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"+" or "-" indicates if the gene sequences have been found (+) or not been found (-) transcribed (T) and/or translated into protein (Pr). Arbitrarily that information is shown on the first line of each gene when the data have been confirmed by several studies.

Functionality is shown between parentheses, (F) and (P), when the accession number refers to rearranged genomic DNA or cDNA and the corresponding germline gene has not yet been isolated.
Functionality is shown between brackets, [F] and [P], when the accession number refers to genomic DNA, but not known as being germline or rearranged.

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IMGT gene name IMGT allele name Fct T Pr Positions in the locus IMGT/LIGM-DB reference sequences IMGT/LIGM-DB sequences from the literature
Breed Clone names Exons Accession numbers Positions in the sequence Secondary accession numbers Breed Clone names Accession numbers Positions in the sequence
IGHA IGHA*01 F Boxer CH1 IMGT000001 [5] MAP 1419857..1420162 Boxer AAEX03006125 [1] complement(108353..108658)
H+CH2 (1) IMGT000001 [5] MAP 1420410..1420751 Boxer AAEX03006125 [1] complement(107764..108105)
CH3 (including CHS) IMGT000001 [5] MAP 1420953..1421338 Boxer AAEX03006125 [1] complement(107177..107562)
M IMGT000001 [5] MAP 1423586..1423797 Boxer AAEX03006125 [1] complement(104718..104929)
IGHA*02 F CH1 L36871 [2] 188..493
H+CH2 (1) L36871 [2] 739..1077
CH3 (including CHS) L36871 [2] 1279..1664
M
IGHD IGHD*01 ORF (3) Boxer CH1 IMGT000001 [5] MAP 1302503..1302787
H1 IMGT000001 [5] MAP 1303096..1303185
H2 IMGT000001 [5] MAP 1304450..1304518
CH2 IMGT000001 [5] MAP 1304784..1305110
CH3 IMGT000001 [5] MAP 1305307..1305618
M1 IMGT000001 [5] MAP 1309381..1309529
M2 IMGT000001 [5] MAP 1309817..1309822
IGHE IGHE*01 F Boxer CH1 IMGT000001 [5] MAP 1406272..1406568 Boxer AAEX03006125 [1] complement(121947..122243)
CH2 IMGT000001 [5] MAP 1406765..1407088 Boxer AAEX03006125 [1] complement(121427..121750)
CH3 IMGT000001 [5] MAP 1407181..1407501 Boxer AAEX03006125 [1] complement(121014..121334)
CH4 (including CHS) IMGT000001 [5] MAP 1407576..1407913 Boxer AAEX03006125 [1] complement(120602..120939)
M1 IMGT000001 [5] MAP 1409868..1409995 Boxer AAEX03006125 [1] complement(118520..118647)
M2 IMGT000001 [5] MAP 1410090..1410170 Boxer AAEX03006125 [1] complement(118345..118425)
IGHE*02 F CH1 L36872 [2] 91..387
CH2 L36872 [2] 584..907
CH3 L36872 [2] 1000..1320
CH4 (including CHS) L36872 [2] 1395..1732
M1
M2
IGHG1 IGHG1*01 (F) + + IgG-A (2) CH1 AF354264 [3] c (s) 481..771
H AF354264 [3] c (s) 772..813
CH2 AF354264 [3] c (s) 814..1143
CH3 (including CHS) AF354264 [3] c (s) 1144..1473
M1
M2
IGHG2 IGHG2*01 F Boxer CH1 IMGT000001 [5] MAP 1360885..1361175 Boxer AAEX03006126 [1] complement(26664..26954)
H IMGT000001 [5] MAP 1361465..1361521 Boxer AAEX03006126 [1] complement(26318..26374)
CH2 IMGT000001 [5] MAP 1361648..1361977 Boxer AAEX03006126 [1] complement(25862..26191)
CH3 (including CHS) IMGT000001 [5] MAP 1362084..1362409 Boxer AAEX03006126 [1] complement(25430..25755)
M1 IMGT000001 [5] MAP 1363846..1363976 Boxer AAEX03006126 [1] complement(23863..23993)
M2 IMGT000001 [5] MAP 1365672..1365752 Boxer AAEX03006126 [1] complement(22087..22167)
IGHG2*02 (F) + + IgG-B (2) CH1 AF354265 [3] c (s) 446..736
H AF354265 [3] c (s) 737..793
CH2 AF354265 [3] c (s) 794..1123
CH3 (including CHS) AF354265 [3] c (s) 1124..1450
M1
M2
IGHG3 IGHG3*01 (F) + + IgG-C (2) CH1 AF354266 [3] c (s) 455..745
H AF354266 [3] c (s) 746..796
CH2 AF354266 [3] c (s) 797..1126
CH3 (including CHS) AF354266 [3] c (s) 1127..1453
M1
M2
IGHG4 IGHG4*01 (F) + + IgG-D (2) CH1 AF354267 [3] c (s) 465..755
H AF354267 [3] c (s) 756..797
CH2 AF354267 [3] c (s) 798..1127
CH3 (including CHS) AF354267 [3] c (s) 1128..1457
M1
M2
IGHM IGHM*01 F Boxer CH1 IMGT000001 [5] MAP 1290316..1290633 Boxer AAEX03006126 [1] complement(97206..97523)
CH2 IMGT000001 [5] MAP 1290713..1291051 Boxer AAEX03006126 [1] complement(96788..97126)
CH3 IMGT000001 [5] MAP 1291309..1291626 Boxer AAEX03006126 [1] complement(96213..96530)
CH4 (including CHS) IMGT000001 [5] MAP 1291730..1292121 Boxer AAEX03006126 [1] complement(95718..96109)
M1 IMGT000001 [5] MAP 1294683..1294798 Boxer AAEX03006126 [1] complement(93041..93156)
M2 IMGT000001 [5] MAP 1294903..1294908 Boxer AAEX03006126 [1] complement(92931..92936)

MAP: Mapped reference sequences.
c: cDNA sequence.
(s): transcript of secreted chain.

IMGT notes:
  1. (1) In the IGHA gene, the hinge (H) and CH2 are joined in a single exon.
  2. (2) Canine IgG subclass biological characterization (modified from Table 8 [4]).

    Canine IgGIgG1IgG2IgG3IgG4
    Induction of cytolytic activity (ADCC)--/+++++++--
    Complement binding (human C1q)--/+++++--/+
    Fc gamma receptor I (FcγRI)+++++--/+
    Fc gamma receptor IIb (FcγRIIb)++++
    Fc gamma receptor III (FcγRIII)--+--/+--
    Fc neonatal receptor I (FcRn)++++--/+++
    Reactivity with protein A--/++++----
    Reactivity with protein G++++++++


    '+++' indicates very tight binding or high reactivity, '++' indicates good binding, '+' indicates that some binding was observed, '--/+' indicates little to no activation/binding, and '--' represents no binding. The table has been updated with the canine subclass names IgG1, IgG2, IgG3, IgG4, instead of A, B, C and D. For comparison with Structural and biological properties of human immunoglobulins, click here.
  3. (3) Noncanonical DONOR-SPLICE: ngc instead of ngt in H2
IMGT references:
  1. [1] Lindblad-Toh,K. et al., Nature, 438 (7069), 803-819 (2005). PMID: 16341006
  2. [2] Patel M. et al., Immunogenetics, 41, 282-286 (1995). PMID: 7721349
  3. [3] Tang L. et al., Vet. Immunol. Immunopathol., 80, 259-270 (2001). PMID: 11457479
  4. [4] Bergeron L.M. et al, Vet Immunol Immunopathol 157(1-2), 31-41 (2014). PMID: 24268690
  5. [5] Martin J. et al. Immunogenetics 2018 Apr;70(4):223-236 (2018). doi: 10.1007/s00251-017-1028-0. Epub 2017 Sep 19.. PMID: 28924718
More information:
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