Here you are: IMGT Web resources > IMGT Repertoire (IG and TR) > 1. Locus and genes
Citing this page: Folch, G. and Lefranc, M.-P., Exp. Clin. Immunogenet., 17, 42-54 (2000) PMID: 10686482 pdf

"+" or "-" indicates if the gene sequences have been found (+) or not been found (-) rearranged (R), transcribed (T) and/or translated into protein (Pr). Arbitrarily that information is shown on the first line of each gene when the data have been confirmed by several studies.

Functionality is shown between parentheses, (F) and (P), when the accession number refers to rearranged genomic DNA or cDNA and the corresponding germline gene has not yet been isolated.
Functionality is shown between brackets, [F] and [P], when the accession number refers to genomic DNA, but not known as being germline or rearranged.

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Rearranged (R) and transcribed (T) information are from Assignment of rearranged cDNAs and gDNAs to germline genes: Human TRBV.

IMGT subgroup IMGT gene name IMGT allele name Fct Chromosomal localization R T Pr Positions in the locus IMGT/LIGM-DB reference sequences IMGT/LIGM-DB sequences from the literature
Clone names Accession numbers Positions in the sequence
(L-V-GENE-UNIT)
Secondary accession numbers Clone names Accession numbers Positions in the sequence
(L-V-GENE-UNIT)
TRBV1 TRBV1 TRBV1*01 P (1) 7q34 - - 91000-92750 V1 MAP L36092 [11] (37) 91557-92006 U66059 [11] (37) MAP IMGT000021 67666..68154
TRBV2 TRBV2 TRBV2*01 F 7q34 + + + 92751-97500 V2 MAP L36092 [11] (37) 93552-93986 U66059 [11] (37) MAP IMGT000021 69653..70126
TRBV2*02 (F) 7q34 + + + Vbeta23 M62379 [19] (41) #c
TRBV2*03 (F) 7q34 + + + Vbeta22 M64351 [20] (41) #c
TRBV3 TRBV3-1 TRBV3-1*01 F 7q34 + + + 97501-103500 (36) V9S1 MAP U07977 [14] 5475..5973 V3-1 MAP L36092 [11] (37) 101150..101648
U66059 [11] (37) 101150..101648
MAP IMGT000021 77244..77742
TRBV3-1*02 (F) 7q34 + + + Vbeta9.n L06889 [21] (41) #c 58..>336
TRBV3-2 TRBV3-2*01 P (2) 7q34 + + 147001-153700 (36) V3-2 MAP L36092 [11] (37) 151879..152377 U66059 [11] (37) 151879..152377
TRBV3-2*02 P (2) 7q34 + + V9S2P MAP U07978 [14] 17328..17827
TRBV3-2*03 (P) (2) 7q34 + + Vbeta-VW114 MAP M33240 [45] #c 36..321
TRBV4 TRBV4-1 TRBV4-1*01 F 7q34 + + 103501-110000 (36) V7S1 MAP U07977 [14] 10102..10593 V4-1 MAP L36092 [11] (37) 105774-106227
U66059 [11] (37) 105774..106266
MAP IMGT000021 81868..82360
TRBV4-1*02 (F) 7q34 + + Vbeta7.1 MAP M13855 [22] (41) #c <1..259
TRBV4-2 TRBV4-2*01 F 7q34 + + 131001-140300 (36) V7S2 MAP U07975 [14] 311..802 V7S2 MAP U07976 [14] 311..802
U07978 [14] 3734..4225
V4-2 MAP L36092 [11] (37) 138078..138570
U66059 [11] (37) 138078..138570
L36190 [11] (37) 1725..2217
V7S3 MAP AF009660 [38] 401..893
MAP IMGT000021 114187..114679
TRBV4-2*02 (F) 7q34 + + Vbeta7 X58811 [23] (41) #c 169..450
TRBV4-3 TRBV4-3*01 F 7q34 + + 153701-160000 (36) V7S3 MAP U07978 [14] 20774..21265 V4-3 MAP L36092 [11] (37) 155338..155830
U66059 [11] (37) 155338..155830
TRBV4-3*02 (F) 7q34 + + Vbeta7 X58812 [23] (41) #c 73..354
TRBV4-3*03 (F) 7q34 + + Vbeta7.n2 L06888 [21] (41) #c 58..339
TRBV4-3*04 (F) 7q34 + + Vbeta7.2b X57616 [24] (41) #c <1..231
TRBV5 TRBV5-1 TRBV5-1*01 F 7q34 + + + 110001-117500 V5-1 MAP L36092 [11] (37) 113622-114091 U66059 [11] (37) MAP IMGT000021 89730..90238
TRBV5-1*02 (F) 7q34 + + ph24 M14271 [10] (41) #c <1..328
TRBV5-2 TRBV5-2*01 P (3) 7q34 - - 180001-194000 V5-2 MAP L36092 [11] (37) 187166..187645 U66059 [11] (37) AF009660 [38] 27297..27776
MAP IMGT000021 141128..141607
TRBV5-3 TRBV5-3*01 ORF (4) 7q34 - - 202001-205500 (36) Vbeta5.5 MAP X61439 [4] 236..741 V5-3 MAP L36092 [11] (37) 203911..204416
U66059 [11] (37) 203911..204416
MAP IMGT000021 157857..158362
TRBV5-3*02 ORF (4) 7q34 - - V5S5 AF009660 [38] 44024..44529
TRBV5-4 TRBV5-4*01 F 7q34 + + 274001-280000 V5-4 MAP L36092 [11] (37) 277826..278329 U66060 [11] (37) V5S5 AF009663 [38] 22475..22978
V5S6 AF009662 [38] 18254..18757
MAP IMGT000021 231772..232275
TRBV5-4*02 (F) 7q34 + + Vbeta5.6 X57615 [24] (41) #c 65..346
TRBV5-4*03 (F) 7q34 + + Vbeta5.5 S50547 [25] # <1..>234
TRBV5-4*04 (F) 7q34 + + Vbeta5 X58804 [23] (41) #c <1..192
TRBV5-5 TRBV5-5*01 F 7q34 + + + 282251-300000 V5-5 MAP L36092 [11] (37) 297271..297774 U66060 [11] (37) AF009663 [38] 41913..42416
MAP IMGT000021 251210..251713
TRBV5-5*02 (F) 7q34 + + Vbeta5.3a X57611 [24] (41) #c 65..346
TRBV5-5*03 (F) 7q34 + + Vbeta5 X58801 [23] (41) #c 129..410
TRBV5-6 TRBV5-6*01 F 7q34 + + + 311001-319000 V5-6 MAP L36092 [11] (37) 314783..315287 U66060 [11] (37) AF009663 [38] 59421..59925
MAP IMGT000021 268724..269228
TRBV5-7 TRBV5-7*01 ORF (5) 7q34 - - 330001-338000 V5-7 MAP L36092 [11] (37) 334800..335305 U66060 [11] (37) AF009663 [38] 79441..79946
BV5S7 MAP L26226 [12] (19) ° <1..>345
MAP IMGT000021 288745..289250
TRBV5-8 TRBV5-8*01 F 7q34 + + 350001-360000 V5-8 MAP L36092 [11] (37) 354936..355441 U66060 [11] (37) AF009663 [38] 99581..100086
TRBV5-8*02 (F) 7q34 + + Vbeta5 X58803 [23] (41) #c <1..238
TRBV6 TRBV6-1 TRBV6-1*01 F 7q34 + + 117501-123000 (36) Vbeta13.3 MAP X61446 [4] 269..737 V6-1 MAP L36092 [11] (37) 120903..121374
U66059 [11] (37) 120903..121374
MAP IMGT000021 97009..97480
TRBV6-2 (40) TRBV6-2*01 F 7q34 + + 140301-147000 (36) Vbeta13.2 MAP X61445 [4] 267..737 V13S2 MAP U07975 [14] 3987..4455
U07976 [14] 4000..4470
U07978 [14] 7424..7894
V6-2 MAP L36092 [11] (37) 141898..142369
U66059 [11] (37) 141898..142369
L36190 [11] (37) 5412..5882
V13S2 AF009660 [38] 4071..4541
MAP IMGT000021 117887..118358
V13S2 X75418 [44] (33) ° 233..>616
X75419 [44] (33) ° 232..>614
TRBV6-3 TRBV6-3*01 F 7q34 + + 160001-166000 (36) V13S2 MAP U07978 [14] 28984..29454 V6-3 MAP L36092 [11] (37) 163579..164050
U66059 [11] (37) 163579..164050
BV13S9 MAP L26229 [12] (19) ° <1..>371
TRBV6-4 TRBV6-4*01 F 7q34 + + 194001-197000 (36) Vbeta13.5 MAP X61653 [4] 280..751 V6-4 MAP L36092 [11] (37) 195522..195995
U66059 [11] (37) 195522..195995
TRBV6-4*02 F 7q34 V13S5 AF009660 [38] 35649..36122
TRBV6-5 TRBV6-5*01 F 7q34 + + + 260001-268000 V6-5 MAP L36092 [11] (37) 265721..266195 U66059 [11] (37) V13S1 AF009662 [38] 6150..6624
AF009663 [38] 10371..10845
U66060 [11] (37) V13S1 AF009662 [38] 6150..6624
AF009663 [38] 10371..10845
IMGT000021 219668..220142
TRBV6-6 TRBV6-6*01 F 7q34 + + + 260001-286500 V6-6 MAP L36092 [11] (37) 284296..284767 U66060 [11] (37)
TRBV6-6*02 F 7q34 + + V13S6 AF009662 [38] 24718..25189 AF009663 [38] 28939..29410
MAP IMGT000021 238236..238707
TRBV6-6*03 (F) 7q34 + + Vbeta13 X58815 [23] (41) #c 64..345
TRBV6-6*04 (F) 7q34 + + Vbeta13.4 MAP X74848 [26] (41) #c 105..389
TRBV6-6*05 (F) 7q34 + + Vbeta13.n3 L06892 [21] (41) #c 58..339
TRBV6-7 TRBV6-7*01 ORF (6) 7q34 + - 300001-304500 V6-7 MAP L36092 [11] (37) 302579..303050 U66060 [11] (37) AF009663 [38] 47221..47692
BV13S8 MAP L26227 [12] (19) ° <1..>353
MAP IMGT000021 256518..256989
TRBV6-8 TRBV6-8*01 F 7q34 + - 319001-324500 V6-8 MAP L36092 [11] (37) 322095..322562 U66060 [11] (37) AF009663 [38] 66734..67201
BV13S7 MAP L26228 [12] (19) ° <1..>332
MAP IMGT000021 276037..276504
TRBV6-9 TRBV6-9*01 F 7q34 - - 338001-344500 (36) Vbeta13.4 MAP X61447 [4] 240..705 V6-9 MAP L36092 [11] (37) 342106..342576
U66060 [11] (37) 84588..85058
AF009663 [38] 86748..87221
TRBV7 TRBV7-1 TRBV7-1*01 ORF (8) 7q34 - - 123001-131000 (36) Vbeta6.10 MAP X61444 [4] 1135..1628 V7-1 MAP L36092 [11] (37) 124764..125259
U66059 [11] (37) 124764..125259
MAP IMGT000021 100870..101400
TRBV7-2 TRBV7-2*01 F 7q34 + + 166001-170000 (36) Vbeta6.7a MAP X61442 [4] 336..873 V6S7 MAP U07976 [14] 7627..>8045
U07978 [14] 32617..33037
V7-2 MAP L36092 [11] (37) 167212..167747
U66059 [11] (37) 167212..167747
MAP IMGT000021 121521..122054
TRBV7-2*02 F 7q34 + + V7-2 MAP L36190 [11] 9043..9564 Vbeta6.7b MAP X61443 [4] 1..475
V6S7 MAP AF009660 [38] 7702..8223
TRBV7-2*03 F 7q34 + + V6S7 MAP U07975 [14] 7610..8131
TRBV7-2*04 (F) 7q34 + + Vbeta6.6 MAP M27387 [27] (41) #c 19..307
TRBV7-3 TRBV7-3*01 F 7q34 + + + 197001-200000 (36) Vbeta6.1 MAP X61440 [4] 581..1076 BV6S1 L33104 [15] <1..>347
V7-3 MAP L36092 [11] (37) 199093..199588
U66059 [11] (37) 199093..199588
Tcrb-V6.1A M67511 [41] (26) ° <1..>201
Tcrb-V6.1B M67512 [41] (27) ° <1..>201
TRBV7-3*02 ORF (15) 7q34 + + Vbeta6.1 M97943 [5] 229..732 BV6S1 L33103 [15] <1..>347
TRBV7-3*03 ORF (15) 7q34 + + V6S1 AF009660 [38] 39201..39702 BV6S1 L33105 [15] <1..>347
MAP IMGT000021 153034..153535
TRBV7-3*04 (F) 7q34 + + Vbeta6.1 MAP X74843 [26] (41) #c 140..426
TRBV7-3*05 (F) 7q34 + + M13550 [28] (41) #c <1..231
TRBV7-4 TRBV7-4*01 F 7q34 - - 268001-274000 V7-4 MAP L36092 [11] (37) 269879..270379 U66060 [11] (37) V6S11 AF009662 [38] 10311..10811
AF009663 [38] 14532..15032
MAP IMGT000021 223829..224329
Vbeta6.11c L14432 [29] (17) ° 1..>405
Vbeta6.11d L14459 [29] (18) ° 1..>203
TRBV7-4*02 [P] (10) 7q34 Vbeta6.11a L13762 [29] ° 1..>404 Vbeta6.11b L14431 [29] (7) ° 1..>404
TRBV7-5 TRBV7-5*01 P (10) 7q34 - - 286501-292250 V7-5 MAP L36092 [11] (37) 288811-289282 U66060 [11] (37) V6S12 AF009662 [38] 29233..29744
Vbeta6.12b L14475 [29] (18) ° 1..>216
Vbeta6.12a M97503 [29] (28) ° <1..>415
TRBV7-5*02 P (10) 7q34 - - AF009663 [38] 33454..33966 MAP IMGT000021 240730..247236
TRBV7-6 TRBV7-6*01 F 7q34 + + 304501-311000 V7-6 MAP L36092 [11] (37) 306894..307425 U66060 [11] (37) AF009663 [38] 51535..52066
MAP IMGT000021 260832..261369
Vbeta6.13b L14480 [29] (17) ° 1..>443
Vbeta6.13a M97504 [29] (29) ° <1..>234
TRBV7-6*02 (F) 7q34 + + Vbeta6 X58806 [23] (41) #c 67..351
TRBV7-7 TRBV7-7*01 F 7q34 + + 324501-330000 V7-7 MAP L36092 [11] (37) 326337..326877 U66060 [11] (37) AF009663 [38] 70977..71517
MAP IMGT000021 280281..280821
Vbeta6.14b L14483 [29] (19) ° 1..>444
M97505 [29] (30) ° <21..>243
TRBV7-7*02 (F) 7q34 + + Vbeta6.7 X57607 [24] (41) #c 4..288
TRBV7-8 TRBV7-8*01 F 7q34 + + 344501-350000 (36) Vbeta.ATL12-2 MAP M11953 [3] 21..543 V7-8 MAP L36092 [11] (37) 346720..347242
U66060 [11] (37) 89202..89724
AF009663 [38] 91363..91887
TRBV7-8*02 F 7q34 + + Vbeta6.3 MAP X61441 [4] 303..825
TRBV7-8*03 (F) 7q34 + + Vbeta6.3 MAP M27384 [27] (41) #c 25..312
TRBV7-9 TRBV7-9*01 F 7q34 + + 360001-367500 V7-9 MAP L36092 [11] (37) 364137..364648 U66060 [11] (37) AF009661 [38] 3846..4357
BV6S4 MAP U03115 [8] <1..297
Vbeta6.9 X64741 [37] (32) ° <1..>183
TRBV7-9*02 (F) 7q34 + + M15564 [36] (41) #c 88..377
TRBV7-9*03 F 7q34 + + AF009663 [38] 108780..109292
TRBV7-9*04 (F) 7q34 + + ph22 M14261 [10] (41) #c 58..342
TRBV7-9*05 (F) 7q34 + + Vbeta6.5 MAP M27385 [27] (41) #c 34..321
TRBV7-9*06 (F) 7q34 + + Vbeta6.5 MAP X74844 [26] (41) #c 100..387
TRBV7-9*07 (F) 7q34 + + L14854 [31] (41) #c <1..203
TRBV8 TRBV8-1 TRBV8-1*01 P (9) 7q34 - - 170001-180000 V8-1 MAP (9) L36092 [11] (37) >173315..173643 (9) U66059 [11] (37) AF009660 [38] >13455..13781
TRBV8-1*02 P (9) 7q34 - - 170001-180000 MAP (9) IMGT000021 (37) >127286..127572
TRBV8-2 TRBV8-2*01 P (10) 7q34 - - 200001-202000 V8-2 MAP L36092 [11] (37) 200895..201394 U66059 [11] (37) AF009660 [38] 41009..41508
TRBV8-2*02 P (10) 7q34 - - 200001-202000 MAP (9) IMGT000021 (37) 154842..155341
TRBV9 TRBV9 TRBV9*01 F 7q34 + + + 205501-210000 V9 MAP L36092 [11] (37) 206647..207160 U66059 [11] (37)
TRBV9*02 F 7q34 + + AF009660 [38] 46760..47273 IMGT000021 160593..161106
TRBV9*03 (F) 7q34 + + Vbeta1.1 MAP M27380 [27] (41) #c 31..312
TRBV10 TRBV10-1 TRBV10-1*01 F 7q34 + + 210001-219000 (36) V10-1 MAP L36092 [11] (37) 214638..215126 U66059 [11] (37) BV12S4 MAP U17050 [16] <1..406
L26230 [12] (19) ° <1..>365
TRBV10-1*02 F 7q34 + + AF009660 [38] 54750..55238 IMGT000021 168583..169071
TRBV10-1*03 [P] (11) 7q34 + BV12S4 MAP U17051 [16] ° <1..>215
TRBV10-2 TRBV10-2*01 F 7q34 + + 234001-244000 (36) V10-2 MAP L36092 [11] (37) 239704..240192 U66059 [11] (37) BV12S3 MAP U17049 [16] <1..406
TRBV10-2*02 [F] 7q34 + BV12S3 MAP U17048 [16] ° <1..217
TRBV10-2*03 F 7q34 + MAP IMGT000021 193671..194159
TRBV10-3 TRBV10-3*01 F 7q34 + + + 375001-384500 (36) BV12S2 MAP U03115 [8] 14717..15206 V10-3 MAP L36092 [11] (37) 379068..379556
U66060 [11] (37) 121550..122038
AF009661 [38] 18787..19275
AF009663 [38] 123740..124227
MAP IMGT000021 312891..313380
Vbeta12.2 L33100 [32] (23) ° <1..>273
TRBV10-3*02 F 7q34 + + + BV12S2 MAP U17047 [16] <1..406
TRBV10-3*03 [F] 7q34 + Vbeta12.2 L33101 [32] ° <1..>273
TRBV10-3*04 [F] 7q34 + Vbeta12.2 L33102 [32] ° <1..>273
TRBV11 TRBV11-1 TRBV11-1*01 F 7q34 + + 219001-226000 (36) V21.1 MAP M33233 [13] 589..1074 V11-1 MAP L36092 [11] (37) 222397..222882
U66059 [11] (37) 222397..222882
MAP IMGT000021 [11] 176344..176829
TRBV11-2 TRBV11-2*01 F 7q34 + + + 244001-255200 V11-2 MAP L36092 [11] (37) 248664..249141 U66059 [11] (37)
TRBV11-2*02 [F] 7q34 + V21.3 MAP M33235 [13] ° 22..>455
TRBV11-2*03 (F) 7q34 + + + 244001-255200 IMGT000021 202611..203088 Vbetaw21 X58796 [23] #c 81..365
TRBV11-3 TRBV11-3*01 F 7q34 + + 384501-393000 (36) V21.2 MAP U03115 [8] (35) 25365..25841 BV21S2 MAP
V11-3 MAP L36092 [11] (37) 389716..390192
U66060 [11] (37) 132198..132674
AF009661 [38] 29432..29908
AF009663 [38] 134386..134862
TRBV11-3*02 (F) 7q34 + + Vbetaw21 X58797 [23] (41) #c 103..>387
TRBV11-3*03 (F) 7q34 + + Vbeta21 M62377 [19] (41) #c <1..>269 MAP IMGT000021 323536..324012
TRBV11-3*04 (F) 7q34 + + Vbeta21.4a AB305924 [37,47] (41) #c 87..375 AB305822 [37,47] (39)(41) #c 79..366
TRBV12 TRBV12-1 TRBV12-1*01 P (11) 7q34 - - 226001-234000 (36) v-beta8.4 X07224 [7] 225..706 V12-1 MAP L36092 [11] (37) 229930-230372
U66059 [11] (37) 229930..230411
MAP IMGT000021 183879..184360
TRBV12-2 TRBV12-2*01 P (11) 7q34 + - 255201-260000 (36) V-beta8.5 X06936 [7] V12-2 MAP L36092 [11] (37) 255591..256072
U66059 [11] (37) 241..722
AF009663 [38] 255591..256072
MAP IMGT000021 209538..210019
TRBV12-3 TRBV12-3*01 F 7q34 + + + 393001-397000 (36) v-beta8.1 X07192 [7] 269..754 BV8S1 MAP U03115 [8] 30967..31452
V12-3 MAP L36092 [11] (37) 395318..395803
U66060 [11] (37) 137800..138285
AF009661 [38] 35019..35504
MAP IMGT000021 329140..329625
TRBV12-4 TRBV12-4*01 F 7q34 + + + 397001-405000 (36) VbetaM3-2 MAP K02546 [6] 1..486 v-beta8.2 X07222 [7] 266..752
BV8S2 MAP U03115 [8] 34290..34775
V12-4 MAP L36092 [11] (37) 398641..399126
U66060 [11] (37) 141123..141608
MAP IMGT000021 332454..332940
TRBV12-4*02 (F) 7q34 + + ph8 M14264 [10] (41) #c 58..345
TRBV12-5 TRBV12-5*01 F 7q34 - + 405001-419000 (36) v-beta8.3 X07223 [7] 235..720 BV8S3 MAP U03115 [8] 51481..51966
V12-5 MAP L36092 [11] (37) 415832..416317
U66060 [11] (37) 158314..158799
MAP IMGT000021 349636..350121
TRBV13 TRBV13 TRBV13*01 F 7q34 + + 367501-375000 (36) BV23S1 MAP U03115 [8] 6305..6828 V13 MAP L36092 [11] (37) 370656..371179
U66060 [11] (37) 113138..113661
AF009661 [38] 10365..10887
AF009663 [38] 115299..115821
Vbeta23 U96844 [43] (31) 161..>659
MAP IMGT000021 304464..304986
TRBV13*02 (F) 7q34 + + Vbeta22 M62378 [19] (41) #c 128..409
TRBV14 TRBV14 TRBV14*01 F 7q34 + + + 419001-423500 (36) Vbeta16 MAP X06154 [9] 140..611 BV16S1 MAP U03115 [8] 58424..58895
V14 MAP L36092 [11] (37) 422775..423246
U66060 [11] (37) 165257..165728
TRBV14*02 (F) 7q34 + + Vbeta16b X57722 [24] (41) #g 46..330
TRBV15 TRBV15 TRBV15*01 F 7q34 + + 423501-430000 (36) BV24S1 MAP U03115 [8] 63499..64006 V15 MAP L36092 [11] (37) 427850..428357
U66060 [11] (37) 170332..170839
TRBV15*02 (F) 7q34 + + 423501-430000 IMGT000021 361660..362167 Vbetaw24 X58800 [23] (41) #c 85..366
TRBV15*03 (F) 7q34 + + Vbeta24 M62376 [19] (41) #c 135..416
TRBV16 TRBV16 TRBV16*01 F 7q34 + + BV25S1 MAP L26231 [12] 255..747 MAP IMGT000021 366671..367163
TRBV16*02 P (11) 7q34 - + 430001-435000 (36) BV25S1 MAP U03115 [8] 68508..69000 V16 MAP L36092 [11] (37) 432859..433351
U66060 [11] (37) 175341..175833
TRBV16*03 (F) 7q34 + + L26054 [33] (41) #c 58..342
TRBV17 TRBV17 TRBV17*01 ORF (13) 7q34 - - 435001-445000 (36) BV26S1 MAP U03115 [8] 72124..72897 V17 MAP L36092 [11] (37) 436475..437248
U66060 [11] (37) 178957..179730
TRBV17*02 ORF (13) 7q34 - - 435001-445000 (36) MAP IMGT000021 370283..371054
TRBV18 TRBV18 TRBV18*01 F 7q34 + + + 445001-452700 V18 MAP L36092 [11] (37) 450546..451203 U66060 [11] (37)
MAP IMGT000021 384452..385109
TRBV19 TRBV19 TRBV19*01 F 7q34 + + + 452701-458000 V19 MAP L36092 [11] (37) 453806..454320 U66060 [11] (37)
U66061 [11] (37)
MAP IMGT000021 387712..388226
TRBV19*02 F 7q34 + + BV17S1 U48259 [17] 50..564 BV17S1 U48260 [17] 50..564
TRBV19*03 (F) 7q34 + + Vbeta17.1 M97725 [34] (41) #c 58..338
TRBV20 TRBV20-1 TRBV20-1*01 F 7q34 + + + 458001-467000 (36) Vbeta.MT1-1 MAP M11955 [3] 47..758 V20-1 MAP L36092 [11] (37) 461476..462187
U66060 [11] (37) 203958..204669
U66061 [11] (37) 9153..9864
TRBV20-1*02 F 7q34 + + BV2S1 X72719 [2] 1..>668
TRBV20-1*03 (F) 7q34 + + Vbeta.MT1-1 MAP M11954 [3] (41) #g 427..714
TRBV20-1*04 (F) 7q34 + + ph34 M14263 [10] (41) #c 46..336
TRBV20-1*05 (F) 7q34 + + Vbeta2.1b X57604 [24] #g 396..>686
TRBV20-1*06 (F) 7q34 + + Vbeta2.3a D13088 [30] (41) #c 43..330
TRBV20-1*07 (F) 7q34 + + Vbeta2.1 MAP X74852 [26] (41) #c 64..354
TRBV21 TRBV21-1 TRBV21-1*01 P (12) 7q34 + + 467001-474000 V21-1 MAP L36092 [11] (37) 471659..472158 U66060 [11] (37) BV10 L27608 [18] <1..>377
V10S1 L48728 [39] 219..718
U66061 [11] (37) BV10 L27608 [18] <1..>377
V10S1 L48728 [39] 219..718
TRBV21-1*02 P (12) 7q34 + + 467001-474000 MAP IMGT000021 405579..406078
TRBV22 TRBV22-1 TRBV22-1*01 P (10) 7q34 - - 474001-478500 V22 MAP L36092 [11] (37) 476480..476969 U66061 [11] (37) MAP IMGT000021 410401..410890
TRBV23 TRBV23-1 TRBV23-1*01 ORF (4) 7q34 + + 478501-485000 V23 MAP L36092 [11] (37) 480699..481234 U66061 [11] (37) L48730 [39] 125..665
BV19 L27614 [18] (21) ° <1..>267
MAP IMGT000021 414616..415161
TRBV24 TRBV24-1 TRBV24-1*01 F 7q34 + + 485001-497500 (36) Vbeta.ATL2-1 MAP M11951 [3] 1..515 BV15 L27612 [18] <1..>397
V24-1 MAP L36092 [11] (37) 490040..490555
U66061 [11] (37) 37717..38232
TRBV24-1*02 F 7q34 + + 485001-497500 (36) MAP IMGT000021 425392..425907
TRBV25 TRBV25-1 TRBV25-1*01 F 7q34 + + + 497501-510000 V25-1 MAP L36092 [11] (37) 504415..504921 U66061 [11] (37) BV11 L27610 [18] <1..>393
IMGT000021 439432..439938
TRBV26 TRBV26 TRBV26*01 P (14) 7q34 - - 522001-537500 V26 MAP L36092 [11] (37) 529336..529859 U66061 [11] (37) IMGT000021 464354..464877
TRBV27 TRBV27 TRBV27*01 F 7q34 + + + 547201-552000 V27 MAP L36092 [11] (37) 549038..549549 U66061 [11] (37) IMGT000021 484044..484555
TRBV28 TRBV28 TRBV28*01 F 7q34 + + + 552001-565000 (36) V3S1 U08314 [42] 214..733 V28 MAP L36092 [11] (37) 554328-554808
U66061 [11] (37) 102005..102524
Vbeta2 MAP M18464 [37] (24) ° 29..>270
IMGT000021 489335..489854
TRBV29 TRBV29-1 TRBV29-1*01 F 7q34 + + 565001-579000 V29-1 MAP L36092 [11] (37) 573946..574598 U66061 [11] (37) VB4 L27623 [18] (22) ° <1..>299
IMGT000021 508928..509588
TRBV29-1*02 (F) 7q34 + + Vbeta4 MAP M13847 [22] #c 17..304
TRBV29-1*03 (F) 7q34 + + Vbeta4.3 X04926 [35] #c <1..231
TRBV30 TRBV30 (34) TRBV30*01 F 7q34 + + + 659001-684973 V30 MAP L36092 [11] (37) 667298-666920 U66061 [11] (37) IMGT000021 [11] complement(581202..581942)
TRBV30*02 F 7q34 + + + Vbeta18 Z13967 [1] 1..738
TRBV30*03 P (16) 7q34 Vbeta18 [1]
TRBV30*04 (F) 7q34 + + M13554 [28] #c <1..276
TRBV30*05 (F) 7q34 + + Vbeta20.n1 L06893 [21] #c 52..333
TRBVA TRBVA TRBVA*01 P (10) 7q34 - - 510001-522000 L36092 [11] (37) 515043..515536 U66061 [11] (37) 62720..63213
TRBVA*02 P (10) 7q34 - - 510001-522000 IMGT000021 [11] (37)(41) 450070..450563
TRBVB TRBVB TRBVB*01 P (11) 7q34 - - 537501-547200 L36092 [11] (37) 545032..545579 U66061 [11] (37) 92709..93256
TRBVB*02 P (11) 7q34 - - 537501-547200 IMGT000021 [11] (37) 480039..480793
TRBVC TRBVC TRBVC*01 P (38) 7q34 + - - L36092 [11] (37)(41) complement(550560..550648) U66061 [11] (37)(41) complement(98237..98325)
TRBVC*02 P (38) 7q34 + - - IMGT000021 [11] (37)(41) complement(485567..485655)

#: Rearranged
#c: rearranged cDNA
#g: rearranged genomic DNA.
°: DNA genomic sequence, but not known as being germline or rearranged.
MAP: Mapped reference sequences.

IMGT notes:
  1. (1) STOP-CODON in L-PART1; 1st-CYS replaced by Arg in V-EXON.
  2. (2) 1st_CYS replaced by STOP-CODON in V-EXON.
  3. (3) Frameshift in V-EXON; V-HEPTAMER violates consensus.
  4. (4) GT replaced by AT in DONOR-SPLICE.
  5. (5) CONSERVED-TRP replaced by Ser in V-EXON.
  6. (6) CONSERVED-TRP replaced by Arg in V-EXON.
  7. (7) L14431 differs from TRBV7-4*01 by the nucleotide DELETION (c255>del) and (t266>del) which create a frameshift.
  8. (8) 1st_CYS replaced by Tyr in V-EXON; missing V-SPACER and V-NONAMER.
  9. (9) Frameshift in V-EXON, L-PART1 is missing.
  10. (10) Frameshift in V-EXON. Although it is not excluded that the sequence 172780-172829 in L66059, L36092 may represent a very degenerate leader peptide, it was not labeled as L-PART1 for the following reasons (i) the translated sequence is not particularly hydrophobic (ii) the sequence shows no similarity with the other TRBV L-PART1, included the one from TRBV8-2, also a pseudogene but with a clearly identified L-PART1 (iii) the DONOR-SPLICE displays a codon-start 2 instead of being a codon-start 3 (note by M.-P. Lefranc, added on 07/04/2004, following a question by V. Herle).
  11. (11) One amino acid replaced by STOP-CODON in V-EXON.
  12. (12) Frameshift in L-PART1.
  13. (13) 2nd-CYS replaced by Tyr in V-EXON.
  14. (14) STOP-CODON in L-PART1; 2nd_CYS replaced by Tyr in V-EXON.
  15. (15) 2nd_CYS replaced by Arg in V-EXON.
  16. (16) Arg replaced by STOP-CODON in V-EXON.
  17. (17) V-GENE is partial: partial L-PART1, no V-HEPTAMER, no V-NONAMER and V-REGION is partial: AA 100 to 108 are absent (partial FR3-IMGT and no CDR3-IMGT).
  18. (18) V-GENE is partial: partial L-PART1, no V-HEPTAMER, no V-NONAMER and V-REGION is partial: AA 21 to 108 are absent (partial FR1-IMGT, no CDR1-IMGT, no FR2-IMGT, no CDR2-IMGT, no FR3-IMGT, no CDR3-IMGT).
  19. (19) V-GENE is partial: no L-PART1, no V-HEPTAMER, no V-NONAMER and V-REGION is partial: AA 100 to 108 are absent (partial FR3-IMGT and no CDR3-IMGT).
  20. (20) V-GENE is partial: no L-PART1, no V-HEPTAMER, no V-NONAMER and V-REGION is partial: AA 92 to 108 are absent (partial FR3-IMGT and no CDR3-IMGT).
  21. (21) V-GENE is partial: no L-PART1, no V-HEPTAMER, no V-NONAMER and V-REGION is partial: AA 90 to 108 are absent (partial FR3-IMGT and no CDR3-IMGT).
  22. (22) V-GENE is partial: no L-PART1, no V-HEPTAMER, no V-NONAMER and V-REGION is partial: AA 99 to 108 are absent (partial FR3-IMGT and no CDR3-IMGT).
  23. (23) V-REGION is partial: AA 105 to 108 are absent (no CDR3-IMGT).
  24. (24) V-GENE is partial: no V-HEPTAMER, no V-NONAMER and V-REGION is partial: AA 9 to 108 are absent (partial FR1-IMGT, no CDR1-IMGT, no FR2-IMGT, no CDR2-IMGT, no FR3-IMGT, no CDR3-IMGT).
  25. (25) V-J-GENE is partial: partial L-PART1, no J-REGION.
  26. (26) V-REGION is partial: AA 1 to 24 and 106 to 108 are absent (partial FR1-IMGT, partial CDR3-IMGT). AA position 55, 83 are missing, probably typing errors.
  27. (27) V-REGION is partial: AA 1 to 24 and 106 to 108 are absent (partial FR1-IMGT, no CDR1-IMGT, no FR2-IMGT, no CDR2-IMGT, no FR3-IMGT, partial CDR3-IMGT). G position 47 is missing, ACT position 70 to 72 are missing, A position 110 inserted, GGA position 139 to 141 are missing and A position 73 replaced by G, probably typing errors.
  28. (28) V-GENE is partial: partial L-PART1, no V-HEPTAMER, no V-NONAMER and V-REGION is partial: AA 100 to 108 are absent (partial FR3-IMGT and no CDR3-IMGT).
  29. (29) V-GENE is partial: partial L-PART1, no V-HEPTAMER, no V-NONAMER and V-REGION is partial: AA 25 to 108 are absent (partial FR1-IMGT, no CDR1-IMGT, no FR2-IMGT, no CDR2-IMGT, no FR3-IMGT, no CDR3-IMGT).
  30. (30) V-GENE is partial: Partial L-PART1, no V-HEPTAMER, no V-NONAMER and V-REGION is partial: AA 24 to 108 are absent (partial FR1-IMGT, no CDR1-IMGT, no FR2-IMGT, no CDR2-IMGT, no FR3-IMGT, no CDR3-IMGT).
  31. (31) V-GENE is partial: no V-NONAMER.
  32. (32) V-REGION is partial: AA 1 to 3 and 76 to 108 are absent (partial FR1-IMGT, partial FR3-IMGT, no CDR3-IMGT).
  33. (33) V-GENE is partial: no V-HEPTAMER, no V-NONAMER and V-REGION is partial: AA 93 to 108 are absent (partial FR3-IMGT and no CDR3-IMGT).
  34. (34) In the human TRB locus, the TRBV30 gene is localized in 3' from the TRBC2 gene and is in inverted orientation of transcription. Due to its polarity opposite to the TRB D-J-C-CLUSTERs, TRBV30 rearranges by an inversional joining [11].
  35. (35) This gene was previously entered in the databases as V21.2, M33234 [13], but has been shown to contain several nucleotide errors.
  36. (36) Arbitrary limits of the DNA sequence assigned to the different TRBV genes. V-GENE positions are those in the Accession number L36092.
  37. (37) The original L36092 sequence (684973 bp) has been split in EMBL into three sequences of 267156 bp (U66059), 215422 bp (U66060) and 232650 bp (U66061), L36092 has become secondary accession number of U66059, U66060 and U66061. In IMGT, the original sequence L36092 which is fully annotated has also been kept as primary accession number, in addition to U66059, U66060 and U66061 [11].
  38. (38) The pseudogene TRBVC, originally identified by its unproductive rearrangement in the T cell line MT-1 (M11957) [46], is localized between TRBV27 and TRBV28 (E. Carillon and M.-P. Lefranc, 13/09/2013). It is truncated and only comprises the 3' end of the V-REGION and the V-RS.
  39. (39) The insertion of 1 nt in the L-PART1 of AB305822, compared to the L-PART1 of AB305924, may be due to a sequencing error.
  40. (40) The not confirmed TRBV6-2*02 (P) and TRBV6-2*03 (P) alleles were deleted (13/07/2018). M31347 (g#) (formerly TRBV6-2*02 (P)) was assigned to TRBV6-2*01 with a deletion of 1 nt 'g' (nt 147) due to a probable sequencing error in V-REGION (Assignment of rearranged cDNAs and gDNAs to germline genes: Human TRBV).
  41. (41) V-REGION positions
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Created:
07/10/1996
Last updated:
08/11/2018
Authors:
Géraldine Folch, Imène Chentli
Editor:
Chantal Ginestoux