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"+" or "-" indicates if the gene sequences have been found (+) or not been found (-) transcribed (T) and/or translated into protein (Pr). Arbitrarily that information is shown on the first line of each gene when the data have been confirmed by several studies.

Functionality is shown between parentheses, (F) and (P), when the accession number refers to rearranged genomic DNA or cDNA and the corresponding germline gene has not yet been isolated.
Functionality is shown between brackets, [F] and [P], when the accession number refers to genomic DNA, but not known as being germline or rearranged.

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Positions in the sequence: limits from the first nucleotide of C-REGION to the last nucleotide.

IMGT gene name IMGT allele name Fct T Pr Positions in the locus IMGT/LIGM-DB reference sequences IMGT/LIGM-DB sequences from the literature
Strain Clone names Exons Accession numbers Positions in the sequence (exons) Secondary accession numbers Strain Clone names Accession numbers Positions in the sequence (exons)
IGHD IGHD*01 P (1) CH1 BX510335 [1] 31804-32085
CH2 BX510335 [1] 32199-32528
CH3 BX510335 [1] 32557-32868
CH4 BX510335 [1] 32986-33276
CH2D BX510335 [1] 34046-34336
CH3D BX510335 [1] 34428-34739
CH4D BX510335 [1] 34857-35147
CH2D2 BX510335 [1] 35972-36262
CH3D2 BX510335 [1] 36355-36666
CH4D2 BX510335 [1] 36784-37074
CH2D3 BX510335 [1] 37891-38181
CH3D3 BX510335 [1] 38273-38584
CH4D3 BX510335 [1] 38702-38992
CH5 BX510335 [1] 39101-39415
CH6 BX510335 [1] 39490-39804
CH7 BX510335 [1] 42949-43236
M BX510335 [1] 43318-43478
IGHM IGHM*01 F CH1 BX510335 [1] 25626-25934
CH2 BX510335 [1] 26367-26687
CH3 BX510335 [1] 26783-27094
CH4 BX510335 [1] 27266-27636
M1 BX510335 [1] 28583-28719
M2 BX510335 [1] 30003-30008
IGHM*02 (F) + + CH1 AF281480 [2] #c(s) 334-642
CH2 AF281480 [2] #c(s) 643-963
CH3 AF281480 [2] (2) #c(s) 964-1275 AF281479 [2] (3) #c(m)
CH4 AF281480 [2] (2) #c(s) 1276-1647
M1 AF281479 [2] (2) #c(m) 283-420
M2 AF281479 [2] #c(m) 421-426
IGHM*03 (F) + + CH1 AF406819 [3] #c(s) 433-741
CH2 AF406819 [3] #c(s) 742-1062
CH3 AF406819 [3] (2) #c(s) 1063-1374
CH4 AF406819 [3] (2) #c(s) 1375-1746
IGHZ IGHZ*01 F CH1 BX649502 [1] 241017-241295
CH2 BX649502 [1] 241436-241711
CH3 BX649502 [1] 241830-242132
CH4 BX649502 [1] 242347-242672
M1 BX649502 [1] 243646-243800
M2 BX649502 [1] 243959-243967

#c: rearranged cDNA.
(s) Trancript of a secreted chain.
(m) Trancript of a membrane chain.

IMGT notes:
  1. (1) Pseudogene because frameshifts in CH2
  2. (2) Functional but CH3 is spliced to CH4 in secretory mu cDNA, whereas it is spliced to the M1 exon in membrane mu cDNA (see [2])
  3. (3) Functional but the C-REGION is partial in 5': CH3 is partial
IMGT references:
  1. [1] Danilova N. et al., Nat Immunol., 6, 295-302 (2005). PMID: 15685175
  2. [2] Danilova N. and Steiner L.A., Unpublished (2001).
  3. [3] Liu F. and Wen Z., Unpublished (2001).
See also (IMGT Scientific chart):