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"+" or "-" indicates if the gene sequences have been found (+) or not been found (-) transcribed (T) and/or translated into protein (Pr). Arbitrarily that information is shown on the first line of each gene when the data have been confirmed by several studies.

Functionality is shown between parentheses, (F) and (P), when the accession number refers to rearranged genomic DNA or cDNA and the corresponding germline gene has not yet been isolated.
Functionality is shown between brackets, [F] and [P], when the accession number refers to genomic DNA, but not known as being germline or rearranged.

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IMGT gene name IMGT allele name Fct Haplotypes T Pr Positions in the locus IMGT/LIGM-DB reference sequences IMGT/LIGM-DB sequences from the literature
Isolate Clone names Exons Accession numbers Positions in the sequence Secondary accession numbers Isolate Clone names Accession numbers Positions in the sequence
IGHA1 IGHA1*01 (F) + Glennie CH1 AY055778 [2] c(s)
H+CH2 (1) AY055778 [2] c(s)
CH3 AY055778 [2] c(s)
M
IGHA1*02 P (2) Glennie CH1 NW_001777603 [1]
H+CH2 (1) NW_001777603 [1]
CH3(including CHS) NW_001777603 [1]
M
IGHA2 IGHA2*01 F Glennie CH1 NW_001794226 [1]
H+CH2 (1) NW_001794226 [1]
CH3(including CHS) NW_001794226 [1]
M NW_001794226 [1]
IGHA2*02 (F) + Glennie CH1 AY055779 [2] c(s)
H+CH2 (1) AY055779 [2] c(s)
CH3(including CHS) AY055779 [2] c(s)
M
IGHD IGHD*01 F Glennie CH1 NW_001794226 [1]
H1 NW_001794226 [1]
H2 NW_001794226 [1]
CH2 NW_001794226 [1]
CH3 NW_001794226 [1]
CH4 NW_001794226 [1]
CH5 NW_001794226 [1]
CH6 NW_001794226 [1]
CH7 NW_001794226 [1]
CH8 NW_001794226 [1]
CH9 NW_001794226 [1]
CH10 NW_001794226 [1]
CHS NW_001794226 [1]
M1 NW_001794226 [1]
M2 NW_001794226 [1]
IGHD*02 (F) + CH1 EU503149 [3] (4) c
H EU503149 [3] (4) c
CH2 EU503149 [3] (4) c
CH3 EU503149 [3] (4) c
CH4 EU503149 [3] (4) c
CH5 EU503149 [3] (4) c
CH6 EU503149 [3] (4) c
CH7 EU503149 [3] (4) c
CH8 EU503149 [3] (4) c
CH9 EU503149 [3] (4) c
CH10 EU503149 [3] (4) c
M1 EU503149 [3] (4) c
M2
IGHE IGHE*01 F Glennie CH1 NW_001794226 [1]
CH2 NW_001794226 [1]
CH3 NW_001794226 [1]
CH4(including CHS) NW_001794226 [1]
M1 NW_001794226 [1]
M2 NW_001794226 [1]
IGHE*02 (F) + Glennie CH1 AY055780 [2] c(s)
CH2 AY055780 [2] c(s)
CH3 AY055780 [2] c(s)
CH4(including CHS) AY055780 [2] c(s)
M1
M2
IGHG1 IGHG1*01 F Glennie CH1 NW_001794226 [1]
H NW_001794226 [1]
CH2 NW_001794226 [1]
CH3(including CHS) NW_001794226 [1]
M1 NW_001794226 [1]
M2 NW_001794226 [1]
IGHG1*02 (F) CH1 AY055781 [2] (s)
H AY055781 [2] (s)
CH2 AY055781 [2] (s)
CH3(including CHS) AY055781 [2] (s)
M1
M2
IGHG2 IGHG2*01 F + Glennie CH1 NW_001705893 [1] AY055782 [2] c(s)
H NW_001705893 [1] AY055782 [2] c(s)
CH2 NW_001705893 [1] AY055782 [2] c(s)
CH3(including CHS) NW_001705893 [1] AY055782 [2] c(s)
M1
M2
IGHM IGHM*01 F + Glennie CH1 NW_001794226 [1] AY168639 [4] c(s)
CH2 NW_001794226 [1] AY168639 [4] c(s)
CH3 NW_001794226 [1] AY168639 [4] c(s)
CH4(including CHS) NW_001794226 [1] AY168639 [4] c(s)
M1 NW_001794226 [1]
M2 NW_001794226 [1]
IGHO IGHO*01 F Glennie CH1 NW_001794226 [1] (3)
H+CH2 (1) NW_001794226 [1] (3)
CH3 NW_001794226 [1] (3)
CH4(including CHS) NW_001794226 [1] (3)
M1 NW_001794226 [1] (3)
M2 NW_001794226 [1] (3)
IGHO*02 (F) + CH1 EU503150 [3] (3) c
H+CH2 (1) EU503150 [3] (3) c
CH3 EU503150 [3] (3) c
CH4(including CHS) EU503150 [3] (3) c
M1
M2

c: cDNA sequence.
(s): Transcript of a secreted chain.

IMGT notes:
  1. (1) The hinge (H) and the CH2 are joined in a single exon.
  2. (2) Frameshift in CH1
  3. (3) The determination of CH2 is arbitrarily based on the 5' delimitation of IGHE CH2. Partial CH4 in 3'
  4. (4) Partial M1 in 3'
IMGT references:
  1. [1] Warren,W.C. et al., Nature. 453(7192):175-183 (2008).
  2. [2] Vernersson M, et al., Eur. J. Immunol. 32(8):2145-2155 (2002). PMID: 12209626
  3. [3] Zhao Y. et al., J. Immunol. 183(5):3285-3293(2009). PMID: 19675164
  4. [4] Belov,K and all (2010).
See also (IMGT Scientific chart):