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"+" or "-" indicates if the gene sequences have been found (+) or not been found (-) transcribed (T) and/or translated into protein (Pr). Arbitrarily that information is shown on the first line of each gene when the data have been confirmed by several studies.

Functionality is shown between parentheses, (F) and (P), when the accession number refers to rearranged genomic DNA or cDNA and the corresponding germline gene has not yet been isolated.
Functionality is shown between brackets, [F] and [P], when the accession number refers to genomic DNA, but not known as being germline or rearranged.

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Positions in the sequence: limits from the first nucleotide of C-REGION to the last nucleotide.

IMGT gene name IMGT allele name Fct T Pr Positions in the locus IMGT/LIGM-DB reference sequences IMGT/LIGM-DB sequences from the literature
Strain Clone names Exons Accession numbers Positions in the sequence (exons) Secondary accession numbers Strain Clone names Accession numbers Positions in the sequence (exons)
IGHM1 IGHM1*01 F CH1 DQ400445 [1] 209722-210027
CH2 DQ400445 [1] 211807-212112
CH3 DQ400445 [1] 212559-212861
CH4 DQ400445 [1] 213096-213484
M1 DQ400445 [1] 215390-215523
M2 DQ400445 [1] 217807-217812
IGHM1*02 F lambda12c CH1 X52617 [2] 99-404 C7 M74041 [3] (1)
X79482 [4] 2129-2434 NG70 M27230 [5] c(s)
CH2 X52617 [2] 2172-2477 NG70 M27230 [5] c(s)
X79482 [4] 4202-4507 HG103 M23733 [6] (2) c(s)
CH3 X52617 [2] (3) 2925-3227 NG70 M27230 [5] c(s)
X79482 [4] (3) 4955-5257 HG103 M23733 [6] c(s)
CH4 X52617 [2] (3) 3462-3850 NG70 M27230 [5] c(s)
X79482 [4] (3) 5492-5880 HG103 M23733 [6] c(s)
M1 X52617 [2] (3) 5743-5876
X79482 [4] (3) 7773-7906
M2 X52617 [2] 8163-8168
X79482 [4] 10193-10198
IGHM1*03 (F) M5 CH1 U67437 [7] (4) c(m) 418-723 3B11D1 U67440 [7] (6) c(m)
40.VH6 U67445 [7] (7) c(m)
3B11M1 CH1 U67439 [7] (5) c(m) 350-655 21.VH2 U67441 [7] (7) c(m)
CH2 U67439 [7] (5) c(m) 656-781
IGHM2 IGHM2*01 P IgD-6 CH2 AF363449 [8] (8,9) 1863-2128
CH3 AF363449 [8] (9) 4803-5042
CH4 AF363449 [8] (9) 5282-5389
IGHM3 IGHM3*01 P Cu1 CH1 AF068137 [9] (10,8) 5901-6183
Cu2 CH2 AF068137 [9] (10) 9409-9695
IGHD1 IGHD1*01 F CH1 DQ400445 [1] 219399-219704
CH2 DQ400445 [1] 219787-220077
CH3 DQ400445 [1] 220458-220763
CH4 DQ400445 [1] 221733-222014
CH2D DQ400445 [1] 222130-222420
CH3D DQ400445 [1] 222805-223110
CH4D DQ400445 [1] 224078-224359
CH2D2 DQ400445 [1] 224475-224765
CH3D2 DQ400445 [1] 225122-225427
CH4D2 DQ400445 [1] 225994-226290
CH5 DQ400445 [1] (11) 226410-226733
CH6 DQ400445 [1] 227513-227830
CH7 DQ400445 [1] 228839-229126
M DQ400445 [1] 229427-229587
IGHD1*02 F IgD-2 CH1 AF363448 [8] 1323-1628 lambda12c X79482 [4]
CH2 AF363448 [8] (10) 1711-2001 lambda12c X79482 [4]
CH3 AF363448 [8] 2346-2651
CH4 AF363448 [8] 3618-3899
CH2D AF363448 [8] 4015-4305
CH3D AF363448 [8] 4674-4979
CH4D AF363448 [8] 5546-5842
CH5 AF363448 [8] 5962-6288
CH6 AF363448 [8] 7067-7384
CH7 AF363448 [8] 8471-8758
M1 AF363448 [8] 9059-9207
M2 AF363448 [8] 10080-10085
IGHD1*03 (F) M5 CH1 U67437 [7] (4) c(m) 724-1029 3B11D1 U67440 [7] (6) c(m)
CH2 U67437 [7] c(m) 1030-1320 3B11D1 U67440 [7] (6) c(m)
CH3 U67437 [7] c(m) 1321-1626
CH4D U67437 [7] c(m) 1627-1923
CH5 U67437 [7] c(m) 1924-2247
CH6 U67437 [7] c(m) 2248-2565
CH7 U67437 [7] c(m) 2566-2853
M U67437 [7] c(m) 2854-3015
IGHD1*04 (F) 21.VH2 CH1 U67441 [7] (7) c(m) 685-986
IGHD1*05 (F) 40.VH6 CH1 U67445 [7] (7) c(m) 325-630
IGHD2 IGHD2*01 F IgD-6 CH1 AF363449 [8] (12) 7671-7976
CH2 AF363449 [8] (12) 8059-8349
CH3 AF363449 [8] (12) 8750-9055
CH4 AF363449 [8] (12) 10046-10327
CH2D AF363449 [8] (12) 10443-10733
CH3D AF363449 [8] (12) 11106-11411
CH4D AF363449 [8] (12) 11978-12274
CH5 AF363449 [8] (12) 12394-12720
IGHD2*02 F IgD-3 CH1 AF363450 [8] (1) 1-33
CH2 AF363450 [8] (1) 115-405
CH3 AF363450 [8] (1) 790-1095
CH4 AF363450 [8] (1) 2067-2348
CH2D AF363450 [8] (1) 2464-2754
CH3D AF363450 [8] (1) 3127-3432
CH4D AF363450 [8] (1) 3999-4295
CH5 AF363450 [8] (1) 4415-4741
CH6 AF363450 [8] (1) 5499-5816
CH7 AF363450 [8] (1) 6740-7027
CHS AF363450 [8] (1) 7340-7410
IGHD2*03 (F) S1 CH6 U67438 [7] (13) c(s) 1-137
CH7 U67438 [7] (13) c(s) 138-425
CHS U67438 [7] (13) c(s) 426-497

(s) Trancript of a secreted chain.
(m) Trancript of a membrane chain.

IMGT notes:
  1. (1) Functional but C-GENE is partial: CH1 partial in 5'.
  2. (2) Functional but C-GENE is partial: CH2 partial in 5'.
  3. (3) Functional but CH3 is spliced to CH4 in secretory mu cDNA, whereas it is spliced to the M1 exon in membrane mu cDNA (see [5]).
  4. (4) Functional but CH1 mu is spliced to CH1 delta in delta cDNA (see [7]).
  5. (5) Functional but C-GENE is partial: CH2 partial in 3'.
  6. (6) Functional but C-GENE is partial in 3': only CH1 (mu and delta) and CH2 delta are present.
  7. (7) Functional but C-GENE is partial in 3': only CH1 (mu and delta)are present, CH1 delta partial in 3'.
  8. (8) Pseudogene because of frameshifts in C-GENE.
  9. (9) Don't affect functionality but C-GENE is partial in 5' and 3': no CH1 and CH4 partial in 3'.
  10. (10) Don't affect functionality but C-GENE is partial in 3': only CH1 and CH2 are present.
  11. (11) Functional but there is a mutation in DONOR-SPLICE.
  12. (12) Functional but C-GENE is partial in 3': CH6, CH7 and CHS are missing.
  13. (13) Functional but C-GENE is partial in 5': only CH6, CH7 and CHS are present, CH6 partial in 5'.
IMGT references:
  1. [1] Bengtén E. et al., Immunogenetics, 58, 831-844 (2006). PMID: 16941126
  2. [2] Wilson M.R. et al., Nucleic Acids Res., 18, 5227-5233 (1990). PMID: 2119496
  3. [3] Ghaffari S.H. et al., Mol. Immunol., 29, 151-159 (1992). PMID: 1347400
  4. [4] Magor B.G. et al., J. Immunol., 153, 5556-5563 (1994). PMID: 7989757
  5. [5] Ghaffari S.H. et al., J. Immunol., 143, 2730-2739 (1989). PMID: 2507636
  6. [6] Ghaffari S.H. et al., J. Immunol., 142, 1356-1365 (1989). PMID: 2492581
  7. [7] Wilson M. et al., Proc. Natl. Acad. Sci. U.S.A., 94, 4593-4597 (1997). PMID: 9114035
  8. [8] Bengten E. et al., J Immunol., 169, 2488-2497 (2002). PMID: 12193718
  9. [9] Ghaffari S.H. et al., J. Immunol., 162, 1519-1529 (1999). PMID: 9973409
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