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"+" or "-" indicates if the gene sequences have been found (+) or not been found (-) transcribed (T) and/or translated into protein (Pr). Arbitrarily that information is shown on the first line of each gene when the data have been confirmed by several studies.

Functionality is shown between parentheses, (F) and (P), when the accession number refers to rearranged genomic DNA or cDNA and the corresponding germline gene has not yet been isolated.
Functionality is shown between brackets, [F] and [P], when the accession number refers to genomic DNA, but not known as being germline or rearranged.

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IMGT gene name IMGT allele name Fct Haplotypes T Pr Positions in the locus IMGT/LIGM-DB reference sequences IMGT/LIGM-DB sequences from the literature
Strain Clone names Exons Accession numbers Positions in the sequence Secondary accession numbers Strain Clone names Accession numbers Positions in the sequence
IGHA IGHA*01 F ch28.MF.Ig epsillon-alpha.5 CH1 X53705 [2] 291-590 ch28.MF.Ig epsillon-alpha.10 X53389 [1] (2) 291-590
H+CH2 (1) X53705 [2] 804-1130 ch28.MF.Ig epsillon-alpha.10 X53389 [1] (2) 804->868
CH3(including CHS) X53705 [2] 1341-1732
M
IGHA*02 F CH1
UTS362A H+CH2 (1) AB013758 [6] (3) 9-45 (8)
CH3(including CHS)
M
IGHA*03 F CH1
UTS362B H+CH2 (1) AB013764 [6] (3) 9-51 (8)
CH3(including CHS)
M
IGHD IGHD*01 ORF (6) CH1 Macfas_2_Chr7 [9] complement(1658122-1658430)
H1 Macfas_2_Chr7 [9] complement(1657537-1657638)
H2 Macfas_2_Chr7 [9] complement(1654027-1654090)
CH2 Macfas_2_Chr7 [9] complement(1652972-1653295)
CH3 Macfas_2_Chr7 [9] complement(1652345-1652668)
CHS Macfas_2_Chr7 [9] complement(1650397-1650422)
M1 Macfas_2_Chr7 [9] complement(1649438-1649595)
M2 Macfas_2_Chr7 [9] complement(1649149-1649154)
IGHG1 IGHG1*01 F CH1 Macfas_2_Chr7 [9] complement(1582921-1583214)
H Macfas_2_Chr7 [9] complement(1582476-1582529)
CH2 Macfas_2_Chr7 [9] complement(1582028-1582357)
CH3(including CHS) Macfas_2_Chr7 [9] complement(1581611-1581930)
M1 Macfas_2_Chr7 [9] complement(1580180-1580310)
M2 Macfas_2_Chr7 [9] complement(1580255-1580310)
IGHG1*02 (F) + 4D5 CH1 AF045536 [5] c(s) 1-294
H AF045536 [5] c(s) 295-348
CH2 AF045536 [5] c(s) 349-678
CH3(including CHS) AF045536 [5] c(s) 679-999
M1
M2
IGHG1*03 (F) + CH1 CS101552 [7] c(s) 1-294
H CS101552 [7] c(s) 295-348
CH2 CS101552 [7] c(s) 349-678
CH3(including CHS) CS101552 [7] c(s) 679-999
M1
M2
IGHG1*04 F + CH1 JQ868728 [8] (4) 25-301 (7)
H JQ868728 [8] (4) 691-744
CH2 JQ868728 [8] (4) 863-1192
CH3(including CHS) JQ868728 [8] (4) 1290-1561 (8)
M1
M2
IGHG1*05 (F) + CH1 L13307 [3] (5) c(s) 373-666
H L13307 [3] (5) c(s) 667-720
CH2 L13307 [3] (5) c(s) 721-1038
CH3(including CHS) L13307 [3] (5) c(s) 1039-1359
M1
M2
IGHG2 IGHG2*01 F CH1 CS101554 [7] 2-295
H CS101554 [7] 684-719
CH2 CS101554 [7] 838-1164
CH3(including CHS) CS101554 [7] 1262-1581
M1
M2
IGHG2*02 F CH1 JQ868729 [8] (4) 25-301 (7)
H JQ868729 [8] (4) 690-725
CH2 JQ868729 [8] (4) 844-1170
CH3(including CHS) JQ868729 [8] (4) 1268-1539 (8)
M1
M2
IGHG3 IGHG3*01 (F) + CH1 CS101564 [7] c(s) 10-300 (7)
H CS101564 [7] c(s) 301-351
CH2 CS101564 [7] c(s) 352-681
CH3(including CHS) CS101564 [7] c(s) 682-1002
M1
M2
IGHG3*02 F CH1 JQ868730 [8] (4) 25-301 (7)
H JQ868730 [8] (4) 691-741
CH2 JQ868730 [8] (4) 860-1189
CH3(including CHS) JQ868730 [8] (4) 1287-1558 (8)
M1
M2
IGHG4 IGHG4*01 F CH1 CS101556 [7] 2-295
H CS101556 [7] 685-714
CH2 CS101556 [7] 833-1162
CH3(including CHS) CS101556 [7] 1260-1579
M1
M2
IGHG4*02 F CH1 JQ868731 [8] (4) 25-301 (7)
H JQ868731 [8] (4) 695-724
CH2 JQ868731 [8] (4) 843-1172
CH3(including CHS) JQ868731 [8] (4) 1270-1541 (8)
M1
M2
IGHM IGHM*01 F CH1 Macfas_2_Chr7 [9] complement(1669701-1670015)
CH2 Macfas_2_Chr7 [9] complement(1669274-1669609)
CH3 Macfas_2_Chr7 [9] complement(1668734-1669051)
CH4(including CHS) Macfas_2_Chr7 [9] complement(1668162-1668553)
M1 Macfas_2_Chr7 [9] complement(1666047-1666087) (8)
M2

c: cDNA sequence.
(s): trancript of a secreted chain.

IMGT notes:
  1. (1) In the IGHA gene, the hinge (H) and CH2 are joined in a single exon.
  2. (2) Partial C-GENE: CH2 is partial in 3'.
  3. (3) Partial C-GENE: no CH1 and CH2 is partial in 3'.
  4. (4) Partial C-GENE: CH1 is partial in 5' and CH3 is partial in 3'.
  5. (5) Deletion of 4 amino acids AA79 to AA82 (QTKP) in CH2
  6. (6) noncanonical ACCEPTOR-SPLICE
  7. (7) Partial in 5'
  8. (8) Partial in 3'
IMGT references:
  1. [1] Kawamura S. et al., J. Mol. Biol., 215, 201-206 (1990). PMID: 2120447
  2. [2] Kawamura S. et al., Mol. Biol. Evol., 8, 743-752 (1991). PMID: 1775062
  3. [3] Lewis A.P. et al., Dev. Comp. Immunol., 17, 549-560 (1993). PMID: 8299853
  4. [4] Samuelsson A. et al., Virology, 207, 495-502 (1995). PMID: 7886953
  5. [5] Calvas P. et al., Scand. J. Immunol., 49, 595-610 (1999). PMID: 10354371
  6. [6] Sumiyama K. et al., Mol. Biol. Evol., 19, 1093-1099 (2002). PMID: 12082128
  7. [7] Aldrich T. et al Patent number WO2005047325-A/1, (2005).Amgen Inc. (US).
  8. [8] Attanasio R. Unpublished (2012).
  9. [9] Yu G. et al., Immunogenetics, 68, 417-428 (2016). PMID: 27233955
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