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"+" or "-" indicates if the gene sequences have been found (+) or not been found (-) rearranged (R), transcribed (T) and/or translated into protein (Pr). Arbitrarily that information is shown on the first line of each gene when the data have been confirmed by several studies.

Functionality is shown between parentheses, (F) and (P), when the accession number refers to rearranged genomic DNA or cDNA and the corresponding germline gene has not yet been isolated.
Functionality is shown between brackets, [F] and [P], when the accession number refers to genomic DNA, but not known as being germline or rearranged.

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All the Arabian camel (Camelus dromedarius) IGHV genes belong to a single subgroup IGHV1. This subgroup corresponds to the human IGHV3 subgroup (1).

IMGT subgroup IMGT gene name IMGT allele name Fct R T Pr Positions in the locus IMGT/LIGM-DB reference sequences IMGT/LIGM-DB sequences from the literature
Strain Clone names Accession numbers Positions in the sequence Secondary accession numbers Strain Clone names Accession numbers Positions in the sequence
IGHV1 IGHV1S1 IGHV1S1*01 F cvh1 AF000603 [1]
IGHV1S1*02 [F] cvhp01 AJ245149 [2] (2,3) °
IGHV1S1*03 [F] cvhp13 AJ245161 [2] (2,3) °
IGHV1S1*04 [F] cvhp15 AJ245163 [2] (2,3) °
IGHV1S2 IGHV1S2*01 [F] cvhp03 AJ245151 [2] (2,3) °
IGHV1S3 IGHV1S3*01 [F] cvhp04 AJ245152 [2] (2,3) °
IGHV1S4 IGHV1S4*01 [F] cvhp05 AJ245153 [2] (2,3) °
IGHV1S5 IGHV1S5*01 [F] cvhp06 AJ245154 [2] (2,3) °
IGHV1S6 IGHV1S6*01 [F] cvhp07 AJ245155 [2] (2,3) °
IGHV1S7 IGHV1S7*01 [F] cvhp09 AJ245157 [2] (2,3) °
IGHV1S8 IGHV1S8*01 [F] cvhp10 AJ245158 [2] (2,3) °
IGHV1S9 IGHV1S9*01 [F] cvhp11 AJ245159 [2] (2,3) °
IGHV1S10 IGHV1S10*01 [F] cvhp12 AJ245160 [2] (2,3) °
IGHV1S11 IGHV1S11*01 [F] cvhp16 AJ245164 [2] (2,3) °
IGHV1S12 IGHV1S12*01 [F] cvhp17 AJ245165 [2] (2,3) °
IGHV1S12*02 [F] cvhp18 AJ245166 [2] (2,3) °
IGHV1S13 IGHV1S13*01 [F] cvhp19 AJ245167 [2] (2,3) °
IGHV1S14 IGHV1S14*01 [F] cvhp20 AJ245168 [2] (2,3) °
IGHV1S15 IGHV1S15*01 [F] cvhp22 AJ245170 [2] (2,3) °
IGHV1S16 IGHV1S16*01 [F] cvhp23 AJ245171 [2] (2,3) °
IGHV1S17 IGHV1S17*01 [F] cvhp25 AJ245173 [2] (2,3) °
IGHV1S18 IGHV1S18*01 [F] cvhp26 AJ245174 [2] (2,3) °
IGHV1S19 IGHV1S19*01 [F] cvhp08 AJ245156 [2] (2,3) °
IGHV1S20 IGHV1S20*01 [F] cvhp29 AJ245177 [2] (2,3) °
IGHV1S21 IGHV1S21*01 [F] cvhp30 AJ245178 [2] (2,3) °
IGHV1S22 IGHV1S22*01 [F] cvhp35 AJ245183 [2] (2,3) °
IGHV1S23 IGHV1S23*01 [F] cvhp37 AJ245185 [2] (2,3) °
IGHV1S24 IGHV1S24*01 [F] cvhp38 AJ245186 [2] (2,3) °
IGHV1S25 IGHV1S25*01 [F] cvhp39 AJ245187 [2] (2,3) °
IGHV1S26 IGHV1S26*01 [F] cvhp41 AJ245189 [2] (2,3) °
IGHV1S27 IGHV1S27*01 [F] cvhp43 AJ245191 [2] (2,3) °
IGHV1S28 IGHV1S28*01 [F] cvhp44 AJ245192 [2] (2,3) °
IGHV1S29 IGHV1S29*01 [F] cvhp45 AJ245193 [2] (2,3) °
IGHV1S30 IGHV1S30*01 [F] cvhp46 AJ245194 [2] (2,3) °
IGHV1S31 IGHV1S31*01 [F] cvhp47 AJ245195 [2] (2,3) °
IGHV1S32 IGHV1S32*01 [F] cvhp31 AJ245179 [2] (2,3) °
IGHV1S33 IGHV1S33*01 [F] cvhp32 AJ245180 [2] (2,3) °
IGHV1S34 IGHV1S34*01 [F] cvhp34 AJ245182 [2] (2,3) °
IGHV1S35 IGHV1S35*01 [F] cvhp42 AJ245190 [2] (2,3) °
IGHV1S36 IGHV1S36*01 [F] cvhp48 AJ245196 [2] (2,3) °
IGHV1S37 IGHV1S37*01 [F] cvhp49 AJ245197 [2] (2,3) °
IGHV1S38 IGHV1S38*01 [F] cvhp33 AJ245181 [2] (2,3) °
IGHV1S39 IGHV1S39*01 [F] cvhp50 AJ245198 [2] (2,3) °
IGHV1S40 IGHV1S40*01 [P] (4) cvhp51 AJ245199 [2] (2,3) °
IGHV1S41 IGHV1S41*01 [P] (5) cvhp52 AJ245200 [2] (2,3) °
IGHV1S42 IGHV1S42*01 [F] cvhhp42 AJ245148 [2] (2,3) °
IGHV1S43 IGHV1S43*01 [F] cvhhp09 AJ245115 [2] (2,3) °
IGHV1S44 IGHV1S44*01 [F] cvhhp12 AJ245118 [2] (2,3) °
IGHV1S45 IGHV1S45*01 [F] cvhhp08 AJ245114 [2] (2,3) °
IGHV1S46 IGHV1S46*01 [F] cvhhp10 AJ245116 [2] (2,3) °
IGHV1S47 IGHV1S47*01 [F] cvhhp11 AJ245117 [2] (2,3) °
IGHV1S48 IGHV1S48*01 [F] cvhhp29 AJ245135 [2] (2,3) °
IGHV1S49 IGHV1S49*01 [F] cvhhp31 AJ245137 [2] (2,3) °
IGHV1S50 IGHV1S50*01 [F] cvhhp28 AJ245134 [2] (2,3) °
IGHV1S51 IGHV1S51*01 [F] cvhhp06 AJ245112 [2] (2,3) °
IGHV1S52 IGHV1S52*01 [F] cvhhp07 AJ245113 [2] (2,3) °
IGHV1S53 IGHV1S53*01 [F] cvhhp16 AJ245122 [2] (2,3) °
IGHV1S54 IGHV1S54*01 [F] cvhhp18 AJ245124 [2] (2,3) °
IGHV1S55 IGHV1S55*01 [F] cvhhp20 AJ245126 [2] (2,3) °
IGHV1S56 IGHV1S56*01 [F] cvhhp21 AJ245127 [2] (2,3) °
IGHV1S57 IGHV1S57*01 [F] cvhhp22 AJ245128 [2] (2,3) °
IGHV1S58 IGHV1S58*01 [F] cvhhp26 AJ245132 [2] (2,3) °
IGHV1S59 IGHV1S59*01 [F] cvhhp27 AJ245133 [2] (2,3) °
IGHV1S60 IGHV1S60*01 [F] cvhhp13 AJ245119 [2] (2,3) °
IGHV1S61 IGHV1S61*01 [F] cvhhp23 AJ245129 [2] (2,3) °
IGHV1S62 IGHV1S62*01 [F] cvhhp24 AJ245130 [2] (2,3) °
IGHV1S63 IGHV1S63*01 [F] cvhhp25 AJ245131 [2] (2,3) °
IGHV1S64 IGHV1S64*01 [F] cvhhp32 AJ245138 [2] (2,3) °
IGHV1S65 IGHV1S65*01 [F] cvhhp30 AJ245136 [2] (2,3) °
IGHV1S66 IGHV1S66*01 [F] cvhhp34 AJ245140 [2] (2,3) °
IGHV1S67 IGHV1S67*01 [F] cvhhp33 AJ245139 [2] (2,3) °
IGHV1S68 IGHV1S68*01 [F] cvhhp35 AJ245141 [2] (2,3) °
IGHV1S69 IGHV1S69*01 [F] cvhhp36 AJ245142 [2] (2,3) °
IGHV1S70 IGHV1S70*01 [F] cvhhp37 AJ245143 [2] (2,3) °
IGHV1S71 IGHV1S71*01 [F] cvhhp38 AJ245144 [2] (2,3) °
IGHV1S72 IGHV1S72*01 F cvhhc1 AF000604 [1]
IGHV1S72*02 [F] cvhhp01 AJ245107 [2] (2,3) °
IGHV1S73 IGHV1S73*01 [F] cvhhp04 AJ245110 [2] (2,3) °
IGHV1S74 IGHV1S74*01 [F] cvhhp05 AJ245111 [2] (2,3) °

°: genomic DNA, but not known as being germline or rearranged.

IMGT notes:
  1. (1) The Arabian camel (Camelus dromedarius) IGHV1 genes belong to two sets based on amino acid sequences and on the presence or lack of light chain in the antibodies.
    The first set, which corresponds to the IGHV1S1 to IGHV1S41, is used in conventional tetrameric IgG1.
    The second set, which corresponds to IGHV1S42 to IGHV1S74, is expressed in heavy gamma 2 and gamma 3 chains both characterized by the absence of the CH1 domain, and therefore not associated with light chains (see Gene and allele table: Arabian camel (Camelus dromedarius) IGHC).
    Four FR2-IMGT positions (42, 49, 50 and 52 in the IMGT unique numbering) show amino acid differences which are characteristic of each set:
    FR2-IMGT amino acid positions42495052
    IGHV1S1 to IGHV1S41VGLW
    IGHV1S42 to IGHV1S74F,YE,QC,RF,G,L,W
  2. (2) Genomic data are needed to confirm that the sequences AJ245107-AJ245200 are from germline genomic DNA. Indeed the PCR amplification was done with a 3' primer which encompasses the end of the FR3-IMGT (AA 97 to 104).
  3. (3) V-REGION is partial: no CDR3-IMGT.
  4. (4) In frame STOP-CODON (positions 79-81) at codon 27 in CDR2-IMGT.
  5. (5) DELETION of one nucleotide (at position 267 in the IMGT unique numbering) leading to a frameshift in FR3-IMGT.
IMGT references:
  1. [1] Nguyen V.K. et al., J. Mol. Biol., 275, 413-418 (1998). PMID: 9466919
  2. [2] Nguyen V.K. et al., EMBO J., 19, 921-930 (2000). PMID: 10698934
See also (IMGT Scientific chart):