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"+" or "-" indicates if the gene sequences have been found (+) or not been found (-) rearranged (R), transcribed (T) and/or translated into protein (Pr). Arbitrarily that information is shown on the first line of each gene when the data have been confirmed by several studies.

Functionality is shown between parentheses, (F) and (P), when the accession number refers to rearranged genomic DNA or cDNA and the corresponding germline gene has not yet been isolated.
Functionality is shown between brackets, [F] and [P], when the accession number refers to genomic DNA, but not known as being germline or rearranged.

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Although the TRDV1 gene was also found rearranged to a TRAJ gene and therefore expressed with the TRAC gene [12,13] (Assignment of rearranged cDNAs), it is considered as a TRDV gene. The first five Homo sapiens TRAV genes found rearranged, not only as expected to TRAJ but also to TRDD-TRDJ genes and with the designation TRAV/DV are reported in the Gene table: Human (Homo sapiens) TRAV. They include Homo sapiens TRAV14/DV4, TRAV29/DV5, TRAV23/DV6, TRAV36/DV7 and TRAV38-2/DV8 genes.

IMGT subgroup IMGT gene name IMGT allele name Fct Chromosomal localization R T Pr Positions in the locus IMGT/LIGM-DB reference sequences IMGT/LIGM-DB sequences from the literature
Clone names Accession numbers Positions in the sequence Secondary accession numbers Clone names Accession numbers Positions in the sequence
TRDV1 TRDV1 TRDV1*01 F 14q11.2 + + + (6) Vdelta1 M22198 [1] DV101S1 U32547 [8] (2)
AE000660 [9]
TRDV2 TRDV2 TRDV2*01 F 14q11.2 + + + (7) V2*A1 X15275 [4] (8) DV102S1 U32548 [8] (2)
X15207 [3] (1) DV102S1 U32548 [8] (2)
TRDV2*02 F 14q11.2 V2*A2 Y13426 [7] (2)
TRDV2*03 F 14q11.2 + + DV102S1 AE000661 [9] Vdelta2 X53849 [11] #c
TRDV3 TRDV3 (5) TRDV3*01 F 14q11.2 + + + V3 M23326 [2] Vdelta3 X13954 [5]
DV103S1 U32549 [8] (2,3)
M94081 [10] (4)
DV103S1 AE000661 [9] (4)
TRDV3*02 F 14q11.2 Vdelta3 X15261 [6]

#c: Rearranged cDNA.

IMGT notes:
  1. (1) These sequences overlap by 4 nucleotides including the INIT-CODON ATG.
  2. (2) V-REGION is partial.
  3. (3) The t243>c and c244>t substitutions (inversion of two nucleotides) in U32549 EMBL flat file are probably typing errors.
  4. (4) Reverse and complement V-GENE. See note (5).
  5. (5) The TRDV3 gene is localized in 3' from the TRDC gene and is in inverted orientation of transcription. Due to its polarity opposite to the TRD D-J-C-CLUSTER, TRDV3 rearranges by an inversional joining [2, 5, 6].
  6. (6) A TRDV1 antigenic determinant is recognized by the anti-A13 mAb [12].
  7. (7) A TRDV2 antigenic determinant is recognized by the anti-TiV delta2 mAb [12].
  8. (8) 5'UTR of the gene.
IMGT references:
  1. [1] Satyanarayana K. et al., Proc. Natl. Acad. Sci. USA, 85, 8166-8170 (1988). PMID: 3186718
  2. [2] Loh E.Y. et al., Proc. Natl. Acad. Sci. USA, 85, 9714-9718 (1988). PMID: 2974163
  3. [3] Dariavach P. and Lefranc M.-P., Nucleic Acids Res., 17, 4880 (1989). PMID: 2526321
  4. [4] Dariavach P. et al., FEBS Lett., 256, 185-191 (1989). PMID: 2806544
  5. [5] Hata S. et al., J. Exp. Med., 169, 41-57 (1989). PMID: 2521243
  6. [6] Takihara Y. et al., Eur. J. Immunol., 19, 571-574 (1989). PMID: 2523312
  7. [7] Zhang X.M. and Lefranc M.-P., Hum. Genet., 92, 100 (1993). PMID: 8103500
  8. [8] Boysen C. et al., Immunogenetics, 44, 121-127 (1996). PMID: 8662074
  9. [9] Boysen C. et al., Unpublished.
  10. [10] Koop B.F. et al., Unpublished.
  11. [11] Triebel F. et al., Eur. J. Immunol., 18, 2021-2027 (1988). PMID: 2975601
  12. [12] Miossec C. et al., J. Exp. Med., 171, 1171-1188 (1990). PMID: 2182762
  13. [13] Ueno T. et al., Eur. J. Immunol., 33, 2910-2916 (2003). PMID: 14515275
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