Assignment of rearranged cDNAs and gDNAs to germline genes: Human TRBV

In this table are listed the rearranged complementary DNAs (cDNAs) and genomic DNAs (gDNAs) which are quoted in Arden, B. et al., Immunogenetics, 42, 455-500 (1995), or which represent potential new alleles without known germline sequences.

Rearranged cDNAs (#c) and gDNAs (#g) TRBV sequences have been assigned to IMGT TRBV genes and alleles as described in Germline gene tables, Alignments of alleles and Tables of alleles. Assignments were performed using IMGT/V-QUEST.

References are presented chronologically whenever possible.
Click here for correspondence between nomenclatures.

TRBV
gene name
Reference sequences Rearranged cDNAs and gDNAs CDR lengths JUNCTION (9)
Allele name Accession
number
Clone name Accession numbers
2 TRBV2*01 L36092 IGRb03 X58798 [24]#c [5.6.x]  
HT2.10 X57727 [23]#c [5.6.x]  
TRBV2*02 M62379 #c   M62379 [29]#c [5.6.x]  
TRBV2*03 M64351 #c   M64351 [35]#c [5.6.12] +
3-1 TRBV3-1*01 U07977   M13576 [14]p5'#g [x.x.10] +
DE5 Z23044 [40]p5'#c [5.6.12] +
HT307 X57614 [23]#c [5.6.x]  
IGRb20 X58814 [24]#c [5.6.x]  
PL2.6 M13859 [7]p5'#c [5.6.15] +
TRBV3-1*02 L06889 #c   L06889 [43]#c [5.6.x]  
3-2 TRBV3-2*02 U07978 HT307.1 X57608 [23](1)#c [5.6.x]  
TRBV3-2*03 M33240 #c VW114 M33240 [26](1)#c [5.6.x] -
4-1 TRBV4-1*01 U07977 IGRb19 X58813 [24]#c [5.6.x]  
HT459 X57728 [23]#c [5.6.x]  
3.24 X74842 [36]#c [5.6.13] +
TRBV4-1*02 M13855 #c PL4.9 M13855 [7]p5'#c [5.6.17] +
4-2 TRBV4-2*01 U07975 HT267.2 X57617 [23]p5'#c [5.6.x]  
  D13083 [37](2)#c [5.6.x]  
TRBV4-2*02 X58811 #c IGRb17 X58811 [24]#c [5.6.x]  
4-3 TRBV4-3*01 U07978 HT267 X57618 [23]p5'#c [5.6.x]  
  L06887 [43](3)#c [5.6.x]  
TRBV4-3*02 X58812 #c IGRb18 X58812 [24]#c [5.6.x]  
TRBV4-3*03 L06888 #c   L06888 [43]#c [5.6.x]  
TRBV4-3*04 X57616 #c HT267.1 X57616 [23]p5'#c [5.6.x]  
PL4.19 M13856 [7]p5'#c [x.x.17] +
5-1 TRBV5-1*01 L36092 HBVP51 X04927 [9]#c [5.6.11] +
PL7.16 M13849 [7]#c [5.6.13] +
PL4.16 M13848 [7]p5'#c [x.6.11] +
Al61.102 M97705 [38]#c [5.6.13] +
S14.4 M97715 [38]#c [5.6.13] +
TRBV5-1*02 M14271 #c ph24 M14271 [8]#c [5.6.12] +
5-4 TRBV5-4*01 L36092 AL61.270 M97707 [38]#c [5.6.13] +
8.19 X74847 [36]#c [5.6.13] +
  M73465 [33]#c [5.6.12] +
  X68527 [39]#c [5.6.17] +
  X56142 [22]#c [5.6.13] +
TRBV5-4*02 X57615 #c HT415 X57615 [23]#c [5.6.x]  
TRBV5-4*03 S50547 #g R1F3 S50547 [32]p5'#g [5.6.x]  
TRBV5-4*04 X58804 #c IGRb07 X58804 [24]p5'#c [x.6.x]  
5-5 TRBV5-5*01 L36092 HT415.3 X57612 [23]#c [5.6.x]  
TRBV5-5*02 X57611 #c HT415.9 X57611 [23]#c [5.6.x]  
12A1 M13551 [10]#c [5.6.9] +
WM-3 M86362 [31]#c [5.6.15] +
12A1 M14299 [11]#c [5.6.9] +
TRBV5-5*03 X58801 #c IGRb08 X58801 [24]#c [5.6.x]  
HPB-b2 X01411 [1](4)p5'#c [x.x.9] +
5-6 TRBV5-6*01 L36092 IGRb09 X58802 [24]#c [5.6.x]  
PL2.5 M13850 [7]p5'#c [5.6.9] +
5-8 TRBV5-8*01 L36092 AL62.24 M97709 [38]#c [5.6.12] +
TRBV5-8*02 X58803 #c IGRb06 X58803 [24]p5'#c [5.6.x]  
6-1 TRBV6-1*01 X61446 IGRb14 X58809 [24]#c [5.6.x]  
  L06890 [43]#c [5.6.x]  
8.30 X74850 [36]#c [5.6.13] +
6-2 TRBV6-2*01 X61445 PL5.3 M13864 [7]p5'#c [x.6.13] +
CEM.1 M13575 [14]#g [5.6.x]  
RFL3.8b M77498 [25]#c [5.6.10] +
M31347#g lHPB-2 M31347 [15](13)#g [5.6.x]  
6-4 TRBV6-4*01 X61653 IGRb15 X58810 [24]#c [5.6.x]  
  L06891 [43](5)#c [5.6.x]  
6-5 TRBV6-5*01 L36092 PL4.24 M13863 [7]#c [5.6.11] +
HBVP34 X04932 [9]#c [5.6.14] +
  Z26594 [13]#c [5.6.11] +
6-6 TRBV6-6*01 L36092 HT165.2 X57606 [23]#c [5.6.x]  
ALI1.1 S60794 [28]#c [5.6.15] +
TRBV6-6*02 AF009662 HT165 X57721 [23]#c [5.6.x]  
TRBV6-6*03 X58815 #c IGRb16 X58815 [24]p3'#c [5.6.x]  
TRBV6-6*04 X74848 #c 3.1 X74848 [36]#c [5.6.11] +
TRBV6-6*05 L06892 #c   L06892 [43]#c [5.6.x]  
7-2 TRBV7-2*01 X61442 ph16 M14262 [8]#c [5.6.11] +
ph79 M15221 [8]#c [5.6.15] +
UA-S2 M24089 [21]#g [5.6.14] +
TRBV7-2*04 M27387 #c HBVT45 M27387 [17]#c [5.6.14] +
IGRb12 X58807 [24]p5'#c [5.6.x]  
7-3 TRBV7-3*01 X61440 HBVP50 X04934 [9]#c [5.6.14] +
TRBV7-3*04 X74843 #c 1.26 X74843 [36]#c [5.6.10] +
TRBV7-3*05 M13550 #c 4D1 M13550 [10]p5'#c [5.6.x] -
4D1 M12883 [4]p5'#c [5.6.x] -
PL4.14 M13852 [7]p5'#c [5.x.10] +
HBP04 X04922 [9]p5'#c [x.x.14] +
7-6 TRBV7-6*01 L36092 HBP25 X04931 [9]p5'#c [5.6.9] +
TRBV7-6*02 X58806 #c IGRb11 X58806 [24]#c [5.6.x]  
7-7 TRBV7-7*02 X57607 #c HT147 X57607 [23]#c [5.6.x]  
7-8 TRBV7-8*01 M11953 ph5 M14260 [8]#c [5.6.12] +
HBVT23 M27383 [17]#c [5.6.14] +
TRBV7-8*03 M27384 #c HBVT10 M27384 [17]#c [5.6.16] +
PL5.10 M13854 [7]p5'#c [x.6.17] +
7-9 TRBV7-9*01 L36092 IGRb10 X58805 [24]#c [5.6.x]  
HBVT11 M27386 [17]#c [5.6.9] +
TRBV7-9*02 M15564 #c L17b M15564 [12]#c [5.6.12] +
L17b M13552 [10]#c [5.6.12] +
TRBV7-9*03 AF009663 WBDM28A D13085 [37]#c [5.6.x]  
IW28 X64742 [34]#c [5.6.12] +
TRVB7-9*04 M14261 #c ph22 M14261 [8]#c [5.6.11] +
TRBV7-9*05 M27385 #c HBVT23 M27385 [17]#c [5.6.16] +
TRBV7-9*06 X74844 #c 1.40 X74844 [36]#c [5.6.13] +
TRBV7-9*07 L14854 #c   L14854 [42]p5'#c [x.6.12] +
9 TRBV9*01 L36092 PL5.2 M13836 [7]#c [5.6.13] +
PL5.6 M13837 [7]#c [5.6.14] +
PL6.1 M13838 [7]#c [5.6.15] +
PL6.4 M13839 [7]#c [5.6.12] +
Sup-T1 M16834 [16]#g [5.6.11] +
308G M27912 [20]#g [5.6.x]  
2.44 X74841 [36]#c [5.6.13] +
HBVT73 M27381 [17]#c [5.6.14] +
TRBV9*02 M27904 #g 308C M27904 [20]#g [5.6.x]  
TRBV9*03 M27380 #c HBVT96 M27380 [17]#c [5.6.11] +
10-1 TRBV10-1*01 U01750 IGRb13 X58808 [24]#c [5.6.x]  
GM2.11 M64352 [35]#c [5.6.13] +
TRBV10-1*02 AF009660 WBDM21C D13084 [37]#c [5.6.x]  
10-2 TRBV10-2*01 U17050 HT96 X57609 [23]p5'#c [x.5.x]  
10-3 TRBV10-3*01 U03115 ph27 M14268 [8]#c [5.6.x] -
HBP54 X04935 [9]p5'#c [5.6.11] +
TRBV10-3*03 L33101 PL4.2 M13862 [7]p5'#c [5.6.12] +
11-1 TRBV11-1*01 M33233 B17ct7 D16584 [41]#c [5.6.x]  
11-2 TRBV11-2*01 L36092 DD11 Z23042 [40]#c [5.6.13] +
TRBV11-2*03 X58796 #c IGRb01 X58796 [24]#c [5.6.x]  
11-3 TRBV11-3*01 U03115 IW6 X56665 [34]#c [5.6.13] +
TRBV11-3*02 X58797 #c IGRb02 X58797 [24]#c [5.6.x]  
TRBV11-3*03 M62377 #c   M62377 [29]#c [5.6.x]  
12-3 TRBV12-3*01 X07192 YT35 K01571/X00437 [3](10)#c [5.6.14] +
4D8 K02885/X01417 [2](11)p5'#c [5.6.14] +
ph11 M14265 [8](6)#c [5.6.11] +
12-4 TRBV12-4*01 K02546 HT242 X57720 [23]#c [5.6.x]  
HBP41 X04925 [9]#c [5.6.x]  
PL3.3 M13858/M16307 [7]p5'#c [5.6.11] +
8B3 M81773 [27]#c [5.6.15] +
TRBV12-4*02 M14264 #c ph8 M14264 [8]#c [5.6.13] +
HT2.12 X57619 [23]#c [5.6.x]  
13 TRBV13*01 U03115 HT183 X57613 [23]#c [5.6.x]  
IGRb04 X58799 [24]#c [5.6.x]  
TRBV13*02 M62378 #c   M62378 [29]#c [5.6.x]  
14 TRBV14*01 X06154 HBP42 X04933 [9]p5'#c [5.6.11] +
HT370 X57723 [23]#c [5.6.x]  
TRBV14*02 X57722 #g HT219 X57722 [23]#g [5.6.x]  
15 TRBV15*02 X58800 #c IGRb05 X58800 [24]#c [5.6.x]  
HT77 X57725 [23]#c [5.6.x]  
  M73464 [33]#c [5.6.12] +
TRBV15*03 M62376 #c   M62376 [24]#c [5.6.x]  
16 TRBV16*03 L26054 #c HsVB25 L26054 [44]#c [5.6.x]  
18 TRBV18*01 L36092 HBVT56 M27389 [17]#c [5.6.15] +
ph29 M14270 [8]#c [5.6.14] +
ph26 M15223 [8]#c [5.6.13] +
S14.107 M97711 [38]#c [5.6.11] +
19 TRBV19*01 U48260 HBVT02 M27388 [17]#c [5.6.13] +
TRBV19*03 M97725 #c S30.10 M97725 [38]#c [5.6.11] +
20-1 TRBV20-1*01 M11955 MOLT 4 (12) M12886 [6]#c [6.7.14] +
PL6.21 (12) M13842 [7]#c [6.7.14] +
PL2.13 M13840 [7]#c [6.7.13] +
HT1.9 X57603 [23]#g [6.7.x]  
  D13082 [37]#c [6.7.x]  
B14.6 M97719 [38]#c [6.7.11] +
TRBV20-1*02 X72719 WBDP25G D13087 [37]#c [6.7.x]  
S25.13 M97721 [38]#c [6.7.10] +
TRBV20-1*03 M11954 #g MT1-1 M11954 [5]#g [6.7.11] +
TRBV20-1*04 M14263 #c ph7 M15222 [8]#c [6.7.12] +
ph34 M14263 [8]#c [6.7.10] +
TRBV20-1*05 X57604 #g HT120 X57604 [23]#g [6.7.x]  
TRBV20-1*06 D13088 #c WBDM11D D13088 [37]#c [6.7.x]  
TRBV20-1*07 X74852 #c 4.49 X74852 [36]#c [6.7.14] +
23-1 TRBV23-1*01 L36092 HBVT72 M27390 [17]#c [5.6.12] +
24-1 TRBV24-1*01 M11951 ph32 M14269 [8]#c [5.6.14] +
25-1 TRBV25-1*01 L36092 PL3.12 M13861 [7]#c [5.6.11] +
ph15 M14266 [8]#c [5.6.11] +
1.3 X74845 [36](7)#c [5.6.14] +
27 TRBV27*01 L36092 ph21 M14267 [8]#c [5.6.11] +
PL8.1 M13865/M16314 [7]#c [5.6.11] +
HBP55 X04928 [9]p5'#c [5.6.11] +
8.9 M17200 [18]#g [5.6.x] -
28 TRBV28*01 U08314 HT12 X57610 [23]#c [5.6.x]  
HBVT22 M27382 [17]#c [5.6.11] +
PL4.4 M13843 [7]#c [5.6.13] +
3.9 X74846 [36]#c [5.6.12] +
DT259 X04929 [9](8)#c [5.6.11] +
DE49 Z22967 [40]#c [5.6.12] +
HA1.7 X63456 [30]#c [5.6.12] +
B2-59 M18462 [19]#c [5.6.12] +
29-1 TRBV29-1*01 L36092 115E15 Z29580 [45]#c [5.7.15] +
PL2.14 M13846 [7]#c [5.7.11] +
2G2b M13553 [10]#c [5.7.14] +
DT110 X04921 [9]#c [5.7.10] +
B1-75 M18461 [19]#c [5.7.10] +
S26.2 M97723 [38]#c [5.7.13] +
TRBV29-1*02 M13847 #c PL5.7 M13847 [7]#c [5.7.9] +
TRBV29-1*03 X04926 #c HBP48 X04926 [9]p5'#c [5.7.13] +
30 TRBV30*01 L36092 WBDM30A D13086 [37]#c [6.5.x]  
TRBV30*04 M13554 #c HUT102 M13554 [10]#c [6.5.12] +
TRBV30*05 L06893 #c   L06893 [43]#c [6.5.x]  

p3': partial in 3', p5': partial in 5' (more than 10 amino acids missing in 5').
#: rearranged, #c: rearranged cDNA, #g: rearranged genomic DNA.

IMGT notes:
(1) 1st_CYS replaced by STOP-CODON in V-EXON.
(2) It is not known if the nucleotide differences and the amino acid change (c5>a, g6>c, T2>N; a48>g) represent a new allele polymorphism or result from a typing or sequencing error.
(3) Chimeric sequence. L06887 (clone Vb7.nl) is an intragenic recombinant that was most likely generated during PCR, with its 5' part (nt1-222) derived from TRBV3-2 (L36092/U07978, U66059) (t44>c, M15>T; a69>c, *23>c) and its 3' part (nt223-321) derived from TRBV4-3*01 (U07978).
(4) The sequence being partial, it is not possible to decide if the gene belongs to the allele *01, *02 or *03. Note that the one G inserted at position 11 (209^210>ins^g, according to the IMGT unique numbering) probably results from a typing error.
(5) It is not known if the two nucleotide differences and the amido acid change (g175>c, c176>g, A59>R) represent a new allele polymorphism or result from a typing or sequencing error.
(6) It is not known if the nucleotide difference (t3>c) between M14265 and allele TRBV12-3*01 (X07192) is a polymorphic mutation corresponding to a new allele.
(7) X74845 differs from the IMGT reference sequence TRBV25*01 (L27610) in the 39 first nucleotides and the corresponding 13 aminoacids, and for the following V-REGION nucleotides and amino acids (a66>g; c84>g; c290>t, S97>L). It is not known if these differences result from a cloning artefact and/or typing or sequencing errors.
(8) DT259 (X04929) has a 3 nucleotide deletion (cag 73-75>del, Q25>del) and a 3 nucleotide insertion (126^127>ins^Q) compared to TRBV28*01 (U08314). It is not known if these differences result from a cloning artefact and/or typing or sequencing errors.
(9) + indicates in-frame JUNCTION, - indicates out-of-frame JUNCTION, a blank indicates not defined.
(10) Based on [2], this sequence from clone YT35 probably derives from the JM/Jurkat cell line (see K02885/X01417) and not from MOLT-3. The accession number of a patent for YT35 (E00685) has an identical sequence to X00437, whereas the accession number of an artificial sequence for YT35 (A16547) differs by one nucleotide at position 48.
(11) Clone 4D8 is from JM cell line that is identical to Jurkat cell line. The sequence has only one difference (additional nucleotide t at position 866 in the 3'UTR) compared to the YT35 sequence (K01571), confirming that YT35 derives from the JM/Jurkat cell line [2].The difference in K01571 may result from a sequencing or typing error. The sequence X02515 said to be from HPB-ALL most probably also derives from JM/Jurkat. The 4D8 rearrangement corresponds to TRBV12-3*01 - TRBJ1-2*01 (no D is recognizable).
(12) The TRBV-D-J rearranged sequence of MOLT 4 and PL6.21 differ by a deletion of 3 nucleotides in the L-PART1.
(13) M31347 (g#) was assigned to TRBV6-2*01 with a deletion of 1 nt 'g' (nt 147) due to a probable sequencing error in V-REGION (13/07/2018).

References:
[1] Yoshikai, Y. et al., Nature 312, 521-524 (1984).
[2] Sims, J.E., et al., Nature 312, 541-545 (1984).
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[8] Tillinghast, J. P. et al., Science 233, 879-883 (1986).
[9] Kimura, N. et al., J. Exp. Med. 164, 739-750 (1986).
[10] Leiden, J. M. and Strominger, J. L., Proc. Natl. Acad. Sci. USA 83, 4456-4460 (1986).
[11] Leiden, J. M. et al., Mol. Cell. Biol. 6, 3207-3214 (1986).
[12] Leiden, J. M. et al., Immunogenetics 24, 17-23 (1986).
[13] Karp, unpublished.
[14] Duby, A. D. and Seidman, J. G., Proc. Natl. Acad. Sci. USA 83, 4890-4894 (1986).
[15] Ikuta, K. et al., Nucleic Acids Res. 14, 4899-4909 (1986).
[16] Reynolds,T. C. et al., Cell 50, 107-117 (1987).
[17] Kimura, N., et al., Eur. J. Immunol. 17, 375-383 (1987).
[18] Beall, S. et al., J. Immunol. 139, 1320-1325 (1987).
[19] Triebel, F. et al., J. Immunol. 140, 300-104 (1988).
[20] Robinson, M. A., Proc.Natl. Acad. Sci., USA 89, 9422-9426 (1989).
[21] Hinkkanen, A. E. et al., Immunogenetics 29, 131-133 (1989).
[22] George, unpublished.
[23] Plaza, A. et al., J. Immunol. 147, 4360-4365 (1991).
[24] Ferradini, L. et al., Eur. J. Immunol. 21, 935-942 (1991).
[25] Novotny, J. et al., Proc. Natl. Acad. Sci. USA 88: 8646-8650 (1991).
[26] Hansen, T. et al., Tissue Antigens 38, 99-103 (1991).
[27] Sensi, M. et al., Melanoma. Res. 1, 261-271 (1991).
[28] Devaux, B. et al., Eur. J. Immunol. 21, 2111-2119 (1991).
[29] Robinson, M. A., J. Immunol. 146, 4392-4397 (1991).
[30] Hewitt, C. R. A., et al., J. Exp. Med. 175, 1493-1499 (1992).
[31] Korthäuer, U. et al., Scand. J. Immunol.36, 855-863 (1992).
[32] Van Schooten, W. C. et al., Proc. Natl. Acad. Sci. USA 89, 11244-11248 (1992).
[33] Lunardi, C. et al., Immunogenetics 36, 314-318 (1992).
[34] Hansen, T. et al., Scand. J. Immunol. 36, 285-290 (1992).
[35] Boitel, B. et al., J. Exp. Med. 175, 765-777 (1992).
[36] Jores, R, and Meo, T., J. Immunol. 151, 6110-6122 (1993).
[37] Obata, F. et al., Immunogenetics 38, 67-70 (1993).
[38] Hurley, C. K. et al., J. Immunol. 150, 1314-1324 (1993).
[39] Bowman, unpublished.
[40] Wedderburn, L. R. et al., Proc. Natl. Acad. Sci. USA 90, 8214-8218 (1993).
[41] Tsuruta, Y. et al., J. Immunol. Meth.161, 7-21 (1993).
[42] Hoffman, R. et al., J Immunol. 151, 6460-6469 (1993).
[43] Santamaria, P. et al., Immunogenetics 38, 163 (1993).
[44] Hall, M. A., et al., Eur. J. Immunol. 24, 641-645 (1994).
[45] Kalams, S. A. et al., J. Exp. Med. 179, 1261-1271 (1994).


Created: 28/03/2001
Last updated: Monday, 16-Jul-2018 11:10:00 CEST
Authors: Isabelle Lefranc, Géraldine Folch

Software material and data coming from IMGT server may be used for academic research only, provided that it is referred to IMGT®, and cited as "IMGT®, the international ImMunoGeneTics information system® http://www.imgt.org (founder and director: Marie-Paule Lefranc, Montpellier, France)." References to cite: Lefranc, M.-P. et al., Nucleic Acids Res., 27:209-212 (1999); doi: 10.1093/nar/27.1.209 Full text Cover; Ruiz, M. et al., Nucleic Acids Res., 28:219-221 (2000); doi: 10.1093/nar/28.1.219 Full text; Lefranc, M.-P., Nucleic Acids Res., 29:207-209 (2001); doi: 10.1093/nar/29.1.207 Full text; Lefranc, M.-P., Nucleic Acids Res., 31:307-310 (2003); doi: 10.1093/nar/gkg085 Full text; Lefranc, M.-P. et al., In Silico Biol., 5, 0006 (2004) [Epub], 5:45-60 (2005); Lefranc, M.-P. et al., Nucleic Acids Res., 33:D593-597 (2005); doi: 10.1093/nar/gki065 Full text; Lefranc, M.-P. et al., Nucleic Acids Res., 37:D1006-1012 (2009); doi: 10.1093/nar/gkn838 Full text; Lefranc, M.-P. et al., Nucleic Acids Res., 43:D413-422 (2015); doi: 10.1093/nar/gku1056 Full text.
For any other use please contact Marie-Paule Lefranc Marie-Paule.Lefranc@igh.cnrs.fr.

CNRS Université de Montpellier European Commission
IMGT® Founder and Executive Director Emeritus:
Marie-Paule Lefranc Marie-Paule.Lefranc@igh.cnrs.fr
IMGT® Director:
Sofia Kossida Sofia.Kossida@igh.cnrs.fr
Bioinformatics manager:
Véronique Giudicelli Veronique.Giudicelli@igh.cnrs.fr
Computer manager:
Patrice Duroux Patrice.Duroux@igh.cnrs.fr
Webmaster:
Amélie Houles

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