 gDNA   --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                   
  Y14737   IGHG1*03  (F)  CH1 cDNA   --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                   
  JN582178 IGHG1*04  (F)  CH1 cDNA   --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                   
  AL122127 IGHG1*05   F   CH1 gDNA   --- --- --- ... ... ... --- --- --- --a --- --- --- --- --- --- --- --- --- ---


                                     _______BC___________________                            _____________CD_________
                                                                                             45.1    45.3    45.5
                                      30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                      P           E   P   V   T   V   S   W   N   S   G   A   L   T   S            
  J00228   IGHG1*01   F   CH1 gDNA   ccc ... ... gaa ccg gtg acg gtg tcg tgg aac tca ggc gcc ctg acc agc ... ... ...
                                                                                                                   
  Z17370   IGHG1*02   F   CH1 gDNA   --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ...
                                                                                                                   
  Y14737   IGHG1*03  (F)  CH1 cDNA   --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ...
                                                                                                                   
  JN582178 IGHG1*04  (F)  CH1 cDNA   --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ...
                                                                                                                   
  AL122127 IGHG1*05   F   CH1 gDNA   --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ...


                                     ____                                ___________________________DE_______________
                                     45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                          77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5
                                          G   V   H   T   F   P   A   V   L   Q   S   S                           G
  J00228   IGHG1*01   F   CH1 gDNA   ... ggc gtg cac acc ttc ccg gct gtc cta cag tcc tca ... ... ... ... ... ... gga
                                                                                                                   
  Z17370   IGHG1*02   F   CH1 gDNA   ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ---
                                                                                                                   
  Y14737   IGHG1*03  (F)  CH1 cDNA   ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ---
                                                                                                                   
  JN582178 IGHG1*04  (F)  CH1 cDNA   ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ---
                                                                                                                   
  AL122127 IGHG1*05   F   CH1 gDNA   ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ---


                                     ____________                                                ___EF___            
                                         85.2                                                    96.1
                                     85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                      L   Y   S   L   S   S   V   V   T   V   P   S   S   S   L               G   T
  J00228   IGHG1*01   F   CH1 gDNA   ctc tac tcc ctc agc agc gtg gtg acc gtg ccc tcc agc agc ttg ... ... ... ggc acc
                                                                                                                   
  Z17370   IGHG1*02   F   CH1 gDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... --- ---
                                                                                                                   
  Y14737   IGHG1*03  (F)  CH1 cDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... --- ---
                                                                                                                   
  JN582178 IGHG1*04  (F)  CH1 cDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... --- ---
                                                                                                                   
  AL122127 IGHG1*05   F   CH1 gDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... --- ---


                                                         _________________________FG_________________________        

                                     100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                      Q   T   Y   I   C   N   V   N   H   K   P           S   N   T   K   V   D   K
  J00228   IGHG1*01   F   CH1 gDNA   cag acc tac atc tgc aac gtg aat cac aag ccc ... ... agc aac acc aag gtg gac aag
                                                                                                                   
  Z17370   IGHG1*02   F   CH1 gDNA   --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- --- ---
                                                                                                                   
  Y14737   IGHG1*03  (F)  CH1 cDNA   --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- --- ---
                                                                                                                   
  JN582178 IGHG1*04  (F)  CH1 cDNA   --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- --- ---
                                                                                                                   
  AL122127 IGHG1*05   F   CH1 gDNA   --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- --- ---


                                             

                                     120 121 
                                      K   V
  J00228   IGHG1*01   F   CH1 gDNA   aaa gtt
                                           
  Z17370   IGHG1*02   F   CH1 gDNA   --- ---
                                      R    
  Y14737   IGHG1*03  (F)  CH1 cDNA   -g- ---
                                           
  JN582178 IGHG1*04  (F)  CH1 cDNA   --- ---
                                           
  AL122127 IGHG1*05   F   CH1 gDNA   --- ---




                                    1   2   3   4   5   6   7   8   9   10  11  12  13  14  15
                                    E   P   K   S   C   D   K   T   H   T   C   P   P   C   P
  J00228   IGHG1*01   F   H gDNA   gag ccc aaa tct tgt gac aaa act cac aca tgc cca ccg tgc cca
                                     
  Z17370   IGHG1*02   F   H gDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                     
  Y14737   IGHG1*03  (F)  H cDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                     
  JN582178 IGHG1*04  (F)  H cDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                     
  AL122127 IGHG1*05   F   H gDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---




                                                                                                                    

                                     1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                              A   P   E   L   L   G   G   P   S   V   F   L   F   P   P   K   P   K
  J00228   IGHG1*01   F   CH2 gDNA           gca cct gaa ctc ctg ggg gga ccg tca gtc ttc ctc ttc ccc cca aaa ccc aag
                                                                                                                   
  Z17370   IGHG1*02   F   CH2 gDNA           --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                   
  Y14737   IGHG1*03  (F)  CH2 cDNA           --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                   
  JN582178 IGHG1*04  (F)  CH2 cDNA           --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                   
  AL122127 IGHG1*05   F   CH2 gDNA           --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                                 _____AB_____                                            ____________
                                                 15.1    15.3
                                      13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                      D   T   L   M   I       S   R   T   P   E   V   T   C   V   V   V   D   V   S
  J00228   IGHG1*01   F   CH2 gDNA   gac acc ctc atg atc ... tcc cgg acc cct gag gtc aca tgc gtg gtg gtg gac gtg agc
                                                                                                                   
  Z17370   IGHG1*02   F   CH2 gDNA   --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                   
  Y14737   IGHG1*03  (F)  CH2 cDNA   --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                   
  JN582178 IGHG1*04  (F)  CH2 cDNA   --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                   
  AL122127 IGHG1*05   F   CH2 gDNA   --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                     _______BC___________________                            _____________CD_________
                                                                                             45.1    45.3    45.5
                                      30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                      H   E   D   P   E   V   K   F   N   W   Y   V   D   G   V   E   V   H        
  J00228   IGHG1*01   F   CH2 gDNA   cac gaa gac cct gag gtc aag ttc aac tgg tac gtg gac ggc gtg gag gtg cat ... ...
                                                                                                                   
  Z17370   IGHG1*02   F   CH2 gDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ...
                                                                                                                   
  Y14737   IGHG1*03  (F)  CH2 cDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ...
                                                                                                                   
  JN582178 IGHG1*04  (F)  CH2 cDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ...
                                                                                                                   
  AL122127 IGHG1*05   F   CH2 gDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ...


                                     ____                                ___________________________DE_______________
                                     45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                          77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5
                                          N   A   K   T   K   P   R   E   E   Q   Y   N                           S
  J00228   IGHG1*01   F   CH2 gDNA   ... aat gcc aag aca aag ccg cgg gag gag cag tac aac ... ... ... ... ... ... agc
                                                                                                                   
  Z17370   IGHG1*02   F   CH2 gDNA   ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ---
                                                                                                                   
  Y14737   IGHG1*03  (F)  CH2 cDNA   ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ---
                                                                                                                   
  JN582178 IGHG1*04  (F)  CH2 cDNA   ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ---
                                                                                                                   
  AL122127 IGHG1*05   F   CH2 gDNA   ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ---


                                     ____________                                                ___EF___            
                                         85.2                                                    96.1
                                     85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                      T   Y   R   V   V   S   V   L   T   V   L   H   Q   D   W           L   N   G
  J00228   IGHG1*01   F   CH2 gDNA   acg tac cgg gtg gtc agc gtc ctc acc gtc ctg cac cag gac tgg ... ... ctg aat ggc
                                                                                                                   
  Z17370   IGHG1*02   F   CH2 gDNA   --- --- --t --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---
                                                                                                                   
  Y14737   IGHG1*03  (F)  CH2 cDNA   --- --- --t --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---
                                                                                                                   
  JN582178 IGHG1*04  (F)  CH2 cDNA   --- --- --t --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---
                                                                                                                   
  AL122127 IGHG1*05   F   CH2 gDNA   --- --- --t --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---


                                                         _________________________FG_________________________        

                                     100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                      K   E   Y   K   C   K   V   S   N   K   A           L   P   A   P   I   E   K
  J00228   IGHG1*01   F   CH2 gDNA   aag gag tac aag tgc aag gtc tcc aac aaa gcc ... ... ctc cca gcc ccc atc gag aaa
                                                                                                                   
  Z17370   IGHG1*02   F   CH2 gDNA   --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- --- ---
                                                                                                                   
  Y14737   IGHG1*03  (F)  CH2 cDNA   --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- --- ---
                                                                                                                   
  JN582178 IGHG1*04  (F)  CH2 cDNA   --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- --- ---
                                                                                                                   
  AL122127 IGHG1*05   F   CH2 gDNA   --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- --- ---


                                                             

                                     120 121 122 123 124 125 
                                      T   I   S   K   A   K
  J00228   IGHG1*01   F   CH2 gDNA   acc atc tcc aaa gcc aaa
                                                           
  Z17370   IGHG1*02   F   CH2 gDNA   --- --- --- --- --- ---
                                                           
  Y14737   IGHG1*03  (F)  CH2 cDNA   --- --- --- --- --- ---
                                                           
  JN582178 IGHG1*04  (F)  CH2 cDNA   --- --- --- --- --- ---
                                                           
  AL122127 IGHG1*05   F   CH2 gDNA   --- --- --- --- --- ---




                                                                                                                         

                                         1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1  1   2   3   4   5   6   7   8   9   10  11  12 
                                                          G   Q   P   R   E   P   Q   V   Y   T   L   P   P   S   R   D
  J00228   IGHG1*01   F   CH3-CHS gDNA                   ggg cag ccc cga gaa cca cag gtg tac acc ctg ccc cca tcc cgg gat
                                                                                                                       
  Z17370   IGHG1*02   F   CH3-CHS gDNA                   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                      E
  Y14737   IGHG1*03  (F)  CH3-CHS cDNA                   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --g
                                                                                                                       
  JN582178 IGHG1*04  (F)  CH3-CHS cDNA                   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                       
  AL122127 IGHG1*05   F   CH3-CHS gDNA                   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                                     _____AB_____                                            ____________
                                                     15.1    15.3
                                          13  14  15     15.2     16  17  18  19  20  21  22  23  24  25  26  27  28  29 
                                          E   L   T               K   N   Q   V   S   L   T   C   L   V   K   G   F   Y
  J00228   IGHG1*01   F   CH3-CHS gDNA   gag ctg acc ... ... ... aag aac cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat
                                                                                                                       
  Z17370   IGHG1*02   F   CH3-CHS gDNA   --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                              M                                                                        
  Y14737   IGHG1*03  (F)  CH3-CHS cDNA   --- a-- --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                       
  JN582178 IGHG1*04  (F)  CH3-CHS cDNA   --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                                       
  AL122127 IGHG1*05   F   CH3-CHS gDNA   --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---


                                         _______BC___________________                            _____________CD_________
                                                                                                 45.1    45.3    45.5
                                          30  31  34  35  36  37  38  39  40  41  42  43  44  45     45.2    45.4    45.6
                                          P           S   D   I   A   V   E   W   E   S   N   G   Q   P   E   N        
  J00228   IGHG1*01   F   CH3-CHS gDNA   ccc ... ... agc gac atc gcc gtg gag tgg gag agc aat ggg cag ccg gag aac ... ...
                                                                                                                       
  Z17370   IGHG1*02   F   CH3-CHS gDNA   --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ...
                                                                                                                       
  Y14737   IGHG1*03  (F)  CH3-CHS cDNA   --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ...
                                                                                                                       
  JN582178 IGHG1*04  (F)  CH3-CHS cDNA   --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ...
                                                                                                                       
  AL122127 IGHG1*05   F   CH3-CHS gDNA   --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ...


                                         ____                                ___________________________DE_______________
                                         45.7                                84.1    84.3    84.5    84.7    85.6    85.4
                                              77  78  79  80  81  82  83  84     84.2    84.4    84.6    85.7    85.5
                                              N   Y   K   T   T   P   P   V   L   D   S   D                           G
  J00228   IGHG1*01   F   CH3-CHS gDNA   ... aac tac aag acc acg cct ccc gtg ctg gac tcc gac ... ... ... ... ... ... ggc
                                                                                                                       
  Z17370   IGHG1*02   F   CH3-CHS gDNA   ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ---
                                                                                                                       
  Y14737   IGHG1*03  (F)  CH3-CHS cDNA   ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ---
                                                                                                                       
  JN582178 IGHG1*04  (F)  CH3-CHS cDNA   ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ---
                                                                                                                       
  AL122127 IGHG1*05   F   CH3-CHS gDNA   ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ---


                                         ____________                                                ___EF___            
                                             85.2                                                    96.1
                                         85.3    85.1 85  86  87  88  89  90  91  92  93  94  95  96     96.2 97  98  99 
                                          S   F   F   L   Y   S   K   L   T   V   D   K   S   R   W           Q   Q   G
  J00228   IGHG1*01   F   CH3-CHS gDNA   tcc ttc ttc ctc tac agc aag ctc acc gtg gac aag agc agg tgg ... ... cag cag ggg
                                                                                                                       
  Z17370   IGHG1*02   F   CH3-CHS gDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---
                                                                                                                       
  Y14737   IGHG1*03  (F)  CH3-CHS cDNA   --- --- --- --- --t --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---
                                                                                                                       
  JN582178 IGHG1*04  (F)  CH3-CHS cDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---
                                                                                                                       
  AL122127 IGHG1*05   F   CH3-CHS gDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---


                                                             _________________________FG_________________________        

                                         100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 
                                          N   V   F   S   C   S   V   M   H   E   A       L   H   N   H   Y   T   Q   K
  J00228   IGHG1*01   F   CH3-CHS gDNA   aac gtc ttc tca tgc tcc gtg atg cat gag gct ... ctg cac aac cac tac acg cag aag
                                                                                                                       
  Z17370   IGHG1*02   F   CH3-CHS gDNA   --- --- --- --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- --- ---
                                                                                                                       
  Y14737   IGHG1*03  (F)  CH3-CHS cDNA   --- --- --- --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- --- ---
                                              I                                                                        
  JN582178 IGHG1*04  (F)  CH3-CHS cDNA   --- a-- --- --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- --- ---
                                                                                                                       
  AL122127 IGHG1*05   F   CH3-CHS gDNA   --- --- --- --- --- --- --- --- --- --- --- ... --- --- --- --- --- --a --- ---


                                                                             __CHS___

                                         120 121 122 123 124 125 126 127 128 129 130 
                                          S   L   S   L   S   P               G   K
  J00228   IGHG1*01   F   CH3-CHS gDNA   agc ctc tcc ctg tct ccg ... ... ... ggt aaa
                                                                                   
  Z17370   IGHG1*02   F   CH3-CHS gDNA   --- --- --- --- --- --- ... ... ... --- ---
                                                                                   
  Y14737   IGHG1*03  (F)  CH3-CHS cDNA   --- --- --- --- --c --- ... ... ... --- ---
                                                                                   
  JN582178 IGHG1*04  (F)  CH3-CHS cDNA   --- --- --- --- --- --- ... ... ... --- ---
                                                                                   
  AL122127 IGHG1*05   F   CH3-CHS gDNA   --- --- --- --- --- --- ... ... ... --- ---





                                     1   2   3   4   5   6   7   8   9   10  11  12  13  14  15  16  17  18  19  20
                                     G   A   A   T   G   G   E   L   C   G   G   A   G   R   G   A   G   R   A   V
  X52847   IGHG1*01   F   M1 cDNA   gga gct gca act gga gga gag ctg tgc gga ggc gca gga cgg gga gct gga cgg gct gtg
                                          
  AL122127 IGHG1*05   F   M1 gDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---




                                     21  22  23  24  25  26  27  28  29  30  31  32  33  34  35  36  37  38  39  40
                                     D   D   H   H   H   L   H   H   T   L   P   V   K   R   V   L   Q   C   H   R
  X52847   IGHG1*01   F   M1 cDNA   gac gac cat cac cat ctt cat cac act ctt cct gtt aag cgt gtg cta cag tgc cac cgt

  AL122127 IGHG1*05   F   M1 gDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---




                                     41  42  43  44
                                     H   L   L   Q
  X52847   IGHG1*01   F   M1 cDNA   cac ctt ctt caa g

  AL122127 IGHG1*05   F   M1 gDNA   --- --- --- --- -





                                     1   2   3   4   5   6   7   8   9   10  11  12  13  14  15  16  17  18  19  20
                                     V   K   W   I   F   S   S   V   V   D   L   K   Q   T   I   I   P   D   Y   R
  X52847   IGHG1*01   F   M2 cDNA   gtg aag tgg atc ttc tcc tcg gtg gtg gac ctg aag cag acc atc atc ccc gac tac agg
                                      
  AL122127 IGHG1*05   F   M2 gDNA   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---




                                     21  22  23  24  25  26  27
                                     N   M   I   G   Q   G   A
  X52847   IGHG1*01   F   M2 cDNA   aac atg atc gga cag ggg gcc

  AL122127 IGHG1*05   F   M2 gDNA   --- --- --- --- --- --- ---



IMGT note:

Note that Ala 126 (225) (GCA) in Kabat Entry number 013486 is probably a typing error. The corresponding codon in this allele alignment is Val 98 (GTT), which is the last codon of the CH1 exon (and not the first codon of the hinge as shown in Kabat 013486). The IGHG1 Chimpanzee CH1 3' end is therefore identical to the human one, and Figure 3 and Discussion in Ehrlich P.H. et al., Molecular Immunology, 28, 319-322 (1991) should be revised accordingly. Comments added by M.-P. Lefranc on the 16/12/1999, following a question asked by M. Cerutti (France).

IMGT Reference:

[1] Lefranc, M.-P. and Lefranc, G. Human Gm, Km and Am allotypes and their molecular characterization: a remarkable demonstration of polymorphism. In: B. Tait, F. Christiansen (Eds.), Immunogenetics, chap. 34, Humana Press, Springer, New York, USA. Methods Mol. Biol. 2012; 882, 635-680. PMID: 22665258

This alignment of allele is generated by IMGT/OutilAllele (Patrice Duroux and Mehdi Yousfi).

Created:
20/01/1999
Last updated:
05/10/2016
Authors:
Saida Saljoqi, Joumana Jabado-Michaloud, Christèle Martinez-Jean and Nathalie Bosc