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"+" or "-" indicates if the gene sequences have been found (+) or not been found (-) rearranged (R), transcribed (T) and/or translated into protein (Pr). Arbitrarily that information is shown on the first line of each gene when the data have been confirmed by several studies.

Functionality is shown between parentheses, (F) and (P), when the accession number refers to rearranged genomic DNA or cDNA and the corresponding germline gene has not yet been isolated.
Functionality is shown between brackets, [F] and [P], when the accession number refers to genomic DNA, but not known as being germline or rearranged.

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Click here to see Gene table: Bovine (Bos taurus) TRGV anterior to September 2007

IMGT subgroup IMGT gene name IMGT allele name Fct R T Pr Positions in the locus IMGT/LIGM-DB reference sequences IMGT/LIGM-DB sequences from the literature
Breed Clone names Accession numbers Positions in the sequence Secondary accession numbers Breed Clone names Accession numbers Positions in the sequence
TRGV1 TRGV1-1 TRGV1-1*01 F (1) TRGV1-1, V1 MAP AY644517 [5] (5) Holstein BTGV12, TRGV1S2 D16123 [1] (1) #c
TRGV1-1*02 (F) + + Holstein BTGV25, TRGV1S1 D16119 [1] (1) #c
TRGV1-1*03 (F) + + Holstein BTGV38, TRGV1S3 D16131 [1] (1) #c
TRGV2 TRGV2-1 TRGV2-1*01 F TRGV2-1, V2 MAP AY644517 [5] DQ179591 [3] #c
TRGV3 TRGV3-1 TRGV3-1*01 F + + TRGV3-1 MAP NW_937068 [5] (3)
TRGV3-1*02 (F) + + Brown Swiss Bvg3.2, TRGV3S2 U73187 [2] #c
TRGV3-2 TRGV3-2*01 F + + TRGV3-2 MAP NW_937068 [5] (3)
TRGV3-2*02 (F) + + Brown Swiss Bvg3.1,TRGV3S1 U73186 [2] #c
TRGV4 TRGV4-1 TRGV4-1*01 (F) + + TRGV4S2 DQ179592 [3] #c TRGV4-1 MAP NW_937068 [5] (2)
TRGV5 TRGV5-1 TRGV5-1*01 F (1) TRGV5-1, V6 MAP AY644518 [5]
TRGV5-1*02 (F) + + TRGV5-1 DQ179595 [3] #c
TRGV5-1*03 (F) + + Holstein BTGV17, TRGV5S11 D16126 [1] (1) #c
TRGV5-1*04 (F) + + Holstein BTGV19, TRGV5S5 D16128 [1] (1) #c
TRGV5-1*05 (F) + + Holstein BTGV24, TRGV5S7 D16130 [1] (1) #c
TRGV5-2 TRGV5-2*01 (F) + + TRGV5-2, V2 MAP AY644518 [5] #g BTGV4, TRGV5S19 D16118 [1] (1) #c
BTGV36, TRGV5S13 D13651 [1] (1) #c
BTGV28, TRGV5S17 D13650 [1] (1) #c
BTGV22, TRGV5S6 D16129 [1] (1) #c
TRGV5-2*02 (F) + + Holstein BTGV11, TRGV5S3 D16122 [1] (1) #c BTGV33, TRGV5S10 D16132 [1] (1) #c
BTGV10, TRGV5S2 D16121 [1] (1) #c
TRGV5-2*03 (F) + + Holstein BTGV6, TRGV5S1 D13653 [1] (1) #c BTGV7, TRGV5S14 D13654 [1] (1) #c
BTGV2, TRGV5S18 D16117 [1] (1) #c
TRGV5-2*04 (F) + + Holstein BTGV15, TRGV5S4 D16125 [1] (1) #c
TRGV5-2*05 (F) + + Holstein BTGV18, TRGV5S12 D16127 [1] (1) #c
TRGV5-2*06 (F) + + Holstein BTGV37, TRGV5S9 D13652 [1] (1) #c
TRGV5-2*07 (F) + + Holstein BTGV5, TRGV5S8 D13649 [1] (1) #c
TRGV5-2*08 (F) + + Holstein BTGV14, TRGV5S20 D16124 [1] (1) #c
TRGV5-2*09 (F) (5) + + Holstein BTGV8, TRGV5S15 D16120 [1] (1) #c
TRGV5-2*10 (F) (5) + + Holstein BTGV9, TRGV5S16 D16133 [1] (1) #c
TRGV6 TRGV6-1 TRGV6-1*01 F TRGV6-1, V6-1 MAP AY644518 [5]
TRGV6-1*02 (F) + + TRGV6-1 DQ179597 [3] #c
TRGV6-2 TRGV6-2*01 F + + CH240-248F24 MAP AC172685 TRGV6-2, V6-2 AY644518 [5] #g
DQ179598 [3] #c
Vgamma6Jgamma4 AY560834 [6] #c
TRGV7 TRGV7-1 TRGV7-1*01 F + + TRGV7-1 MAP NW_937068 [5] Brown Swiss BVg7, TRGV4S1 U73188 [2] #c
TRGV7-1*02 (F) + + TRGV7-1 MAP AY735449 [4] #c
TRGV8 TRGV8-1 TRGV8-1*01 F TRGV8-1, V3.2 MAP AY644517 [5] DQ179599 #c
TRGV8-2 TRGV8-2*01 F TRGV8-2, V3.1 MAP AY644517 [5]
TRGV8-2*02 (F) + + TRGV8-2 DQ179600 [3] #c
TRGV8-3 TRGV8-3*01 F TRGV8-3, V5.5 MAP AY644517 [5]
TRGV8-3*02 (F) + + Holstein BTGV1, TRGV2S1 D13648 [1] #c
TRGV8-4 TRGV8-4*01 F TRGV8-4, V5.4 MAP AY644517 [5]
TRGV9 TRGV9-1 TRGV9-1*01 F TRGV9-1, V3.2 MAP AY644517 [5]
TRGV9-2 TRGV9-2*01 F TRGV9-2, V3.1 MAP AY644517 [5]
TRGV10 TRGV10-1 TRGV10-1*01 F (4) TRGV10-1, V3.1 MAP NW_937068 [5] AC172685 (6)

MAP: Mapped reference sequences.
#c: rearranged cDNA.
#g: rearranged genomic DNA.

IMGT notes:
  1. (1) The CONSERVED-TRP (tgg) position 41 of the FR2-IMGT is replaced by Leu (ttg). Although the TRGV1-1 and TRGV5-1 genes are considered as functional (J. Jabado-Michaloud, 24/10/2007).
  2. (2) This sequence contains sequencing errors in the V-REGION.
  3. (3) TRGV3-1, TRGV3-2, TRGV7-1, TRGV10-1 and TRGV4-1 were found in NW_937068 (M.-P. Lefranc, 08/08/2006), they are in reverse complementary orientation. Their positions are the following ones : TRGV3-1 from 23684-23381, TRGV3-2 from 17460 to 17763, TRGV7-1 from 13704 to 13399, TRGV10-1 from 9092 to 9402 (J. Jabado-Michaloud, 20/09/2007), the TRGV4-1 sequence contains sequencing errors and could not be taken as reference sequence.
  4. (4) The absence of known rearrangement in both ovine and bovine may be due to the presence of the nucleotides CA that precede the CACGTTG heptamer and thus create an overlapping non conserved heptamer that differs from a conserved heptamer by the insertion of two nucleotides (underlined in CACACGTTG). However it has not been proven experimentally that this RS is defective, and the bovine TRGV10-1 gene is considered as "functional".
  5. (5) Deletion of one nucleotide T (AA 63) in CDR2-IMGT and insertion of one nucleotide T (between AA 79 and AA 80) in FR3-IMGT, probably due to sequencing errors. These errors lead to a frameshift in V-REGION.
  6. (6) Probable sequencing error, t 195 is missing (codon 65).
IMGT references:
  1. [1] Ishiguro N. et al., Immunogenetics, 38, 437-443 (1993). PMID: 8406615
  2. [2] Hein W. R. et al., Immunology, 91, 58-64 (1997). PMID: 9203966
  3. [3] Herzig C. et al., Immunogenetics, 58, 138-151 (2006). PMID: 16541255
  4. [4] Lahmers K.K. et al., J. Leukoc. Biol., 77, 199-208 (2005). PMID: 15522917
  5. [5] Conrad M. et al., Vet. Immunol. Immunopathol., 115, 346-356 (2007). PMID: 17141331
  6. [6] Vaccarelli G.et al., Gene, 357, 103-114 (2005). PMID: 16125878
See also (IMGT Scientific chart):