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"+" or "-" indicates if the gene sequences have been found (+) or not been found (-) rearranged (R), transcribed (T) and/or translated into protein (Pr). Arbitrarily that information is shown on the first line of each gene when the data have been confirmed by several studies.

Functionality is shown between parentheses, (F) and (P), when the accession number refers to rearranged genomic DNA or cDNA and the corresponding germline gene has not yet been isolated.
Functionality is shown between brackets, [F] and [P], when the accession number refers to genomic DNA, but not known as being germline or rearranged.

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The Horn shark (Heterodontus francisci) IGHV genes and alleles have a temporary designation based on the IMGT gene name nomenclature rules for the unmapped genes, the incomplete loci, or the cDNAs in the absence of germline genes.

IMGT subgroup IMGT gene name IMGT allele name Fct R T Pr Positions in the locus IMGT/LIGM-DB reference sequences IMGT/LIGM-DB sequences from the literature
Strain Clone names Accession numbers Positions in the sequence Secondary accession numbers Strain Clone names Accession numbers Positions in the sequence
IGHV1 IGHV1S1 IGHV1S1*01 F V(H) 1315 X13447 [1]
IGHV1S2 IGHV1S2*01 (F) V(H) F101 X13449 [1] ~VDJ
IGHV1S3 IGHV1S3*01 F + + 1403 Z11777 [2] (3) HXIA M12195 [4]
12215 Z11780 [2] (3) #c
IGHV1S4 IGHV1S4*01 F 33141 Z11778 [2] (3)
IGHV1S5 IGHV1S5*01 (F) + + 12271 Z11781 [2] #c
IGHV1S6 IGHV1S6*01 (F) + + 12272 Z11782 [2] (3) #c
IGHV1S7 IGHV1S7*01 (F) + + 12214 Z11783 [2] (3) #c
IGHV1S8 IGHV1S8*01 (F) + + 12241 Z11784 [2] #c
IGHV1S9 IGHV1S9*01 (F) + + 12221 Z11785 [2] #c
IGHV1S10 IGHV1S10*01 (F) + + 12273 Z11786 [2] #c
IGHV1S11 IGHV1S11*01 (F) + + 12251 Z11787 [2] #c
IGHV1S12 IGHV1S12*01 (F) + + HN 13 Z11788 [2] #c
IGHV1S13 IGHV1S13*01 (F) + + Z11789 [2] (3) #c
IGHV1S14 IGHV1S14*01 (F) + + X13448 [1] ~VDJ
IGHV1S15 IGHV1S15*01 F 1113 Z11776 [2] (3) HN84 Z11790 [2] (3) #c
IGHV1S16 IGHV1S16*01 (F) + + HN 21 Z11791 [2] (3) #c
IGHV1S17 IGHV1S17*01 (F) + + HN 72 Z11792 [2] (3) #c
IGHV1S18 IGHV3S1*01 (P) (2) + + HC-3 X03748 [3] (1) #c

#c: rearranged cDNA.
~VDJ: VDJ genomic DNA rearranged in the cassette.

IMGT notes:
  1. (1) Partial V-REGION: AA 27 to 29 are absent (partial CDR1-IMGT) and no FR1-IMGT.
  2. (2) IGHV3S1 gene has a 1 nucleotide DELETION in FR2-IMGT which leads to a frameshift.
  3. (3) In the absence of genomic sequences and maps, it is not possible to know if sequences differing by a few nucleotides derive from allelic genes or from duplicated clusters. Reference sequences which differ by <5 nucleotides are shown below with their nucleotide differences:
    IGHV gene and allele names (Accession number)Nucleotide differences
    IGHV1S3*01 (Z11777)IGHV1S4*01 (Z11778)a4>g; c154>t; g158>c; t270>c
    IGHV1S3*01 (Z11777)IGHV1S6*01 (Z11782)g149>c; g92>c; g290>a
    IGHV1S3*01 (Z11777)IGHV1S7*01 (Z11783)g92>a; g126>a; c150>t; a268>t
    IGHV1S3*01 (Z11777)IGHV1S13*01 (Z11789)a4>g; g43>a; t119>g
    IGHV1S15*01 (Z11776)IGHV1S16*01 (Z11791)g92>a; a162>c; c174>t
    IGHV1S15*01 (Z11776)IGHV1S17*01 (Z11792)g22>a; c58>a; g92>a; c279>t
IMGT references:
  1. [1] Kokubu F. et al., EMBO J., 7, 3413-3422 (1988). PMID: 3145194
  2. [2] Hinds-Frey K.R. et al., J. Exp. Med., 178, 815-824 (1993). PMID: 8350055
  3. [3] Hinds K.R. et al., Nature, 320, 546-549 (1986). PMID: 3083268
  4. [4] Litman G.W. et al., Proc. Natl. Acad. Sci. USA, 82, 2082-2086 (1985). PMID: 3920659
  5. [5] Roman T. et al., Immunogenetics, 43, 325-326 (1996). PMID: 9110939
See also (IMGT Scientific chart):