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"+" or "-" indicates if the gene sequences have been found (+) or not been found (-) rearranged (R), transcribed (T) and/or translated into protein (Pr). Arbitrarily that information is shown on the first line of each gene when the data have been confirmed by several studies.

Functionality is shown between parentheses, (F) and (P), when the accession number refers to rearranged genomic DNA or cDNA and the corresponding germline gene has not yet been isolated.
Functionality is shown between brackets, [F] and [P], when the accession number refers to genomic DNA, but not known as being germline or rearranged.

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The hits to sequences other than IMGT000046 are given for completeness but information on the positions in the contig and chromosomal localization of these sequences should be taken with great caution owing to the uncertainties regarding the genome assembly, and to the difficulty of assigning genes due to the duplications in the IGL locus.
Several pairs of genes have high percentage of identity of their V-REGION, reaching 100% of identity for the functional IGLV1-52*01 and IGLV1-47*01 genes and for the pseudogenes IGLV1-53*01, IGLV1-48*01 and IGLV1-29*01, IGLV8-44*01 and IGLV8-27*01, and IGLV(IV)-42*01 and IGLV(IV)-30*01. Arbitrarily these sequences are assigned to the gene with the smallest number.

IMGT subgroup IMGT gene name IMGT allele name Fct Chromosomal
localization
R T Pr IMGT/LIGM-DB locus reference sequences IMGT/LIGM-DB sequences from the literature
Breed Clone names Accession numbers Positions in the sequence
(L-V-GENE-UNIT)
Secondary accession numbers Breed Clone names Accession numbers Positions in the sequence
(L-V-GENE-UNIT)
IGLV1 IGLV1-12 IGLV1-12*01 F 17 + + Hereford IMGT000046 MAP 283945..284445 Hereford NW_001493546 51575..52075
IGLV1-14 IGLV1-14*01 P (1) 17 Hereford IMGT000046 MAP 277379..277874 Hereford NW_001493546 45009..45504
IGLV1-16 IGLV1-16*01 P (2) 17 Hereford IMGT000046 MAP 265778..266278
IGLV1-16*02 F 17 Hereford NW_001493546 (20) 31803..32304
IGLV1-17 IGLV1-17*01 P (3) 17 Hereford IMGT000046 MAP 262207..262701
IGLV1-17*02 P (3) 17 Hereford NW_001493546 (20) 28230..28724
IGLV1-18 IGLV1-18*01 P (4) 17 Hereford IMGT000046 MAP 252819..253314 Hereford NW_001493546 17993..18488
IGLV1-21 IGLV1-21*01 F 17 + + Hereford IMGT000046 MAP 242094..242594 Hereford NW_001493546 7214..7714
IGLV1-21*02 P (5) 16 U31892 [1] (20) 165..>412 (21)
IGLV1-22 IGLV1-22*01 P (3) 17 Hereford IMGT000046 MAP 238786..239275 Hereford NW_001493546 3906..4395
IGLV1-26 IGLV1-26*01 F 17 Hereford IMGT000046 MAP 219528..220026
IGLV1-28 IGLV1-28*01 P (6) 17 Hereford IMGT000046 MAP 209006..209506
IGLV1-29 IGLV1-29*01 P (7) 17 Hereford IMGT000046 MAP 205719..206213
IGLV1-31 IGLV1-31*01 F 17 + + Hereford IMGT000046 MAP 197133..197631 Hereford NW_001493549 205976..206474
IGLV1-31*02 F 8 U31887 [1] (20) 167..>417 (21)
IGLV1-31*03 F 20 U31894 [1] (20) 170..>420 (21)
IGLV1-31*04 P (3) 28 U31898 [1] (20) 165..>412 (21)
IGLV1-36 IGLV1-36*01 ORF (8) 17 Hereford IMGT000046 MAP 178564..179067
IGLV1-40 IGLV1-40*01 F 17 + + Hereford IMGT000046 MAP 163591..164094
IGLV1-40*02 F 15 U31891 [1] (20) 170..>420 (21)
IGLV1-41 IGLV1-41*01 P (7) 17 Hereford IMGT000046 MAP 159989..160482 Hereford NW_001493549 (22) 214561..215054
IGLV1-41*02 P (7) 17 Hereford NW_001493549 (20,22) 195999..196492
IGLV1-43 IGLV1-43*01 F 17 Hereford IMGT000046 MAP 151403..151901 Hereford NW_001493549 199292..199790
IGLV1-46 IGLV1-46*01 P (9) 17 Hereford IMGT000046 MAP 132711..133214
IGLV1-47 IGLV1-47*01 F 17 + + Hereford IMGT000046 MAP 127435..127936 HM596895 [2,3] 1..296 (21)
Hereford NW_001493549 217850..218351
10 U31889 [1] 167..>414 (21)
11 U31890 [1] 170..>417 (21)
22 U31896 [1] 172..>419 (21)
IGLV1-47*02 F 7 U31886 [1] (20) 172..>419 (21)
IGLV1-47*03 F 21 U31895 [1] (20) 172..>419 (21)
IGLV1-47*04 F 27 U31897 [1] (20) 172..>419 (21)
IGLV1-47*05 F 29 U31899 [1] (20) 172..>419 (21)
IGLV1-48 IGLV1-48*01 P (7) 17 Hereford IMGT000046 MAP 124146..124639
IGLV1-51 IGLV1-51*01 P (10) 17 Hereford IMGT000046 MAP 104855..105358
IGLV1-52 IGLV1-52*01 F 17 + + Hereford IMGT000046 MAP 99588..100088
IGLV1-53 IGLV1-53*01 P (7) 17 Hereford IMGT000046 MAP 96299..96792
IGLV1-55 IGLV1-55*01 F 17 Hereford IMGT000046 MAP complement(83753..84249)
IGLV1-57 IGLV1-57*01 P (3) 17 Hereford IMGT000046 MAP complement(75675..76167)
IGLV1-58 IGLV1-58*01 F 17 Hereford IMGT000046 MAP complement(71041..71541)
IGLV1-59 IGLV1-59*01 P (1) 17 Hereford IMGT000046 MAP complement(65819..66312)
IGLV1-60 IGLV1-60*01 P (11) 17 Hereford IMGT000046 MAP complement(62521..63023)
IGLV1-61 IGLV1-61*01 P (6) 17 Hereford IMGT000046 MAP complement(57244..57746)
IGLV1-63 IGLV1-63*01 F 17 Hereford IMGT000046 MAP complement(47153..47649)
IGLV1-64 IGLV1-64*01 F 17 Hereford IMGT000046 MAP complement(43716..44219)
IGLV1-66 IGLV1-66*01 P (7) 17 Hereford IMGT000046 MAP complement(35447..35940)
IGLV1-66*02 P (7) 17 Hereford NW_001493549 (20) 184889..185382
IGLV1-67 IGLV1-67*01 F 17 + + Hereford IMGT000046 MAP complement(32126..32626)
IGLV1-67*02 F 17 + + Hereford NW_001493549 (20) 188203..188703 HM596892 [2,3] 1..296 (21)
IGLV1-67*03 F 9 U31888 [1] (20) 171..>421 (21)
IGLV1-67*04 F 17 U31893 [1] (20) 171..>418 (21)
IGLV1-70 IGLV1-70*01 F 17 Hereford IMGT000046 MAP 24075..24577 HM596891 [2,3] 1..299 (21)
Hereford NW_001493549 176607..177110
IGLV1-71 IGLV1-71*01 F 17 Hereford IMGT000046 MAP 20646..21142 HM596894 [2,3] 1..293 (21)
Hereford NW_001493549 173177..173673
IGLV1-73 IGLV1-73*01 F 17 Hereford IMGT000046 MAP 14841..15344 HM596893 [2,3] 1..299 (21)
Hereford NW_001493549 167372..167875
IGLV2 IGLV2-6 IGLV2-6*01 F 17 Hereford IMGT000046 MAP 392984..393491 Hereford NW_001493546 159555..160062
IGLV2-7 IGLV2-7*01 ORF (12) 17 Hereford IMGT000046 MAP 376890..377399 Hereford NW_001493546 144619..145128
IGLV2-8 IGLV2-8*01 P (3) 17 Hereford IMGT000046 MAP 373630..374135 Hereford NW_001493546 141359..141864
IGLV2-9 IGLV2-9*01 F 17 Hereford IMGT000046 MAP 370583..371091 HM596896 [2,3] 1..297 (21)
Hereford NW_001493546 138311..138820
IGLV3 IGLV3-1 IGLV3-1*01 P (2) 17 Hereford IMGT000046 MAP 430841..431594 Hereford NW_001493546 197591..198344
IGLV3-2 IGLV3-2*01 F 17 Hereford IMGT000046 MAP 427000..427518 Hereford NW_001493546 193750..194268
IGLV3-3 IGLV3-3*01 F 17 Hereford IMGT000046 MAP 422271..422818 Hereford NW_001493546 189021..189568
IGLV3-4 IGLV3-4*01 F 17 Hereford IMGT000046 MAP 410181..410718 Hereford NW_001493546 176830..177368
IGLV3-5 IGLV3-5*01 F 17 Hereford IMGT000046 MAP 403792..404314 HM596897 [2,3] <1..282 (21)
Hereford NW_001493546 170363..170885
IGLV5 IGLV5-11 IGLV5-11*01 P (3) 17 Hereford IMGT000046 MAP 286732..287252 Hereford NW_001493546 54362..54882
IGLV5-13 IGLV5-13*01 P (13) 17 Hereford IMGT000046 MAP 281737..282051 (21) Hereford NW_001493546 49366..49680 (21)
IGLV5-45 IGLV5-45*01 ORF (14) 17 Hereford IMGT000046 MAP 141389..141884
IGLV5-50 IGLV5-50*01 ORF (14) 17 Hereford IMGT000046 MAP 113554..114049
IGLV5-62 IGLV5-62*01 P (5) 17 Hereford IMGT000046 MAP complement(50136..50665)
IGLV5-72 IGLV5-72*01 F 17 Hereford IMGT000046 MAP 17629..18157 Hereford NW_001493549 170160..170688
IGLV5-74 IGLV5-74*01 P (2) 17 Hereford IMGT000046 MAP 10001..10523
IGLV5-74*02 P (2) 17 Hereford NW_001493549 (20) 162532..163054
IGLV8 IGLV8-19 IGLV8-19*01 P (15) 17 Hereford IMGT000046 MAP 249994..250479
IGLV8-19*02 P (15) 17 Hereford NW_001493546 (20) 15108..15593
IGLV8-24 IGLV8-24*01 P (2) 17 Hereford IMGT000046 MAP 226159..226651
IGLV8-27 IGLV8-27*01 P (9) 17 Hereford IMGT000046 MAP 215678..216165
IGLV8-32 IGLV8-32*01 P (15) 17 Hereford IMGT000046 MAP 193277..193763
IGLV8-37 IGLV8-37*01 P (16) 17 Hereford IMGT000046 MAP 174973..175264 (21)
IGLV8-38 IGLV8-38*01 F 17 Hereford IMGT000046 MAP 170586..171079
IGLV8-44 IGLV8-44*01 P (9) 17 Hereford IMGT000046 MAP 147554..148041
IGLV8-49 IGLV8-49*01 P (9) 17 Hereford IMGT000046 MAP 116031..116518
IGLV8-54 IGLV8-54*01 P (17) 17 Hereford IMGT000046 MAP complement(87606..88094)
IGLV13 IGLV13-23 IGLV13-23*01 ORF (18) 17 Hereford IMGT000046 MAP 233085..233602
IGLV(I) IGLV(I)-10 IGLV(I)-10*01 P (19) 17 Hereford IMGT000046 MAP <367810..367985 (21) Hereford NW_001493546 <135537..135712 (21)
IGLV(I)-35 IGLV(I)-35*01 P (19) 17 Hereford IMGT000046 MAP <179904..180147 (21)
IGLV(IV) IGLV(IV)-15 IGLV(IV)-15*01 P (19) 17 Hereford IMGT000046 MAP <270460..270704 (21)
IGLV(IV)-15*02 P (19) 17 Hereford NW_001493546 (20) <36480..36724 (21)
IGLV(IV)-20 IGLV(IV)-20*01 P (19) 17 Hereford IMGT000046 MAP <244899..245143 (21) Hereford NW_001493546 <10019..10263 (21)
IGLV(IV)-25 IGLV(IV)-25*01 P (19) 17 Hereford IMGT000046 MAP <221998..222242 (21)
IGLV(IV)-30 IGLV(IV)-30*01 P (19) 17 Hereford IMGT000046 MAP <199604..199848 (21) Hereford NW_001493549 <208447..208691 (21)
IGLV(IV)-33 IGLV(IV)-33*01 P (19) 17 Hereford IMGT000046 MAP <187395..187639 (21)
IGLV(IV)-34 IGLV(IV)-34*01 P (19) 17 Hereford IMGT000046 MAP <181049..181294 (21)
IGLV(IV)-39 IGLV(IV)-39*01 P (19) 17 Hereford IMGT000046 MAP <166103..166348 (21)
IGLV(IV)-42 IGLV(IV)-42*01 P (19) 17 Hereford IMGT000046 MAP <153874..154118 (21)
IGLV(IV)-56 IGLV(IV)-56*01 P (19) 17 Hereford IMGT000046 MAP complement(81539..>81783) (21)
IGLV(IV)-65 IGLV(IV)-65*01 P (19) 17 Hereford IMGT000046 MAP complement(41833..>42038) (21) Hereford NW_001493549 <178789..178994 (21)
IGLV(IV)-68 IGLV(IV)-68*01 P (19) 17 Hereford IMGT000046 MAP complement(29941..>30138) (21)
IGLV(IV)-69 IGLV(IV)-69*01 P (19) 17 Hereford IMGT000046 MAP <26254..26459 (21)

MAP: Mapped reference sequences.

IMGT notes:
  1. (1) frameshift in V-REGION: deletion of 2 nt in FR3-IMGT
  2. (2) frameshift in L-PART1
  3. (3) frameshifts in V-REGION: several deletions
  4. (4) no INIT-CODON: Thr instead of Met, frameshift in V-REGION: deletion of 1 nt in CDR1-IMGT
  5. (5) frameshifts in V-REGION: several insertions and deletions
  6. (6) frameshift in V-REGION: deletion of 1 nt in FR3-IMGT
  7. (7) STOP-CODON in V-REGION: position 75, frameshift in V-REGION: deletion of 2 nt in FR3-IMGT
  8. (8) no 1st-CYS: Ser instead of Cys, no CONSERVED-TRP: Gln instead of Trp
  9. (9) several STOP-CODON in V-REGION
  10. (10) STOP-CODON in V-REGION: position 75
  11. (11) frameshifts in V-REGION: several insertions
  12. (12) no 2nd-CYS: Trp instead of Cys
  13. (13) no INIT-CODON: Val instead of Met, frameshift in L-PART1, frameshift in V-REGION: deletion of 1 nt in CDR1-IMGT, no V-NONAMER
  14. (14) deletions in V-REGION: AA 102 to 110 are missing
  15. (15) frameshift in V-REGION: deletion of 1 nt in CDR1-IMGT
  16. (16) no L-PART1, frameshift in V-REGION: deletion of 1 nt in CDR1-IMGT
  17. (17) frameshift in V-REGION: insertion of 1 nt in FR1-IMGT
  18. (18) noncanonical V-HEPTAMER: cgcggtg instead of cacagtg
  19. (19) truncated pseudogene not assigned to subgroups with functional genes
  20. (20) sequence not in locus reference sequence (assembly ARS-UCD1.2)
  21. (21) positions of V-REGION
  22. (22) duplication of IGHV1-41 may result from assembly error
IMGT references:
  1. [1] Sinclair M.C., et al., J. Immunol. 155(6):3068-3078 (1995). PMID: 7673723
  2. [2] Saini S.S., et al., Int. Immunol. 15(7):845-853 (2003). PMID: 12807823
  3. [3] Pasman Y., et al., Vet. Immunol. Immunopathol. 135(3-4):306-313 (2010). PMID: 20171743
Created:
23/05/2019
Last updated:
03/07/2019
Authors:
Perrine Pégorier and Marie-Paule Lefranc
Editors:
Chantal Ginestoux and Marie-Paule Lefranc