Here you are: IMGT Web resources > IMGT Repertoire (IG and TR) > 1. Locus and genes

"+" or "-" indicates if the gene sequences have been found (+) or not been found (-) transcribed (T) and/or translated into protein (Pr). Arbitrarily that information is shown on the first line of each gene when the data have been confirmed by several studies.

Functionality is shown between parentheses, (F) and (P), when the accession number refers to rearranged genomic DNA or cDNA and the corresponding germline gene has not yet been isolated.
Functionality is shown between brackets, [F] and [P], when the accession number refers to genomic DNA, but not known as being germline or rearranged.

Click on:

Click on the strain name to get information on the strain (link to MGD).

IMGT gene name IMGT allele name Fct Chromosomal localization T Pr Positions in the locus IMGT/LIGM-DB reference sequences IMGT/LIGM-DB sequences from the literature
Strain Clone names Exons Accession numbers Positions in the sequence Secondary accession numbers Strain Clone names Accession numbers Positions in the sequence
IGHA IGHA*01 F 12 (58.0 cM) BALB/c CH1 J00475 [10] BALB/c M37125 [29] (5)
H+CH2 (1) J00475 [10] (20)
CH3 (including CHS) J00475 [10]
M K00691 [21] (2)
IGHA*02 F 12 (58.0 cM) CH1
ChM167-alpha-10 H+CH2 (1) K02101 [8] (4) BALB/c ChM603-alpha-6 K02102 [8] (4)
CH3(including CHS)
M
IGHA*03 F (3) 12 (58.0 cM) BALB/c IgH703 CH1 D11468 [31]
H+CH2 (1) D11468 [31]
CH3(including CHS) D11468 [31]
M
IGHA*04 F 12 (58.0 cM) I/St CH1 AF175973 [37]
H+CH2 (1) AF175974 [37]
CH3(including CHS) AF175975 [37]
M
IGHA*05 F 12 (58.0 cM) DBA/2J CH1 AY045744 [38]
H+CH2 (1) AY045745 [38]
CH3(including CHS) AY045746 [38]
M
IGHA*06 F 12 (58.0 cM) C57BL/10.A/SgSnJ CH1 AY045741 [38]
H+CH2 (1) AY045742 [38]
CH3(including CHS) AY045743 [38]
M
IGHA*07 F 12 (58.0 cM) AKR/J CH1 AY045747 [38]
H+CH2 (1) AY045748 [38]
CH3(including CHS) AY045749 [38]
M
IGHA*08 F 12 (58.0 cM) CE/J CH1 AY045750 [38]
H+CH2 (1) AY045751 [38] (4)
CH3(including CHS) AY045752 [38]
M
IGHD (14) IGHD*01 F 12 (58.0 cM) BALB/c CH1 V00786 [6] PJS5; PCP18; PGG-mu-9 K02138 [20]
K02150 [23] (5)
J00447 [6,23] (17)
M64566 [30] (5)
C57BL/6 M74520 [36] (6)
H V00787 [6] BALB/c J00448 [6]
CH3 V00788 [6] BALB/c J00449 [6]
CHS J00450 [12]
M1 J00450 [12]
M2 J00450 [12]
IGHE IGHE*01 F 12 (58.0 cM) BALB/c CH1 X01857 [13] (7) 2-C-30; Ig-epsilon-1 J00476 [14] (16) c(s)
CH2 X01857 [13] (7) 2-C-30; Ig-epsilon-1 J00476 [14] (16) c(s)
CH3 X01857 [13] (7) BALB/c M22933 [25]
2-C-30; Ig-epsilon-1 J00476 [14] (16) c(s)
CH4(including CHS) X01857 [13] (7) 2-C-30; Ig-epsilon-1 J00476 [14] (16) c(s)
M1 X03624 [13] K00690 DBA L31854 [26] (9)
M2 X03624 [13] K00690
IGHE*02 F 12 (58.0 cM) BALB/c CH1 M23104 [25] (6)
CH2
BALB/c CH3
CH4(including CHS) M22934 [25] (6)
subclone of Epsilon-6 clone, provided by T. Honjo M1 U08933 [32] (8)
M2 U08933 [32] (8) BALB/c X99259 [34]
IGHE*03 F 12 (58.0 cM) B10.A CH1 M23085 [25]
CH2 M22929 [25] B10.A M22932 [25]
CH3 M22930 [25]
CH4(including CHS) M22931 [25] (15)
M1
M2
IGHG1 IGHG1*01 F 12 (58.0 cM) BALB/c CH1 J00453 [1] V00793 (22) BALB/c MEP 10,12 clone 8,13,17 D78344 [33]
C57BL/6 AJ487681
DJ058755
H J00453 [1] V00793 (22) BALB/c MEP 10,12 clone 8,13,17 D78344 [33]
C57BL/6 AJ487681
DJ058755
CH2 J00453 [1] V00793 (22) BALB/c MEP 10,12 clone 8,13,17 D78344 [33]
C57BL/6 AJ487681
DJ058755
CH3(including CHS) J00453 [1] V00793 (22) BALB/c MEP 10,12 clone 8,13,17 D78344 [33]
C57BL/6 AJ487681
DJ058755
M1 J00454 [16,17,41] (16) BALB/c MEP 10,12 clone 8,13,17 D78344 [33]
J00453 [1] V00793 (22) C57BL/6 AJ487681
M2 J00455 [16] BALB/c MEP 10,12 clone 8,13,17 D78344 [33]
IGHG1*02 F 12 (58.0 cM) C57BL/6 CH1 L35252 [1] c(s)
H L35252 [1] c(s)
CH2 L35252 [1] c(s)
CH3(including CHS) L35252 [1] c(s)
M1
M2
IGHG2A IGHG2A*01 F 12 (58.0 cM) BALB/c gamma2a (Igh-1a) CH1 V00825 [11] V00766 [9]
BALB/c J00470 [9,11,40] (16)
MEP 10,12 clone 8,13,17 D78344 [33]
H V00825 [11] V00766 [9]
BALB/c J00470 [9,11,40] (16)
MEP 10,12 clone 8,13,17 D78344 [33]
CH2 V00825 [11] V00766 [9]
BALB/c J00470 [9,11,40] (16)
MEP 10,12 clone 8,13,17 D78344 [33]
CH3(including CHS) V00825 [11] V00766 [9]
BALB/c J00470 [9,11,40] (16)
MEP 10,12 clone 8,13,17 D78344 [33]
M1 J00471 [17] BALB/c MEP 10,12 clone 8,13,17 D78344 [33]
M2 J00471 [17] BALB/c MEP 10,12 clone 8,13,17 D78344 [33]
IGHG2A*02 F 12 (58.0 cM) MAI (10) MAI 2a CH1 X16997 [28]
H X16997 [28]
CH2 X16997 [28]
CH3(including CHS) X16997 [28]
M1
M2
IGHG2B IGHG2B*01 F 12 (58.0 cM) BALB/c Cgamma2b CH1 V00763 [2]
H V00763 [2]
CH2 V00763 [2]
CH3(including CHS) V00763 [2]
M1 J00462 [17]
M2 J00462 [17]
IGHG2B*02 F 12 (58.0 cM) gamma2b CH1 V00801 [7] BALB/c J00461 [39] (19)
MEP 10,12 clone 8,13,17 D78344 [33]
H V00801 [7] BALB/c J00461 [39] (19)
MEP 10,12 clone 8,13,17 D78344 [33]
CH2 V00801 [7] BALB/c J00461 [39] (19)
MEP 10,12 clone 8,13,17 D78344 [33]
CH3(including CHS) V00801 [7] BALB/c J00461 [39] (19)
D78345 [33]
BALB/c MEP 10,12 clone 8,13,17 M1 D78344 [33]
M2 D78344 [33]
IGHG2C (11) IGHG2C*01 F 12 (58.0 cM) C57BL/6 gamma2a (Igh-1b) CH1 J00479 [19]
H J00479 [19]
CH2 J00479 [19]
CH3(including CHS) J00479 [19]
M1
M2
IGHG2C*02 F 12 (58.0 cM) MAI (10) MAI 2c CH1 X16998 [28]
H X16998 [28]
CH2 X16998 [28]
CH3(including CHS) X16998 [28]
M1
M2
IGHG2C*03 F 12 (58.0 cM) NOD/Lt. (12) CH1 Y10606 [35]
H Y10606 [35]
CH2 Y10606 [35]
CH3(including CHS) Y10606 [35]
M1
M2
IGHG3 IGHG3*01 F 12 (58.0 cM) BALB/c CH1 X00915 [24] BALB/c D78343 [33]
J00451 [24,42] (16)
H X00915 [24] BALB/c D78343 [33]
J00451 [24,42] (16)
CH2 X00915 [24] BALB/c D78343 [33]
J00451 [24,42] (16)
CH3(including CHS) X00915 [24] BALB/c D78343 [33]
J00451 [24,42] (16)
M1 X00915 [24] BALB/c D78343 [33]
J00451 [24,42] (16)
M2 X00915 [24] BALB/c D78343 [33]
J00451 [24,42] (16)
IGHG3*02 F 12 (58.0 cM) CH1
H
CH2
CH3(including CHS)
M1 V01526 [18]
M2 V01526 [18]
IGHM IGHM*01 F 12 (58.0 cM) BALB/c CH1 V00818 [5]
CH2 V00818 [5]
CH3 V00818 [5]
CH4(including CHS) V00818 [5] BALB/c V00817 [4] (13)
PJS5; PCP18; PGG-mu-9 K02138 [20] (13)
M1 J00444 [4] PJS5; PCP18; PGG-mu-9 K02138 [20]
M2 J00444 [4] PJS5; PCP18; PGG-mu-9 K02138 [20]
IGHM*02 F 12 (58.0 cM) BALB/c CH1 J00443 [43,44] (18)
CH2 J00443 [43,44] (18)
CH3 J00443 [43,44] (18)
CH4(including CHS) J00443 [43,44] (18)
M1
M2
IGHM*03 F 12 (58.0 cM) Ch-H76-mu-1 CH1 K02103 [3]
CH2
CH3
CH4(including CHS)
M1
M2

c: cDNA sequence
(s): transcript of a secreted chain.

IMGT notes:
  1. (1) In the IGHA gene, the hinge (H) and the CH2 are joined in a single exon
  2. (2) Sequence assigned arbitrarily and temporarily to allele*01 in the absence of cDNA and complete genomic sequence.
  3. (3) The DELETION of one nucleotide (between positions 5898/5899 in the EMBL flat file) in the CH1 seems to be a typing error.
  4. (4) Partial C-GENE: partial CH2 in 3'.
  5. (5) Partial C-GENE: partial CH1 in 3'.
  6. (6) Partial C-GENE: partial CH1 in 5'.
  7. (7) Sequencing errors of the original K00689 accession number have been corrected in this X01857 accession number.
  8. (8) Sequence assigned arbitrarily and temporarily to allele*02 in the absence of cDNA and complete genomic sequence.
  9. (9) Partial C-GENE: partial M1 in 3'.
  10. (10) Mus musculus musculus wild-derived mice from Austria.
  11. (11) Duplicated IGHG2 genes were found in Japanese mice, Mus musculus molossinus [15] and Mus musculus subspecies of Chinese wild mice [22], and in Mus musculus musculus strain MAI [27]. Sequence analysis comparison shows that the gene previously defined as gamma2a in C57BL/6 [19] corresponds in fact to IGHG2C [22,28].
  12. (12) The NOD mouse is a model of human insulin-dependent diabetes. This mouse strain was bred from mice in Japan and thus does not share any particular close lineage with BALB/c or C57BL/6 mice [35].
  13. (13) Partial C-GENE: partial CH4 in 5'.
  14. (14) The mouse IGHD gene lacks the CH2 exon but shows a relic sequence just to the right of a (CT)30-(CA)30 repeat in the intron between CH1 and CH3 [20]. The mouse IGHD gene has an additional unusual exon designated as CH-X between the CHS and M1 exons [12]. This unusual exon (J00450.1: 745..812) has only been located in genomic DNA (AC073553: 153760..153827, RP23-270B12, strain C57BL/6J ; AJ851868: 1229276..1229343, strain 129/Sv), but not in cDNA. This exon was not identified in Rattus norvegicus (Norway rat) genomic sequence (31/10/06, F. Bellahcene and M.-P. Lefranc).
  15. (15) Partial C-GENE: partial CH4 in 3'.
  16. (16) Partial C-GENE: partial CH1 in 5'.
  17. (17) Contig.
  18. (18) Contig: from 1 to 2293 bp [43] and from 2290-2472 [44].
  19. (19) Contig: from 1 to 1921 bp [1] and from 113-1931 [39].
  20. (20) The CH2 codon 50 amino acid difference with the MOPC511 protein sequence was noted by the authors [10]. However, it is not excluded, from the allele alignment, that the ct nucleotide inversion in J00475 may result from a sequencing error.
  21. (21) It is possible, from the allele alignment, that the CH3 codon 91 gt nucleotide inversion in J00479 may result from a sequencing error.
  22. (22) V00793 is a secondary accession number of J00453, however it differs from J00453, the Mus musculus IGHG1*01 reference sequence by one nucleotide difference (CH1 g250.2>c, E84.2>Q) which is an assembly sequencing error.
IMGT references:
  1. [1] Honjo T. et al., Cell, 18, 559-568 (1979). PMID: 115593
  2. [2] Tucker P.W. et al., Science, 206, 1303-1306 (1979). PMID: 117549
  3. [3] Bernard O. and Gough N.M., Proc. Natl. Acad. Sci. U.S.A, 77, 3630-3634 (1980). PMID: 6251474
  4. [4] Early P. et al., Cell, 20, 313-319 (1980). PMID: 6771020
  5. [5] Kawakami T. et al., Nucleic Acids Res., 8, 3933-3945 (1980). PMID: 6255422
  6. [6] Tucker P.W. et al., Science, 209, 1353-1360 (1980). PMID: 6968091
  7. [7] Yamawaki-Kataoka Y. et al., Nature, 283, 786-789 (1980). PMID: 6766534
  8. [8] Kim S. et al., Cell, 27, 573-581 (1981). PMID: 6101208
  9. [9] Ollo R. et al., Proc. Natl. Acad. Sci. U.S.A., 78, 2442-2446 (1981). PMID: 6787604
  10. [10] Tucker P.W. et al., Proc. Natl. Acad. Sci. U.S.A., 78, 7684-7688 (1981). PMID: 6801659
  11. [11] Yamawaki-Kataoka Y. et al., Nucleic Acids Res., 9, 1365-1381 (1981). PMID: 6262729
  12. [12] Cheng H.L. et al., Nature, 296, 410-415 (1982). PMID: 6801528
  13. [13] Ishida N. et al., EMBO J., 1, 1117-1123 (1982). PMID: 6329728
  14. [14] Liu F.T. et al., Proc. Natl. Acad. Sci. U.S.A., 79, 7852-7856 (1982). PMID: 6818553
  15. [15] Shimizu A. et al., Nature, 298, 82-84 (1982). PMID: 6283372
  16. [16] Tyler B.M. et al., Proc. Natl. Acad. Sci. U.S.A., 79, 2008-2012 (1982). PMID: 6804950
  17. [17] Yamawaki-Kataoka Y. et al., Proc. Natl. Acad. Sci. U.S.A., 79, 2623-2627 (1982). PMID: 6283537
  18. [18] Komaromy M. et al., Nucleic Acids Res., 11, 6775-6785 (1983). PMID: 6314258
  19. [19] Ollo R. and Rougeon F., Cell, 32, 515-523 (1983). PMID: 6297797
  20. [20] Richards J.E. et al., Nature, 306, 483-487 (1983). PMID: 6417547
  21. [21] Word C.J. et al., EMBO J., 2, 887-898 (1983). PMID: 6416835
  22. [22] Fukui K. et al., J. Mol. Cell. Immunol., 1, 321-330 (1984). PMID: 6336561
  23. [23] Gilliam A.C. et al., Proc. Natl. Acad. Sci. U.S.A., 81, 4164-4168 (1984). PMID: 6429663
  24. [24] Wels J.A. et al., EMBO J., 3, 2041-2046 (1984). PMID: 6092053
  25. [25] Shinkai Y. et al., Immunogenetics, 27, 288-292 (1988). PMID: 3346043
  26. [26] Hellman L. et al., Gene, 68, 93-100 (1988). PMID: 3146527
  27. [27] Jouvin-Marche E. et al., Immunogenetics, 29, 92-97 (1989). PMID: 2563358
  28. [28] Morgado M.G. et al., EMBO J., 8, 3245-3251 (1989). PMID: 2510996
  29. [29] Lebman D.A. et al., Proc. Natl. Acad. Sci. U.S.A., 87, 3962-3966 (1990). PMID: 2339132
  30. [30] Owens J.D. et al., Mol. Cell. Biol., 11, 5660-5670 (1991). PMID: 1922069
  31. [31] Arakawa H. et al., J. Biol. Chem., 268, 4651-4655 (1993). PMID: 8444838
  32. [32] Janz S. and Roschke V.V., Immunogenetics, 43, 101-104 (1996). PMID: 8537111
  33. [33] Akahori Y. and Kurosawa Y., Genomics., 41, 100-104 (1997). PMID: 9126488
  34. [34] Anand S. et al., Mol. Immunol., 34, 175-183 (1997). PMID: 9188850
  35. [35] Martin R.M. et al., Immunogenetics, 46, 167-168 (1997). PMID: 9162106
  36. [36] Owens J.D. et al., Unpublished (1991).
  37. [37] van Kuik-Romeijn P. et al., Unpublished (1999).
  38. [38] Phillips-Quagliata J.M, Unpublished (2001).
  39. [39] Ollo R. and Rougeon F., Nature, 296, 761-763 (1982). PMID: 6803173
  40. [40] Sikorav J.L. et al., Nucleic Acids Res., 8, 3143-3155 (1980). PMID: 6777755
  41. [41] Rogers J. et al., Cell, 26, 19-27 (1981). PMID: 6799207
  42. [42] Stanton L.W. and Marcu K.B., Nucleic Acids Res., 10, 5993-6006 (1982). PMID: 6292864
  43. [43] Goldberg G.I. et al., Gene, 15, 33-42 (1981). PMID: 6795090
  44. [44] Nikaido T. et al., J. Biol. Chem., 257, 7322-7329 (1982). PMID: 6282840
See also (IMGT Scientific chart):