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"+" or "-" indicates if the gene sequences have been found (+) or not been found (-) transcribed (T) and/or translated into protein (Pr). Arbitrarily that information is shown on the first line of each gene when the data have been confirmed by several studies.

Functionality is shown between parentheses, (F) and (P), when the accession number refers to rearranged genomic DNA or cDNA and the corresponding germline gene has not yet been isolated.
Functionality is shown between brackets, [F] and [P], when the accession number refers to genomic DNA, but not known as being germline or rearranged.

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IMGT gene name IMGT allele name Fct T Pr Positions in the locus IMGT/LIGM-DB reference sequences IMGT/LIGM-DB sequences from the literature
Breed Clone names Exons Accession numbers Positions in the sequence Secondary accession numbers Breed Clone names Accession numbers Positions in the sequence
IGHA IGHA*01 F boxer CH1 AAEX03006125 [1]
H+CH2 (1) AAEX03006125 [1]
CH3 (including CHS) AAEX03006125 [1]
M AAEX03006125 [1]
IGHA*02 F CH1 L36871 [2]
H+CH2 (1) L36871 [2]
CH3 (including CHS) L36871 [2]
IGHE IGHE*01 F boxer CH1 AAEX03006125 [1]
CH2 AAEX03006125 [1]
CH3 AAEX03006125 [1]
CH4 (including CHS) AAEX03006125 [1]
M1 AAEX03006125 [1]
M2 AAEX03006125 [1]
IGHE*02 F CH1 L36872 [2]
CH2 L36872 [2]
CH3 L36872 [2]
CH4 (including CHS) L36872 [2]
IGHG1 IGHG1*01 (F) IgG-A (2) CH1 AF354264 [3] c (s)
H AF354264 [3] c (s)
CH2 AF354264 [3] c (s)
CH3 (including CHS) AF354264 [3] c (s)
IGHG2 IGHG2*01 F boxer CH1 AAEX03006126 [1]
H AAEX03006126 [1]
CH2 AAEX03006126 [1]
CH3 (including CHS) AAEX03006126 [1]
M1 AAEX03006126 [1]
M2 AAEX03006126 [1]
IGHG2*02 (F) IgG-B (2) CH1 AF354265 [3] c (s)
H AF354265 [3] c (s)
CH2 AF354265 [3] c (s)
CH3 (including CHS) AF354265 [3] c (s)
IGHG3 IGHG3*01 (F) IgG-C (2) CH1 AF354266 [3] c (s)
H AF354266 [3] c (s)
CH2 AF354266 [3] c (s)
CH3 (including CHS) AF354266 [3] c (s)
IGHG4 IGHG4*01 (F) IgG-D (2) CH1 AF354267 [3] c (s)
H AF354267 [3] c (s)
CH2 AF354267 [3] c (s)
CH3 (including CHS) AF354267 [3] c (s)
IGHM IGHM*01 F boxer CH1 AAEX03006126 [1]
CH2 AAEX03006126 [1]
CH3 AAEX03006126 [1]
CH4 (including CHS) AAEX03006126 [1]
M1 AAEX03006126 [1]
M2 AAEX03006126 [1]

c: cDNA sequence.
(s): transcript of secreted chain.

IMGT notes:
  1. (1) In the IGHA gene, the hinge (H) and CH2 are joined in a single exon.
  2. (2) Canine IgG subclass biological characterization (modified from Table 8 [4]).

    Canine IgGIgG1IgG2IgG3IgG4
    Induction of cytolytic activity (ADCC)--/+++++++--
    Complement binding (human C1q)--/+++++--/+
    Fc gamma receptor I (FcγRI)+++++--/+
    Fc gamma receptor IIb (FcγRIIb)++++
    Fc gamma receptor III (FcγRIII)--+--/+--
    Fc neonatal receptor I (FcRn)++++--/+++
    Reactivity with protein A--/++++----
    Reactivity with protein G++++++++

    '+++' indicates very tight binding or high reactivity, '++' indicates good binding, '+' indicates that some binding was observed, '--/+' indicates little to no activation/binding, and '--' represents no binding. The table has been updated with the canine subclass names IgG1, IgG2, IgG3, IgG4, instead of A, B, C and D. For comparison with Structural and biological properties of human immunoglobulins, click here.

IMGT references:
  1. [1] Lindblad-Toh,K. et al., Nature, 438 (7069), 803-819 (2005). PMID: 16341006
  2. [2] Patel M. et al., Immunogenetics, 41, 282-286 (1995). PMID: 7721349
  3. [3] Tang L. et al., Vet. Immunol. Immunopathol., 80, 259-270 (2001). PMID: 11457479
  4. [4] Bergeron L.M. et al, Vet Immunol Immunopathol 157(1-2), 31-41 (2014). PMID: 24268690
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