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"+" or "-" indicates if the gene sequences have been found (+) or not been found (-) rearranged (R), transcribed (T) and/or translated into protein (Pr). Arbitrarily that information is shown on the first line of each gene when the data have been confirmed by several studies.

Functionality is shown between parentheses, (F) and (P), when the accession number refers to rearranged genomic DNA or cDNA and the corresponding germline gene has not yet been isolated.
Functionality is shown between brackets, [F] and [P], when the accession number refers to genomic DNA, but not known as being germline or rearranged.

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IMGT subgroup IMGT gene name IMGT allele name Fct Chromosomal localization R T Pr Positions in the locus IMGT/LIGM-DB reference sequences IMGT/LIGM-DB sequences from the literature
Clone names Accession numbers Positions in the sequence (5'D-NONAMER to 3'D-NONAMER) Secondary accession numbers Clone names Accession numbers Positions in the sequence (5'D-NONAMER to 3'D-NONAMER)
IGHD1 IGHD1-1 IGHD1-1*01 F 14q32.33 23599-35048 D1-1 X97051 [8] 33686-33758 AB019441 [9]
IGHD1-7 IGHD1-7*01 F 14q32.33 43057-44649 (6) DM1 X13972 [5] (1) M37277 [5] (1) X97051 [8] 43272-43344
AB019441 [9]
IGHD1-14 IGHD1-14*01 ORF (3) 14q32.33 52325-53909 (6) DM2 X13972 [5] (1,2) M37277 [5] (1,2) X97051 [8] 52540-52612
AB019441 [9]
IGHD1-20 IGHD1-20*01 F 14q32.33 61770-63337 D1-20 X97051 [8] 61987-62059 AB019441 [9]
IGHD1-26 IGHD1-26*01 F 14q32.33 71927-79765 D1-26 X97051 [8] 72141-72216 AB019441 [9]
IGHD2 IGHD2-2 IGHD2-2*01 F 14q32.33 D4 J00232 [1]
IGHD2-2*02 F 14q32.33 35049-37615 D2-2 X97051 [8] 36339-36425 AB019441 [9]
IGHD2-2*03 F 14q32.33 D4 M35648 [3] M35649 [3]
IGHD2-8 IGHD2-8*01 F 14q32.33 44650-47262 (6) DLR1 X13972 [5] (1) M37277 [5] (1) X97051 [8] 45954-46040
M35650 [3]
AB019441 [9]
IGHD2-8*02 F 14q32.33 D1 J00233 [1]
IGHD2-15 IGHD2-15*01 F 14q32.33 53910-56408 (6) D2 J00234 [1] X97051 [8] 55207-55293
AB019441 [9]
IGHD2-21 IGHD2-21*01 F 14q32.33 D3 J00235 [1]
IGHD2-21*02 F 14q32.33 63338-65916 D2-21 X97051 [8] 64616-64699 AB019441 [9]
IGHD3 IGHD3-3 IGHD3-3*01 F 14q32.33 37616-39425 (6) DXP4 X13972 [5] (1) M37277 [5] (1) X97051 [8] 38806-38892
AB019441 [9]
IGHD3-3*02 F 14q32.33 D23/7 X93618 [4]
IGHD3-9 IGHD3-9*01 F 14q32.33 47263-48619 (6) DXP1 X13972 [5] (1) M37277 [5] (1) M37485 [7]
D21/0.5 X93613 [4]
X97051 [8] 48484-48570
AB019441 [9]
IGHD3-10 IGHD3-10*01 F 14q32.33 48620-49158 (6) DXP'1 X13972 [5] (1) M37277 [5] (1) M37485 [7]
X97051 [8] 48668-48754
AB019441 [9]
IGHD3-10*02 F 14q32.33 D21/7 X93615 [4]
IGHD3-16 IGHD3-16*01 F 14q32.33 D21/10 X93614 [4]
IGHD3-16*02 F 14q32.33 56409-58143 X97051 [9] 57524-57616 AB019441 [9]
IGHD3-22 IGHD3-22*01 F 14q32.33 65917-67762 (6) D21/9 X93616 [4] X97051 [8] 67133-67219
AB019441 [9]
IGHD4 IGHD4-4 IGHD4-4*01 F 14q32.33 39426-40474 (6) DA4 X13972 [5] (1) M37277 [5] (1) X97051 [8] 39958-40029
AB019441 [9]
IGHD4-11 IGHD4-11*01 ORF (4) 14q32.33 49159-50078 (6) DA1 X13972 [5] (1) M37277 [5] (1) X97051 [8] 49563-49634
AB019441 [9]
IGHD4-17 IGHD4-17*01 F 14q32.33 58144-59187 D4-17 X97051 [8] 58671-58742 AB019441 [9]
IGHD4-23 IGHD4-23*01 ORF (4) 14q32.33 67763-68826 D4-23 X97051 [8] 68306-68380 AB019441 [9]
IGHD5 IGHD5-5 IGHD5-5*01 F 14q32.33 40475-41880 (6) DK4 X13972 [5] (1) M37277 [5] (1) X97051 [8] 40919-40994
AB019441 [9]
IGHD5-12 IGHD5-12*01 F 14q32.33 50079-51316 (6) DK1 X13972 [5] (1) M37277 [5] (1) X97051 [8] 50523-50601
AB019441 [9]
IGHD5-18 IGHD5-18*01 F 14q32.33 59188-60591 D5-18 X97051 [8] 59633-59708 AB019441 [9]
IGHD5-24 IGHD5-24*01 ORF (5) 14q32.33 68827-70492 D5-24 X97051 [8] 69272-69347 AB019441 [9]
IGHD6 IGHD6-6 IGHD6-6*01 F 14q32.33 41881-43056 (6) DN4 X13972 [5] (1) M37277 [5] (1) X97051 [8] 42767-42840
42767-42840 M37277 [5] (1) AB019441 [9]
IGHD6-13 IGHD6-13*01 F 14q32.33 51317-52324 (6) DN1 X13972 [5] (1) M37277 [5] (1) X97051 [8] 52032-52108
AB019441 [9]
IGHD6-19 IGHD6-19*01 F 14q32.33 60592-61769 D6-19 X97051 [8] 61475-61551 AB019441 [9]
IGHD6-25 IGHD6-25*01 F 14q32.33 70493-71926 D6-25 X97051 [8] 71638-71711 AB019441 [9]
IGHD7 IGHD7-27 IGHD7-27*01 F 14q32.33 87428-87515 (6) DHQ52 J00256 [2] X97051 [8] 87431-87497
X86355 [6]
X86356 [6]
X86357 [6]
X86358 [6]
X86359 [6]

c: cDNA sequence.
(s): Transcript of a secreted chain.

IMGT notes:
  1. (1) The original sequence is X13972 (14928 bp), M37277 (14929 bp) secondary accession number presents an INSERTION of one nucleotide C between positions 14587/14588 (in X13972).
  2. (2) INSERTION of one nucleotide C between positions 14587/14588 is after the coding region of the IGHD1-14, and do not concern the recombination signals either.
  3. (3) ORF, because unusual 5'D HEPTAMER CACAGCG instead of CACAGTG.
  4. (4) ORF, because unusual 5'D HEPTAMER TGCTGTG instead of CACAGTG.
  5. (5) ORF, because unusual 5'D HEPTAMER GGCCGTG instead of CACAGTG.
  6. (6) Arbitrary limits of the DNA sequence assigned to the different D-GENEs. D-GENE positions are those in the Accession number X97051.
IMGT references:
  1. [1] Siebenlist, U. et al., Nature, 294, 631-635 (1981). PMID: 7312051
  2. [2] Ravetch, J.V. et al., Cell, 27, 583-591 (1981). PMID: 6101209
  3. [3] Zong, S.Q. et al., Immunol. Lett., 17, 329-333 (1988).. PMID: 3372011
  4. [4] Buluwela, L. et al., EMBO J., 7, 2003-2010 (1988). PMID: 3138112
  5. [5] Ichihara, Y. et al., EMBO J., 7, 4141-4150 (1988). PMID: 3243276
  6. [6] Mattila, P.S. et al., Eur. J. Immunol., 25, 2578-2582 (1995). PMID: 7589129
  7. [7] Huang, C. et al., Unpublished.
  8. [8] Corbett, S. et al., J. Mol. Biol., 270, 587-597 (1997). PMID: 9245589
  9. [9] Matsuda et al., J. Exp. Med., 188, 2151-2162 (1998). PMID: 9841928
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