Here you are: IMGT Web resources > IMGT Repertoire (IG and TR) > 1. Locus and genes

"+" or "-" indicates if the gene sequences have been found (+) or not been found (-) rearranged (R), transcribed (T) and/or translated into protein (Pr). Arbitrarily that information is shown on the first line of each gene when the data have been confirmed by several studies.

Functionality is shown between parentheses, (F) and (P), when the accession number refers to rearranged genomic DNA or cDNA and the corresponding germline gene has not yet been isolated.
Functionality is shown between brackets, [F] and [P], when the accession number refers to genomic DNA, but not known as being germline or rearranged.

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Positions in the sequence: limits from the first nucleotide of V-REGION to the last nucleotide.

genes find on cDNA and not assigned to germline are shown only in the pages Protein display and Alignments of alleles

IMGT subgroup IMGT gene name IMGT allele name Fct R T Pr Positions in the locus IMGT/LIGM-DB reference sequences IMGT/LIGM-DB sequences from the literature
Strain Clone names Accession numbers Positions in the sequence
(L-V-GENE-UNIT)
Secondary accession numbers Strain Clone names Accession numbers Positions in the sequence (V-REGION)
IGHV1 IGHV1-1 IGHV1-1*01 F DKEY-204F11 BX649502 [1] (9) 178660..179121
IGHV1-2 IGHV1-2*01 F DKEY-204F11 BX649502 [1] 184733..185195
IGHV1-3 IGHV1-3*01 F DKEY-204F11 BX649502 [1] 209885..210361
IGHV1-4 IGHV1-4*01 F DKEY-204F11 BX649502 [1] 216703..217164
IGHV1-5 IGHV1-5*01 F VHE1 AF273897 [2] (1)(9) 1-940
IGHV2 IGHV2-1 IGHV2-1*01 F DKEY-204F11 BX649502 [1] 176919..177418
IGHV2-2 IGHV2-2*01 F DKEY-204F11 BX649502 [1] 183066..183549
IGHV2-3 IGHV2-3*01 F DKEY-204F11 BX649502 [1] 207844..208358
IGHV3 IGHV3-1 IGHV3-1*01 P DKEY-204F11 BX649502 [1] (3,10) 173255..175871
IGHV3-2 IGHV3-2*01 F DKEY-204F11 BX649502 [1] 206760..207241
IGHV3-3 IGHV3-3*01 P DKEY-204F11 BX649502 [1] (4,10) 202651..203934
IGHV4 IGHV4-1 IGHV4-1*01 F DKEY-204F11 BX649502 [1] 122893..123380
IGHV4-2 IGHV4-2*01 F DKEY-204F11 BX649502 [1] 124941..125408
IGHV4-3 IGHV4-3*01 F DKEY-204F11 BX649502 [1] 131137..131621
IGHV4-4 IGHV4-4*01 P DKEY-204F11 BX649502 [1] (5) 135414..135861
IGHV4-5 IGHV4-5*01 F DKEY-204F11 BX649502 [1] 141792..142306
IGHV4-6 IGHV4-6*01 F DKEY-204F11 BX649502 [1] 145905..146360
IGHV4-7 IGHV4-7*01 F DKEY-204F11 BX649502 [1] 148323..148836
IGHV4-8 IGHV4-8*01 F DKEY-204F11 BX649502 [1] 151401..151870
IGHV4-9 IGHV4-9*01 F DKEY-204F11 BX649502 [1] 153486..153957
IGHV5 IGHV5-1 IGHV5-1*01 F DKEY-204F11 BX649502 [1] 132308..132772
IGHV5-2 IGHV5-2*01 ORF DKEY-204F11 BX649502 [1] (6) 136718..137187
IGHV5-3 IGHV5-3*01 F DKEY-204F11 BX649502 [1] 140061..140559
IGHV5-4 IGHV5-4*01 ORF DKEY-204F11 BX649502 [1] (6) 143572..144056
IGHV5-5 IGHV5-5*01 ORF DKEY-204F11 BX649502 [1] (6) 149478..149966
IGHV5-6 IGHV5-6*01 P DKEY-204F11 BX649502 [1] (4) 152296..152777
IGHV5-7 IGHV5-7*01 F DKEY-204F11 BX649502 [1] 156496..156959
IGHV5-8 IGHV5-8*01 ORF DKEY-204F11 BX649502 [1] (6) 157770..158248
IGHV6 IGHV6-1 IGHV6-1*01 F DKEY-204F11 BX649502 [1] 138079..138546
IGHV6-2 IGHV6-2*01 ORF DKEY-204F11 BX649502 [1] (6) 162740..163245
IGHV7 IGHV7-1 IGHV7-1*01 F DKEY-204F11 BX649502 [1] 161972..162439
IGHV8 IGHV8-1 IGHV8-1*01 F DKEY-204F11 BX649502 [1] 163973..164529
IGHV8-2 IGHV8-2*01 F DKEY-204F11 BX649502 [1] 166333..166806
IGHV8-3 IGHV8-3*01 F DKEY-204F11 BX649502 [1] 168328..168796
IGHV8-4 IGHV8-4*01 F DKEY-204F11 BX649502 [1] 198716..199188
IGHV9 IGHV9-1 IGHV9-1*01 F DKEY-204F11 BX649502 [1] 169142..169652
IGHV9-2 IGHV9-2*01 F DKEY-204F11 BX649502 [1] 172231..172705
IGHV9-3 IGHV9-3*01 F DKEY-204F11 BX649502 [1] 199537..200065
IGHV9-4 IGHV9-4*01 F DKEY-204F11 BX649502 [1] 201715..202191
IGHV10 IGHV10-1 IGHV10-1*01 F DKEY-204F11 BX649502 [1] 171387..171859
IGHV10-2 IGHV10-2*01 P DKEY-204F11 BX649502 [1] (4) 200898..201337
IGHV11 IGHV11-1 IGHV11-1*01 F DKEY-204F11 BX649502 [1] 185897..186423
IGHV11-2 IGHV11-2*01 F DKEY-204F11 BX649502 [1] 204281..204770
IGHV12 IGHV12-1 IGHV12-1*01 P DKEY-204F11 BX649502 [1] (7) 190126..190613
IGHV12-2 IGHV12-2*01 P DKEY-204F11 BX649502 [1] (4) 215166..215653
IGHV13 IGHV13-1 IGHV13-1*01 P DKEY-204F11 BX649502 [1] (8,10) 190869..195154
IGHV13-2 IGHV13-2*01 F DKEY-204F11 BX649502 [1] 206760..207241
IGHV14 IGHV14-1 IGHV14-1*01 F DKEY-204F11 BX649502 [1] 211628..212112

#c: rearranged cDNA.

IMGT notes:
  1. (1) The gene IGHV1-5 was previously designated IGHV1S1
  2. (2) Not entered in IMGT/GENE-DB and IMGT/V-QUEST because cDNA and partial V-REGION: AA 1 to 4 are missing (partial FR1-IMGT) and FR3-IMGT partial in 3'.
  3. (3) Pseudogene because of putatives limites for FR3-IMGT and V-RS
  4. (4) Pseudogene because of frameshift in V-REGION, and no INIT-CODON in L-PART1
  5. (5) Pseudogene because of frameshift in V-REGION
  6. (6) ORF because AA 41 is a Phenylalanine (PHE) instead of the CONSERVED-TRP expected
  7. (7) Pseudogene because of STOP-CODON in V-REGION
  8. (8) Pseudogene because of putatives limites for FR3-IMGT, no 2nd-CYS and CDR3-IMGT and V-RS are not define
  9. (9) With 98.299% identity with IGHV1-1*01 (BX649502), it was suggested that the isolated IGHV1-5*01 sequence (AF273897) might represent an allele of IGHV1-1, however the localization in the locus being unknown the assignment remains uncertain and the IGHV1-5*01 name remains unmodified.
  10. (10) V-REGION positions.
IMGT references:
  1. [1] Danilova N. et al., Nat. Immunol., 6, 295-302 (2005). PMID: 15685175
  2. [2] Danilova N. et al., Immunogenetics, 53, 82-5 (2000). PMID: 11132160
Created:
28/02/2010
Last updated:
01/02/2018
Authors:
Amandine Lacan
Editor:
Chantal Ginestoux