Table of alleles: Human IGHC

Functionality is shown between parentheses, (F) and (P), when the accession number refers to a cDNA sequence and the corresponding genomic gene has not yet been isolated.

Click on a gene name to get the alignment of the corresponding C-REGION alleles.
Click on an accession number to get the sequence and additional information (IMGT annotations, IMGT flat file, Coding regions...).

IGHC
gene name
Exons Fct IGHC
allele name
Accession numbers Confirmed
by
genetics
and or
data
Description of mutations
IGHA1 CH1 F IGHA1*01 J00220 +  
H F IGHA1*01 J00220 +  
CH2 F IGHA1*01 J00220 +  
CH3
(including CHS)
F IGHA1*01 J00220    
M F IGHA1*01 M60193    
IGHA2 CH1 F IGHA2*01 J00221   c343  ,P115  |c371  ,P124  |
IGHA2*02 M60192   c343>t,P115>S|c371>g,P124>R|
IGHA2*03 S71043   c343>t,P115>S|c371>g,P124>R|
H F IGHA2*01 J00221    
IGHA2*02 M60192    
IGHA2*03 S71043    
CH2 F IGHA2*01 J00221    
IGHA2*02 M60192,AJ012264    
IGHA2*03 S71043    
CH3
(including CHS)
F IGHA2*01 J00221   t254.2  ,F85.2  |g255  |c279  |c300  ,D100  |t370  ,L124  |t399  |g400  ,V134  |t428  ,V143  |c432  |
IGHA2*02 AJ012264   t254.2>a,F85.2>Y|g255>a|c279>t|c300>g,D100>E|t370>a,L124>M|t399>c|g400>a,V134>I|t428>c,V143>A|c432>t|
IGHA2*03 S71043    
M F IGHA2*02 M60194    
IGHD CH1 F IGHD*01 K02875    
IGHD*02 X57331    
H1 F IGHD*01 K02876   c27  |
IGHD*02 X57331   c27>a|
H2 F IGHD*01 K02877    
IGHD*02 X57331    
CH2 F IGHD*01 K02878    
IGHD*02 X57331    
CH3 F IGHD*01 K02879   t18  |
IGHD*02 X57331   t18>c|
CHS F IGHD*01 K02880    
IGHD*02 X57331    
M1 F IGHD*01 K02881    
IGHD*02 X57331    
M2 F IGHD*01 K02882    
IGHD*02 X57331    
IGHE CH1 F IGHE*01 J00222   c123  ,C41  |
IGHE*02 L00222   c123>g,C41>W|
IGHE*03 [1](1)    
CH2 F IGHE*01 J00222    
IGHE*02 V00555/L00222    
IGHE*03 [1](1)    
CH3 F IGHE*01 J00222    
IGHE*02 V00555/L00222    
IGHE*03 [1](1)    
CH4
(including CHS)
F IGHE*01 J00222   g122  ,W41  |
IGHE*02 V00555/L00222    
IGHE*03 [1](1)   g122>t,W41>L|
M1 F IGHE*01 X63693    
IGHE*03 M55420    
M2 F IGHE*01 X63693    
IGHE*03 M55420    
IGHEP1 CH3 P IGHEP1*01 J00223   a1.3  ,c3.3  ,N1.3  |a3.2  |a1.1  ,g2.1  ,a3.1  ,R1.1  |g1  ,G1  |c9  ,S3  |c11  ,A4  |g265  ,V89  |a294  |a330  ,Q110  |
IGHEP1*02 X84668   a1.3>c,c3.3>a,N1.3>Q|a3.2>c|a1.1>g,g2.1>a,a3.1>g,R1.1>E|g1>a,G1>R|                    |g265>c,V89>L|      |a330>c,Q110>H|
IGHEP1*03 X84669                                                                    |c9>g,S3>R|c11>t,A4>V|g265>c,V89>L|a294>g|a330>c,Q110>H|
CH4
(including CHS)
P IGHEP1*01 J00223     
IGHG1 CH1 F IGHG1*01 J00228   a359  ,K120  |
F IGHG1*02 Z17370    
(F) IGHG1*03 Y14737   a359>g,K120>R|
H F IGHG1*01 J00228    
F IGHG1*02 Z17370    
(F) IGHG1*03 Y14737    
CH2 F IGHG1*01 J00228   g255.1  |
F IGHG1*02 Z17370   g255.1>t|
(F) IGHG1*03 Y14737   g255.1>t|
CH3
(including CHS)
F IGHG1*01 J00228   t36  ,D12  |c40  ,L14  |c258  |t372  |
F IGHG1*02 Z17370    
(F) IGHG1*03 Y14737   t36>g,D12>E|c40>a,L14>M|c258>t|t372>c|
M1 (F) IGHG1*01 X52847    
M2 (F) IGHG1*01 X52847    
IGHG2 CH1 F IGHG2*01 J00230   c57  |a246  |c274  ,P92  |a284  ,N95  |c288  ,F96  |
IGHG2*02 AJ250170   c57>g|a246>g|c274>a,P92>T|
IGHG2*03 AF449616   c57>g|
IGHG2*04 AF449617   c57>g|                   |a284>g,N95>S|c288>g,F96>L|
IGHG2*05 AF449618   c57>g|
IGHG2*06 AL928742   c57>g|a246>g|
H F IGHG2*01 J00230 +  
IGHG2*02 AJ250170 +  
IGHG2*03 AF449616    
IGHG2*04 AF449617    
IGHG2*05 AF449618    
IGHG2*06 AL928742    
CH2 F IGHG2*01 J00230 + g135.1  ,V45.1  |t273  |
IGHG2*02 AJ250170 + g135.1>a,V45.1>M|t273>c|
IGHG2*03 AF449616    
IGHG2*04 AF449617    
IGHG2*05 AF449618    
IGHG2*06 AL928742                   |t273>c|
CH3
(including CHS)
F IGHG2*01 J00230 + g106        |a243  |g351  |
IGHG2*02 AJ250170 +                    |g351>a|
IGHG2*03 AF449616    
IGHG2*04 AF449617    
IGHG2*05 AF449618               |a243>g|
IGHG2*06 AL928742   g106>t,A36>S|      |g351>a|
M1 F IGHG2*01 AB00675   g21  |
IGHG2*06 AL928742   g21>c|
M2 F IGHG2*01 AB00676    
IGHG2*06 AL928742    
IGHG3 CH1 F IGHG3*01 X03604 + t3.4  |c90  |c251.3  ,S84.3  |g284  ,S95  |g288  ,L96  |
IGHG3*02 K01313    
IGHG3*03 X16110 +  
IGHG3*04 X99549   t3.4>c|
IGHG3*05 AJ390236    
IGHG3*06 AJ390237         |c90>a|
IGHG3*07 AJ390238 +  
IGHG3*08 AJ390241    
IGHG3*09 AJ390242 +  
IGHG3*10 AJ390246         |c90>a|
IGHG3*11 AJ390247 +  
IGHG3*12 AJ390252 +  
IGHG3*13 AJ390244 +  
IGHG3*14 AJ390254 +  
IGHG3*15 AJ390260 +  
IGHG3*16 AJ390262 +  
IGHG3*17 AJ390272 +                              |g284>a,S95>N|g288>c,L96>F|
IGHG3*18 AJ390276 +             |c251.3>a,S84.3>Y|
IGHG3*19 AJ390279 +  
H1 F IGHG3*01 M12958 +  
IGHG3*02 K01313    
IGHG3*03 X16110 +  
IGHG3*04 X99549    
IGHG3*05 AJ390236    
IGHG3*06 AJ390237    
IGHG3*07 AJ390238 +  
IGHG3*08 AJ390241    
IGHG3*09 AJ390242 +  
IGHG3*10 AJ390246    
IGHG3*11 AJ390247 +  
IGHG3*12 AJ390252 +  
IGHG3*13 AJ390244 +  
IGHG3*14 AJ390254 +  
IGHG3*15 AJ390260 +  
IGHG3*16 AJ390262 +  
IGHG3*17 AJ390272 +  
IGHG3*18 AJ390276 +  
IGHG3*19 AJ390279 +  
H2 F IGHG3*01 M12958 + c6  |
IGHG3*02 K01313   c6>t|
IGHG3*03 X16110 +  
IGHG3*04 X99549    
IGHG3*05 AJ390236    
IGHG3*06 AJ390237    
IGHG3*07 AJ390238 +  
IGHG3*08 AJ390241    
IGHG3*09 AJ390242 +  
IGHG3*10 AJ390246    
IGHG3*11 AJ390247 +  
IGHG3*12 AJ390252 +  
IGHG3*13 AJ390244 +  
IGHG3*14 AJ390254 +  
IGHG3*15 AJ390260 +  
IGHG3*16 AJ390262 +  
H3 F IGHG3*01 M12958 + c6  |a30  |
IGHG3*02 K01313   c6>t|a30>g|
IGHG3*03 X16110 +  
IGHG3*04 X99549    
IGHG3*05 AJ390236    
IGHG3*06 AJ390237    
IGHG3*07 AJ390238 +  
IGHG3*08 AJ390241    
IGHG3*09 AJ390242 +  
IGHG3*10 AJ390246    
IGHG3*11 AJ390247 +  
IGHG3*12 AJ390252 +  
IGHG3*13 AJ390244 +  
IGHG3*14 AJ390254 +  
IGHG3*15 AJ390260 +  
IGHG3*16 AJ390262 +  
IGHG3*17 AJ390272 +     |a30>g|
IGHG3*18 AJ390276 +     |a30>g|
IGHG3*19 AJ390279 +     |a30>g|
H4 F IGHG3*01 M12958 + g30  |a37  |
IGHG3*02 K01313    
IGHG3*03 X16110 +  
IGHG3*04 X99549    
IGHG3*05 AJ390236    
IGHG3*06 AJ390237    
IGHG3*07 AJ390238 +  
IGHG3*08 AJ390241    
IGHG3*09 AJ390242 +  
IGHG3*10 AJ390246    
IGHG3*11 AJ390247 + g30>a|a37>c|
IGHG3*12 AJ390252 + g30>a|a37>c|
IGHG3*13 AJ390244 +  
IGHG3*14 AJ390254 +  
IGHG3*15 AJ390260 +  
IGHG3*16 AJ390262 +  
IGHG3*17 AJ390272 +  
IGHG3*18 AJ390276 +  
IGHG3*19 AJ390279 +  
CH2 F IGHG3*01 M12958 + a27  |c245  ,P82  |c247  ,R83  |a251.3  ,Y84.3  |c274  ,L92  |a370  ,T124  |
IGHG3*02 K01313   a27>t|
IGHG3*03 X16110 +  
IGHG3*04 X99549    
IGHG3*05 AJ390236    
IGHG3*06 AJ390237    
IGHG3*07 AJ390238 +  
IGHG3*08 AJ390241    
IGHG3*09 AJ390242 +                                                 |c274>g,L92>V|
IGHG3*10 AJ390246    
IGHG3*11 AJ390247 +                                |a251.3>t,Y84.3>F|
IGHG3*12 AJ390252 +                                |a251.3>t,Y84.3>F|
IGHG3*13 AJ390244 +  
IGHG3*14 AJ390254 +      |c245>t,P82>L|
IGHG3*15 AJ390260 +      |c245>t,P82>L|
IGHG3*16 AJ390262 +      |c245>t,P82>L|                                          |a370>g,T124>A|
IGHG3*17 AJ390272 +  
IGHG3*18 AJ390276 +                   |c247>t,R83>W|
IGHG3*19 AJ390279 +                   |c247>t,R83>W|
CH3
(including CHS)
F IGHG3*01 M12958 + a3.4  |g115  ,V39  |g131  ,c132  ,S44  |c134.2  |g133.3  ,g135.3  ,E45.3  |c237  ,N79  |g243  |a250  ,M84  |a263  ,K88  |c267  |c270  |c292  ,Q98  |c300  |a301  ,I101  |g344  ,R115  |t347  ,F116  |
IGHG3*02 K01314                                          |c134.2>a|g133.3>a,g135.3>c,E45.3>N|
IGHG3*03 X16110 +                                                                                               |a250>g,M84>V|a263>g,K88>R|c267>a|      |c292>g,Q98>E|c300>t|a301>g,I101>V|
IGHG3*04 X99549    
IGHG3*05 AJ390236    
IGHG3*06 AJ390237   a3.4>g|                                                                   |c237>g,N79>K|
IGHG3*07 AJ390238 + a3.4>g|                                                                   |c237>g,N79>K|
IGHG3*08 AJ390241                      |g131>a,c132>t,S44>N|
IGHG3*09 AJ390242 +                                                                                                                                |c270>t|
IGHG3*10 AJ390246    
IGHG3*11 AJ390247 +  
IGHG3*12 AJ390252 +  
IGHG3*13 AJ390244 +                                                                           |c237>g,N79>K|g243>a|                                       |c292>g,Q98>E|
IGHG3*14 AJ390254 +                    |g131>a,c132>t,S44>N|                                                                                                                                              |t347>a,F116>Y|
IGHG3*15 AJ390260 +                    |g131>a,c132>t,S44>N|                                  |c137>g,N79>K|                                                                                              |t347>a,F116>Y|
IGHG3*16 AJ390262 +                    |g131>a,c132>t,S44>N|                                                                                                                                              |t347>a,F116>Y|
IGHG3*17 AJ390272 +       |g115>a,V39>M|                                                      |c237>g,N79>K|      |a250>g,M84>V|                                                            |g344>a,R115>H|t347>a,F116>Y|
IGHG3*18 AJ390276 +       |g115>a,V39>M|                                                      |c237>g,N79>K|      |a250>g,M84>V|                                                            |g344>a,R115>H|t347>a,F116>Y|
IGHG3*19 AJ390279 +       |g115>a,V39>M|                                                      |c237>g,N79>K|      |a250>g,M84>V|                                                            |g344>a,R115>H|t347>a,F116>Y|
M1
F IGHG3*01 D78345   c78  ,F26  |
IGHG3*03 M60195   c78>g,F26>L|
M2
F IGHG3*01 D78345    
IGHG3*03 M60196    
IGHG4 CH1 F IGHG4*01 K01316    
H F IGHG4*01 K01316   a21  |
IGHG4*02 AJ001563   a21>g|
CH2 F IGHG4*01 K01316   c274  ,L92  |
IGHG4*02 AJ001563   c274>g,L92>V|
IGHG4*03 AJ001564    
CH3
(including CHS)
F IGHG4*01 K01316   g263  ,R88  |a267  |t300  |a351  |
IGHG4*02 AJ001563                             |a351>g|
IGHG4*03 AJ001564   g263>a,R88>K|a267>c|t300>c|a351>g|
IGHGP CH1 ORF IGHGP*01 X06766    
H ORF IGHGP*01 X06766    
CH2 ORF IGHGP*01 X06766    
CH3
(including CHS)
ORF IGHGP*01 X06766    
M1 ORF IGHGP*01 X52849    
M2 ORF IGHGP*01 X52848    
IGHM CH1 F IGHM*01 X14940   g117  ,L39  |t231  |
IGHM*02 K01307    
IGHM*03 X57331   g117>c,L39>F|t231>c|
CH2 F IGHM*01 X14940   c3.3  |g292  ,G98  |
IGHM*02 K01308,K01309   c3.3>t|
IGHM*03 X57331   c3.3>t|g292>a,G98>S|
CH3 F IGHM*01 X14940   c45.1  |c294  |
IGHM*02 K01309,V00561 + c45.1>g|c294>g|
IGHM*03 X57331    
CH4
(including CHS)
F IGHM*01 X14940   a279  |316^318        ,105^107      |g327  ,E109  |
IGHM*02 J00260 + a279>g|                             |g327>c,E109>D|
IGHM*03 X57331         |316^318>ins^gtg,105^107>ins^V|
M1 F IGHM*01 X14940    
IGHM*03 X57331    
M2 F IGHM*01 X14940    
IGHM*03 X57331    

IMGT note:
(1)Not submitted but comment in J00222.

Reference:
[1]Max, E.E. et al., Cell, 29, 691-699 (1982).


Created: 29/04/2003
Author: Nathalie Bosc

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