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"+" or "-" indicates if the gene sequences have been found (+) or not been found (-) transcribed (T) and/or translated into protein (Pr). Arbitrarily that information is shown on the first line of each gene when the data have been confirmed by several studies.

Functionality is shown between parentheses, (F) and (P), when the accession number refers to rearranged genomic DNA or cDNA and the corresponding germline gene has not yet been isolated.
Functionality is shown between brackets, [F] and [P], when the accession number refers to genomic DNA, but not known as being germline or rearranged.

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IMGT gene name IMGT allele name Fct Haplotypes T Pr Positions in the locus IMGT/LIGM-DB reference sequences IMGT/LIGM-DB sequences from the literature
Strain Clone names Exons Accession numbers Positions in the sequence (exons) Secondary accession numbers Strain Clone names Accession numbers Positions in the sequence (exons)
IGHA1 IGHA1*01 F cos 28.7 CH1 X51647 [9] 3-290
H+CH2 (1) X51647 [9] 428-766
CH3(including CHS) X51647 [9] 945-1336
M
IGHA1*02 F F-I 27N5 CH1 AY386696 [10] 119223-119510
H+CH2 (1) AY386696 [10] 119645-119983
CH3(including CHS) AY386696 [10] 120162-120553
M AY386696 [10] 122841-123034
IGHA2 IGHA2*01 F cos 28.7 CH1 X82108 [9] 3-302
H+CH2 (1) X82108 [9] 439-816
CH3(including CHS) X82108 [9] 996-1390
M
IGHA2*02 F F-I 27N5 CH1 AY386696 [10] 135838-136137
H+CH2 (1) AY386696 [10] 136274-136651
CH3(including CHS) AY386696 [10] 136831-137225
M AY386696 [10] 139540-139733
IGHA3 IGHA3*01 F cos 24.1 CH1 X82109 [9] 3-308
H+CH2 (1) X82109 [9] 440-796
CH3(including CHS) X82109 [9] 977-1371
M
IGHA4 IGHA4*01 F ph 12.1 CH1 X82110 [9] 3-305
H+CH2 (1) X82110 [9] 442-819
CH3(including CHS) X82110 [9] 998-1389
M
IGHA4*02 F F-I 27N5 CH1 AY386696 [10] 86059-86361
H+CH2 (1) AY386696 [10] 86498-86875
CH3(including CHS) AY386696 [10] 87055-87446
M AY386696 [10] 89577-89788
IGHA5 IGHA5*01 F cos 21.1 CH1 X82111 [9] 3-308
H+CH2 (1) X82111 [9] 439-816
CH3(including CHS) X82111 [9] 996-1387
M
IGHA5*02 F C/E CH1 AF090367 [7] (3) 3-305
H+CH2 (1) AF090367 [7] (7) 436-585
CH3(including CHS)
M
IGHA5*03 F F-I 27N5 CH1 AY386696 [10] 103798-104100
H+CH2 (1) AY386696 [10] 104231-104608
CH3(including CHS) AY386696 [10] 104787-105178
M AY386696 [10] 107245-107438
IGHA6 IGHA6*01 F cos 21.1 CH1 X82112 [9] 3-305
H+CH2 (1) X82112 [9] 443-820
CH3(including CHS) X82112 [9] 997-1388
M
IGHA7 IGHA7*01 F cos 13.2 CH1 X82113 [9] 3-317
H+CH2 (1) X82113 [9] 456-794
CH3(including CHS) X82113 [9] 973-1364
M
IGHA8 IGHA8*01 F ph 1.1 CH1 X82114 [9] 3-317
H+CH2 (1) X82114 [9] 456-827
CH3(including CHS) X82114 [9] 1006-1400
M
IGHA9 IGHA9*01 F ph 1.1 CH1 X82115 [9] 3-299
H+CH2 (1) X82115 [9] 437-775
CH3(including CHS) X82115 [9] 957-1351
M
IGHA10 IGHA10*01 F ph 160.1 CH1 X82116 [9] 3-305
H+CH2 (1) X82116 [9] 450-797
CH3(including CHS) X82116 [9] 979-1370
M
IGHA11 IGHA11*01 F ph 160.1 CH1 X82117 [9] 3-317
H+CH2 (1) X82117 [9] 457-795
CH3(including CHS) X82117 [9] 974-1365
M
IGHA12 IGHA12*01 F ph 13.1 CH1 X82118 [9] 3-290
H+CH2 (1) X82118 [9] 431-757
CH3(including CHS) X82118 [9] 937-1328
M
IGHA13 IGHA13*01 F ph 23a CH1 X82119 [9] 1-257
H+CH2 (1) X82119 [9] 396-761
CH3(including CHS) X82119 [9] 940-1331
M
IGHA13*02 F CH1 X00353 [5] (3) c 1-138
H+CH2 (1) X00353 [5] 139-504
CH3(including CHS) X00353 [5] 505-897
M
IGHA14 IGHA14*01 F E CH1 AF314407 [8] (3) 1-102
H+CH2 (1) AF314407 [8] (7) 219-318
CH3(including CHS)
M
IGHG IGHG*01 F 39-1a; 20b CH1 L29172 [6] 182-466 39-1a; 20b N00008 [6] 182-466
H L29172 [6] 672-704 39-1a; 20b N00008 [6] 672-704
CH2 L29172 [6] 798-1127 39-1a; 20b N00008 [6] 798-1127
CH3(including CHS) L29172 [6] 1220-1539 39-1a; 20b N00008 [6] 1220-1539
M1
M2
IGHG*02 F F-I p-gamma-B1-12,14 CH1 K00752 [3] c 238-522
H K00752 [3] c 523-555
CH2 K00752 [3] c 556-885
CH3(including CHS) K00752 [3] c 886-1206
M1
M2
IGHG*03 F CH1
H
CH2 J00665 [1] (4) c 1-219
CH3(including CHS) J00665 [1] c 220-540
M1
M2
IGHG*04 F CH1 M16426 [2] (3) c 1-24
H M16426 [2] c 25-57
CH2 M16426 [2] c 58-387
CH3(including CHS) M16426 [2] (5) c 388-537
M1
M2
IGHG*05 F F-I 27N5 CH1 AY386696 [10] 55582-55866
H AY386696 [10] 56071-56103
CH2 AY386696 [10] 56201-56530
CH3(including CHS) AY386696 [10] 56623-56942
M1 AY386696 [10] 58984-59114
M2 AY386696 [10] 59205-59285
IGHE IGHE*01 F F-I 27N5 CH1 AY386696 [10] 69246-69545
CH2 AY386696 [10] 69716-70039
CH3 AY386696 [10] 70132-70452
CH4(including CHS) AY386696 [10] 70532-70869
M1 AY386696 [10] 73064-73197
M2 AY386696 [10] 73292-73372
IGHM IGHM*01 F F-I p-mu-3 CH1 J00666 [4] c 473-790
CH2 J00666 [4] c 791-1135
CH3 J00666 [4] c 1136-1453
CH4(including CHS) J00666 [4] c 1454-1846 p-mu-3 K01357 [4] (10) c 1-282
M1 K01357 [4] c 283-399
M2 K01357 [4] c 400-405
IGHM*02 F F-I 219D23 CH1 AY386695 [10] 106867-107184 27N5 AY386696 [10] 3302-3619
CH2 AY386695 [10] 107290-107634 27N5 AY386696 [10] 3725-4069
CH3 AY386695 [10] 107863-108180 27N5 AY386696 [10] 4298-4615
CH4(including CHS) AY386695 [10] 108269-108660 27N5 AY386696 [10] 4704-5095
M1 AY386695 [10] 110499-110614 27N5 AY386696 [10] 6934-7049
M2 AY386695 [10] 110741-110746 27N5 AY386696 [10] 7176-7181

#c: rearranged cDNA sequence.

IMGT notes:
  1. (1) In the IGHA gene, the hinge (H) and the CH2 are joined in a single exon.
  2. (2) The IGHE gene is located between the unique IGHG gene and the IGHA4 gene [8].
  3. (3) Partial C-REGION: partial CH1 in 5'.
  4. (4) Partial C-REGION: partial CH2 in 5'.
  5. (5) Partial C-REGION: partial CH3 in 3'.
  6. (6) The e14 and e15 serological markers e14 and e15 are correlated with an Ala-Thr change at position 309 which corresponds to position CH2 79 in the IMGT exon numbering and CH2 92 in the IMGT unique numbering for C-DOMAINrespectively: e14 Thr 79 (CH2), e15 Ala 79 (CH2).
  7. (7) Partial C-REGION: partial CH2 in 3'.
  8. (8) From the rabbit IGH serological C which has the IGHA f72g74 allotypes [6].
  9. (9) From the rabbit IGH serological E which has the IGHA f71g75 allotypes [6].
  10. (10) Partial C-REGION: partial CH4 in 5'.
IMGT references:
  1. [1] Heidmann O. et al., Nucleic Acids Res., 10, 1535-1545 (1982). PMID: 6280149
  2. [2] Martens C.L. et al., Proc. Natl. Acad. Sci. U.S.A., 79, 6018-6022 (1982). PMID: 6193512
  3. [3] Bernstein K.E. et al., Immunogenetics, 18, 387-397 (1983). PMID: 6313520
  4. [4] Bernstein K.E. et al., J. Immunol., 132, 490-495 (1984). PMID: 6418803
  5. [5] Knight K.L. et al., Nucleic Acids Res., 12, 1657-1670 (1984). PMID: 6322114
  6. [6] Martens C.L. et al., J. Immunol., 133, 1022-1027 (1984). PMID: 6330199
  7. [7] Kingzette M. et al., Proc. Natl. Acad. Sci. U.S.A., 95, 11840-11845 (1998). PMID: 8642322
  8. [8] Volgina V.V. et al., J. Immunol., 165, 6400-6405 (2000). PMID: 11086078
  9. [9] Knight K.L., Unpublished.
  10. [10] Ros F. et al., Gene, 330, 49-59 (2004). PMID: 15087123
See also (IMGT Scientific chart):