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"+" or "-" indicates if the gene sequences have been found (+) or not been found (-) transcribed (T) and/or translated into protein (Pr). Arbitrarily that information is shown on the first line of each gene when the data have been confirmed by several studies.

Functionality is shown between parentheses, (F) and (P), when the accession number refers to rearranged genomic DNA or cDNA and the corresponding germline gene has not yet been isolated.
Functionality is shown between brackets, [F] and [P], when the accession number refers to genomic DNA, but not known as being germline or rearranged.

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IMGT gene name IMGT allele name Fct T Pr Positions in the locus IMGT/LIGM-DB reference sequences IMGT/LIGM-DB sequences from the literature
Isolate Clone names Exons Accession numbers Positions in the sequence (exons) Secondary accession numbers Isolate Clone names Accession numbers Positions in the sequence (exons)
IGHT1 IGHT1*01 P (1) Swanson CM007947.1 CH1 IMGT000043 217956..218254
CH2 IMGT000043 218444..218728
CH3 IMGT000043 218858..219175
CH4 (including CHS) IMGT000043 219512..219850
M1 IMGT000043 220645..220799
M2 IMGT000043 220958..220966
IGHT1D*01 P (2) Swanson CM007946.1 CH1 IMGT000044 377341..377640
CH2 IMGT000044 377842..378126
CH3 IMGT000044 378251..378556
CH4 (including CHS) IMGT000044 378879..379213
M1 IMGT000044 380028..380182
M2 IMGT000044 380663..380671
IGHT2 IGHT2*01 F Swanson CM007947.1 CH1 IMGT000043 272195..272494
CH2 IMGT000043 272701..272985
CH3 IMGT000043 273110..273427
CH4 (including CHS) IMGT000043 273749..274086
M1 IMGT000043 274890..275044
M2 IMGT000043 275413..275421
IGHT2*02 F + IGHT CH1 AY872256 [1] 32066..32365
CH2 AY872256 [1] 32572..32856
CH3 AY872256 [1] 32981..33302
CH4 (including CHS) AY872256 [1] 33620..33957
M1 AY872256 [1] 34749..34903
M2 AY872256 [1] 35243..35251
IGHM IGHM*01 F Swanson CM007947.1 CH1 IMGT000043 93022-93318
CH2 IMGT000043 94474-94815
CH3 IMGT000043 95119-95418
CH4 IMGT000043 95827-96227
M1 IMGT000043 98574-98710
M2 IMGT000043 99573-99578
IGHM*02 F + IGHM1 CH1 AY872256 [1] 93021..93318
CH2 AY872256 [1] 94474..94815
CH3 AY872256 [1] 95116..95418
CH4 AY872256 [1] 95827..96227
M1 AY872256 [1] 98574..98710
M2 AY872256 [1] 99573..99578
IGHM*03 (F) lambda RT15, IGHM1 CH1 X65262 [2] (3) #c(s) 382..519
X65261 [2] (4) #c(s) 1..162
CH2 X65261 [2] #c(s) 163..504
CH3 X65261 [2] (5) #c(s) 505..804
CH4 (including CHS) X65261 [2] (5) #c(s) 805..1206
lambda RTtm, IGHM1 M1 X65263 [2] (5) #c(m) 356..493
M2 X65263 [2] #c(m) 494..499
IGHM*04 (F) cRTVH50, IGHM1 CH1 S63348 [3] #c(s) 403..699
CH2 S63348 [3] #c(s) 700..1041
CH3 S63348 [3] #c(s) 1042..1341
CH4 (including CHS) S63348 [3] (5) #c(s) 1342..1743
IGHM*05 (F) RBTIGTM2, IGHM1 CH1 U04615 [4] #c(m) 403..699
CH2 U04615 [4] #c(m) 700..1041
CH3 U04615 [4] (5) #c(m) 1042..1344
M1 U04615 [4] (5) #c(m) 1345..1482
M2 U04615 [4] #c(m) 1483..1488
IGHM*06 (F) RBTIGTM1, IGHM1 CH1 U04616 [4] #c(m) 406..702
CH2 U04616 [4] #c(m) 703..1044
CH3 U04616 [4] (5) #c(m) 1045..1347
M1 U04616 [4] (5) #c(m) 1348..1485
M2 U04616 [4] #c(m) 1486..1491
IGHMD IGHMD*01 F Swanson CM007946.1 CH1 IMGT000044 93022-93318
CH2 IMGT000044 94474-94815
CH3 IMGT000044 95119-95418
CH4 (including CHS) IMGT000044 95827-96227
M1 IMGT000044 98574-98710
M2 IMGT000044 99573-99578
IGHMD*02 F gRTIgM, IGHM2 CH1 X83372 [5] (4) 1..271
CH2 X83372 [5] 1429..1770
CH3 X83372 [5] 2074..2373
CH4 (including CHS) X83372 [5] (6) 2785..3071
IGHD IGHD*01 p (7) CH1 AY872256 [1] 100661..100999
CH2 AY872256 [1] 101125..101424
CH3 AY872256 [1] 104153..104467
CH4 AY872256 [1] 104627..104920
CH2D AY872256 [1] 105057..105356
P (7) CH3D AY872257 [1] 844..1158
CH4D AY872257 [1] 1318..1611
CH2D2 AY872257 [1] 1748..2047
CH7 (including CHS) AY872257 [1] 6737..7024
M1 AY872257 [1] 7191..7342
M2 AY872257 [1] 7739..7744

#c: rearranged cDNA.
(s) Trancript of a secreted chain.
(m) Trancript of a membrane chain.

IMGT notes:
  1. (1) Frameshift in CH1 and CH4-CHS
  2. (2) Frameshift in CH3
  3. (3) partial C-REGION: CH1 partial in 3'
  4. (4) partial C-REGION: CH1 partial in 5'
  5. (5) Functional but CH3 is spliced to CH4 in secretory mu cDNA, whereas it is spliced to the M1 exon in membrane mu cDNA (see [2]).
  6. (6) partial C-REGION: CH4 partial in 3'
  7. (7) Deletion of several exon, frameshift in CH7-CHS
IMGT references:
  1. [1] Hansen J.D. et al., Proc. Natl. Acad. Sci. U.S.A., 102, 6919-6924 (2005). PMID: 15863615
  2. [2] Lee M.A. et al., Mol. Immunol., 30, 641-648 (1993). PMID: 8487781
  3. [3] Andersson E. and Matsunaga T., Immunogenetics, 38, 243-250 (1993). PMID: 8319974
  4. [4] Hansen J. et al., Mol. Immunol., 31, 499-501 (1994). PMID: 8183286
  5. [5] Andersson E. et al., Immunogenetics, 41, 312-315 (1995). PMID: 7721353
Created:
10/10/2019
Last updated:
14/10/2020
Authors:
Saida Hadi-Saljoqi