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"+" or "-" indicates if the gene sequences have been found (+) or not been found (-) transcribed (T) and/or translated into protein (Pr). Arbitrarily that information is shown on the first line of each gene when the data have been confirmed by several studies.

Functionality is shown between parentheses, (F) and (P), when the accession number refers to rearranged genomic DNA or cDNA and the corresponding germline gene has not yet been isolated.
Functionality is shown between brackets, [F] and [P], when the accession number refers to genomic DNA, but not known as being germline or rearranged.

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IMGT gene name IMGT allele name Fct T Pr Positions in the locus IMGT/LIGM-DB reference sequences IMGT/LIGM-DB sequences from the literature
Strain Clone names Exons Accession numbers Positions in the sequence Secondary accession numbers Strain Clone names Accession numbers Positions in the sequence
IGHM IGHM*01 (F) CH1 AF437724 [1] (1) c(s)
CH2 AF437724 [1] c(s)
CH3 AF437724 [1] c(s)
CH4 (including CHS ) AF437724 [1] c(s)
M1
M2
IGHM*02 (F) CH1 AF437725 [1] (1) c(s) AF437735 [1] (2) c(m)
CH2 AF437725 [1] c(s) AF437735 [1] c(m)
CH3 AF437725 [1] c(s) AF437735 [1] c(m)
CH4 (including CHS) AF437725 [1] c(s) AF437735 [1] c(m)
M1 AF437735 [1] c(m)
M2 AF437735 [1] c(m)
IGHW (3) IGHW*01 (F) CH1 AF437727 [1] (1) c(s) AF437726 [1] c
CH2 AF437727 [1] c(s) AF437727 [1] c
CH3 AF437727 [1] c(s)
CH4 AF437727 [1] c(s)
CH5 AF437727 [1] c(s)
CH6 AF437727 [1] c(s)
CH7 (including CHS) AF437727 [1] c(s)

c: cDNA sequence.
(s): transcript of a secreted chain.
(m): transcript of a membrane chain.

IMGT notes:
  1. (1) The 1st-CYS is not conserved in CH1.
  2. (2) Partial C-REGION: partial CH1 in 5'.
  3. (3) The IGHW gene has two transcribed forms: a short form which consists of only the CH1 and the CH2 exons, and a long form which consists of the CH1 to CH7 exons. Nucleotide sequence analysis suggests that these short and long forms derive from an alternative splicing [1].
IMGT references:
  1. [1] Ota T. et al., Proc. Natl. Acad. Sci. U.S.A., 100, 2501-2506 (2003). PMID: 12606718
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