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"+" or "-" indicates if the gene sequences have been found (+) or not been found (-) rearranged (R), transcribed (T) and/or translated into protein (Pr). Arbitrarily that information is shown on the first line of each gene when the data have been confirmed by several studies.

Functionality is shown between parentheses, (F) and (P), when the accession number refers to rearranged genomic DNA or cDNA and the corresponding germline gene has not yet been isolated.
Functionality is shown between brackets, [F] and [P], when the accession number refers to genomic DNA, but not known as being germline or rearranged.

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IMGT subgroup IMGT gene name IMGT allele name Fct R T Pr Positions in the locus IMGT/LIGM-DB reference sequences IMGT/LIGM-DB sequences from the literature
Strain Clone names Accession numbers Positions in the sequence Secondary accession numbers Strain Clone names Accession numbers Positions in the sequence
IGHV3 (6) IGHV3S1 IGHV3S1*01 F cvh1 AF000603 [1]
IGHV3S1*02 [F] cvhp01 AJ245149 [2] (2,3) °
IGHV3S1*03 [F] cvhp13 AJ245161 [2] (2,3) °
IGHV3S1*04 [F] cvhp15 AJ245163 [2] (2,3) °
IGHV3S2 IGHV3S2*01 [F] cvhp03 AJ245151 [2] (2,3) °
IGHV3S3 IGHV3S3*01 [F] cvhp04 AJ245152 [2] (2,3) °
IGHV3S4 IGHV3S4*01 [F] cvhp05 AJ245153 [2] (2,3) °
IGHV3S5 IGHV3S5*01 [F] cvhp06 AJ245154 [2] (2,3) °
IGHV3S6 IGHV3S6*01 [F] cvhp07 AJ245155 [2] (2,3) °
IGHV3S7 IGHV3S7*01 [F] cvhp09 AJ245157 [2] (2,3) °
IGHV3S8 IGHV3S8*01 [F] cvhp10 AJ245158 [2] (2,3) °
IGHV3S9 IGHV3S9*01 [F] cvhp11 AJ245159 [2] (2,3) °
IGHV3S10 IGHV3S10*01 [F] cvhp12 AJ245160 [2] (2,3) °
IGHV3S11 IGHV3S11*01 [F] cvhp16 AJ245164 [2] (2,3) °
IGHV3S12 IGHV3S12*01 [F] cvhp17 AJ245165 [2] (2,3) °
IGHV3S12*02 [F] cvhp18 AJ245166 [2] (2,3) °
IGHV3S13 IGHV3S13*01 [F] cvhp19 AJ245167 [2] (2,3) °
IGHV3S14 IGHV3S14*01 [F] cvhp20 AJ245168 [2] (2,3) °
IGHV3S15 IGHV3S15*01 [F] cvhp22 AJ245170 [2] (2,3) °
IGHV3S16 IGHV3S16*01 [F] cvhp23 AJ245171 [2] (2,3) °
IGHV3S17 IGHV3S17*01 [F] cvhp25 AJ245173 [2] (2,3) °
IGHV3S18 IGHV3S18*01 [F] cvhp26 AJ245174 [2] (2,3) °
IGHV3S19 IGHV3S19*01 [F] cvhp08 AJ245156 [2] (2,3) °
IGHV3S20 IGHV3S20*01 [F] cvhp29 AJ245177 [2] (2,3) °
IGHV3S21 IGHV3S21*01 [F] cvhp30 AJ245178 [2] (2,3) °
IGHV3S22 IGHV3S22*01 [F] cvhp35 AJ245183 [2] (2,3) °
IGHV3S23 IGHV3S23*01 [F] cvhp37 AJ245185 [2] (2,3) °
IGHV3S24 IGHV3S24*01 [F] cvhp38 AJ245186 [2] (2,3) °
IGHV3S25 IGHV3S25*01 [F] cvhp39 AJ245187 [2] (2,3) °
IGHV3S26 IGHV3S26*01 [F] cvhp41 AJ245189 [2] (2,3) °
IGHV3S27 IGHV3S27*01 [F] cvhp43 AJ245191 [2] (2,3) °
IGHV3S28 IGHV3S28*01 [F] cvhp44 AJ245192 [2] (2,3) °
IGHV3S29 IGHV3S29*01 [F] cvhp45 AJ245193 [2] (2,3) °
IGHV3S30 IGHV3S30*01 [F] cvhp46 AJ245194 [2] (2,3) °
IGHV3S31 IGHV3S31*01 [F] cvhp47 AJ245195 [2] (2,3) °
IGHV3S32 IGHV3S32*01 [F] cvhp31 AJ245179 [2] (2,3) °
IGHV3S33 IGHV3S33*01 [F] cvhp32 AJ245180 [2] (2,3) °
IGHV3S34 IGHV3S34*01 [F] cvhp34 AJ245182 [2] (2,3) °
IGHV3S35 IGHV3S35*01 [F] cvhp42 AJ245190 [2] (2,3) °
IGHV3S36 IGHV3S36*01 [F] cvhp48 AJ245196 [2] (2,3) °
IGHV3S37 IGHV3S37*01 [F] cvhp49 AJ245197 [2] (2,3) °
IGHV3S38 IGHV3S38*01 [F] cvhp33 AJ245181 [2] (2,3) °
IGHV3S39 IGHV3S39*01 [F] cvhp50 AJ245198 [2] (2,3) °
IGHV3S40 IGHV3S40*01 [P] (4) cvhp51 AJ245199 [2] (2,3) °
IGHV3S41 IGHV3S41*01 [P] (5) cvhp52 AJ245200 [2] (2,3) °
IGHV3S42 IGHV3S42*01 [F] cvhhp42 AJ245148 [2] (2,3) °
IGHV3S43 IGHV3S43*01 [F] cvhhp09 AJ245115 [2] (2,3) °
IGHV3S44 IGHV3S44*01 [F] cvhhp12 AJ245118 [2] (2,3) °
IGHV3S45 IGHV3S45*01 [F] cvhhp08 AJ245114 [2] (2,3) °
IGHV3S46 IGHV3S46*01 [F] cvhhp10 AJ245116 [2] (2,3) °
IGHV3S47 IGHV3S47*01 [F] cvhhp11 AJ245117 [2] (2,3) °
IGHV3S48 IGHV3S48*01 [F] cvhhp29 AJ245135 [2] (2,3) °
IGHV3S49 IGHV3S49*01 [F] cvhhp31 AJ245137 [2] (2,3) °
IGHV3S50 IGHV3S50*01 [F] cvhhp28 AJ245134 [2] (2,3) °
IGHV3S51 IGHV3S51*01 [F] cvhhp06 AJ245112 [2] (2,3) °
IGHV3S52 IGHV3S52*01 [F] cvhhp07 AJ245113 [2] (2,3) °
IGHV3S53 IGHV3S53*01 [F] cvhhp16 AJ245122 [2] (2,3) °
IGHV3S54 IGHV3S54*01 [F] cvhhp18 AJ245124 [2] (2,3) °
IGHV3S55 IGHV3S55*01 [F] cvhhp20 AJ245126 [2] (2,3) °
IGHV3S56 IGHV3S56*01 [F] cvhhp21 AJ245127 [2] (2,3) °
IGHV3S57 IGHV3S57*01 [F] cvhhp22 AJ245128 [2] (2,3) °
IGHV3S58 IGHV3S58*01 [F] cvhhp26 AJ245132 [2] (2,3) °
IGHV3S59 IGHV3S59*01 [F] cvhhp27 AJ245133 [2] (2,3) °
IGHV3S60 IGHV3S60*01 [F] cvhhp13 AJ245119 [2] (2,3) °
IGHV3S61 IGHV3S61*01 [F] cvhhp23 AJ245129 [2] (2,3) °
IGHV3S62 IGHV3S62*01 [F] cvhhp24 AJ245130 [2] (2,3) °
IGHV3S63 IGHV3S63*01 [F] cvhhp25 AJ245131 [2] (2,3) °
IGHV3S64 IGHV3S64*01 [F] cvhhp32 AJ245138 [2] (2,3) °
IGHV3S65 IGHV3S65*01 [F] cvhhp30 AJ245136 [2] (2,3) °
IGHV3S66 IGHV3S66*01 [F] cvhhp34 AJ245140 [2] (2,3) °
IGHV3S67 IGHV3S67*01 [F] cvhhp33 AJ245139 [2] (2,3) °
IGHV3S68 IGHV3S68*01 [F] cvhhp35 AJ245141 [2] (2,3) °
IGHV3S69 IGHV3S69*01 [F] cvhhp36 AJ245142 [2] (2,3) °
IGHV3S70 IGHV3S70*01 [F] cvhhp37 AJ245143 [2] (2,3) °
IGHV3S71 IGHV3S71*01 [F] cvhhp38 AJ245144 [2] (2,3) °
IGHV3S72 IGHV3S72*01 F cvhhc1 AF000604 [1]
IGHV3S72*02 [F] cvhhp01 AJ245107 [2] (2,3) °
IGHV3S73 IGHV3S73*01 [F] cvhhp04 AJ245110 [2] (2,3) °
IGHV3S74 IGHV3S74*01 [F] cvhhp05 AJ245111 [2] (2,3) °

°: genomic DNA, but not known as being germline or rearranged.

IMGT notes:
  1. (1) The Arabian camel (Camelus dromedarius) IGHV3 genes belong to two sets based on amino acid sequences and on the presence or lack of light chain in the antibodies.
    The first set, which corresponds to the IGHV3S1 to IGHV3S41, is used in conventional tetrameric IgG1.
    The second set, which corresponds to IGHV3S42 to IGHV3S74, is expressed in heavy gamma 2 and gamma 3 chains both characterized by the absence of the CH1 domain, and therefore not associated with light chains (see Gene and allele table: Arabian camel (Camelus dromedarius) IGHC).
    Four FR2-IMGT positions (42, 49, 50 and 52 in the IMGT unique numbering) show amino acid differences which are characteristic of each set:
    FR2-IMGT amino acid positions42495052
    IGHV3S1 to IGHV3S41VGLW
    IGHV3S42 to IGHV3S74F,YE,QC,RF,G,L,W
  2. (2) Genomic data are needed to confirm that the sequences AJ245107-AJ245200 are from germline genomic DNA. Indeed the PCR amplification was done with a 3' primer which encompasses the end of the FR3-IMGT (AA 97 to 104).
  3. (3) V-REGION is partial: no CDR3-IMGT.
  4. (4) In frame STOP-CODON (positions 79-81) at codon 27 in CDR2-IMGT.
  5. (5) DELETION of one nucleotide (at position 267 in the IMGT unique numbering) leading to a frameshift in FR3-IMGT.
  6. (6) Previously annotated as IGHV1 sugroup
IMGT references:
  1. [1] Nguyen V.K. et al., J. Mol. Biol., 275, 413-418 (1998). PMID: 9466919
  2. [2] Nguyen V.K. et al., EMBO J., 19, 921-930 (2000). PMID: 10698934
Created:
05/02/2002
Last updated:
04/12/2018
Authors:
Joumana Jaabado-Michaloud and Nathalie Bosc
Editor:
Chantal Ginestoux