Here you are: IMGT Web resources > IMGT Repertoire (IG and TR) > 1. Locus and genes
Citing this page: Folch, G. and Lefranc, M.-P., Exp. Clin. Immunogenet., 17, 42-54 (2000) PMID: 10686482 pdf

"+" or "-" indicates if the gene sequences have been found (+) or not been found (-) rearranged (R), transcribed (T) and/or translated into protein (Pr). Arbitrarily that information is shown on the first line of each gene when the data have been confirmed by several studies.

Functionality is shown between parentheses, (F) and (P), when the accession number refers to rearranged genomic DNA or cDNA and the corresponding germline gene has not yet been isolated.
Functionality is shown between brackets, [F] and [P], when the accession number refers to genomic DNA, but not known as being germline or rearranged.

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Rearranged (R) and transcribed (T) information are from Assignment of rearranged cDNAs and gDNAs to germline genes: Human TRBV.

IMGT subgroup IMGT gene name IMGT allele name Fct Chromosomal localization R T Pr Positions in the locus IMGT/LIGM-DB reference sequences IMGT/LIGM-DB sequences from the literature
Clone names Accession numbers Positions in the sequence (from INIT-CODON to the end of V-REGION) Secondary accession numbers Clone names Accession numbers Positions in the sequence (from INIT-CODON to the end of V-REGION)
TRBV1 TRBV1 TRBV1*01 P (1) 7q34 - - 91000-92750 V1 MAP L36092 [11] (37) 91557-92006 U66059 [11] (37)
TRBV2 TRBV2 TRBV2*01 F 7q34 + + + 92751-97500 V2 MAP L36092 [11] (37) 93552-93986 U66059 [11] (37)
TRBV2*02 (F) 7q34 + + + Vbeta23 M62379 [19] #c
TRBV2*03 (F) 7q34 + + + Vbeta22 M64351 [20] #c
TRBV3 TRBV3-1 TRBV3-1*01 F 7q34 + + + 97501-103500 (36) V9S1 MAP U07977 [14] V3-1 MAP L36092 [11] (37) 101150-101609
U66059 [11] (37)
TRBV3-1*02 (F) 7q34 + + + Vbeta9.n L06889 [21] #c
TRBV3-2 TRBV3-2*01 P (2) 7q34 + + 147001-153700 (36) V3-2 MAP L36092 [11] (37) 151879-152338 U66059 [11] (37)
TRBV3-2*02 P (2) 7q34 + + V9S2P MAP U07978 [14]
TRBV3-2*03 (P) (2) 7q34 + + Vbeta-VW114 MAP M33240 [48] #c
TRBV4 TRBV4-1 TRBV4-1*01 F 7q34 + + 103501-110000 (36) V7S1 MAP U07977 [14] V4-1 MAP L36092 [11] (37) 105774-106227
U66059 [11] (37)
TRBV4-1*02 (F) 7q34 + + Vbeta7.1 MAP M13855 [22] #c
TRBV4-2 TRBV4-2*01 F 7q34 + + 131001-140300 (36) V7S2 MAP U07975 [14] V7S2 MAP U07976 [14]
U07978 [14]
V4-2 MAP L36092 [11] (37) 138078-138531
U66059 [11] (37)
L36190 [11] (37)
V7S3 MAP AF009660 [41]
TRBV4-2*02 (F) 7q34 + + Vbeta7 X58811 [23] #c
TRBV4-3 TRBV4-3*01 F 7q34 + + 153701-160000 (36) V7S3 MAP U07978 [14] V4-3 MAP L36092 [11] (37) 155338-155791
U66059 [11] (37)
TRBV4-3*02 (F) 7q34 + + Vbeta7 X58812 [23] #c
TRBV4-3*03 (F) 7q34 + + Vbeta7.n2 L06888 [21] #c
TRBV4-3*04 (F) 7q34 + + Vbeta7.2b X57616 [24] #c
TRBV5 TRBV5-1 TRBV5-1*01 F 7q34 + + + 110001-117500 V5-1 MAP L36092 [11] (37) 113622-114091 U66059 [11] (37)
TRBV5-1*02 (F) 7q34 + + ph24 M14271 [10] #c
TRBV5-2 TRBV5-2*01 P (3) 7q34 - - 180001-194000 V5-2 MAP L36092 [11] (37) 187166-187605 U66059 [11] (37) AF009660 [41]
TRBV5-3 TRBV5-3*01 ORF (4) 7q34 - - 202001-205500 (36) Vbeta5.5 MAP X61439 [4] V5-3 MAP L36092 [11] (37) 203911-204377
U66059 [11] (37)
TRBV5-3*02 ORF (4) 7q34 - - V5S5 AF009660 [41]
TRBV5-4 TRBV5-4*01 F 7q34 + + 274001-280000 V5-4 MAP L36092 [11] (37) 277826-278290 U66060 [11] (37) V5S5 AF009663 [41]
V5S6 AF009662 [41]
TRBV5-4*02 (F) 7q34 + + Vbeta5.6 X57615 [24] #c
TRBV5-4*03 (F) 7q34 + + Vbeta5.5 S50547 [25] #
TRBV5-4*04 (F) 7q34 + + Vbeta5 X58804 [23] #c
TRBV5-5 TRBV5-5*01 F 7q34 + + + 282251-300000 V5-5 MAP L36092 [11] (37) 297271-297735 U66060 [11] (37) AF009663 [41]
TRBV5-5*02 (F) 7q34 + + Vbeta5.3a X57611 [24] #c
TRBV5-5*03 (F) 7q34 + + Vbeta5 X58801 [23] #c
TRBV5-6 TRBV5-6*01 F 7q34 + + + 311001-319000 V5-6 MAP L36092 [11] (37) 314783-315248 U66060 [11] (37) AF009663 [41]
TRBV5-7 TRBV5-7*01 ORF (5) 7q34 - - 330001-338000 V5-7 MAP L36092 [11] (37) 334800-335266 U66060 [11] (37) AF009663 [41]
BV5S7 MAP L26226 [12] (19) °
TRBV5-8 TRBV5-8*01 F 7q34 + + 350001-360000 V5-8 MAP L36092 [11] (37) 354936-355402 U66060 [11] (37) AF009663 [41]
TRBV5-8*02 (F) 7q34 + + Vbeta5 X58803 [23] #c
TRBV6 TRBV6-1 TRBV6-1*01 F 7q34 + + 117501-123000 (36) Vbeta13.3 MAP X61446 [4] V6-1 MAP L36092 [11] (37) 120903-121335
U66059 [11] (37)
TRBV6-2 TRBV6-2*01 F 7q34 + + 140301-147000 (36) Vbeta13.2 MAP X61445 [4] V13S2 MAP U07975 [14]
U07976 [14]
U07978 [14]
V6-2 MAP L36092 [11] (37) 141898-142330
U66059 [11] (37)
L36190 [11] (37)
V13S2 AF009660 [41]
X75418 [47] (33) °
X75419 [47] (33) °
TRBV6-2*02 (P) (10) 7q34 + + Vbeta.HPB-2 MAP M31347 [26] #g
TRBV6-2*03 (P) (10) 7q34 + + [27] #
TRBV6-3 TRBV6-3*01 F 7q34 + + 160001-166000 (36) V13S2 MAP U07978 [14] V6-3 MAP L36092 [11] (37) 163579-164011
U66059 [11] (37)
BV13S9 MAP L26229 [12] (19) °
TRBV6-4 TRBV6-4*01 F 7q34 + + 194001-197000 (36) Vbeta13.5 MAP X61653 [4] V6-4 MAP L36092 [11] (37) 195522-195956
U66059 [11] (37)
TRBV6-4*02 F 7q34 V13S5 AF009660 [41]
TRBV6-5 TRBV6-5*01 F 7q34 + + + 260001-268000 V6-5 MAP L36092 [11] (37) 265721-266156 U66059 [11] (37) V13S1 AF009662 [41]
AF009663 [41]
U66060 [11] (37) V13S1 AF009662 [41]
AF009663 [41]
TRBV6-6 TRBV6-6*01 F 7q34 + + + 260001-286500 V6-6 MAP L36092 [11] (37) 284296-284728 U66060 [11] (37)
TRBV6-6*02 F 7q34 + + V13S6 AF009662 [41] AF009663 [41]
TRBV6-6*03 (F) 7q34 + + Vbeta13 X58815 [23] #c
TRBV6-6*04 (F) 7q34 + + Vbeta13.4 MAP X74848 [28] #c
TRBV6-6*05 (F) 7q34 + + Vbeta13.n3 L06892 [21] #c
TRBV6-7 TRBV6-7*01 ORF (6) 7q34 + - 300001-304500 V6-7 MAP L36092 [11] (37) 302579-303011 U66060 [11] (37) AF009663 [41]
BV13S8 MAP L26227 [12] (19) °
TRBV6-8 TRBV6-8*01 F 7q34 + - 319001-324500 V6-8 MAP L36092 [11] (37) 322095-322523 U66060 [11] (37) AF009663 [41]
BV13S7 MAP L26228 [12] (19) °
TRBV6-9 TRBV6-9*01 F 7q34 - - 338001-344500 (36) Vbeta13.4 MAP X61447 [4] V6-9 MAP L36092 [11] (37) 342106-342537
U66060 [11] (37)
AF009663 [41]
TRBV7 TRBV7-1 TRBV7-1*01 ORF (8) 7q34 - - 123001-131000 (36) Vbeta6.10 MAP X61444 [4] V7-1 MAP L36092 [11] (37) 124764-125252
U66059 [11] (37)
TRBV7-2 TRBV7-2*01 F 7q34 + + 166001-170000 (36) Vbeta6.7a MAP X61442 [4] V6S7 MAP U07976 [14]
U07978 [14]
V7-2 MAP L36092 [11] (37) 167212-167708
U66059 [11] (37)
TRBV7-2*02 F 7q34 + + V7-2 MAP L36190 [11] Vbeta6.7b MAP X61443 [4]
V6S7 MAP AF009660 [41]
TRBV7-2*03 F 7q34 + + V6S7 MAP U07975 [14]
TRBV7-2*04 (F) 7q34 + + Vbeta6.6 MAP M27387 [29] #c
TRBV7-3 TRBV7-3*01 F 7q34 + + + 197001-200000 (36) Vbeta6.1 MAP X61440 [4] BV6S1 L33104 [15]
V7-3 MAP L36092 [11] (37) 199093-199549
U66059 [11] (37)
Tcrb-V6.1A M67511 [44] (26) °
Tcrb-V6.1B M67512 [44] (27) °
TRBV7-3*02 ORF (15) 7q34 + + Vbeta6.1 M97943 [5] BV6S1 L33103 [15]
TRBV7-3*03 ORF (15) 7q34 + + V6S1 AF009660 [41] BV6S1 L33105 [15]
TRBV7-3*04 (F) 7q34 + + Vbeta6.1 MAP X74843 [28] #c
TRBV7-3*05 (F) 7q34 + + M13550 [30] #c
TRBV7-4 TRBV7-4*01 F 7q34 - - 268001-274000 V7-4 MAP L36092 [11] (37) 269879-270340 U66060 [11] (37) V6S11 AF009662 [41]
AF009663 [41]
Vbeta6.11c L14432 [31] (17) °
Vbeta6.11d L14459 [31] (18) °
TRBV7-4*02 [P] (10) 7q34 Vbeta6.11a L13762 [31] ° Vbeta6.11b L14431 [31] (7) °
TRBV7-5 TRBV7-5*01 P (10) 7q34 - - 286501-292250 V7-5 MAP L36092 [11] (37) 288811-289282 U66060 [11] (37) V6S12 AF009662 [41]
Vbeta6.12b L14475 [31] (18) °
Vbeta6.12a M97503 [31] (28) °
TRBV7-5*02 P (10) 7q34 - - AF009663 [41]
TRBV7-6 TRBV7-6*01 F 7q34 + + 304501-311000 V7-6 MAP L36092 [11] (37) 306894-307386 U66060 [11] (37) AF009663 [41]
Vbeta6.13b L14480 [31] (17) °
Vbeta6.13a M97504 [31] (29) °
TRBV7-6*02 (F) 7q34 + + Vbeta6 X58806 [23] #c
TRBV7-7 TRBV7-7*01 F 7q34 + + 324501-330000 V7-7 MAP L36092 [11] (37) 326337-326838 U66060 [11] (37) AF009663 [41]
Vbeta6.14b L14483 [31] (19) °
M97505 [31] (30) °
TRBV7-7*02 (F) 7q34 + + Vbeta6.7 X57607 [24] #c
TRBV7-8 TRBV7-8*01 F 7q34 + + 344501-350000 (36) Vbeta.ATL12-2 MAP M11953 [3] V7-8 MAP L36092 [11] (37) 346720-347203
U66060 [11] (37)
AF009663 [41]
TRBV7-8*02 F 7q34 + + Vbeta6.3 MAP X61441 [4]
TRBV7-8*03 (F) 7q34 + + Vbeta6.3 MAP M27384 [29] #c
TRBV7-9 TRBV7-9*01 F 7q34 + + 360001-367500 V7-9 MAP L36092 [11] (37) 364137-364609 U66060 [11] (37) AF009661 [41]
BV6S4 MAP U03115 [8]
Vbeta6.9 X64741 [40] (32) °
TRBV7-9*02 (F) 7q34 + + M15564 [39] #c
TRBV7-9*03 F 7q34 + + AF009663 [41]
TRBV7-9*04 (F) 7q34 + + ph22 M14261 [10] #c
TRBV7-9*05 (F) 7q34 + + Vbeta6.5 MAP M27385 [29] #c
TRBV7-9*06 (F) 7q34 + + Vbeta6.5 MAP X74844 [28] #c
TRBV7-9*07 (F) 7q34 + + L14854 [33] #c
TRBV8 TRBV8-1 TRBV8-1*01 P (9) 7q34 - - 170001-180000 V8-1 MAP (9) L36092 [11] (37) -173604 (9) U66059 [11] (37) AF009660 [41]
TRBV8-2 TRBV8-2*01 P (10) 7q34 - - 200001-202000 V8-2 MAP L36092 [11] (37) 200895-201355 U66059 [11] (37) AF009660 [41]
TRBV9 TRBV9 TRBV9*01 F 7q34 + + + 205501-210000 V9 MAP L36092 [11] (37) 206647-207121 U66059 [11] (37)
TRBV9*02 F 7q34 + + AF009660 [41]
TRBV9*03 (F) 7q34 + + Vbeta1.1 MAP M27380 [29] #c
TRBV10 TRBV10-1 TRBV10-1*01 F 7q34 + + 210001-219000 (36) V10-1 MAP L36092 [11] (37) 214638-215087 U66059 [11] (37) BV12S4 MAP U17050 [16]
L26230 [12] (19) °
TRBV10-1*02 F 7q34 + + AF009660 [41]
TRBV10-1*03 [P] (11) 7q34 + BV12S4 MAP U17051 [16] °
TRBV10-2 TRBV10-2*01 F 7q34 + + 234001-244000 (36) V10-2 MAP L36092 [11] (37) 239704-240153 U66059 [11] (37) BV12S3 MAP U17049 [16]
TRBV10-2*02 [F] 7q34 + BV12S3 MAP U17048 [16] °
TRBV10-3 TRBV10-3*01 F 7q34 + + + 375001-384500 (36) BV12S2 MAP U03115 [8] V10-3 MAP L36092 [11] (37) 379068-379517
U66060 [11] (37)
AF009661 [41]
AF009663 [41]
Vbeta12.2 L33100 [35] (23) °
TRBV10-3*02 F 7q34 + + + BV12S2 MAP U17047 [16]
TRBV10-3*03 [F] 7q34 + Vbeta12.2 L33101 [35] °
TRBV10-3*04 [F] 7q34 + Vbeta12.2 L33102 [35] °
TRBV11 TRBV11-1 TRBV11-1*01 F 7q34 + + 219001-226000 (36) V21.1 MAP M33233 [13] V11-1 MAP L36092 [11] (37) 222397-222844
U66059 [11] (37)
TRBV11-2 TRBV11-2*01 F 7q34 + + + 244001-255200 V11-2 MAP L36092 [11] (37) 248664-249102 U66059 [11] (37)
TRBV11-2*02 [F] 7q34 + V21.3 MAP M33235 [13] °
TRBV11-2*03 (F) 7q34 + + Vbetaw21 X58796 [23] #c
TRBV11-3 TRBV11-3*01 F 7q34 + + 384501-393000 (36) V21.2 MAP U03115 [8] (35) BV21S2 MAP
V11-3 MAP L36092 [11] (37) 389716-390153
U66060 [11] (37)
AF009661 [41]
AF009663 [41]
TRBV11-3*02 (F) 7q34 + + Vbetaw21 X58797 [23] #c
TRBV11-3*03 (F) 7q34 + + Vbeta21 M62377 [19] #c
TRBV11-3*04 (F) 7q34 + + Vbeta21.4a [40] #
TRBV12 TRBV12-1 TRBV12-1*01 P (11) 7q34 - - 226001-234000 (36) v-beta8.4 X07224 [7] V12-1 MAP L36092 [11] (37) 229930-230372
U66059 [11] (37)
TRBV12-2 TRBV12-2*01 P (11) 7q34 + - 255201-260000 (36) V-beta8.5 X06936 [7] V12-2 MAP L36092 [11] (37) 255591-256033
U66059 [11] (37)
AF009663 [41]
TRBV12-3 TRBV12-3*01 F 7q34 + + + 393001-397000 (36) v-beta8.1 X07192 [7] BV8S1 MAP U03115 [8]
V12-3 MAP L36092 [11] (37) 395318-395764
U66060 [11] (37)
AF009661 [41]
TRBV12-4 TRBV12-4*01 F 7q34 + + + 397001-405000 (36) VbetaM3-2 MAP K02546 [6] v-beta8.2 X07222 [7]
BV8S2 MAP U03115 [8]
V12-4 MAP L36092 [11] (37) 398641-399087
U66060 [11] (37)
TRBV12-4*02 (F) 7q34 + + ph8 M14264 [10] #c
TRBV12-5 TRBV12-5*01 F 7q34 - + 405001-419000 (36) v-beta8.3 X07223 [7] BV8S3 MAP U03115 [8]
V12-5 MAP L36092 [11] (37) 415832-416278
U66060 [11] (37)
TRBV13 TRBV13 TRBV13*01 F 7q34 + + 367501-375000 (36) BV23S1 MAP U03115 [8] V13 MAP L36092 [11] (37) 370656-371139
U66060 [11] (37)
AF009661 [41]
AF009663 [41]
Vbeta23 U96844 [46] (31)
TRBV13*02 (F) 7q34 + + Vbeta22 M62378 [19] #c
TRBV14 TRBV14 TRBV14*01 F 7q34 + + + 419001-423500 (36) Vbeta16 MAP X06154 [9] BV16S1 MAP U03115 [8]
V14 MAP L36092 [11] (37) 422775-423207
U66060 [11] (37)
TRBV14*02 (F) 7q34 + + Vbeta16b X57722 [24] #g
TRBV15 TRBV15 TRBV15*01 F 7q34 + + 423501-430000 (36) BV24S1 MAP U03115 [8] V15 MAP L36092 [11] (37) 427850-428318
U66060 [11] (37)
TRBV15*02 (F) 7q34 + + Vbetaw24 X58800 [23] #c
TRBV15*03 (F) 7q34 + + Vbeta24 M62376 [19] #c
TRBV16 TRBV16 TRBV16*01 F 7q34 + + BV25S1 MAP L26231 [12]
TRBV16*02 P (11) 7q34 - + 430001-435000 (36) BV25S1 MAP U03115 [8] V16 MAP L36092 [11] (37) 432859-433312
U66060 [11] (37)
TRBV16*03 (F) 7q34 + + L26054 [36] #c
TRBV17 TRBV17 TRBV17*01 ORF (13) 7q34 - - 435001-445000 (36) BV26S1 MAP U03115 [8] V17 MAP L36092 [11] (37) 436475-437209
U66060 [11] (37)
TRBV18 TRBV18 TRBV18*01 F 7q34 + + + 445001-452700 V18 MAP L36092 [11] (37) 450546-451164 U66060 [11] (37)
TRBV19 TRBV19 TRBV19*01 F 7q34 + + + 452701-458000 V19 MAP L36092 [11] (37) 453806-454281 U66060 [11] (37)
U66061 [11] (37)
TRBV19*02 F 7q34 + + BV17S1 U48259 [17] BV17S1 U48260 [17]
TRBV19*03 (F) 7q34 + + Vbeta17.1 M97725 [37] #c
TRBV20 TRBV20-1 TRBV20-1*01 F 7q34 + + + 458001-467000 (36) Vbeta.MT1-1 MAP M11955 [3] V20-1 MAP L36092 [11] (37) 461476-462148
U66060 [11] (37)
U66061 [11] (37)
TRBV20-1*02 F 7q34 + + BV2S1 X72719 [2]
TRBV20-1*03 (F) 7q34 + + Vbeta.MT1-1 MAP M11954 [3] #g
TRBV20-1*04 (F) 7q34 + + ph34 M14263 [10] #c
TRBV20-1*05 (F) 7q34 + + Vbeta2.1b X57604 [24] #g
TRBV20-1*06 (F) 7q34 + + Vbeta2.3a D13088 [32] #c
TRBV20-1*07 (F) 7q34 + + Vbeta2.1 MAP X74852 [28] #c
TRBV21 TRBV21-1 TRBV21-1*01 P (12) 7q34 + + 467001-474000 V21-1 MAP L36092 [11] (37) 471659-472119 U66060 [11] (37) BV10 L27608 [18]
V10S1 L48728 [42]
U66061 [11] (37) BV10 L27608 [18]
V10S1 L48728 [42]
TRBV22 TRBV22-1 TRBV22-1*01 P (10) 7q34 - - 474001-478500 V22 MAP L36092 [11] (37) 476480-476930 U66061 [11] (37)
TRBV23 TRBV23-1 TRBV23-1*01 ORF (4) 7q34 + + 478501-485000 V23 MAP L36092 [11] (37) 480699-481195 U66061 [11] (37) L48730 [42]
BV19 L27614 [18] (21) °
TRBV24 TRBV24-1 TRBV24-1*01 F 7q34 + + 485001-497500 (36) Vbeta.ATL2-1 MAP M11951 [3] BV15 L27612 [18]
V24-1 MAP L36092 [11] (37) 490040-490516
U66061 [11] (37)
TRBV25 TRBV25-1 TRBV25-1*01 F 7q34 + + + 497501-510000 V25-1 MAP L36092 [11] (37) 504415-504882 U66061 [11] (37) BV11 L27610 [18]
TRBV26 TRBV26 TRBV26*01 P (14) 7q34 - - 522001-537500 V26 MAP L36092 [11] (37) 529336-529820 U66061 [11] (37)
TRBV27 TRBV27 TRBV27*01 F 7q34 + + + 547201-552000 V27 MAP L36092 [11] (37) 549038-549510 U66061 [11] (37)
TRBV28 TRBV28 TRBV28*01 F 7q34 + + + 552001-565000 (36) V3S1 U08314 [45] V28 MAP L36092 [11] (37) 554328-554808
U66061 [11] (37)
Vbeta2 MAP M18464 [43] (24) °
TRBV29 TRBV29-1 TRBV29-1*01 F 7q34 + + 565001-579000 V29-1 MAP L36092 [11] (37) 573946-574559 U66061 [11] (37) VB4 L27623 [18] (22) °
TRBV29-1*02 (F) 7q34 + + Vbeta4 MAP M13847 [22] #c
TRBV29-1*03 (F) 7q34 + + Vbeta4.3 X04926 [38] #c
TRBV30 TRBV30 (34) TRBV30*01 F 7q34 + + + 659001-684973 V30 MAP L36092 [11] (37) 667298-666920 U66061 [11] (37)
TRBV30*02 F 7q34 + + + Vbeta18 Z13967 [1]
TRBV30*03 P (16) 7q34 Vbeta18 [1]
TRBV30*04 (F) 7q34 + + M13554 [30] #c
TRBV30*05 (F) 7q34 + + Vbeta20.n1 L06893 [21] #c
TRBVA TRBVA TRBVA*01 P (10) 7q34 - - 510001-522000 L36092 [11] (37) 515043-515497 U66061 [11] (37)
TRBVB TRBVB TRBVB*01 P (11) 7q34 - - 537501-547200 L36092 [11] (37) 545032-545572 U66061 [11] (37)
TRBVC TRBVC TRBVC*01 P (38) 7q34 + - - L36092 [11] (37) U66061 [11] (37)

#: Rearranged
#c: rearranged cDNA
#g: rearranged genomic DNA.
°: DNA genomic sequence, but not known as being germline or rearranged.
MAP: Mapped reference sequences.

IMGT notes:
  1. (1) STOP-CODON in L-PART1; 1st-CYS replaced by Arg in V-EXON.
  2. (2) 1st_CYS replaced by STOP-CODON in V-EXON.
  3. (3) Frameshift in V-EXON; V-HEPTAMER violates consensus.
  4. (4) GT replaced by AT in DONOR-SPLICE.
  5. (5) CONSERVED-TRP replaced by Ser in V-EXON.
  6. (6) CONSERVED-TRP replaced by Arg in V-EXON.
  7. (7) L14431 differs from TRBV7-4*01 by the nucleotide DELETION (c255>del) and (t266>del) which create a frameshift.
  8. (8) 1st_CYS replaced by Tyr in V-EXON; missing V-SPACER and V-NONAMER.
  9. (9) Frameshift in V-EXON, L-PART1 is missing.
  10. (10) Frameshift in V-EXON. Although it is not excluded that the sequence 172780-172829 in L66059, L36092 may represent a very degenerate leader peptide, it was not labeled as L-PART1 for the following reasons (i) the translated sequence is not particularly hydrophobic (ii) the sequence shows no similarity with the other TRBV L-PART1, included the one from TRBV8-2, also a pseudogene but with a clearly identified L-PART1 (iii) the DONOR-SPLICE displays a codon-start 2 instead of being a codon-start 3 (note by M.-P. Lefranc, added on 07/04/2004, following a question by V. Herle).
  11. (11) One amino acid replaced by STOP-CODON in V-EXON.
  12. (12) Frameshift in L-PART1.
  13. (13) 2nd-CYS replaced by Tyr in V-EXON.
  14. (14) STOP-CODON in L-PART1; 2nd_CYS replaced by Tyr in V-EXON.
  15. (15) 2nd_CYS replaced by Arg in V-EXON.
  16. (16) Arg replaced by STOP-CODON in V-EXON.
  17. (17) V-GENE is partial: partial L-PART1, no V-HEPTAMER, no V-NONAMER and V-REGION is partial: AA 100 to 108 are absent (partial FR3-IMGT and no CDR3-IMGT).
  18. (18) V-GENE is partial: partial L-PART1, no V-HEPTAMER, no V-NONAMER and V-REGION is partial: AA 21 to 108 are absent (partial FR1-IMGT, no CDR1-IMGT, no FR2-IMGT, no CDR2-IMGT, no FR3-IMGT, no CDR3-IMGT).
  19. (19) V-GENE is partial: no L-PART1, no V-HEPTAMER, no V-NONAMER and V-REGION is partial: AA 100 to 108 are absent (partial FR3-IMGT and no CDR3-IMGT).
  20. (20) V-GENE is partial: no L-PART1, no V-HEPTAMER, no V-NONAMER and V-REGION is partial: AA 92 to 108 are absent (partial FR3-IMGT and no CDR3-IMGT).
  21. (21) V-GENE is partial: no L-PART1, no V-HEPTAMER, no V-NONAMER and V-REGION is partial: AA 90 to 108 are absent (partial FR3-IMGT and no CDR3-IMGT).
  22. (22) V-GENE is partial: no L-PART1, no V-HEPTAMER, no V-NONAMER and V-REGION is partial: AA 99 to 108 are absent (partial FR3-IMGT and no CDR3-IMGT).
  23. (23) V-REGION is partial: AA 105 to 108 are absent (no CDR3-IMGT).
  24. (24) V-GENE is partial: no V-HEPTAMER, no V-NONAMER and V-REGION is partial: AA 9 to 108 are absent (partial FR1-IMGT, no CDR1-IMGT, no FR2-IMGT, no CDR2-IMGT, no FR3-IMGT, no CDR3-IMGT).
  25. (25) V-J-GENE is partial: partial L-PART1, no J-REGION.
  26. (26) V-REGION is partial: AA 1 to 24 and 106 to 108 are absent (partial FR1-IMGT, partial CDR3-IMGT). AA position 55, 83 are missing, probably typing errors.
  27. (27) V-REGION is partial: AA 1 to 24 and 106 to 108 are absent (partial FR1-IMGT, no CDR1-IMGT, no FR2-IMGT, no CDR2-IMGT, no FR3-IMGT, partial CDR3-IMGT). G position 47 is missing, ACT position 70 to 72 are missing, A position 110 inserted, GGA position 139 to 141 are missing and A position 73 replaced by G, probably typing errors.
  28. (28) V-GENE is partial: partial L-PART1, no V-HEPTAMER, no V-NONAMER and V-REGION is partial: AA 100 to 108 are absent (partial FR3-IMGT and no CDR3-IMGT).
  29. (29) V-GENE is partial: partial L-PART1, no V-HEPTAMER, no V-NONAMER and V-REGION is partial: AA 25 to 108 are absent (partial FR1-IMGT, no CDR1-IMGT, no FR2-IMGT, no CDR2-IMGT, no FR3-IMGT, no CDR3-IMGT).
  30. (30) V-GENE is partial: Partial L-PART1, no V-HEPTAMER, no V-NONAMER and V-REGION is partial: AA 24 to 108 are absent (partial FR1-IMGT, no CDR1-IMGT, no FR2-IMGT, no CDR2-IMGT, no FR3-IMGT, no CDR3-IMGT).
  31. (31) V-GENE is partial: no V-NONAMER.
  32. (32) V-REGION is partial: AA 1 to 3 and 76 to 108 are absent (partial FR1-IMGT, partial FR3-IMGT, no CDR3-IMGT).
  33. (33) V-GENE is partial: no V-HEPTAMER, no V-NONAMER and V-REGION is partial: AA 93 to 108 are absent (partial FR3-IMGT and no CDR3-IMGT).
  34. (34) In the human TRB locus, the TRBV30 gene is localized in 3' from the TRBC2 gene and is in inverted orientation of transcription. Due to its polarity opposite to the TRB D-J-C-CLUSTERs, TRBV30 rearranges by an inversional joining [11].
  35. (35) This gene was previously entered in the databases as V21.2, M33234 [13], but has been shown to contain several nucleotide errors.
  36. (36) Arbitrary limits of the DNA sequence assigned to the different TRBV genes. V-GENE positions are those in the Accession number L36092.
  37. (37) The original L36092 sequence (684973 bp) has been split in EMBL into three sequences of 267156 bp (U66059), 215422 bp (U66060) and 232650 bp (U66061), L36092 has become secondary accession number of U66059, U66060 and U66061. In IMGT, the original sequence L36092 which is fully annotated has also been kept as primary accession number, in addition to U66059, U66060 and U66061 [11].
  38. (38) The pseudogene TRBVC, originally identified by its unproductive rearrangement in the T cell line MT-1 (M11957) [49], is localized between TRBV27 and TRBV28 (E. Carillon and M.-P. Lefranc, 13/09/2013). It is truncated and only comprises the 3' end of the V-REGION and the V-RS.
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See also (IMGT Scientific chart):