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"+" or "-" indicates if the gene sequences have been found (+) or not been found (-) rearranged (R), transcribed (T) and/or translated into protein (Pr). Arbitrarily that information is shown on the first line of each gene when the data have been confirmed by several studies.

Functionality is shown between parentheses, (F) and (P), when the accession number refers to rearranged genomic DNA or cDNA and the corresponding germline gene has not yet been isolated.
Functionality is shown between brackets, [F] and [P], when the accession number refers to genomic DNA, but not known as being germline or rearranged.

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IMGT subgroup IMGT gene name IMGT allele name Fct Chromosomal localization R T Pr Positions in the locus IMGT/LIGM-DB reference sequences IMGT/LIGM-DB sequences from the literature
Clone names Accession numbers Positions in the sequence (L-V-GENE-UNIT) Secondary accession numbers Clone names Accession numbers Positions in the sequence (L-V-GENE-UNIT)
IGHV1 IGHV1-1 (1) IGHV1-1*01 P (2) 851A09 AB513624 [1] 90845-91327 747A01 AB513625 [1] 2341-2823
IGHV1-2 IGHV1-2*01 F 851A09 AB513624 [1] 76020-76509
IGHV1-3 IGHV1-3*01 P (3) 851A09 AB513624 [1]
IGHV1-4 IGHV1-4*01 F 851A09 AB513624 [1] 66808-67288
IGHV1-4*02 F 7q26 AF064686 [1]
IGHV1-5 IGHV1-5*01 F 851A09 AB513624 [1] 60198-60684
IGHV1-6 IGHV1-6*01 F 851A09 AB513624 [1] 48526-49013
IGHV1-6*02 F 7q26 VH2, VHB, VHB2 AF064687 [1] [3] 63-550
IGHV1-7 IGHV1-7*01 P (3) 851A09 AB513624 [1]
IGHV1-8 IGHV1-8*01 F 851A09 AB513624 [1] 42141-42628
IGHV1-9 IGHV1-9*01 P (3) 851A09 AB513624 [1]
IGHV1-10 IGHV1-10*01 F 851A09 AB513624 [1] 34235-34715
IGHV1-11 IGHV1-11*01 F 851A09 AB513624 [1] 27618-28104
IGHV1-12 IGHV1-12*01 F 851A09 AB513624 [1] 15678-16165
IGHV1-13 IGHV1-13*01 P (3) 851A09 AB513624 [1]
IGHV1-14 IGHV1-14*01 F 851A09 AB513624 [1] 9306-9786
IGHV1-15 IGHV1-15*01 F 851A09 AB513624 [1] 3032-3512
IGHV1S2 IGHV1S2*01 F 7q26 VHC AF064688 [2] 63-545
IGHV1S3 IGHV1S3*01 P (4) 7q26 VHI AF064691 [2] 63-548
IGHV1S5 IGHV1S5*01 F 7q26 VHE AF064689 [2] 63-550
IGHV1S6 IGHV1S6*01 F 7q26 VHF AF064690 [2] 63-550
IGHV1S7 IGHV1S7*01 P (5) 7q26 VHK AF064692 [2] 63-550
IGHV1S8 IGHV1S8*01 P (5) VHH DQ886392 [4] 32-519
IMGT notes:
  1. (1) IGHV1-1 is the most 3' IGHV in the locus. It is located 15 kb upstream of the IGHD genes [1, 2].
  2. (2) STOP-CODONs and frameshifts in V-REGION
  3. (3) no L-PART1, STOP-CODONs and frameshift in V-REGION
  4. (4) frameshift in FR3-IMGT, INSERTION of 4 nucleotides (aaca at positions 440-443) and INSERTION of 1 nucleotide (a at position 492) in the FR3-IMGT.
  5. (5) in frame STOP-CODON in L-PART1, INIT-CODON is replaced by Leu
IMGT references:
  1. [1] Eguchi-Ogawa T et al., J. Immunol, 184(7), 3734-3742 (2010). PMID: 20207992
  2. [2] Sun J. et al., J. Immunol, 161, 5070-5078 (1998). PMID: 9794445
  3. [3] Sun J. and Butler J.E., Immunology, 88, 331-339 (1996). PMID: 8774347
  4. [4] Butler J.E. et al., J. Immunol, 177(8), 5459-5470 (2006). PMID: 17015732
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