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"+" or "-" indicates if the gene sequences have been found (+) or not been found (-) rearranged (R), transcribed (T) and/or translated into protein (Pr). Arbitrarily that information is shown on the first line of each gene when the data have been confirmed by several studies.

Functionality is shown between parentheses, (F) and (P), when the accession number refers to rearranged genomic DNA or cDNA and the corresponding germline gene has not yet been isolated.
Functionality is shown between brackets, [F] and [P], when the accession number refers to genomic DNA, but not known as being germline or rearranged.

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The identified Llama (Lama glama) IGHV genes belong to a single subgroup IGHV1. This subgroup corresponds to the human IGHV3 subgroup (3).

IMGT subgroup IMGT gene name IMGT allele name Fct R T Pr Positions in the locus IMGT/LIGM-DB reference sequences IMGT/LIGM-DB sequences from the literature
Strain Clone names Accession numbers Positions in the sequence Secondary accession numbers Strain Clone names Accession numbers Positions in the sequence
IGHV1 (3) IGHV1S1 IGHV1S1*01 F VHH1 AF305944 [1]
IGHV1S2 IGHV1S2*01 F VHH2 AF305945 [1]
IGHV1S3 IGHV1S3*01 F VHH3 AF305946 [1]
IGHV1S4 IGHV1S4*01 F VHH4 AF305947 [1]
IGHV1S5 IGHV1S5*01 F VHH5 AF305948 [1]
IGHV1S6 IGHV1S6*01 F VH1 AF305949 [1]
IGHV1S7 IGHV1S7*01 P (1) Vpseudo1 AF305950 [1]
IGHV1S8 IGHV1S8*01 P (2) Vpseudo2 AF305951 [1]
IMGT notes:
  1. (1) In frame STOP-CODON (positions 127-129) at codon 43 in FR2-IMGT.
  2. (2) In frame STOP-CODON (positions 307-309) at codon 103 in FR3-IMGT.
  3. (3) The Llama (Lama glama) IGHV1 genes belong, as those of the Arabian camel (Camelus dromedarius) IGHV1 genes, to two sets based on amino acid sequences and, probably on the presence or lack of light chain in the antibodies. The functional IGHV1S6 gene and the IGHV1S7 and IGHV1S8 pseudogenes belong to the first set. The functional IGHV1S1 to IGHV1S5 genes belong to the second set. Four FR2-IMGT positions (42, 49, 50 and 52 in the IMGT unique numbering) show amino acid differences characteristic of each set:
    FR2-IMGT amino acid positions 42 49 50 52
    IGHV1S6, IGHV1S7(P), IGHV1S8(P) V G L W
    IGHV1S1 to IGHV1S5 F,Y E R G,L,W
IMGT references:
  1. [1] Woolven B.P. et al., Unpublished.
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Dominique Scaviner
Chantal Ginestoux